Clinical trials: Chronic Low-back Pain (cLBP)
Chronic Low Back Pain
Strategies to Assist With Management of Pain
Chronic low back pain (CLBP) has no known effective treatment. While often treated with long-term opioid therapy, opioids do not work well for many patients and can cause serious side effects, including addiction, poorer mental…
- Trial name
- STAMP (NCT03115359)
- Testing
- Mindfulness Based Therapy, Cognitive Behavioral Therapy
- Where
- 4 sites in United States
- Volunteers
- 770 people
- Sponsor
- University of Wisconsin, Madison
Chronic Low Back Pain (cLBP)
Integration of Virtual Reality and Traditional Acupuncture: From Education to Clinical Practice.
This research project aims to develop and validate whether a "VR-assisted traditional acupuncture therapy model" provides superior pain relief and functional improvement compared to acupuncture alone.
- Trial name
- NCT07816796
- Testing
- VR-Assisted Acupuncture Group, Traditional Acupuncture Group, Conventional Care / Outcome Assessment Only
- Volunteers
- 90 people
- Sponsor
- China Medical University Hospital
Chronic Low Back Pain (CLBP)
Brain and Gene Expression Responses to Exercise in Chronic Back Pain
This study is registered retrospectively for transparency. This mechanistic randomized controlled trial examined whether a 14-week supervised physical exercise training program reduces chronic low back pain (CLBP) by modulating…
- Trial name
- CLBPE (NCT07480460)
- Testing
- Supervised physical exercise training
- Where
- Canada
- Volunteers
- 57 people
- Sponsor
- McGill University
Chronic Low-back Pain (cLBP)
Effects of Vertebral Axial Loading Walking Combined With Core Stabilization Exercises in Individuals With Chronic Low Back Pain
Chronic low back pain is a common musculoskeletal condition persisting for more than three months and is associated with pain, functional limitations, impaired balance, altered proprioception, reduced trunk muscle performance…
- Trial name
- NCT07334782
- Testing
- Exercise - Core Stabilization Exercise Program, Core Stabilization Exercises Plus Vertebral Axial Loading Walking Training
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Hacettepe University
Obesity, Overweight
A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight and Chronic Low Back Pain
The main purpose of this study is to evaluate the efficacy and safety of retatrutide in relieving chronic low back pain in participants who have obesity or overweight. Participation in the study will last about 80 weeks.
- Conditions
- Obesity, Overweight, Chronic Low Back Pain (CLBP)
- Trial name
- TRIUMPH-7 (NCT07035093)
- Testing
- Retatrutide
- Where
- 40 sites in United States, Argentina and 2 more
- Volunteers
- 586 people
- Sponsor
- Eli Lilly and Company
Sciatica, Lumbar Radiculopathy
Brain Mechanisms Supporting Cannabis-induced Pain Relief
Chronic low back pain is a common and disabling condition that affects millions of people in the United States. Many people with chronic low back pain do not get enough relief from current treatments.
- Conditions
- Sciatica, Lumbar Radiculopathy, Lower Back Pain, Degenerative Disc Disease
- Trial name
- NCT04982965
- Testing
- Active Cannabis
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Low Back Pain
Effects of Manipulative Therapy and Pain Education in Individuals With CLBP
The burden of low back pain more than doubled in the last 20 years, probably caused by biopsychosocial factors. Some noninvasive treatments have been applied in individuals with chronic nonspecific low back pain as spinal…
- Trial name
- NCT02982382
- Testing
- Manipulative Therapy, Pain Education
- Where
- Brazil
- Volunteers
- 128 people
- Sponsor
- Santa Catarina Federal University
Chronic Low Back Pain (CLBP)
Movement Quality and Balance Improvement in People With Chronic Low Back Pain Following Trunk Muscle Training
The goal of this project is to assess if Chronic Low Back Pain (CLBP) participant's movement quality and balance variables can change after training that decreases their pain and disability.
- Trial name
- CLBP (NCT06944730)
- Testing
- Structural Exercise, Isolated Trunk Exercise, Back school
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- The Hong Kong Polytechnic University
Chronic Low-back Pain (cLBP)
Static Core Stability vs. Extension Exercises for Chronic Low Back Pain
Chronic back pain is posteriorly occurring multi-causes pain that most commonly occurred due to lumber strains and sprains. It usually lasts 12 weeks (03 months) or longer.
- Trial name
- NCT06751173
- Testing
- Static Core Stability exercises, Mckenzie exercises, Spinal Mobilization
- Where
- Pakistan
- Volunteers
- 38 people
- Sponsor
- Riphah International University
Chronic Osteoarthritis Pain, Chronic Low Back Pain
Study of PIPE-791 for Subjects With Chronic Osteoarthritis Pain or Chronic Low Back Pain
The primary goal of this clinical trial is to learn if PIPE-791 is safe and well-tolerated in adults with chronic osteoarthritis pain (COAP) or chronic low back pain (CLBP).
