Clinical trials: Chronic Metabolic Disorder
Obesity and Overweight
Chronic Intervention With Sulforaphane-Smart® in Overweight and Obese Adults
The Sulforaphane-Smart® formula is a pill, patented by the company INGREDALIA, prepared with broccoli by-products which have been concentrated and enriched in glucosinolates/isothiocyanates (GLS/ITCs).
- Trial name
- SANO-Chronic (NCT06964659)
- Testing
- Sulforaphan-Smart® formula
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Mª Jesús Periago
Type 1 Diabetes Mellitus With Diabetic Nephropathy
Effect of Dietary Protein Restriction on Prognosis in Patients With Diabetic Nephropathy
The purpose of the investigators study was to determine the effect of dietary protein restriction on survival and progression to end stage renal disease (ESRD) in diabetic nephropathy.
- Trial name
- LPD (NCT01521910)
- Testing
- low protein diet, normal protein diet
- Where
- Denmark
- Volunteers
- 82 people
- Sponsor
- Steno Diabetes Center Copenhagen
Diabetic Nephropathy Type 2 - Uncontrolled, Diabetes Mellitus, Type 2
Mixed Methods Study of Health-Related Social Needs in African American Adults With Chronic Kidney Disease and Type 2 Diabetes Mellitus
The overarching goal of this study is to understand facilitators and barriers to self-care, develop and refine a culturally tailored intervention to improve clinical outcomes, quality of life (QOL), and self-care behaviors in…
- Conditions
- Diabetic Nephropathy Type 2 - Uncontrolled, Diabetes Mellitus, Type 2, Chronic Kidney Diseases
- Trial name
- NCT05692388
- Testing
- Patient and Community Stakeholder Interviews, Cross-sectional Study Participants, Focus Groups and Intervention Mapping
- Where
- United States
- Volunteers
- 330 people
- Sponsor
- Medical College of Wisconsin
Diabetes Mellitus Type 2, Cultural Competency
E4E-Health Professional Education for Improving Care for Canadian Aboriginal Populations
Education for Equity (E4E)intervention intends to improve care delivery through a well designed educational program that address not only the issues of diabetes care delivery to Aboriginal patients with diabetes, but also the…
- Trial name
- E4E (NCT01989962)
- Testing
- E4E intervention
- Where
- Canada
- Volunteers
- 860 people
- Sponsor
- Queen's University
Chronic Kidney Disease, Type 2 Diabetes Mellitus
An Observational Study, Called FINEXPLORER, to Learn More About How Well Finerenone Works in Adults in Spain With Chronic Kidney Disease (CKD) Linked to Type 2 Diabetes, by Looking at Changes in a CKD Risk Score
This is a prospective observational study in which data from people with chronic kidney disease (CKD) associated with type 2 diabetes (T2D) who will be receiving finerenone are collected and analyzed.
- Trial name
- FINEXPLORER (NCT07554469)
- Testing
- Finerenone (Kerendia, BAY94-8862)
- Where
- Spain
- Volunteers
- 500 people
- Sponsor
- Bayer
Myelodysplastic Syndromes, Beta-Thalassemia
Evaluating the Efficacy of Deferasirox in Transfusion Dependent Chronic Anaemias (Myelodysplastic Syndrome, Beta-thalassaemia Patients) With Chronic Iron Overload
This study will evaluate the safety and efficacy of deferasirox in transfusion dependent Myelodysplastic Syndrome, Beta-thalassaemia major patients with chronic iron overload
- Trial name
- NCT00564941
- Testing
- deferasirox
- Where
- 4 sites in Hungary
- Volunteers
- 309 people
- Sponsor
- Novartis Pharmaceuticals
Chronic Kidney Disease, Type 2 Diabetes Mellitus
An Observational Study Called FIRST-2.0 to Learn More About the Use of the Study Treatment Finerenone Including How Safe it is and How Well it Works Under Real-world Conditions
This is an observational study, in which data from people in the United States (US) with chronic kidney disease (CKD) together with type 2 diabetes (T2D) are studied.
- Trial name
- FIRST-2 (NCT05703880)
- Testing
- Finerenone (Kerendia, BAY948862)
- Where
- 2 sites in United States
- Volunteers
- 15,948 people
- Sponsor
- Bayer
Angina Pectoris, Diabetes Mellitus, Type 2
Study Protocol for Rosiglitazone Versus Gliclazide in Diabetics With Angina
The principle objective of the trial is to compare rosiglitazone to gliclazide in patients with type 2 diabetes mellitus and chronic stable angina to see how the subjects' angina status changes.
- Trial name
- NCT00225342
- Testing
- Rosiglitazone, Gliclazide (Comparison drug)
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University of Glasgow
Diabetes Mellitus, Periodontitis
Effect of Antioxidant Intake on Resistin Levels In Patients With Gum Disease and Diabetes
To evaluate the effectiveness of non surgical periodontal therapy in addition to antioxidant(ALA) on resistin levels in patients with type 2 diabetes and periodontal disease
- Trial name
- EARGD (NCT02775266)
- Testing
- Alpha lipoic acid, Scaling and Root planing
- Where
- India
- Volunteers
- 40 people
- Sponsor
- Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre
Pediatric Obesity
Energy Intake and Energy Deficit in Obese Adolescents
The aim of the present study is to compare the effect of two weight loss interventions inducing the same energy deficit but one based on exercise and one using dietary restriction, on appetite control in obese adolescents.
