Clinical trials: Chronic Low-back Pain
Back Pain Lower Back Chronic
Safety of BTDS in Subjects With Low Back Pain: A 52-Week Extension Phase of BUP3015
The purpose of the extension phase is to evaluate the long-term safety and tolerability of buprenorphine transdermal system (BTDS).
- Trial name
- NCT01125917
- Testing
- Buprenorphine transdermal patch
- Where
- 84 sites in United States
- Volunteers
- 354 people
- Sponsor
- Purdue Pharma LP
Chronic Pain, Low Back Pain
Evaluation of Effectiveness and Tolerability of Tapentadol Hydrochloride in Subjects With Severe Chronic Low Back Pain Taking Either WHO Step I or Step II Analgesics or no Regular Analgesics
The main objective of the study is to evaluate the effectiveness, tolerability, and safety of tapentadol hydrochloride prolonged release in subjects suffering from severe chronic low back pain (LBP) who are taking either WHO Step…
- Trial name
- NCT00983385
- Testing
- Tapentadol PR, Observation period
- Where
- 46 sites in Austria, Croatia and 7 more
- Volunteers
- 208 people
- Sponsor
- Grünenthal GmbH
Chronic Pain, Back Pain Lower Back Chronic
Virtual Reality Treatment for Adults With Chronic Back Pain
Participants with chronic back pain will complete an online eligibility questionnaire. After signing a consent form, eligible participants enter a two-week baseline period ("Baseline Period") during which they complete a daily…
- Conditions
- Chronic Pain, Back Pain Lower Back Chronic, Back Pain
- Trial name
- NCT04468074
- Testing
- Virtual Reality Therapy for Chronic Pain
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- CognifiSense Inc.
Diabetic Neuropathic Pain, Chronic Low Back Pain
Three Way Interaction Between Gabapentin, Duloxetine, and Donepezil in Patients With Diabetic Neuropathy
The purpose of the study is to determine whether the combination of the the three drugs gabapentin, duloxetine, and donepezil are effective in treating pain in people with diabetic neuropathy or patients with failed low back…
- Trial name
- NCT00619983
- Testing
- donepezil, duloxetine, donepezil 2.5 mg and duloxetine 30mg
- Where
- 2 sites in United States
- Volunteers
- 22 people
- Sponsor
- Wake Forest University
Anxiety Disorders, Anxiety Disorders and Symptoms
Anxiety Level Among Patients With Chronic Low Back Pain
The goal of this observational cross-sectional study is to learn about the intensity of anxiety symptoms among Polish people suffering from chronic lower back pain.
- Conditions
- Anxiety Disorders, Anxiety Disorders and Symptoms, Lower Back Pain, Chronic Pain
- Trial name
- NCT06404788
- Where
- Poland
- Volunteers
- 202 people
- Sponsor
- Medical University of Silesia
Chronic Low Back Pain
tDCS for Chronic Low Back Pain
The goal of this study is to investigate the role of central neural pathways in mediating chronic pain. The aim of the study is to test the effect of stimulating brain regions that are part of a network underlying central pain…
- Trial name
- NCT02771990
- Testing
- transcranial direct current stimulation
- Volunteers
- 30 people
- Sponsor
- Providence VA Medical Center
Osteoarthritis, Rheumatoid Arthritis
Double-Blind Follow-on Safety Study of HZT-501 (Ibuprofen 800 mg/Famotidine 26.6 mg) in Subjects Who Have Completed Participation in HZ-CA-301 (NCT00450658) or HZ-CA-303 (NCT00450216)
The purpose of this study is to evaluate the safety of long-term treatment with HZT-501.
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Chronic Low Back Pain, Chronic Regional Pain Syndrome
- Trial name
- HZ-CA-304 (NCT00613106)
- Testing
- HZT-501, Ibuprofen
- Where
- United States
- Volunteers
- 179 people
- Sponsor
- Amgen
Discogenic Pain, Low Back Pain
Intradiscal Platelet Rich Plasma
To assess changes in pain and function in patients with discogenic low back pain after a standard of care intradiscal injection of Platelet-Rich Plasma (PRP).
- Conditions
- Discogenic Pain, Low Back Pain, Chronic Pain
- Trial name
- NCT04544709
- Testing
- Low back intradiscal injection of platelet rich plasma (PRP)
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Utah
Back Pain Lower Back Chronic
Safety and Efficacy of Buprenorphine Transdermal System (BTDS) in Subjects With Moderate to Severe Low Back Pain
The objective of this study is to demonstrate the effectiveness and tolerability of the buprenorphine transdermal system (BTDS) 20 in comparison to the buprenorphine transdermal system (BTDS) 5 and oxycodone immediate-release in…
- Trial name
- NCT00313014
- Testing
- Buprenorphine, Oxycodone Immediate-Release
- Where
- 85 sites in United States
- Volunteers
- 660 people
- Sponsor
- Purdue Pharma LP
Low Back Pain
A Six Week Study Of The Pain Relieving Effects Of Celecoxib 200 Mg Twice Daily Compared To Tramadol 50 Mg Four Times Daily In Patients With Chronic Low Back Pain
To compare the analgesic effectiveness of celecoxib and tramadol in subjects with Chronic Low Back Pain measured by the Numerical Rating Scale (NRS-Pain) at Week 6
- Trial name
- NCT00662558
- Testing
- celecoxib, tramadol HCL
- Where
- 60 sites in United States
- Volunteers
- 802 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Low Back Pain
Physical Activity for Older Adults Chronic Low Back Pain
Chronic low back pain (cLBP) is one of the most common and disabling conditions among US military Veterans. Although physical activity can improve cLBP outcomes, the majority of Veterans with cLBP are inactive.
