Clinical trials: Chronic Kidney Disease Stage 4
CKD Stage 3/4
Identification of Markers for Determining the Efficacy of Vitamin D Receptor Activator Therapy in Stage 3/4 CKD Patients
The purpose of this study is to identify genes that are responsive to paricalcitol (active vitamin D) therapy. Scientists have found that over 30 different types of cells in the body respond to vitamin D therapy, including blood…
- Trial name
- NCT02018133
- Testing
- Vitamin D 2mg daily for 2 weeks oral paricalcitol
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Illinois Chicago
Kidney Diseases, Metabolic Acidosis
Reduction of Metabolic Acidosis in Patients With Chronic Kidney Disease in Stage 4 and 5
The goal of this clinical trial is to learn about and test the effect of an acid/base diet, in chronic kidney patients with CKD stage 4 and 5 in an interventional study with a historical control.
- Conditions
- Kidney Diseases, Metabolic Acidosis, Renal Insufficiency, CKD
- Trial name
- REMA-CKD (NCT05970094)
- Testing
- Low PRAL
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- University of Copenhagen
Cancer
Antithymocyte Globulin, Clofarabine, and Rituximab in Treating Patients After an Unsuccessful Stem Cell Transplant
RATIONALE: Antithymocyte globulin, clofarabine, and rituximab may stop the patient's immune system from rejecting the donor's stem cells when they do not exactly match the patient's blood.
- Trial name
- NCT00617929
- Testing
- anti-thymocyte globulin, rituximab, clofarabine
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Chronic Kidney Disease, Secondary Hyperparathyroidism
Pharmacokinetics and Safety Pilot Study of Single-Dose Oral and Intravenous CTAP101 in Stage 3 and 4 Chronic Kidney Disease Subjects
This study will investigate how the levels of a single dose of CTAP101 changes in the body over time (pharmacokinetics, PK) and how CTAP101 affects other mineral and hormonal balances (pharmacodynamics, PD) in patients with Stage…
- Conditions
- Chronic Kidney Disease, Secondary Hyperparathyroidism, Chronic Renal Insufficiency, Chronic Renal Failure
- Trial name
- NCT00888069
- Testing
- CTAP101 Capsules, CTAP101 Injection
- Where
- 12 sites in United States
- Volunteers
- 28 people
- Sponsor
- OPKO IP Holdings II, Inc.
Type 2 Diabetes Mellitus, Inflammation, Chronic Low-Grade
Lifestyle Intervention and Its Effects on Inflammatory Cytokines and Oxidative Stress Markers in Diabetic Chronic Kidney Disease Patients: A Randomized Controlled Trial
This randomized controlled trial investigated the effects of a 12-week structured lifestyle intervention-including supervised aerobic exercise and a calorie-restricted diet-on inflammatory cytokines and oxidative stress…
- Conditions
- Type 2 Diabetes Mellitus, Inflammation, Chronic Low-Grade, Chronic Kidney Disease, Stage 3 Chronic Kidney Disease
- Trial name
- Lifestyle Inte (NCT07119892)
- Testing
- Lifestyle Modification (Exercise + Diet)
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Sinai University
End Stage Renal Disease, Inflammation
Evaluation of Biocompatibility and Performances of 4 Dialyzers in Different Mode Treatments
Prospective multicenter randomized cross-over study Number of patients : 32 (8 patients per group) Obtain objectives data to advise each hemodialyzer according to dialysis treatment and patient profile.
- Trial name
- BIOMODAL (NCT03262272)
- Testing
- VIE A Hemodialyzer, Rexsys 27H hemodialyzer, Leoceed 21HX hemodialyzer
- Where
- France
- Volunteers
- 32 people
- Sponsor
- Hemotech
Gout, Chronic Kidney Disease (CKD)
A Phase 4 Safety and Efficacy Study to Evaluate Lesinurad 200 mg in Participants With Gout and Renal Impairment
This study evaluates the safety and efficacy of lesinurad administered with an XOI versus a placebo plus an XOI in gout participants who have moderate renal impairment and who are not at target level of serum urate (sUA).
- Trial name
- NCT03226899
- Testing
- Lesinurad, XOI, colchicine
- Where
- 116 sites in United States, Czechia and 2 more
- Volunteers
- 242 people
- Sponsor
- Ironwood Pharmaceuticals, Inc.
Periodontitis, End-stage Renal Disease
The Role of Toll-like Receptor-4 in Periodontitis Patients With End-stage Renal Disease in a Sample of Egyptian Population
Chronic kidney disease (CKD) is a significant public health issue in Egypt, leading to end-stage renal disease (ESRD). ESRD patients often suffer from oral abnormalities due to the disease and medications.
- Trial name
- NCT06755372
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Chronic Kidney Disease Stage 4, Chronic Kidney Disease Stage 5
Improving Medication Safety for Kidney Disease With a Digital Drug Dosing Tool in Nova Scotia Community Pharmacy Practice.
Chronic kidney disease (CKD) is a common condition. It occurs in approximately 7 out of 100 Canadians and is highest in rural settings. The kidneys are responsible for the removal of many drugs from the body.
- Trial name
- NCT06820372
- Testing
- Electronic Drug Dosing and Decision Support Kidney (eDoseCKD) Tool
- Volunteers
- 125 people
- Sponsor
- Nova Scotia Health Authority
Renal Insufficiency, Chronic
Feasibility of Estimating the Prevalence and Management of Stage 4 CKD the Gard, France
The main objective of this study is to evaluate the feasibility of estimating the prevalence of stage 4 and 5 chronic kidney disease in the Gard department of France from data obtained via laboratory databases.
