Clinical trials: Chronic Hypertension
Atrial Fibrillation, Hypertension
Graz Study on the Risk of Atrial Fibrillation
Atrial fibrillation (AF) is the most common clinical arrhythmia. AF is associated with increased risk for stroke due to blood clots formed in the fibrillating atria.
- Conditions
- Atrial Fibrillation, Hypertension, Diabetes, Chronic Heart Failure
- Trial name
- GRAF (NCT01461434)
- Testing
- Medtronic Reveal XT implantable loop recorder
- Where
- Austria
- Volunteers
- 82 people
- Sponsor
- Medical University of Graz
Pulmonary Vascular Disorder, Pulmonary Artery Hypertension
HA Residents With PVD, Pulmonary Artery Pressure (PAP) Assessed at HA (2840m) With and Without Supplemental Oxygen Therapy (SOT)
To study the effect of SOT in patients with pulmonary vascular diseases (PVD) defined as pulmonary arterial hypertension or chronic thromboembolic pulmonary hypertension (PH) who permanently live >2500m on pulmonary artery…
- Conditions
- Pulmonary Vascular Disorder, Pulmonary Artery Hypertension, Chronic Thromboembolic Pulmonary Hypertension
- Trial name
- NCT06084559
- Testing
- Supplemental oxygen therapy
- Where
- Switzerland
- Volunteers
- 24 people
- Sponsor
- University of Zurich
Splenomegaly; Congestive, Chronic, Panhematopenia; Splenic
Ultrasound Guided Microwave Ablation of Splenomegaly in Children
Children with liver cirrhosis frequently develops portal hypertension. One of the serious complications to portal hypertension is splenomegaly, which may result in pancytopenia, especially thrombocytopenia that may cause bleeding…
- Conditions
- Splenomegaly; Congestive, Chronic, Panhematopenia; Splenic, Portal Hypertension
- Trial name
- NCT05050994
- Testing
- Microwave ablation
- Where
- Sweden
- Volunteers
- 10 people
- Sponsor
- Karolinska Institutet
Hypertension in Pregnancy, Gestational Hypertension
Virtual Cardiac Wellness Program Following Hypertensive Disorders of Pregnancy
Hypertensive disorders of pregnancy (HDP) are now well-recognized risk factors for adverse outcomes in the postpartum period and for development of future cardiovascular disease (CVD).
- Conditions
- Hypertension in Pregnancy, Gestational Hypertension, Preeclampsia, Chronic Hypertension With Pre-Eclampsia
- Trial name
- NCT04998942
- Testing
- virtual cardiac wellness program
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
Hypertension and Chronic Heart Failure
Safety, Tolerability, Pharmacokinetic, Including Food Interaction, and Pharmacodynamic Profile of BIA 5-1058.
The purpose of this study is to to assess the safety and tolerability of BIA 5 1058 after single and multiple oral doses
- Trial name
- NCT02151994
- Testing
- BIA 5-1058
- Where
- Netherlands
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Bial - Portela C S.A.
Asthma, Pulmonary Disease, Chronic Obstructive
Understanding and Appraising the New Medicine Service in England
About 25% medicines prescribed for long term conditions are not taken as directed, and approximately 15% people receiving a new medicine take few, if any, doses.
