Clinical trials: Chronic Hypertension
Attention Deficit Disorder With Hyperactivity, Asthma
Study of an Intervention to Improve Problem List Accuracy and Use
The aim of this study is to identify patients with problem list gaps and intervene to correct these gaps by creating clinical decision support interventions that alert providers to likely problem list gaps and offer clinicians…
- Conditions
- Attention Deficit Disorder With Hyperactivity, Asthma, COPD, Breast Cancer
- Trial name
- MAPLE (NCT01105923)
- Testing
- MAPLE
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Brigham and Women's Hospital
Hypertension, Pulmonary
Phase IV Study of Chronic Infusional Epoprostenol for Severe Primary Pulmonary Hypertension
OBJECTIVES: I. Provide epoprostenol (Flolan, prostaglandin I2) by chronic infusion to patients with severe primary pulmonary hypertension for whom no alternative therapy is available. II.
- Trial name
- NCT00004754
- Testing
- epoprostenol
- Sponsor
- National Center for Research Resources (NCRR)
High Blood Pressure, Kidney Disease, Chronic
Health Literacy 3D Kidney Model Patient Education Trial
High blood pressure has a different rate effect on many minoritized individuals. African Americans, as a result of high blood pressure, are six times more likely to go through kidney failure compared to white counterparts.
- Trial name
- NCT06683573
- Testing
- 3D Kidney model, Standard medical treatment
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Hilary L Surratt, PhD
Metabolic Syndrome, Diabetes
Evaluation of a Novel Self-Sampling Earwax Tool for Chronic Disease Biomarkers [TREARS STUDIES II]
Trears Biomarkers: A New Way to Manage Chronic Diseases Trears Biomarkers are changing how we care for chronic diseases by focusing on patients' needs.
- Conditions
- Metabolic Syndrome, Diabetes, Hypertension, Obesity and Obesity-related Medical Conditions
- Trial name
- Trears-II (NCT06932601)
- Volunteers
- 258 people
- Sponsor
- Trears
Pulmonary Hypertension
A Randomized Controlled Multicenter Trial of Exercise Training in Pulmonary Hypertension in European Countries
Chronic pulmonary hypertension (PH) is associated with impaired exercise capacity, quality of life and right ventricular function.
- Trial name
- EU-TRAIN-01 (NCT03345212)
- Testing
- Exercise training
- Where
- Germany
- Volunteers
- 129 people
- Sponsor
- Heidelberg University
Sickle Cell Disease, Chronic Kidney Disease
Hydroxyurea and Erythropoietin to Treat Sickle Cell Anemia
This study will examine the use of hydroxyurea and erythropoietin for treating sickle cell disease in patients who also have kidney disease or pulmonary hypertension (high blood pressure in the lungs).
- Conditions
- Sickle Cell Disease, Chronic Kidney Disease, Pulmonary Hypertension
- Trial name
- NCT00270478
- Testing
- Erythropoietin and Hydroxyurea
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Lung Cancer, Lung Infection
Identification of Multiple Pulmonary Diseases Using Volatile Organic Compounds Biomarkers in Human Exhaled Breath
The goal of this observational study is to develop an advanced expiratory algorithm model utilizing exhaled breath volatile organic compound (VOC) marker molecules.
- Conditions
- Lung Cancer, Lung Infection, COPD, Bronchitis
- Trial name
- NCT06528418
- Testing
- Gas chromatography-mass spectrometry(GC-MS) and micro Gas Chromatography-photoionisation detector (μGC-PID) system
- Where
- China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- ChromX Health
Chronic Respiratory Failure
Fibroblast Growth Factor 23 in Chronic Respiratory Failure
Fibroblast growth factor 23 (FGF23) is a key hormone of the mineral metabolism produced in bone and acting on the kidney to lower phosphatemia.
- Trial name
- EFIC-RES (NCT05258370)
- Testing
- Dosage, Cardiac echography
- Volunteers
- 50 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Vascular Disease
Manchester Antenatal Vascular Service
25-30% of women with preexisting vascular disease (chronic hypertension/diabetes/obesity) will develop pre-eclampsia and or growth restriction.
- Trial name
- MAViS (NCT02244385)
- Testing
- no intervention
- Where
- United Kingdom
- Volunteers
- 750 people
- Sponsor
- Manchester University NHS Foundation Trust
Chronic Kidney Diseases, High Blood Pressure
Diet and Hypertension Management in African Americans With Chronic Kidney Disease
The purpose of this study is to determine cultural and disease-related barriers and facilitators to following the Dietary Approaches to Stop Hypertension (DASH) dietary pattern among Black Americans with moderate chronic kidney…
- Trial name
- NCT04084574
- Testing
- DASH diet counseling
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Duke University
High Blood Pressure
Safety Study of Nebivolol for COPD Patients
The purpose of this study is to demonstrate the safety and effectiveness of the study drug Nebivolol, in people who suffer with high blood pressure with Chronic Obstructive Pulmonary Disease (COPD).
- Trial name
- NCT01939990
- Testing
- Nebivolol
- Where
- United States
- Sponsor
- University of Chicago
Chronic Kidney Diseases
Pioglitazone to Reduce Sympathetic Overactivity in CKD Patients
Chronic kidney disease (CKD) is associated with a higher risk of cardiovascular disease and death. An overactive sympathetic nervous system in CKD patients is one of the major mechanisms increasing the cardiovascular risks in…
- Trial name
- NCT03471117
- Testing
- Pioglitazone
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- The University of Texas at Arlington
Hypertension in Pregnancy, Hypertension in Postpartum
Is Procardia XL 60 mg Q Daily Equivalent to 30 mg XL Given Twice Daily?
Antihypertensive therapy has been used in pregnant patients antepartum to improve blood pressure (BP) elevation in cases of chronic hypertension, and postpartum for persistent hypertension after delivery in cases of gestational…
- Trial name
- NCT03595982
- Testing
- Procardia XL 30Mg, Procardia XL 60Mg
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Premature Baby, Pulmonary Hypertension of Newborn
Measuring Heart Health in Both Term, Preterm and Unwell Newborn Babies With an Advanced Ultrasound Method: Speckle Tracking Echocardiography
This study aims to improve how neonatologists check the heart function of newborn babies, especially those who are sick. While standard heart ultrasound scans are useful, a more advanced and sensitive technique called 2D speckle…
- Conditions
- Premature Baby, Pulmonary Hypertension of Newborn, Hypoxic Ischaemic Encephalopathy (HIE), Congenital Diaphragmatic Hernia
- Trial name
- NCT07364682
- Where
- United Kingdom
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Birmingham Women's NHS Foundation Trust
Chronic Heart Failure, Hypertension
Nebivolol Versus Carvedilol in Patients With Heart Failure
BACKGROUND Beta-blockers improve left ventricular (LV) systolic function and prognosis in patients with chronic heart failure. Both carvedilol and nebivolol have hemodynamic and clinical benefits in chronic heart failure (CHF)…
- Trial name
- NCT00511888
- Where
- Italy
- Volunteers
- 160 people
- Sponsor
- IRCCS San Raffaele
Osteoarthritis Pain, Myocardial Infarction (MI)
Community Physical Exercise Program in Chronic Disease
This study focuses on promoting physical activity (PA) through the implementation of a Community Physical Exercise Program for Chronic Diseases (CPEP-CD), targeting individuals aged 50 years and older with at least two of the…
- Conditions
- Osteoarthritis Pain, Myocardial Infarction (MI), Hypertension, Dyslipidemia
- Trial name
- CPEPCD (NCT06771024)
- Testing
- Physical Exercise
- Where
- Portugal
- Volunteers
- 150 people
- Sponsor
- Associação para o Desenvolvimento do Centro Académico de Investigação e Formação Biomédica do Algarv
Venous Thromboembolism
Thrombosis Outcomes in Pediatric Venous Thromboembolism
'The TOP Study' is a prospective cohort study whose main objective is to develop better prognostic biomarkers and identify children at risk of adverse thrombotic outcomes very early in the course after an initial venous…
- Trial name
- TOP (NCT03068923)
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Texas Southwestern Medical Center
Metabolic Syndrome X
Study of Chronic Degenerative Diseases
The prevalence of obesity and type 2 diabetes mellitus (DM) in children have been increasing in parallel at an alarming rate. In particular, the increasing prevalence of type 2 DM is attributable to genetic factors, clinical…
- Trial name
- NCT02495961
- Where
- Mexico
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Asociación Científica Latina A.C.
Liver Cirrhosis, Liver Fibrosis
Liver and Spleen Stiffness Measured by TE and 2D-SWE for Diagnosis of CSPH in Patients With cACLD
A observational diagnostic study will be conducted to compare the performance of liver stiffness and spleen stiffness measured by 2D-shear wave elastography (2D-SWE) and transient elastography (TE) for diagnosing clinically…
- Conditions
- Liver Cirrhosis, Liver Fibrosis, Portal Hypertension
- Trial name
- NCT06147947
- Testing
- Diagnostic Test: Transient elastography (TE) and 2D-shear wave elastography (2D-SWE)
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Fifth Affiliated Hospital, Sun Yat-Sen University
Diabetes, Hypertension
Care Guides in the Primary Care Office (Phase II)
Trained lay persons ("care guides") working with chronic disease patients and their providers can help outpatients with diabetes, hypertension, and congestive heart failure achieve standard clinical care goals
- Conditions
- Diabetes, Hypertension, Congestive Heart Failure
- Trial name
- NCT01156974
- Testing
- education and care guide, education only
- Where
- United States
- Volunteers
- 2,135 people
- Sponsor
- Allina Health System
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