- Trial name
- MRC-Gard (NCT02938611)
- Where
- 4 sites in France
- Volunteers
- 3,375 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Time Restricted Feeding, Renal Insufficiency, Chronic
Effects of TRF on Obese Patients With CKD Stage 3-4
Obesity is associated with glomerular hyperfiltration leading to renal impairment and is a risk factor for the progression of kidney disease.Weight loss can reduce proteinuria and improve eGFR.Intermittent fasting is safe and…
- Conditions
- Time Restricted Feeding, Renal Insufficiency, Chronic, Obesity
- Trial name
- NCT05037747
- Testing
- Time-restricted feeding(TRF)
- Where
- China
- Volunteers
- 28 people
- Sponsor
- Guangdong Provincial Hospital of Traditional Chinese Medicine
Type 2 Diabetes Mellitus, Chronic Kidney Disease Stage 4
A Study to Evaluate Safety and Effects of Sotagliflozin 400 and 200 mg on Glucose Control in Participants With Type 2 Diabetes, Severe Impairment of Kidney Function and Inadequate Blood Sugar Control
Primary Objective: To demonstrate the superiority of sotagliflozin 400 milligrams (mg) versus placebo with respect to hemoglobin A1c (HbA1c) reduction at Week 26 in participants with Type 2 diabetes who have inadequate glycemic…
- Trial name
- SOTA-CKD4 (NCT03242018)
- Testing
- Sotagliflozin
- Where
- 106 sites in United States, Argentina and 13 more
- Volunteers
- 277 people
- Sponsor
- Lexicon Pharmaceuticals
Hypertension, Renal Insufficiency, Chronic
A Research Study to Show Aprocitentan is Efficacious and Safe to Treat Patients With Uncontrolled Blood Pressure and Chronic Kidney Disease.
The purpose of this research study is to show the blood pressure lowering effect of aprocitentan, a new drug, when added to the background antihypertensive therapy in patients with uncontrolled blood pressure and chronic kidney…
- Trial name
- INSPIRE-CKD (NCT04162366)
- Testing
- Aprocitentan 25 mg
- Sponsor
- Idorsia Pharmaceuticals Ltd.
Chronic Kidney Disease (Stage 3-4), Chronic Kidney Disease (Stages 4 and 5)
Prospective Analysis of Self Medication With Phytotherapy in Nephropatic Patients.
We propose the following hypotheses: The use of herbal medicine is common among patients with chronic kidney disease in Réunion island. This use could influence the progression of kidney disease in these patients.
- Trial name
- PASSION (NCT07444515)
- Testing
- series of questions which can change patient care
- Where
- 4 sites in France
- Volunteers
- 400 people
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Breast Cancer, Chronic Myeloproliferative Disorders
Biological Therapy Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Cancer
RATIONALE: Biological therapies use different ways to stimulate the immune system and stop cancer cells from growing. Combining chemotherapy and peripheral stem cell transplantation with biological therapy may kill more cancer…
- Conditions
- Breast Cancer, Chronic Myeloproliferative Disorders, Gestational Trophoblastic Tumor, Kidney Cancer
- Trial name
- NCT00003408
- Testing
- aldesleukin, recombinant interferon alfa, sargramostim
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Cancer Treatment Centers of America
CKD Stage 4
Could Ketoanalogue-supplemented Low Protein Diet Defer Dialysis in Advanced Diabetic Kidney Disease? (K-DDD)
This is a prospective single center open label randomized controlled trial aiming to assess the effectiveness and safety of a low protein diet (0.6 g/kg-day, mainly vegetarian) supplemented with ketoanalogues of essential…
- Trial name
- K-DDD (NCT03415074)
- Testing
- Protein restriction
- Where
- Romania
- Volunteers
- 120 people
- Sponsor
- Anemia Working Group Romania
Chronic Kidney Diseases
Dapagliflozin in Non-diabetic Stage IV CKD
This is a phase 2b, prospective, randomized, cross-over, double-blind, placebo-controlled trial primarily aimed at assessing whether the SGLT2 inhibitor dapagliflozin ameliorates hyperfiltration and reduces proteinuria as…
- Trial name
- ADAPT (NCT04794517)
- Testing
- Dapagliflozin 10Mg Tab
- Where
- Italy
- Volunteers
- 32 people
- Sponsor
- Mario Negri Institute for Pharmacological Research
Chronic Renal Insufficiency
Very Low Protein Diet and Renal Death in Chronic Kidney Disease (CKD)-ERIKA Study
The purpose of this study is to determine whether the use of a very low protein diet is effective in delaying the start of chronic dialysis treatment in patients affected by chronic kidney disease (CKD).
- Trial name
- NCT00323713
- Testing
- Very low protein diet, Low protein diet
- Where
- 17 sites in Italy
- Volunteers
- 360 people
- Sponsor
- Azienda Sanitaria ASL Avellino 2
Chronic Kidney Disease, Stage 5, Secondary Hyperparathyroidism
A Study of Zemplar® Injection and Hectorol® Injection on Intestinal Absorption of Calcium in Chronic Kidney Disease
The purpose of this study is to evaluate the effects of Zemplar® Injection and Hectorol® Injection on intestinal calcium absorption in Chronic Kidney Disease Stage 5 subjects on hemodialysis.
- Trial name
- NCT00257920
- Testing
- Zemplar® injection, Hectorol® injection
- Where
- 2 sites in United States
- Volunteers
- 41 people
- Sponsor
- Abbott
Cancer
Laboratory Assay in Determining Cancer Resistance in Patients With Metastatic Cancer and in Healthy Participants
RATIONALE: Studying samples of blood and tissue in the laboratory from patients with cancer and from healthy participants may help doctors learn more about cancer.
- Trial name
- NCT00899496
- Testing
- immunological diagnostic method, physiologic testing
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences