Clinical trials: Chronic Major Depression
Pulmonary Disease, Chronic Obstructive, Depression
Problem-Solving Therapy for People With Major Depression and Chronic Obstructive Pulmonary Disease
This study will evaluate the effectiveness of problem-solving therapy combined with treatment adherence procedures in treating older people with major depression and chronic obstructive pulmonary disease.
- Trial name
- NCT00601055
- Testing
- Problem Solving-Rx Adherence (PSA), PID-C
- Where
- 2 sites in United States
- Volunteers
- 101 people
- Sponsor
- Weill Medical College of Cornell University
Randomized Controlled Trial
Cost-utility and Physiological Effects of ACT and BATD in Patients With Chronic Pain and Depression
Objectives: (1) To analyze the effectiveness of adding a group-based form of Acceptance and Commitment Therapy (ACT) or a behavioural activation program for depression (TACD) to the treatment as usual (TAU) for patients diagnosed…
- Trial name
- IMPACT (NCT04140838)
- Testing
- Acceptance and Commitment Therapy (ACT), Behavioral Activation Therapy for Depression (BATD), Treatment as Usual (TAU)
- Where
- 2 sites in Spain
- Volunteers
- 234 people
- Sponsor
- Fundació Sant Joan de Déu
Major Depressive Disorder, Chronic Major Depression, Recurrent
Establishing Multimodal Brain Biomarkers for Treatment Selection in Depression
The purpose of the study is to identify brain biomarkers and characteristics that predict individual responses to treatment of major depression with the antidepressant drug sertraline (tradename Zoloft), a common selective…
- Trial name
- Re-EMBARC (NCT05892744)
- Testing
- Sertraline
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Texas at Austin
Treatment Resistant Depression, Suicidal Ideation
The Safety and Efficacy of Psilocybin in Patients With Treatment-resistant Depression and Chronic Suicidal Ideation
This study aims to explore the safety and tolerability of a single dose of psilocybin (25mg) administered under supportive conditions to adult participants with TRD and chronic suicidal ideation
- Trial name
- NCT05220410
- Testing
- Psilocybin
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Sheppard Pratt Health System
Fibromyalgia, Chronic Pain
Transcranial Magnetic Stimulation for Treating Women With Chronic Widespread Pain
While acute pain after surgery or trauma comes on suddenly and lasts for a limited amount of time, chronic pain persists and can continue for months and even years.
- Conditions
- Fibromyalgia, Chronic Pain, Depression
- Trial name
- NCT00524420
- Testing
- rTMS
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Washington
Chronic Visceral Pain, Major Depressive Disorder
Esketamine Adjuvant Therapy for Patients With Chronic Visceral Pain Comorbid Major Depressive Disorder
Ketamine is a dissociative anesthetic and powerful analgesic. At low doses, ketamine can desensitize the central pain pathway and modulate opioid receptors.
- Trial name
- NCT04847245
- Testing
- Pregabalin 75mg tid + Duloxetine, Intravenous administration of esketamine 0.125 mg/kg+Duloxetine, Intravenous administration of esketamine 0.25 mg/kg +Duloxetine
- Volunteers
- 80 people
- Sponsor
- Peking University
Major Depressive Disorder, Back Pain
Duloxetine Treatment of Major Depression and Chronic Low Back Pain For Older Adults
The following primary hypotheses will be tested: 1. During Step 1: Major Depressive Disorder (MDD) or Chronic Low Back Pain (CLBP) in < 40% of the initial 60 subjects treated with duloxetine (DUL) + Clinical Management(CM) during…
- Conditions
- Major Depressive Disorder, Back Pain, Aged
- Trial name
- ACHIEVE2 (NCT00696293)
- Testing
- Duloxetine
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Pittsburgh
Chronic Major Depressive Disorder
Schema Focused Therapy for Chronic Depression
Schema focused therapy (SFT) is an innovative treatment approach to chronic, lifelong problems that incorporates cognitive, behavioral, experiential and psychodynamic elements and techniques.
