Clinical trials: Chronic Lung Disease
Ischemic Heart Disease, Heart Failure
Trial of an Internet-based Platform for Managing Chronic Diseases at a Distance
In 2005, more then one-third of Canadians were burdened with one or more chronic diseases. Patients with one chronic disease often have, or are at risk for, another chronic disease.
- Conditions
- Ischemic Heart Disease, Heart Failure, Chronic Kidney Disease, Diabetes
- Trial name
- iCDM (NCT01342263)
- Testing
- iCDM
- Where
- Canada
- Volunteers
- 234 people
- Sponsor
- Simon Fraser University
BPH, Nocturia
Use of Autologous Adipose-Derived Stem/Stromal Cells (AD-cSVF) in Symptomatic Benign Prostate Hypertrophy
Benign prostate hypertrophy (BPH) and inflammation are common non-cancerous enlargement of the prostate, which result in urinary interference and incomplete drainage of the bladder.
- Conditions
- BPH, Nocturia, BPH With Urinary Obstruction, Prostatism
- Trial name
- SVF-BPN (NCT02961114)
- Testing
- Microcannula Harvest Adipose, Centricyte 1000, IV Sterile Normal Saline
- Where
- 2 sites in United States
- Sponsor
- Robert W. Alexander, MD, FICS
Asthma
A Study of MK0359 in Patients With Chronic Asthma (0359-013)
A study to test the effect of MK0359 in lessening the symptoms of asthma as compared to placebo.
- Trial name
- NCT00482898
- Testing
- MK0359
- Volunteers
- 56 people
- Sponsor
- Merck Sharp & Dohme LLC
Pulmonary Disease, Chronic Obstructive
Efficacy and Safety of GSK3923868 Inhalation Powder, During Experimental Human Rhinovirus Infection in Participants With Mild Asthma
This is a Phase 1b, single center study designed to evaluate the efficacy, safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of GSK3923868 following repeat doses in mild asthmatics during experimental human…
- Trial name
- NCT05398198
- Testing
- GSK3923868
- Where
- United Kingdom
- Volunteers
- 48 people
- Sponsor
- GlaxoSmithKline
Pulmonary Disease, Chronic Obstructive
Tiotropium 18ug Inhalation Capsule Using a Handihaler® Among Korean COPD Patients
This is a descriptive observational open non-comparative study of the safety and efficacy of tiotropium inhalation capsule given at 18mcg once a day for 30 days among Korean patients with COPD.
- Trial name
- NCT00620516
- Where
- 71 sites in South Korea
- Volunteers
- 3,008 people
- Sponsor
- Boehringer Ingelheim
Bronchopulmonary Dysplasia, Neonatal Disease
The Baby Lung Study
The introduction of exogenous surfactant therapy has significantly improved the mortality in preterm infants born between 23- and 28-weeks of gestation.
- Trial name
- NCT05152316
- Testing
- Observational study
- Where
- United Kingdom
- Volunteers
- 61 people
- Sponsor
- University College, London
COPD, COPD (Chronic Obstructive Pulmonary Disease)
Impact of Home Non Invasive Ventilation in Patients With Chronic Obstructive Pulmonary Disease Discharged From Assiut University Hospital
This study aims to evaluate the impact of long-term home non-invasive ventilation (NIV) on patients with COPD
- Conditions
- COPD, COPD (Chronic Obstructive Pulmonary Disease), Ventilation Therapy, Non Invasive Ventilation (NIV)
- Trial name
- NCT07198880
- Testing
- BiPAP device (non invasive ventilation), Optimal Medical Management ( long acting beta agonist , long acting muscarinic antagonist and inhaled corticosteroids)
- Volunteers
- 40 people
- Sponsor
- Assiut University
Pulmonary Disease, Chronic Obstructive, Emphysema
Evaluating the Clinical Effectiveness of 3D Printing for a Patient-specific Silicone Stent Airway Implant
The goal of the small feasibility trial is to establish a method, material, and patient-specific design that is superior to what is in use today.
- Trial name
- NCT03111888
- Testing
- Silicone Stent Airway Implant
- Where
- United States
- Sponsor
- The Cleveland Clinic
COPD, COPD Exacerbation
Effects of Blocking TSLP on Airway Inflammation and the Epithelial Immune-response to Exacerbation Triggers in Patients With COPD
A phase 2, multicentre, randomized, double-blind, placebo-controlled, parallel group study to evaluate the effect of tezepelumab on airway inflammation in patients with COPD.
- Conditions
- COPD, COPD Exacerbation, COPD Bronchitis, Airway Disease
- Trial name
- UPSTREAM-COPD (NCT05507242)
- Testing
- Tezepelumab
- Where
- 2 sites in Denmark, United Kingdom
- Volunteers
- 80 people
- Sponsor
- Asger Sverrild
COPD Patients
The Effect of Home-Based Monitoring, Exercise Training
Chronic obstructive pulmonary disease (COPD); From time to time, significant involvement in dusts or gases and abnormal disease outbreaks are observed, which are observed throughout life in the period when the cause has just…
- Trial name
- NCT06128902
- Testing
- tele health
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Ordu University
Chronic Graft vs Host Disease, Chronic Graft-Versus-Host Disease
Alvelestat (MPH966), an Oral Neutrophil Elastase Inhibitor, in Bronchiolitis Obliterans Syndrome After Allogeneic Hematopoietic Stem Cell Transplantation
Background: Bronchiolitis obliterans syndrome (BOS) is a complication people can experience after hematopoietic stem cell transplant. It usually affects people with chronic graft versus host disease (cGVHD).
