Clinical trials: Chronic Hypertension
Chronic Kidney Diseases, Hypertension
Chronotherapy in Children With Chronic Kidney Disease
This is a pilot, crossover trial in which the investigator will determine if retiming of one anti-hypertensive medication from morning to evening can effectuate normal blood pressure dipping patterns in children and adolescents…
- Trial name
- NCT05353335
- Testing
- Re-timing of anti-hypertensive drug, Current regimen
- Where
- United States
- Sponsor
- Yale University
Covid19 Pneumonia, Chronic Thromboembolic Pulmonary Hypertension
COVID-19 Pneumonia: Pulmonary Physiology, Health-related Quality of Life and Benefit of a Rehabilitation Program
The pathophysiological processes involved in COVID-19 pneumonia are not fully understood. Specific alterations of the airways, lung parenchyma and pulmonary vascular tree could explain a severe ventilation/perfusion heterogeneity…
- Conditions
- Covid19 Pneumonia, Chronic Thromboembolic Pulmonary Hypertension, Myopathy, Restrictive Lung Disease
- Trial name
- COVISQAR (NCT04881214)
- Testing
- Pulmonary rehabilitation
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- University Hospital, Geneva
Chronic Myeloid Leukemia
Pulmonary Vasculopathy Under Second-line Therapy of Chronic Myeloid Leukemia
Chronic myelogenous leukemia (CML) is a chronic myeloproliferative disorder characterized by a translocation between chromosome 9 and 22, leading to a pathogenic tyrosine kinase signal transduction protein.
- Trial name
- NCT01805843
- Testing
- Echo, exercise echo, and if indicated, right heart catheter
- Where
- Austria
- Volunteers
- 16 people
- Sponsor
- Medical University of Graz
Hypertension, Cardiovascular Disease
Detecting and Treating High Blood Pressure in Aboriginal Population and Low and Middle Income Countries
Heart disease and stroke are the number one killers world-wide. When someone has hypertension, the constantly elevated blood pressure damages their blood vessels and the organs that they supply blood to.
- Conditions
- Hypertension, Cardiovascular Disease, Diabetes
- Trial name
- DREAM-GLOBAL (NCT02111226)
- Testing
- SMS text messaging
- Where
- Canada
- Volunteers
- 360 people
- Sponsor
- Sunnybrook Health Sciences Centre
Hypertension, Chronic Kidney Disease
Prevalence of Chronic KIdney Disease in Hypertensive Patients
Prevention of progressive renal disease needs a clear understanding of prevalence of early stage of chronic kidney disease in a community.
- Trial name
- NCT00383968
- Where
- Pakistan
- Volunteers
- 248 people
- Sponsor
- Aga Khan University
Hypertension, Chronic Kidney Disease
Accuracy of 1.5 T Versus 3 T Magnetic Resonance Arterial Spin Labeling to Measure Renal Blood Flow
In this study we want to compare the accuracy of two methods to measure renal perfusion by MRI spin labelling technique: the first measurement done with the 1.5 T MRI versus the second one obtained with the 3.0 T MRI (Siemens MRI…
- Trial name
- NCT02746549
- Testing
- renal perfusion
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Chronic Kidney Diseases, Hypertension
CENtral Blood Pressure Targeting: A Pragmatic RAndomized Pilot triaL in Advanced Chronic Kidney Disease
Background: Emerging data favors aortic blood pressure (BP) over brachial cuff BP in predicting CV and renal complications, as this BP directly impacts the heart, brain and kidneys.
- Trial name
- CENTRAL-CKD (NCT05163158)
- Testing
- Central vs brachial systolic blood pressure targeting
- Where
- Canada
- Volunteers
- 116 people
- Sponsor
- Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal
Venous Thromboembolism (VTE), Chronic Thromboembolic Pulmonary Hypertension
Pulmonary Embolism Registry From Short-Term Emergency to Long-Term Follow-Up and Surveillance
PERSEUS is an academic, investigator-initiated, multicenter observational registry of adults with acute pulmonary embolism (PE), promoted by Azienda Ospedaliero-Universitaria Careggi (Florence, Italy).
- Conditions
- Venous Thromboembolism (VTE), Chronic Thromboembolic Pulmonary Hypertension, Right Ventricular Dysfunction, Pulmonary Embolism (PE)
- Trial name
- PERSEUS (NCT07855679)
- Testing
- Routine clinical care (no study intervention)
- Where
- 16 sites in Italy, Poland and 1 more
- Volunteers
- 5,000 people
- Sponsor
- Azienda Ospedaliero-Universitaria Careggi
Hypertension, CKD - Chronic Kidney Disease
The Effects of Dietary Nitrate in Patients With Hypertensive Kidney Injury
The study aims to study the effects of diatery nitrate in patients with hypertension and hypertensive kidney injury. The study is a randomized, placebo-controlled, double-blinded crossover trial.
- Trial name
- DINO-CKD (NCT07290842)
- Testing
- Beetroot Juice - Active
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Gødstrup Hospital
Heart Failure, Pulmonary Disease, Chronic Obstructive
Telehome Monitoring for Chronic Disease Management
People living in rural areas are at increased risk for poor health outcomes due to: long distance to health care facilities, less available health care resources such as primary care and specialty services, transportation…
- Conditions
- Heart Failure, Pulmonary Disease, Chronic Obstructive, Hypertension, Diabetes Mellitus
- Trial name
- NCT02035566
- Testing
- Telehome Care Monitoring
- Where
- 2 sites in United States
- Volunteers
- 23 people
- Sponsor
- University of Maryland, Baltimore
Chronic Thromboembolic Pulmonary Hypertension
Early Non-invasive Detection of CTEPH After Pulmonary Embolism
This is a prospective, international, multicenter outcome cohort study. This study starts at the moment patients visit the outpatient clinic 3 to 6 months after a diagnosis of acute PE as part of routine medical care.