- Trial name
- NCT01153867
- Testing
- Schema Focused Therapy
- Where
- Netherlands
- Volunteers
- 25 people
- Sponsor
- Maastricht University Medical Center
Mental Illness, Schizophrenia
Cognitive Training to Enhance VA Work Program Outcomes
The purpose of this study is to determine whether augmenting work services with cognitive remediation can improve vocational outcomes for psychiatrically disabled participants in VA work services.
- Conditions
- Mental Illness, Schizophrenia, Depression, PTSD
- Trial name
- NCT00829400
- Testing
- Cognitive Remediation, Nintendo Brain Age
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- VA Connecticut Healthcare System
Fibromyalgia
Vagus Nerve Stimulation for Treating Adults With Severe Fibromyalgia
Fibromyalgia syndrome (FMS) is a long-term disorder that is characterized by widespread body pain and tender points in joints, muscles, tendons, and other soft tissues.
- Trial name
- NCT00294281
- Testing
- Vagus Nerve Stimulation (VNS) Therapy
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Medicine and Dentistry of New Jersey
Sequelae of; Infection, Post Infection Glomerulonephritis
Recovering Damaged Cells for Sequelae Caused by COVID-19, SARS-CoV-2
Post-acute sequelae of SARS-CoV-2 infection can cause multiple system function disorders, and complicated symptoms last for an extended period.
- Conditions
- Sequelae of; Infection, Post Infection Glomerulonephritis, Post-Infectious Peripheral Neuralgia, Post-Infectious Disorder (Disorder)
- Trial name
- sequelae (NCT04846010)
- Testing
- PurWet, FurFat, PurApo
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- All Natural Medicine Clinic, LLC
Major Depression, End Stage Renal Disease
Bupropion for Depression in ESRD Patients on Hemodialysis
The proposed study will evaluate the response and remission rates for major depressive disorder (MDD) in end-stage renal disease (ESRD) patients undergoing maintenance hemodialysis (HD) treated with bupropion or fluoxetine for 12…
- Trial name
- NCT02238977
- Testing
- Fluoxetine, Bupropion
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Arkansas
Schizophrenia, Schizoaffective Disorder
Understanding How Cognitive Remediation Works
This study is aimed at evaluating whether the computer-based cognitive exercises in the Thinking Skills for Work (TSW) program are critical to improving work and cognitive outcomes in consumers with serious mental illness and…
- Conditions
- Schizophrenia, Schizoaffective Disorder, Chronic Mental Disorder, Major Depression
- Trial name
- Cog-2 (NCT01683539)
- Testing
- The Thinking Skills for Work Program, The Cognitive Skills for Work Program
- Where
- 2 sites in United States
- Volunteers
- 203 people
- Sponsor
- Boston University Charles River Campus
Depression Disorders, Depression - Major Depressive Disorder
Comparing the Efficacy of Heated Yoga and Sauna as a Treatment for Depression
This project explores whether heated yoga, sauna, and a mindfulness app reduce depressive symptoms
- Conditions
- Depression Disorders, Depression - Major Depressive Disorder, Depression Disorder, Depression Chronic
- Trial name
- SHINE (NCT07082998)
- Testing
- heated yoga, sauna, mindfulness app
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Massachusetts General Hospital
Major Depressive Disorder, Dysthymic Disorder
Mindfulness Based Cognitive Therapy for Chronic Pain and Comorbid Unipolar Depression
The primary aim of this study is to test the feasibility and efficacy of Mindfulness Based Cognitive Therapy (MBCT) training for the treatment of depressive symptoms in patients with chronic pain.
- Conditions
- Major Depressive Disorder, Dysthymic Disorder, Depressive Disorder NOS, Chronic Pain
- Trial name
- NCT01473615
- Testing
- Mindfulness Based Cognitive Therapy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Massachusetts General Hospital