- Conditions
- Chronic Graft vs Host Disease, Chronic Graft-Versus-Host Disease, Bronchiolitis Obliterans Syndrome
- Trial name
- NCT02669251
- Testing
- MPH966
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- National Cancer Institute (NCI)
COPD, Eosinophilia
Mepolizumab for COPD Hospital Eosinophilic Admissions Pragmatic Trial
This is a single-centre, double-blinded, randomised, placebo controlled trial comparing mepolizumab 100mg versus placebo in patients with eosinophilic COPD, started following their index admission to hospital.
- Trial name
- COPD-HELP (NCT04075331)
- Testing
- Mepolizumab
- Where
- United Kingdom
- Volunteers
- 238 people
- Sponsor
- University of Leicester
Congestive Heart Failure, Cancer
Team-based Versus Primary Care Clinician-led Advance Care Planning in Practice-based Research Networks
This project compares two models of the Serious Illness Care Program (SICP) in primary care: clinician-focused SICP and team-based SICP.
- Conditions
- Congestive Heart Failure, Cancer, Chronic Obstructive Pulmonary Disease, Cerebrovascular Accident
- Trial name
- NCT03577002
- Testing
- Serious Illness Care Program (SICP)
- Where
- 7 sites in United States, Canada
- Volunteers
- 1,120 people
- Sponsor
- Oregon Health and Science University
Long COVID
Stellate Ganglion Block for Long COVID Symptoms: A Randomized Controlled Trial
This single-center, randomized, controlled, single-blind clinical trial evaluates whether a stellate ganglion block (SGB) using bupivacaine can improve persistent symptoms in adults with long COVID.
- Trial name
- STAR-CO (NCT07374562)
- Testing
- Stellate Ganglion Block (Bupivacaine)
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Centre intégré universitaire de santé et de services sociaux de la Mauricie-et-du-Centre-du-Québec
Infection, Heart Failure
Remote Physician Care for Home Hospital Patients
This study examines the implications of providing remote physician care to home hospitalized patients compared to usual home hospital care with in-person/in-home physician visits.
- Conditions
- Infection, Heart Failure, Chronic Obstructive Pulmonary Disease, Asthma
- Trial name
- NCT04080570
- Testing
- Remote Visit
- Where
- 2 sites in United States
- Volunteers
- 172 people
- Sponsor
- Brigham and Women's Hospital
Copd, COPD Exacerbation
Change in Breathing Pattern on Non-invasive Ventilation of COPD Patients Under Home Mechanical Ventilation
Acute exacerbation of COPD (AECOPD) worsen prognosis and quality of life of COPD patients. Telemonitoring could be a useful tool for early identification of AECOPD. Parameters that have to be monitored are not well defined.
- Trial name
- NCT03018470
- Testing
- Analysis of data from NIV built-in software
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Rouen
COPD, Sleep Quality of ICU Patients
Virtual Reality in ICU Patients With COPD
This study aims to evaluate the effect of a virtual reality glasses application on sleep quality, anxiety, and vital signs in patients with chronic obstructive pulmonary disease hospitalized in the intensive care unit.
- Conditions
- COPD, Sleep Quality of ICU Patients, Anxiety
- Trial name
- VR-ICU-COPD (NCT07475650)
- Testing
- virtual reality glasses
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- TC Erciyes University
COPD (Chronic Obstructive Pulmonary Disease), Obesity Hypoventilation Syndrome (OHS)
The Effect of Mask Design on Ventilation Parameters in COPD and OHS Patients on Long-term Home Non-invasive Ventilation. An Experimental Study.
Chronic obstructive pulmonary disease (COPD) and obesity hypoventilation syndrome (OHS) are respiratory conditions that disrupt normal breathing.
- Trial name
- NCT06972589
- Testing
- Investigational Mask, Conventional mask
- Where
- New Zealand
- Volunteers
- 20 people
- Sponsor
- Fisher and Paykel Healthcare
COPD
Effects of Oral Doxofylline and Procaterol on Chronic Obstructive Pulmonary Disease
The goal of this clinical trial is to determine if doxofylline and procaterol are effective in treating patients with stable chronic obstructive pulmonary disease (COPD). It will also assess the safety of both drugs.
- Trial name
- NCT06346691
- Testing
- Doxofylline, Procaterol
- Where
- Thailand
- Volunteers
- 20 people
- Sponsor
- Thammasat University
Chronic Obstructive Pulmonary Disease (COPD)
Efficacy and Tolerability Study in Severe Chronic Obstructive Pulmonary Disease (COPD) Patients
Efficacy and tolerability study in severe chronic obstructive pulmonary disease (COPD) patients.
- Trial name
- SECURE2 (NCT01415518)
- Testing
- Drug: Budesonide/formoterol (Symbicort Turbuhaler, Drug: ipratropium (AtroventTM), theophylline SR
- Where
- 21 sites in China
- Volunteers
- 581 people
- Sponsor
- AstraZeneca
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