Clinical trials: Chronic Hypertension
Hypertension in Pregnancy
Chronic Hypertension and Pregnancy 2 (CHAP2) Pilot Project
The CHAP2 study is designed to provide preliminary data for a larger multicenter study to assess whether treatment of stage 1 hypertension (HTN) in pregnancy improves maternal and or neonatal outcomes.
- Trial name
- CHAP2 (NCT05989581)
- Testing
- Labetalol or Nifedipine
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Chronic Obstructive Pulmonary Disease, Pulmonary Hypertension
Non-invasive Assessment of Pulmonary Vascular Resistance in Elderly Patients With Chronic Obstructive Pulmonary Disease
Many studies have evaluated the viability of measuring the pulmonary vascular resistance (PVR) by non-invasive methods in patients with pulmonary hypertension, pulmonary thromboembolism, ischemic cardiopathy and valvular disease.
- Conditions
- Chronic Obstructive Pulmonary Disease, Pulmonary Hypertension, Cor Pulmonale
- Trial name
- PVR-COPD (NCT01554774)
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Hospital Viamed Valvanera, Spain
Acute Kidney Injury, Chronic Kidney Disease
Severe Sepsis in Children - IMPRESS-C
Sepsis is the most common cause of childhood death worldwide. Millions of children survive, but are left with impaired health. Sepsis-related Acute Kidney Injury (sAKI) is increasingly recognized as a significant factor…
- Conditions
- Acute Kidney Injury, Chronic Kidney Disease, Hypertension
- Trial name
- IMPRESS-C (NCT02598674)
- Testing
- Iodohippurate, 24 hour ambulatory Blood Pressure, Peripheral Arterial Tonometry
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Florida
Chronic Thromboembolic Pulmonary Hypertension
BPA vs. PEA in CTEPH
Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare and potentially life-threatening progressive disease that evolves from unresolved pulmonary embolism.
- Trial name
- GO-CTEPH (NCT05110066)
- Testing
- Pulmonary endarterectomy, Balloon pulmonary angioplasty
- Where
- 2 sites in Denmark, United Kingdom
- Volunteers
- 139 people
- Sponsor
- University of Aarhus
Cardiovascular Diseases, Adherence, Medication
Personalized Patient Data and Behavioral Nudges to Improve Adherence to Chronic Cardiovascular Medications
The study plans to learn if sending different text messages, serving as reminders or encouragement, may help patients take their medication more often if they have had trouble keeping up with their medicines.
- Conditions
- Cardiovascular Diseases, Adherence, Medication, Medication Adherence, Diabetes Mellitus
- Trial name
- NCT03973931
- Testing
- Nudge
- Where
- 4 sites in United States
- Volunteers
- 9,501 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Chronic Kidney Disease, Hemodialysis
Effect of Dry-weight Probing Guided by Lung-Ultrasound on Ambulatory Blood Pressure and Arterial Stiffness in Hemodialysis Patients (LUST Sub-Study)
The most common co-morbidity accompanying Chronic Kidney Disease (CKD) is hypertension, which appears in approximately 80% of all patients with renal dysfunction, whereas its prevalence in general population is remarkably lower…
- Conditions
- Chronic Kidney Disease, Hemodialysis, Hypertension
- Trial name
- LUST ABPM (NCT03058874)
- Testing
- Extra-vascular lung water measurements by ultrasound, Standard protocol of fluid management in hemodialysis
- Where
- 2 sites in Greece, Slovenia
- Volunteers
- 71 people
- Sponsor
- Carmine Zoccali
Hypertension, Peritoneal Dialysis
Blood Pressure Control With Thiazide Diuretics in Peritoneal Dialysis Patients
To evaluate the blood pressure lowering effects of thiazide diuretics in patients on peritoneal dialysis
- Conditions
- Hypertension, Peritoneal Dialysis, End Stage Kidney Disease (ESRD)
- Trial name
- NCT07271420
- Testing
- Hydrochlorothiazide 25mg once per day
- Where
- Hong Kong
- Volunteers
- 40 people
- Sponsor
- Chinese University of Hong Kong
Albuminuria
Towards HOMe-based Albuminuria Screening: an Implementation Study Testing Two Approaches
Chronic Kidney Disease (CKD) is a worldwide major public health problem that is associated with an increased incidence of kidney failure and cardiovascular events, that lead a high burden for affected patients and high costs for…
- Trial name
- THOMAS (NCT04295889)
- Testing
- Approach A (PeeSpot urine collection device)., Approach B (ACR | EU Test kit).
- Where
- Netherlands
- Volunteers
- 15,032 people
- Sponsor
- University Medical Center Groningen
Hypertension, Depression
Patient-Centred Innovations for Persons With Multimorbidity - Ontario
The aim of Patient-Centred Innovations for Persons With Multimorbidity (PACE in MM) study is to reorient the health care system from a single disease focus to a multimorbidity focus; centre on not only disease but also the…
- Conditions
- Hypertension, Depression, Anxiety, Musculoskeletal Pain
- Trial name
- PACEinMM-ON (NCT02742597)
- Testing
- TIP / IMPACT Plus Care Coordination
- Where
- 9 sites in Canada
- Volunteers
- 175 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Peripheral Vascular Diseases, Hyperglycaemia (Diabetic)
Peripheral Nerve Blocks for Above-the-knee Amputations
Surgery performed with nerve blocks and sedation may be safer and provide better pain control compared to general anesthesia and opioid therapy in high-risk patient populations such as elderly and troubled with peripheral…
- Conditions
- Peripheral Vascular Diseases, Hyperglycaemia (Diabetic), Hypertension, Coronary Artery Disease
- Trial name
- NCT03404180
- Testing
- Peripheral nerve block, Intravenous Sedatives, Lateral femoral cutaneous nerve blocks
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Florida
Pulmonary Hypertension, Chronic Obstructive Pulmonary Disease
Safety and Tolerability of Inhaled Treprostinil in Adult PH Due to COPD
This is a multicenter, single-arm trial to evaluate the safety and efficacy of inhaled treprostinil in subjects with pre-capillary pulmonary hypertension (PH) associated with Chronic Obstructive Pulmonary Disease (COPD).
