Clinical trials: Chronic Hypertension
Copd, Hypertension, Pulmonary
Lung Hyperinflation and Response to Pulmonary Vasodilator Therapy
The goal of this retrospective observational study is to evaluate if lung distension disorders can be a predictive factor of bad response to vasodilator therapy in patients with pulmonary hypertension (PH) associated with chronic…
- Conditions
- Copd, Hypertension, Pulmonary, Hyperdistention
- Trial name
- NCT06613321
- Testing
- Respiratory function tests before introduction of vasodilator therapy, 3 month follow up evaluation of response to treatment.
- Where
- France
- Volunteers
- 47 people
- Sponsor
- Central Hospital, Nancy, France
Hypertension on Chronic Maintenance Hemodialysis
The Pharmacokinetics of Nifedipine Controlled Release Tablets in Hypertensive Patients on Hemodialysis
This is a prospective, open, non-randomized, non-controlled study. 20 patients with hypertension on chronic maintenance hemodialysis will be enrolled in the study.
- Trial name
- PICASSO (NCT01021501)
- Testing
- nifedipine controlled release tablets
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Guangzhou First People's Hospital
Hypertension
A Comparison of Compliance Between Clonidine Patch and Methyldopa for the Treatment of Chronic Hypertension in Pregnancy
High blood pressure (BP) before pregnancy is called chronic hypertension (CHTN), and is associated with an increased risk of development of pregnancy related high BP called preeclampsia, preterm delivery, decreased growth of the…
- Trial name
- NCT00329511
- Testing
- methyldopa vs. clonidine, clonidine patch
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Afshan B. Hameed, M.D.
Pulmonary Hypertension, Chronic Obstructive Lung Disease
Pulmonary Hemodynamics in Patients With Severe Emphysema Pre and Post BLVR
This study is designed as a prospective study, with the primary endpoint being changes in pulmonary hemodynamic parameters after ELVR in patients with severe emphysema.
- Trial name
- NCT02778802
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Cairo University
Hypertension, Chronic Heart Failure
Tolerability, Pharmacokinetics and Pharmacodynamics of Six Multiple Rising Dose Regimens of BIA 5-453
The purpose of this study is to assess the tolerability of BIA 5-453 after six multiple rising dose regimens of BIA 5-453.
- Trial name
- NCT02840565
- Testing
- BIA 5-453
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Bial - Portela C S.A.
Hypertension
Efficacy and Safety of Chronic Administration of Telmisartan as Monotherapy or in Combination With Hydrochlorothiazide or Other Antihypertensive Medications in Patients With Mild to Moderate Hypertension
The primary objective of this trial was to assess the efficacy and safety of telmisartan 80 mg during open-label, long-term treatment.
- Trial name
- NCT02177422
- Testing
- Telmisartan, Hydrochlorothiazide
- Volunteers
- 489 people
- Sponsor
- Boehringer Ingelheim
Albuminuria, Chronic Kidney Diseases
Improving Albuminuria Screening Compliance Using a Smartphone Urinalysis Kit
This study will test the effectiveness of mailed, smartphone urinalysis kits to improve albuminuria screening compliance and detection of albuminuria.
- Conditions
- Albuminuria, Chronic Kidney Diseases, Cardiovascular Diseases, Hypertension
- Trial name
- NCT03470701
- Testing
- Mailed Urinalysis Smartphone Kit
- Where
- United States
- Volunteers
- 999 people
- Sponsor
- Geisinger Clinic
Chronic Heart Failure
The IMPULSE Study: Pilot
Continuous-flow (CF) left ventricular assist devices (LVADs) are an important tool in the treatment of end-stage heart failure, affording patients significantly improved quantity and quality of life.
- Trial name
- IMPULSE (NCT02044471)
- Testing
- Remote Ischemic Conditioning (using Sphygmomanometer)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Baylor College of Medicine
Hypertension, Pregnancy-Induced
Reducing the Risk of Chronic Hypertension and Improving Vascular Function Following Preeclampsia
The long-term goal of our work is to evaluate the effect of intensive postpartum blood pressure control on maternal cardiovascular health, risk of chronic hypertension, and reversal of vascular dysfunction generated by…
- Trial name
- REPAIR (NCT06220721)
- Testing
- Nifedipine ER
- Where
- 2 sites in United States
- Volunteers
- 618 people
- Sponsor
- Medical College of Wisconsin
Hypertension, Dyslipidemias
The Effectiveness of Smart Health Management Program for Patients With Chronic Illness
This study verifies efficacy of Smart Health Management Program developed for patients with chronic illness. The aim of the study is to observe the changes in clinical indicators, quality of life and health related behaviors when…
- Conditions
- Hypertension, Dyslipidemias, Diabetes Mellitus
- Trial name
- NCT03294044
- Testing
- ICT programs, A book about chronic disease
- Where
- South Korea
- Volunteers
- 106 people
- Sponsor
- Seoul National University Hospital
Chronic Venous Hypertension With Ulcer
ActiV.A.C.+ Compression Therapy Versus Compression Therapy Alone for the Treatment of Chronic Venous Ulcerations
This is a prospective, randomized, comparative interventional human subject trial. Patients with a chronic venous ulceration of the lower extremity will be enrolled into this study.