- Conditions
- Asthma, Pulmonary Disease, Chronic Obstructive, Diabetes Mellitus, Type 2, Hypertension
- Trial name
- NMS (NCT01635361)
- Testing
- New Medicine Service
- Where
- 4 sites in United Kingdom
- Volunteers
- 504 people
- Sponsor
- University of Nottingham
Chronic Kidney Disease, Diet Interventions
Dine and DASH Into Wellness Pilot Study
The purpose of this study is to determine the feasibility and acceptability of a16-week diet coaching program enhanced with cooking classes to improve adherence to the Dietary Approaches to Stop Hypertension (DASH) diet among…
- Conditions
- Chronic Kidney Disease, Diet Interventions, Disease Prevention
- Trial name
- NCT07175896
- Testing
- Immediate delivery of low-sodium DASH (Dietary Approaches to Stop Hypertension) diet group coaching plus hand-on cooking program, Delayed delivery of low-sodium DASH (Dietary Approaches to Stop Hypertension) diet group coaching plus hand-on cooking program
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Duke University
Hypertension, Chronic Kidney Diseases
Primary Care CKD Registry
This study examines whether a safety-net primary care CKD registry directed at the entire primary care team can enhance the delivery of guideline concordant CKD care, including BP control, ACEi/ARB use and albuminuria…
- Trial name
- NCT03473509
- Testing
- CKD Registry
- Volunteers
- 746 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Atrial Fibrillation (AF), Hypertension
Integrated Approach in Frail Older People with Atrial Fibrillation
The study will verify if a structured multidisciplinary approach (called iABC), aimed to improve the appropriate management of elderly AF patients with multimorbidity (the i-ABC group), would provide a clear evidence of an…
- Conditions
- Atrial Fibrillation (AF), Hypertension, Coronary Arterial Disease (CAD), Heart Failure
- Trial name
- AFFIRMO (NCT06775028)
- Testing
- iABC platform use
- Where
- 50 sites in Bulgaria, Denmark and 4 more
- Volunteers
- 1,250 people
- Sponsor
- Heart Care Foundation
Chronic Obstructive Pulmonary Disease, Pulmonary Artery Hypertension
: Vascular Function in Health and Disease
Many control mechanisms exist which successfully match the supply of blood with the metabolic demand of various tissues under wide-ranging conditions.
- Conditions
- Chronic Obstructive Pulmonary Disease, Pulmonary Artery Hypertension, Heart Failure, Hypertension
- Trial name
- NCT02966665
- Testing
- Maximum Exercise Tests, BH4, L-NMMA, Vitamin C, Vitamin E, α-Lipoic Acid and L-Ascorbate, BQ-123
- Where
- United States
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- D. Walter Wray
Arterial Hypertension
Acute and Chronic Responses to Blood Pressure After Exercise
The study will evaluate the variability of blood pressure in postmenopausal and hypertensive women after only one session and after training of ten weeks of combined physical exercises (aerobic and resisted).
- Trial name
- NCT03160989
- Testing
- physical exercises
- Volunteers
- 14 people
- Sponsor
- Federal University of Uberlandia
Myocardial Infarction, Decompensated Chronic Heart Failure
Pre-discharge Influenza Vaccination in Patients Hospitalized for Acute Cardiac Conditions
Patients hospitalized for acute cardiac conditions-including acute myocardial infarction, acute heart failure, pulmonary embolism, arrhythmias, and hypertensive emergencies-represent a heterogeneous population at very high risk…
- Conditions
- Myocardial Infarction, Decompensated Chronic Heart Failure, Acute Heart Failure (AHF), Pulmonary Embolism Acute
- Trial name
- NCT07617376
- Testing
- Influenza vaccination
- Where
- Poland
- Volunteers
- 400 people
- Sponsor
- Wroclaw Medical University
Chronic Kidney Disease, Diabetic Kidney Disease
"Residual Kidney Function and Oxidative Stress in Incremental vs Standard Peritoneal Dialysis (2 Mexican Centers)"
Title: Comparison of Oxidative Stress and Preservation of Residual Kidney Function Between Incremental and Standard Peritoneal Dialysis in Incident Patients at the Regional General Hospital No.
- Conditions
- Chronic Kidney Disease, Diabetic Kidney Disease, Peritoneal Dialysis (PD), Hypertension
- Trial name
- INSPiRE (NCT07338435)
- Testing
- Standard Peritoneal Dialysis, Incremental Peritonal Dialysis
- Where
- Mexico
- Volunteers
- 100 people
- Sponsor
- Instituto Mexicano del Seguro Social
Pulmonary Vascular Disease, Pulmonary Artery Hypertension
HA Residents With PVD, SDB Assessed at HA (2840m) vs LA (Sea Level)
To study the effect of relocation from 2840m (Quito) to sea level (Pedernales) in patients with pulmonary vascular diseases (PVD) defined as pulmonary arterial hypertension or chronic thromboembolic pulmonary hypertension (PH)…
- Conditions
- Pulmonary Vascular Disease, Pulmonary Artery Hypertension, Chronic Thromboembolic Pulmonary Hypertension
- Trial name
- NCT06072417
- Testing
- Assessment without intervention at High altitude, Relocation to sea level for 2 days
- Where
- Switzerland
- Volunteers
- 24 people
- Sponsor
- University of Zurich
Chronic Kidney Disease and Hypertension
A Phase IIb Study to Evaluate the Effect of Dapagliflozin in Combination With Baxdrostat Compared With Baxdrostat on Albuminuria in Participants With Chronic Kidney Disease and High Blood Pressure.