- Trial name
- InShape2 (NCT02555137)
- Testing
- 'prediction score' and 'rule-out criteria'
- Where
- 5 sites in Belgium, Netherlands and 1 more
- Volunteers
- 424 people
- Sponsor
- Leiden University
Chronic Kidney Disease, Diabetes
Kidney Check: Diabetes, Blood Pressure & Kidney Health Checks & Care in Indigenous Communities.
Faced with limited access to preventative health care services, Indigenous people living in rural and remote communities are at a higher risk of Chronic Kidney Disease (CKD) and kidney failure, when compared to the general…
- Conditions
- Chronic Kidney Disease, Diabetes, Hypertension
- Trial name
- NCT03595267
- Testing
- Point-of-care screening
- Where
- 3 sites in Canada
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Chronic Thromboembolic Pulmonary Hypertension
Dyspnea in Chronic Thromboembolic Pulmonary Hypertension
Pulmonary embolism, or clots blocking the blood vessels of the lungs, is a common clinical condition requiring treatment with blood thinners. In most patients, recovery is complete.
- Trial name
- NCT03786367
- Where
- Canada
- Volunteers
- 28 people
- Sponsor
- Dr. Denis O'Donnell
Resistant Arterial Hypertension, Chronic Kidney Disease (Stage 3-4)
Safety and Efficacy of SC101 Via Perirenal Fat Injection for Resistant Hypertension in Patients With Moderate to Severe Chronic Kidney Disease
This is a single-center, open-label, exploratory clinical study designed to evaluate the safety and efficacy of a single-session injection of SC101, a small interfering RNA (siRNA) agent, into the perirenal fat.
- Trial name
- NCT07483372
- Testing
- SC101
- Where
- China
- Volunteers
- 3 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Pulmonary Arterial Hypertension (PAH) (WHO Group 1 PH), Pulmonary Hypertension (World Health Organization Group 3)
Nailfold Capillaroscopy in PH
Pulmonary hypertension (PH) is an uncommon condition and can often be difficult to diagnose. It means elevated blood pressure in the lungs which can rapidly lead to failure of the right side of the heart and is ultimately fatal.
- Conditions
- Pulmonary Arterial Hypertension (PAH) (WHO Group 1 PH), Pulmonary Hypertension (World Health Organization Group 3), Chronic Thromboembolic Pulmonary Hypertension
- Trial name
- NCT07768644
- Testing
- Standard of Care therapy
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University of Glasgow
Hypertension, Type 2 Diabetes Mellitus (T2DM)
Community-Empowerment and Environmental Enrichment-based Co-management (CEEEC) Model and Mechanisms for Improving Health of Older Stroke Patients With Multimorbidity
This study is a cluster randomized controlled trial with a 2×2 factorial design conducted in community health centers in Kunshan, Wuhan and Shanghai, China.
- Conditions
- Hypertension, Type 2 Diabetes Mellitus (T2DM), Multimorbidity, Stroke
- Trial name
- CEEEC (NCT06975501)
- Testing
- Exercise Intervention, Cognitive Intervention
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Duke Kunshan University
Hypertension, Coronary Disease
Analyzing How Genetics May Affect Response to High Blood Pressure Medications
High blood pressure is one of the most common health problems in the United States. There are many medications to treat high blood pressure, but there is a large variance in how people respond to these medications.
- Conditions
- Hypertension, Coronary Disease, Cerebrovascular Accident
- Trial name
- NCT00563901
- Where
- 2 sites in United States
- Volunteers
- 37,939 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Chronic Thromboembolic Pulmonary Hypertension
The Role of Matrix Metalloproteinase 2 and 9 Enzymes in Developing Chronic Thromboembolic Pulmonary Hypertension
Chronic thromboembolic pulmonary hypertension is an occlusive disease in pulmonary artery.Matrix metalloproteinase enzymes play a substantial role of extracellular matrix remodeling.
- Trial name
- NCT04773028
- Testing
- matrix metalloproteinase enzymes 2 and 9
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- AHMET ZENGIN
Sleep-Disordered Breathing, Chronic Thromboembolic Pulmonary Hypertension
Impact of Pulmonary Endarterectomy on Sleep-Related Breathing Disorders in CTEPH: The IPES Trial
Pulmonary hypertension (PH) has three main types, pre-capillary PH, post-capillary PH, and combined pre-capillary and post-capillary PH, and it is based on mean pulmonary arterial pressure (PAP) > 20 mmHg measured with a right…
- Conditions
- Sleep-Disordered Breathing, Chronic Thromboembolic Pulmonary Hypertension, Post Operative
- Trial name
- IPES (NCT06060366)
- Testing
- Pulmonary endarterectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Marmara University
Renal Insufficiency, Chronic, Hypertension
Chlorthalidone in Chronic Kidney Disease
It is estimated that in the United States there are approximately 8 million individuals who have moderate to severe chronic kidney disease (CKD).
- Trial name
- CLICK (NCT02841280)
- Testing
- Chlorthalidone
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Indiana University
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