- Trial name
- NCT01528293
- Testing
- ActiVAC System, Compression therapy
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Georgetown University
Chronic Thromboembolic Pulmonary Hypertension (CTEPH), Pulmonary Hypertension
U.S. CTEPH Registry
The U.S. CTEPH Registry is a multicenter, observational, U.S.-based study of the clinical course and treatment of patients diagnosed with chronic thromboembolic pulmonary hypertension (CTEPH), WHO Group IV Classification for…
- Trial name
- NCT02429284
- Where
- United States
- Volunteers
- 754 people
- Sponsor
- University of California, San Diego
Chronic Kidney Failure
Clinical Evaluation of Low Sodium Peritoneal Dialysis (PD) Solution on Hypertensive Patients Treated With PD
The aim of this study is to assess the superiority of the new low sodium peritoneal dialysis (PD) solution PDsol 12 in comparison with a conventional, already marketed solution, Gambrosol trio 40, in the treatment of the…
- Trial name
- PDOne (NCT00794326)
- Testing
- Solution for Peritoneal Dialysis
- Where
- 29 sites in Denmark, France and 3 more
- Volunteers
- 140 people
- Sponsor
- Fresenius Medical Care Deutschland GmbH
Hypertension, Pulmonary, Pulmonary Disease, Chronic Obstructive
Single Dose Study in Patients With Chronic Obstructive Pulmonary Disease (COPD) Associated Pulmonary Hypertension.
This study is to demonstrate the safety, tolerability, pharmakokinetic and pharmacodynamic effect of a single oral dose of BAY63-2521 in patients with pulmonary hypertension due to chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT00640315
- Testing
- Riociguat (Adempas, BAY63-2521) 1.0 mg, Riociguat (Adempas, BAY63-2521) 2.5 mg
- Where
- 7 sites in Germany
- Volunteers
- 23 people
- Sponsor
- Bayer
Chronic Thromboembolic Pulmonary Hypertension
The Prospective Risk Factor Evaluation & Discovery In CTEPH Study
This research study wants to find markers in the blood that may help to predict a patient's future risk of developing a disease called CTEPH.
- Trial name
- PREDICT PH (NCT03470207)
- Testing
- Post-pulmonary embolism follow up protocol
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Mark W. Dodson
Pulmonary Arterial Hypertension (PAH), Chronic Thromboembolic Pulmonary Hypertension (CTEPH)
What is the Role of the Exposome in Pulmonary Hypertension
Pulmonary arterial hypertension (PAH) is a rare and incurable disease affecting people of all ages. It is characterized by obstructive remodeling of the small pulmonary arteries, responsible for an increase in pulmonary arterial…
- Trial name
- EXPOSPAH (NCT07172334)
- Testing
- Questionnaires, Samples
- Where
- 10 sites in France
- Volunteers
- 150 people
- Sponsor
- Poitiers University Hospital
Multiple Conditions, Coronary Heart Disease
Improving Monitoring of Patients Receiving Case Management
The UK population is ageing and the likelihood of having a long term health condition increases with age. Three out of every five people over 60 in the UK have a long term condition.
- Conditions
- Multiple Conditions, Coronary Heart Disease, Diabetes, Hypertension
- Trial name
- NCT01597882
- Where
- 2 sites in United Kingdom
- Volunteers
- 114 people
- Sponsor
- University of Southampton
Glaucoma
A Prospective, Multicenter, Open-label, Safety and Preliminary Efficacy Study of the Surgical Implantation of OPKO's Glaucoma Drainage Device (AquashuntTM) in Patients With Refractory Chronic Forms of Open Angle Glaucoma (OAG)
A prospective, multicenter, open-label, safety and preliminary efficacy study of the surgical implantation of OPKO's glaucoma drainage device (AquashuntTM) in patients with refractory chronic forms of open angle glaucoma (OAG).
- Trial name
- NCT00834223
- Testing
- Aquashunt
- Where
- Dominican Republic
- Volunteers
- 15 people
- Sponsor
- OPKO Health, Inc.
Essential Hypertension, Liver Cancer
A Multicentre Study on Features of the Gut Microbiota of Patients With Critical Chronic Diseases in China
The human gut microbiome has been associated with many health factors but variability between studies limits the exploration of effects between them.
- Conditions
- Essential Hypertension, Liver Cancer, Nasopharyngeal Cancer, Pancreatic Cancer
- Trial name
- NCT05638269
- Testing
- no intervention
- Where
- 50 sites in China
- Volunteers
- 12,000 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Chronic Thromboembolic Pulmonary Hypertension
Bosentan Effects in Inoperable Forms of Chronic Thromboembolic Pulmonary Hypertension
The present trial investigates a possible use of oral bosentan, which is currently approved for the treatment of symptoms of pulmonary arterial hypertension (PAH), to patients suffering from inoperable chronic thromboembolic…
- Trial name
- NCT00313222
- Testing
- bosentan
- Volunteers
- 157 people
- Sponsor
- Actelion
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