Clinical trials: Chronic Metabolic Disorder
Metabolic Syndrome X, Type 2 Diabetes Mellitus
Effect of Fish Oil on Insulin Sensitivity
The purpose of this study is to determine whether a prolonged (9 month) high (6g/d) of marine oil improves insulin sensitivity and glucose control in subjects with impaired glucose regulation.
- Conditions
- Metabolic Syndrome X, Type 2 Diabetes Mellitus, Sarcopenia
- Trial name
- NCT01241474
- Testing
- EPAX 6000 (marine omega 3 EPA/DHA fatty acid concentrates, Maize (corn) oil
- Where
- United Kingdom
- Volunteers
- 34 people
- Sponsor
- University of Aberdeen
COPD and Lung Cancer
Environmental Pollutants in COPD and Lung Cancer
Epidemiological studies describe a statistically significant correlation between hospitalization rate and exposure to environmental pollutants such as atmospheric particulates (PM10 and PM2.5) and polycyclic aromatic hydrocarbons…
- Trial name
- NCT06483490
- Testing
- This is a cross-sectional, non pharmacological study
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- University of Campania Luigi Vanvitelli
Hurler Syndrome, Fanconi Anemia
Bone Marrow Transplant With Abatacept for Non-Malignant Diseases
This is a single arm, phase I study to assess the tolerability of abatacept when combined with cyclosporine and mycophenolate mofetil as graft versus host disease prophylaxis in children undergoing unrelated hematopoietic stem…
- Conditions
- Hurler Syndrome, Fanconi Anemia, Glanzmann Thrombasthenia, Wiskott-Aldrich Syndrome
- Trial name
- NCT01917708
- Testing
- Abatacept
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Emory University
Nutrition Disorders, Gastrointestinal Disease
Review of Infant Oral Feeding and Skills
This study evaluates the infant's feeding skill level at discharge from the neonatal intensive care unit. The goal is to determine whether the ability to "full feed by volume" implies "full skill development" for infant oral…
- Conditions
- Nutrition Disorders, Gastrointestinal Disease, Deglutition Disorder, Feeding Difficulties
- Trial name
- RIOS (NCT06736743)
- Testing
- SMART Tool for Feeding Skill Assessment
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- Wake Forest University Health Sciences
Hyperkalemia, Chronic Kidney Disease Requiring Chronic Dialysis
Effect of Viscous Fiber on Postprandial Kalemic Response in Hemodialysis Patients
High blood potassium levels (hyperkalemia) is a major problem for people with kidney failure undergoing hemodialysis treatment. In order to reduce the risk of hyperkalemia, people with kidney failure are advised to limit or avoid…
- Trial name
- NCT05086185
- Testing
- Kalemic Response to Orange Juice, Kalemic Response to Orange Juice with Fiber
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Nevada, Reno
Sjogren-Larsson Syndrome
ADX-629 Therapy for Sjogren-Larsson Syndrome
This research study will determine whether orally administered ADX-629 is safe and has biochemical efficacy in participants with Sjögren-Larsson syndrome (SLS), a rare inherited disorder of fatty aldehyde metabolism The disease…
- Trial name
- NCT05443685
- Testing
- ADX-629
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Nebraska
Hyperphosphatemia, End-stage Renal Disease
Study of Individualized Therapy on Hyperphosphatemia in Maintenance Hemodialysis Patients
This study is designed to study and compare the efficacy and cost-effectiveness of individualized phosphate-lowering therapy in comparison with regular guideline-recommended therapy.
- Trial name
- NCT02684643
- Testing
- enhanced individualised therapy, non-enhanced individualised therapy, regular intervention
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Huashan Hospital
Diabetes, Diabetes Mellitus, Type 1
A Survey to Evaluate Diabetes Management, Control, Chronic Complications, Psychosocial Aspects of Diabetic Subjects in Bangladesh
This study is conducted in Asia. The aim of this observational study is to evaluate current status of diabetes management, control, complications in diabetic subjects in Asia.
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- DiabCare Asia (NCT00839878)
- Testing
- No treatment given
- Where
- Bangladesh
- Volunteers
- 2,092 people
- Sponsor
- Novo Nordisk A/S
Hyperphosphatemia
A Phase 2 Study to Evaluate the Safety and Efficacy of VS-505(AP301) to Treat Hyperphosphatemia in Hemodialysis Patients
A multi-center, open-label, parallel-design, active-controlled phase 2 study to evaluate the tolerability, safety and efficacy of various dosages of VS-505 compared with Sevelamer Carbonate when given orally with meal for 6 weeks…
- Trial name
- NCT04551300
- Testing
- VS-505, Sevelamer Carbonate
- Where
- 23 sites in China
- Volunteers
- 158 people
- Sponsor
- Shanghai Alebund Pharmaceuticals Limited
Chronic Kidney Disease, Renal Dialysis
A Comparative Study of ASP1585 in Chronic Kidney Disease Patients With Hyperphosphatemia on Hemodialysis
This is a multi-center, open-labeled study to examine the non-inferiority of ASP1585 to sevelamer hydrochloride in chronic kidney disease patients with hyperphosphatemia on hemodialysis.