- Trial name
- IDEFIX (NCT03466359)
- Testing
- DEF-EI : Energy restriction induced energy deficit, DEF-EX : Exercise induced energy deficit
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Clermont-Ferrand
Diabetes, Hypoglycaemia
Predicting Hypoglycaemia and Arrhythmias in the Patient With Diabetes and CKD - Validation Study
Patients with insulin-dependent diabetes mellitus (DM) and chronic kidney disease (CKD) exhibit an excessive risk for cardiac arrhythmias, in particular sudden cardiac death (SCD).
- Conditions
- Diabetes, Hypoglycaemia, Chronic Kidney Disease
- Trial name
- HypoArrhythmia (NCT02778269)
- Testing
- 12-lead ECG T-shirt, Dexcom G4-System
- Where
- Germany
- Volunteers
- 7 people
- Sponsor
- RWTH Aachen University
Chronic Insomnia
Effects of Chronic Insomnia on the Neuroendocrine Regulation of Glucose and Lipid Metabolism
We aim to assess the influence of chronic insomnia on the neuroendocrine regulation of the glucose and lipid metabolism to more clearly define the metabolic derangements associated with chronic insomnia and to prove that chronic…
- Trial name
- NCT00442624
- Where
- Switzerland
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Chronic Kidney Disease, Diabetes Mellitus
Facilitating Improvements in Kidney Health Using a Smartphone App Counseling Program in Patients With Diabetes
This pilot study tests the feasibility of dietary app-supported tele-counseling in the treatment of patients with stage 1-3a chronic kidney disease (CKD) and diabetes.
- Conditions
- Chronic Kidney Disease, Diabetes Mellitus, Albuminuria
- Trial name
- FitKidney (NCT03015480)
- Testing
- Remote counseling
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Geisinger Clinic
Diabetic Foot, Neuropathy, Diabetic
Clinical Trial Using the Proteolytic Fraction P1G10 From V. Cundinamarcensis to Heal Diabetic Foot Ulcer
The aim of the study was to investigate the role of the proteolytic fraction from Vasconcellea cundinamarcensis, designated as P1G10, on healing of chronic foot ulcers in neuropathic patients diagnosed with diabetes type 2.
- Conditions
- Diabetic Foot, Neuropathy, Diabetic, Foot Ulcer
- Trial name
- P1G10 (NCT03700580)
- Testing
- Hydrogel treatment, P1G10
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Carlos E Salas
Hepatitis C
Infergen, Ribavirin & Avandia in Previous Relapsers or Nonresponders to Pegylated Interferon and Ribavirin
Genotype 1 hepatitis C virus (HCV) patients who did not respond (did not lose virus during treatment) or relapsed (virus went away on treatment but came back after treatment was stopped) after treatment with at least twelve weeks…
- Trial name
- NCT00207402
- Testing
- rosiglitazone
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Brooke Army Medical Center
Cerebral Palsy, Scoliosis
Effects of Neuromuscular Scoliosis Surgery on Nutritional Metabolism
Cerebral palsy is the primary cause of disability in France. It is a non-progressive condition leading to movement and posture troubles, but also to cognitive and sensory problems.
- Trial name
- SORONOUS (NCT07255495)
- Testing
- Absorptiometry and indirect calorimetry, Questionnaires
- Where
- France
- Volunteers
- 42 people
- Sponsor
- University Hospital, Montpellier
Type 2 Diabetes, Chronic Kidney Disease
Metformin Use in Chronic Kidney Disease: The CKD-Met Study
Metformin is the most widely prescribed oral treatment for diabetes, and the only one that showed a survival benefit. Yet, there is no consensus on the optimal dose and withdrawal of metformin in chronic kidney disease (CKD)…
- Trial name
- CKD-Met (NCT02844153)
- Testing
- modalities of metformin prescription
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Hospices Civils de Lyon
Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
Magnetic Resonance Diagnostics of Diabetic Peripheral Neuropathy
This project aims to develop high field MR techniques to detect nerve lesions in diabetic patients. The MRI findings will be compared to results from conventional evaluations and nerve conduction studies to determine the validity…
- Conditions
- Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Diabetic Polyneuropathy, Hereditary Axonal Neuropathy
- Trial name
- NCT01847937
- Where
- 5 sites in Denmark, Germany
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Diabetic Peripheral Neuropathic Pain
A Study of Medical Cannabis Aerosol Via the Fixed-dose Syqe Inhaler as an Add-on Treatment of Diabetic Peripheral Neuropathic Pain (DPNP)
The primary purpose of this study is to evaluate the safety and efficacy of medical cannabis aerosol containing 0.25, 0.50, 1.0 milligrams (mg) delta (Δ) 9-tetrahydrocannabinol (THC) inhaled three times a day (TID) compared to…
- Trial name
- NCT06490445
- Testing
- Medical Cannabis
- Where
- 38 sites in Australia, Czechia and 3 more
- Volunteers
- 122 people
- Sponsor
- Syqe Medical
CKD, Renal Insufficiency Chronic
The CPH-MBD Cohort Dietary Substudy - Comparison of Methods for Dietary Registrations
The aim of the study is to assess the association between the calcium and phosphorus balance and the stage of kidney disease measured by creatinine clearence in patients with chronic kidney disease stage 4 and 5.
- Conditions
- CKD, Renal Insufficiency Chronic, CKD-MBD - Chronic Kidney Disease Mineral and Bone Disorder, Pre-dialysis
- Trial name
- NCT07312981
- Where
- 2 sites in Denmark
- Volunteers
- 50 people
- Sponsor
- University of Copenhagen
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