International, Multicenter and Double-Blind study. The purpose is to measure the effect of baxdrostat in combination with dapagliflozin compared with baxdrostat/placebo on albuminuria, as well as safety, in participants with…
- Trial name
- BaxDuo-Baltic (NCT07222917)
- Testing
- Baxdrostat/dapagliflozin
- Where
- 55 sites in United States, Argentina and 7 more
- Volunteers
- 222 people
- Sponsor
- AstraZeneca
Hypertension, Pulmonary, Hypertension;Pulmonary;Primary
Endtidal Carbon Dioxide for Earlier Detection of Pulmonary Hypertension
Measurement of the endtidal carbon dioxide by capnography to exclude or to ensure the diagnosis pulmonary hypertension. The aim of the study is to obtain an endtidal carbon dioxide cut-off value for the diagnostic algorithm for…
- Conditions
- Hypertension, Pulmonary, Hypertension;Pulmonary;Primary, Chronic Thromboembolic Pulmonary Hypertension, Vascular Diseases
- Trial name
- EARLIER (NCT03388476)
- Testing
- Capnography
- Where
- Germany
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Giessen
Type 2 Diabetes, Hypertension
iCaReMe Global Registry: Multinational Real-world Evidence in Cardiorenal and Metabolic Diseases
To provide real world data on patient characteristics, disease management, healthcare utilization, and outcomes in patients with type 2 diabetes, Hypertension, Heart failure and/or Chronic kidney diseases
- Conditions
- Type 2 Diabetes, Hypertension, Chronic Kidney Disease, Heart Failure
- Trial name
- iCaReMe (NCT03549754)
- Where
- 76 sites in Brazil, Chile and 18 more
- Volunteers
- 35,000 people
- Sponsor
- AstraZeneca
Chronic Thromboembolic Pulmonary Hypertension
RV Conductance Catheter Assessment During Balloon Pulmonary Angioplasty
Balloon pulmonary angioplasty (BPA) treats patients with inoperable chronic thromboembolic pulmonary hypertension (CTEPH). Intra-procedural markers of success to guide the intervention are lacking.
- Trial name
- RVBPA (NCT04444973)
- Testing
- Balloon pulmonary angioplasty
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Papworth Hospital NHS Foundation Trust
Primary Pulmonary Arterial Hypertension, Chronic Thromboembolic Pulmonary Hypertension
Effects of Riociguat on RIght VEntricular Size and Function in PAH and CTEPH
This is an open-label, single-armed, prospective single-centre clinical study to evaluate the effect of riociguat on right heart size and function in patients with manifest PAH and CTEPH.
- Trial name
- RIVERII (NCT04954742)
- Testing
- Riociguat
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Heidelberg University
COPD (With - Without Rehabilitation), Diffuse Interstitial Lung Diseases
Development of a New Tool for Dyspnea Measurement in Chronic Respiratory Diseases
The purpose of this study is the psychometric validation of a self-administered dyspnea questionnaire, usable in clinical practice in order to assess dyspnea and its impact on patients with chronic respiratory diseases.
- Conditions
- COPD (With - Without Rehabilitation), Diffuse Interstitial Lung Diseases, Pulmonary Arterial Hypertension Primary or Secondary (Post Embolic .....), Cystic Fibrosis of the Adult
- Trial name
- DYSLIM (NCT02229994)
- Testing
- Cross sectional psychometric evaluation of a self-administered dyspnea questionnaire.
- Where
- France
- Volunteers
- 199 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
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