- Conditions
- Chronic Kidney Disease, Renal Dialysis, Renal Insufficiency
- Trial name
- NCT01057407
- Testing
- ASP1585, Sevelamer hydrochloride
- Where
- 3 sites in Japan
- Volunteers
- 110 people
- Sponsor
- Astellas Pharma Inc
Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Hypercapnic Acidosis
Nasal High Flow Versus Non-invasive Ventilation for Early Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease With Hypercapnic Acidosis
The purpose of this study is to determine whether nasal high flow is non inferior to non invasive ventilation (NIV) in the early treatment of patients with acute exacerbation of chronic obstructive pulmonary disease (AE-COPD) and…
- Conditions
- Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Hypercapnic Acidosis, Respiratory Failure With Hypercapnia
- Trial name
- HiCOPD (NCT06114667)
- Testing
- Ventilatory support via nasal high flow, Ventilatory support via NIV
- Where
- 3 sites in France
- Volunteers
- 174 people
- Sponsor
- University Hospital, Montpellier
Hyperkalaemia, Metabolic Acidosis
Study of the Effect of SZC on Serum Potassium and Serum Bicarbonate in Patients With Hyperkalemia and Metabolic Acidosis Associated With Chronic Kidney Disease
The main objective of this study is to evaluate the efficacy of SZC as compared to placebo in maintaining normal sK+ in patients with hyperkalemia and metabolic acidosis associated with CKD
- Conditions
- Hyperkalaemia, Metabolic Acidosis, Chronic Kidney Disease
- Trial name
- NEUTRALIZE (NCT04727528)
- Testing
- Sodium zirconium cyclosilicate
- Where
- 30 sites in United States, Puerto Rico
- Volunteers
- 39 people
- Sponsor
- AstraZeneca
Metabolic Syndrome, Dialysis; Complications
Plasma Biomarkers of Muscle Metabolism During Exercise to the Assessment of Insulin Resistance in CKD Dialysis Patients
This prospective, multicenter, cross-sectional, repeated-measures comparative study compared functional and biochemical response profiles to exercise between 2 groups of chronically ill patients (chronic renal failure dialysis…
- Trial name
- KREBSome-IRC (NCT06360302)
- Testing
- Exercise test, Blood sample, Impedancemetry
- Where
- 2 sites in France
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Type 2 Diabetes, Chronic Kidney Diseases
Impact of GLP-1 RAs Compared to Basal Insulin Start in Patients Living With Type 2 Diabetes and Chronic Kidney Disease
The overall objective of this study is to compare the effectiveness of adding a glucagon-like peptide-1 receptor agonist compared with adding basal insulin for patients with type 2 diabetes and chronic kidney disease, already…
- Trial name
- NCT06236672
- Testing
- GLP-1 receptor agonist, basal insulin
- Where
- Canada
- Volunteers
- 348 people
- Sponsor
- LMC Diabetes & Endocrinology Ltd.
Health Behavior
mACTonHEALTH: Psychological Flexibility and Activity Tracker - Protocol
Obesity and overweight are growing steadily and becoming a global epidemic. Recent researches report a 64% of the adult population as overweight.
- Trial name
- ACTonHEALTH (NCT03351712)
- Testing
- ACT-Based Intervention and Activity Tracker WITH Feedback, Gold Standard Intervention + Activity Tracker WITHOUT Feedback, Gold Standard Intervention and Activity Tracker WITH Feedback
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Istituto Auxologico Italiano
Prescribing Decisions, Diabetes
Optimizing Prescribing Decisions for Hospitalized Older Adults With Chronic Conditions
The goal of this pilot clinical trial is to learn if providing a clinical decision framework for managing older adults chronic conditions during hospitalization to inpatient clinicians improves clinicians' ability to…
- Conditions
- Prescribing Decisions, Diabetes, Multimorbidity, Hypertension
- Trial name
- NCT06605807
- Testing
- Clinical Decision Framework for Managing older adults' chronic conditions during hospitalization.
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- University of Pittsburgh
Pediatric Obesity, Mental Health Wellness 1
The Family Stress Study - Chronic Stress and Child Adiposity: Testing a Bio-behavioural Model
The Family Stress Study is following families with young children in Guelph, Hamilton and surrounding areas over 3 years to understand how chronic stress impacts children's weight gain over time and how this association is…
- Trial name
- NCT05534711
- Where
- 2 sites in Canada
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Guelph
Obstructive Sleep Apnea, End Stage Renal Disease
Effect of Beginning a Renal Replacement Therapy on Obstructive Sleep Apnea in End Stage Renal Disease Patients
The purpose of this study is to investigate the effect of beginning a renal replacement therapy on fluid overload and its consequence on the severity of obstructive sleep apnea, in patients with end stage chronic kidney disease.
- Trial name
- SASinHD_005 (NCT02073344)
- Testing
- Renal replacement therapy, no intervention
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Obesity, Metabolic Syndrome
Weight Loss Improves Renal Hemodynamics
Metabolic syndrome (MS) is a clustering of risk factors for cardiovascular disease (CVD) such as hypertension, hypertriglyceridemia, low HDL-cholesterol levels, disorders of glucose metabolism, and insulin resistance.
- Conditions
- Obesity, Metabolic Syndrome, Chronic Kidney Disease
- Trial name
- NCT01356394
- Testing
- dietary intervention
- Where
- Brazil
- Volunteers
- 58 people
- Sponsor
- Nucleus of Education Interdisciplinary Research and Treatment in Nephrology
Dysequilibrium Syndrome, ESRD
Adding Urea to the Final Dialysis Fluid
At times patients with advanced renal failure present with severe hyperkalemia or acidosis and very high serum blood urea nitrogen (BUN) concentrations.
- Conditions
- Dysequilibrium Syndrome, ESRD, Hyperkalemia, Metabolic Acidosis
- Trial name
- Urea dialysate (NCT06366230)
- Testing
- Urea in the dialysate
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, San Francisco
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