- Trial name
- NCT06810245
- Testing
- PIPE-791
- Where
- 5 sites in United States
- Volunteers
- 43 people
- Sponsor
- Contineum Therapeutics
Mechanical Low Back Pain
Association Between the Duration of Smart Phone Use and Back Dysfunction in Patients With Low Back Pain
This study investigates the association between the duration of smart phone use and back pain and proprioception deficits in patients with chronic mechanical low back pain (CLBP).
- Trial name
- NCT03517410
- Testing
- Smart phone use
- Where
- Egypt
- Volunteers
- 62 people
- Sponsor
- Aliaa Rehan Youssef
Chronic Low Back Pain (CLBP)
Art Therapy for Adults With Chronic Low Back Pain
This project aims to assess the feasibility and preliminary efficacy of a supervised group-based art intervention for adults with chronic low back pain (CLBP).
- Trial name
- NCT07141069
- Testing
- Art therapy combined with Exercise, Exercise
- Where
- 2 sites in Hong Kong
- Volunteers
- 30 people
- Sponsor
- The Hong Kong Polytechnic University
Chronic Low-back Pain (cLBP), High-Impact Chronic Pain (HICP)
Comparing Non-Medicine Strategies for Improving Low Back Pain
The goal of this clinical trial is to help veterans manage high-impact chronic pain (HICP) in the lower back. The trial will use a program, ENCompaSS (Education, Navigated Care, and Supported Self-Management) designed to reduce…
- Trial name
- NCT07679178
- Testing
- ENCompaSS (Education, Navigated Care, and Supported Self-Management) with VA Stepped Usual Care
- Where
- United States
- Volunteers
- 530 people
- Sponsor
- Duke University
Chronic Low Back Pain (CLBP)
Global Postural Reeducation in Nonspecific Chronic Low Back Pain
The aim of this study was to compare the effectiveness of GPR associated to conventional reeducation protocol to that of the conventional reeducation protocol alone on pain, mobility, function and psychological symptoms in…
- Trial name
- GPR-LBP (NCT06914362)
- Testing
- global postural reeducation, conventional rehabilitation
- Where
- Tunisia
- Volunteers
- 26 people
- Sponsor
- Hopital Charles Nicolle
Chronic Low-back Pain (cLBP), Chronic Neck Pain
Investigation of Conservative Treatment Preferences of Patients With Chronic Low Back and Neck Pain
Objective: The aim of this study is to determine the preferences of individuals with chronic low back and neck pain regarding physiotherapy treatment methods and to examine the factors influencing these preferences.
- Trial name
- NCT06898502
- Testing
- Electrotherapy ( TENS, hot pack, and therapeutic ultrasound )
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Istanbul University - Cerrahpasa
Chronic Low Back Pain (CLBP)
Non Invasive Brain Stimulation Treatment for CLBP
This trial is designed to preliminary evaluate the efficacy and safety of NIBS system for treatment of chronic low back pain (CLBP) (over 6 months).
- Trial name
- NIBSTCLBP (NCT02615418)
- Testing
- NIBS system for evaluation and treatment utilizing non invasive brain stimulation
- Volunteers
- 60 people
- Sponsor
- NIBS NeuroScience Technologies
Chronic Low Back Pain (CLBP)
SENECA - Smart Therapies for Chronic Pain
This will be a randomized controlled prospective pilot study: The feasibility and usability of VIVO 2nd GEN therapy + Standard-of-Care (SoC) vs. Standard-of-Care alone will be evaluated.
- Trial name
- SENECA (NCT07628179)
- Testing
- VIVO 2nd GEN, Standard-of-Care Multimodal Pain Therapy
- Where
- Austria
- Volunteers
- 44 people
- Sponsor
- Aurimod GmbH
Chronic Low Back Pain, Chronic Low Back Pain (CLBP)
Bowen Therapy and McGill Stabilization Exercises in Chronic Low Back Pain
This randomized controlled trial aims to compare the effectiveness of Bowen Therapy combined with McGill stabilization exercises versus Bowen Therapy alone in individuals with chronic nonspecific low back pain.
- Trial name
- NCT07694219
- Testing
- Bowen Therapy + McGill Stabilization Exercise, Bowen Therapy
- Where
- Pakistan
- Volunteers
- 70 people
- Sponsor
- Sehat Medical Complex
Chronic Low Back Pain (CLBP)
Neuroimmune Responses to Exercise in Chronic Back Pain
The goal of this mechanistic clinical trial is to learn how physical exercise affects the body and brain in people with chronic low back pain.
- Trial name
- eCLBP (NCT07497425)
- Testing
- Physical Exercise
- Where
- Canada
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- McGill University
Chronic Low Back Pain
CLBP Single-Arm Long-Term Follow-up Study
This is a prospective, noninterventional, observational post market data collection of long-term effectiveness and satisfaction outcomes for "A Prospective, Open-Label, Single-Arm Study of Intraosseous Basivertebral Nerve…
- Trial name
- NCT05207813
- Testing
- Intracept Procedure
- Where
- 2 sites in United States
- Volunteers
- 42 people
- Sponsor
- Boston Scientific Corporation