- Trial name
- PACe-LBP (NCT02327325)
- Testing
- Physical Activity, Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- VA Office of Research and Development
Low Back Pain
The Efficacy of the Kyrobak for Chronic Low Back Pain (LBP-2)
The purpose of this study is to evaluate the efficacy of the Kyrobak continuous passive motion home-use device in relieving low back pain, improving proprioception (balance and fall prevention) and improving the symmetry of…
- Trial name
- LBP-2 (NCT02155283)
- Testing
- Continuous Passive Motion
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Radiancy
Low Back Pain
Buprenorphine and Methadone for Opioid-dependent Chronic Back Pain Patients
Chronic pain patients are treated with prescription opioids and many exhibit opioid addiction. Currently, there are no evidence-based guidelines to better manage patients with chronic pain and coexistent opioid addiction.
- Trial name
- NCT01559454
- Testing
- Methadone, Buprenorphine/naloxone
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- State University of New York at Buffalo
Low Back Pain, Low Back Pain, Recurrent
Blue Light Device for Pain Therapy
The purpose of this study is to determine if the Pain Relief Patch, which shines light of a limited wavelength on the painful area of the back, relieves chronic musculoskeletal back pain.
- Conditions
- Low Back Pain, Low Back Pain, Recurrent, Musculoskeletal Pain, Chronic Pain
- Trial name
- PAINCT02 (NCT01528332)
- Testing
- Pain Relief Patch, Control PRP device
- Where
- 3 sites in Germany
- Volunteers
- 171 people
- Sponsor
- Philips Electronics Nederland BV
Low Back Pain
The McKenzie Method Versus Manipulation for Patients With Chronic Low Back Pain
Introduction: The McKenzie method as well as spinal manipulation is commonly used for the treatment of low back pain throughout the western world.
- Trial name
- NCT00939107
- Testing
- spinal manipulation, McKenzie exercises
- Where
- Denmark
- Volunteers
- 350 people
- Sponsor
- Back and Rehabilitation Center, Copenhagen
Chronic Low-back Pain
ReActiv8 Stimulation Therapy vs Optimal Medical Management: A Randomized Evaluation
This study is a prospective, randomized study comparing ReActiv8 Therapy to Optimal Medical Management (OMM).
- Trial name
- RESTORE (NCT04803214)
- Testing
- ReActiv8
- Where
- 28 sites in United States
- Volunteers
- 203 people
- Sponsor
- Mainstay Medical
Pain, Chronic Pain
Evaluation of Effectiveness and Tolerability of Tapentadol Hydrochloride in Subjects With Severe Chronic Low Back Pain Taking WHO Step III Analgesics But Showing a Lack of Tolerability
The main objective of the study is to evaluate the effectiveness, tolerability, and safety of tapentadol hydrochloride prolonged release in subjects suffering from severe chronic low back pain (LBP) who are taking WHO Step III…
- Conditions
- Pain, Chronic Pain, Low Back Pain, Neuropathic Pain
- Trial name
- NCT00986258
- Testing
- Tapentadol Prolonged Release
- Where
- 27 sites in Belgium, Czechia and 6 more
- Volunteers
- 136 people
- Sponsor
- Grünenthal GmbH
Chronic Pain, Osteoarthritis
A Confirmatory Study of Fentanyl in Participants With Osteoarthritis or Low Back Pain
The purpose of this study is to evaluate efficacy and safety of fentanyl in opioid-naive participants with osteoarthritis (disorder, which is seen mostly in older persons, in which the joints become painful and stuff) or low back…
- Conditions
- Chronic Pain, Osteoarthritis, Low Back Pain
- Trial name
- NCT01008618
- Testing
- Fentanyl
- Where
- 59 sites in Japan
- Volunteers
- 218 people
- Sponsor
- Janssen Pharmaceutical K.K.
Low Back Pain
An Efficacy and Safety Study of Transdermal Therapeutic System (TTS)-Fentanyl in Severe Chronic Low Back Pain
The purpose of this study is to evaluate the efficacy and safety of Transdermal Therapeutic System (TTS)-fentanyl patch (transdermal patch containing a drug that is put on the skin so the drug will enter the body through the…
- Trial name
- NCT01774903
- Testing
- TTS-fentanyl
- Where
- Thailand
- Volunteers
- 45 people
- Sponsor
- Janssen-Cilag Ltd.,Thailand
Chronic Low Back Pain, Sacroiliitis
Effectiveness of Ultrasound Guided Platelet Rich Plasma Injections in the Sacroiliac Joint
This prospective study will be quantitatively analyzing the effectiveness of platelet-rich-plasma (PRP) injections into the sacroiliac (SI) joint in relieving sacroiliitis and low back pain originating from the SI joint.
- Conditions
- Chronic Low Back Pain, Sacroiliitis, Sacroiliac; Backache, Platelet Rich Plasma
- Trial name
- NCT03122119
- Testing
- Platelet Rich Plasma Joint Injection
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Star Spine and Sport