- Trial name
- NCT03012646
- Testing
- Inhaled Treprostinil
- Sponsor
- United Therapeutics
Hypertensive Nephrosclerosis, Chronic Renal Insufficiency
African American Study of Kidney Disease and Hypertension
The AASK is a multicenter, randomized, controlled clinical trial using a 2 × 3 factorial design to evaluate the effects of level of blood pressure control and type of anti-hypertensive medication on progression of chronic renal…
- Trial name
- AASK (NCT04364139)
- Testing
- MAP goal less than or equal to 92 mm Hg, MAP goal 102-107 mm Hg, Ramipril
- Volunteers
- 1,094 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Chronic Thromboembolic Pulmonary Hypertension, CTEPH
Riociguat in Patients With Operable CTEPH Prior to Pulmonary Endarterectomy (PEA Bridging Study)
This is a randomised, double-blind, placebo-controlled, multicentre, multinational, prospective study in patients with operable chronic thromboembolic pulmonary hypertension (CTEPH) prior to pulmonary endarterectomy (PEA) with…
- Trial name
- NCT03273257
- Testing
- Riociguat, Pulmonary endarterectomy
- Where
- 4 sites in United States, France and 2 more
- Volunteers
- 14 people
- Sponsor
- International CTEPH Association
Cardiovascular Disease, Chronic Kidney Disease
Effects of an Exercise Program in Patients With Hypertensive Chronic Kidney Disease
Introduction: Chronic kidney disease (CKD) is now an important public health issue. While 0.1% of the population is on dialysis, approximately 4.5% of subjects have renal dysfunction (glomerular filtration rate <60 ml/min/1.73…
- Conditions
- Cardiovascular Disease, Chronic Kidney Disease, Chronic Renal Disease, Hypertension
- Trial name
- NCT01155128
- Testing
- exercise aerobic
- Where
- Brazil
- Volunteers
- 200 people
- Sponsor
- Federal University of Pelotas
COPD, PTE - Pulmonary Thromboembolism
Registry for Chronic Obstructive Pulmonary Disease With Pulmonary Thromboembolism in China
Chronic obstructive pulmonary disease (COPD) is closely related to venous thromboembolism (VTE). But it is difficult to identify VTE in COPD patients in clinical practice. Therefore, the prevalence data of PTE in COPD is limited.
- Trial name
- NCT03185377
- Where
- China
- Volunteers
- 1,708 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Hypogonadism, Male, Endocrine Disease
Anticipated Stigma, Illness Identity, and Quality of Life in Male Hypogonadism
This study aims to systematically compare the levels of anticipated illness stigma and illness identity among men diagnosed with hypogonadism to those of men with other chronic endocrine conditions (e.g., diabetes mellitus…
- Conditions
- Hypogonadism, Male, Endocrine Disease, Hypertension
- Trial name
- NCT07752511
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Hacettepe University
Cardiovascular Diseases, Venous Thromboembolism
Study on the Clinical Course Of Pulmonary Embolism
The course of both pulmonary embolism (PE) and one of its more relevant late complications, i.e. chronic thromboembolic pulmonary hypertension (CTEPH) is still substantially unknown.
- Conditions
- Cardiovascular Diseases, Venous Thromboembolism, Pulmonary Hypertension
- Trial name
- SCOPE (NCT01781858)
- Volunteers
- 700 people
- Sponsor
- University of Padova
Chronic Thromboembolic Pulmonary Hypertension
3D Echocardiographic Assessment of RV Function in Patients Undergoing Pulmonary Endarterectomy
Chronic thromboembolic pulmonary hypertension causes progressive right heart hypertrophy, dilatation and dysfunction. Surgical treatment is pulmonary endarterectomy, which although only carried out in a single UK centre, provides…
- Trial name
- NCT02426203
- Testing
- Pulmonary endarterectomy
- Volunteers
- 51 people
- Sponsor
- Papworth Hospital NHS Foundation Trust
Renal Failure Chronic Requiring Hemodialysis
Effects of Intensified Sodium Management in Hemodialysis Patients
The primary aim of this study is to investigate whether intensive sodium management by dietary sodium restriction and by preventing positive sodium balance during dialysis can be successfully applied in chronic hemodialysis…
- Trial name
- NCT01015313
- Testing
- intensive sodium management
- Where
- 3 sites in United States
- Sponsor
- Renal Research Institute
Cirrhosis, Chronic Liver Disease
The Association With Peptic Ulcer Disease and Hepatic Vein Pressure Gradient
The aim of this study is to assess the role of portal hypertension of peptic ulcer disease in liver cirrhosis and chronic hepatitis.
- Trial name
- NCT01944878
- Where
- South Korea
- Volunteers
- 455 people
- Sponsor
- Chuncheon Sacred Heart Hospital
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