Clinical trials: Chronic Metabolic Disorder
Musculoskeletal Pain, Osteoarthritis
Integrated Healthy Lifestyle and Pain Care for People With Musculoskeletal Conditions Living in Rural Areas.
This study aims to compare the effects of an in-person physiotherapist-led lifestyle-focused pain care intervention with a virtual multidisciplinary lifestyle-focused pain care intervention on pain impact in people with…
- Conditions
- Musculoskeletal Pain, Osteoarthritis, Low Back Pain
- Trial name
- HeLP-R (NCT07173335)
- Testing
- In-person physiotherapist led integrated healthy lifestyle and pain care, Virtual multidisciplinary integrated healthy lifestyle and pain care
- Where
- 3 sites in Australia
- Volunteers
- 354 people
- Sponsor
- University of Sydney
Iron Deficiency, Chronic Heart Failure
A Study to Compare the Use of Ferric Carboxymaltose With Placebo in Patients With Chronic Heart Failure and Iron Deficiency
The purpose of this study is to determine, relative to placebo, the effect of iron repletion therapy using intravenous (IV) ferric carboxymaltose on exercise capacity in patients with chronic heart failure and iron deficiency.
- Trial name
- CONFIRM-HF (NCT01453608)
- Testing
- Ferinject (ferric carboxymaltose)
- Where
- 2 sites in Poland, Russia
- Volunteers
- 304 people
- Sponsor
- Vifor Pharma
Inflammatory Bowel Diseases, Irritable Bowel Syndrome
Fecal Calprotectin Collection Protocol
The primary objective is to obtain stool samples from subjects diagnosed with , and displaying signs and/or symptoms of IBD and/or IBS will be evaluated in this study.
- Conditions
- Inflammatory Bowel Diseases, Irritable Bowel Syndrome, Ulcerative Colitis, Crohn Disease
- Trial name
- CALFE (NCT03143517)
- Testing
- Stool collection
- Where
- 13 sites in United States
- Volunteers
- 240 people
- Sponsor
- DiaSorin Inc.
Diabetes, End Stage Renal Disease
Continuous Glucose Monitoring and Inflammation in Nondiabetic and Diabetic Patients Undergone Hemodialysis
Evaluation of different glycemic variations between the dialysis period and non-dialysis period in two groups: nondiabetic and diabetic patients undergone two different hemodialysis methods.
- Trial name
- NCT01049152
- Testing
- Continuous Glucose Monitoring (CGM)
- Where
- Italy
- Volunteers
- 36 people
- Sponsor
- University of Pavia
Obesity
Application of Dietary Guidelines for the Brazilian Population by Teleconsultation in Obesity in Primary Care
Obesity is a chronic disease that is highly prevalent in Brazil. It is associated with diabetes and hypertension. Obesity may decrease quality of life.
- Trial name
- NCT05171907
- Testing
- Teleobesity
- Where
- Brazil
- Volunteers
- 578 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Chronic Myeloproliferative Disorders, Drug/Agent Toxicity by Tissue/Organ
Combination Chemotherapy Plus Amifostine in Treating Patients With Advanced Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumors from dividing so they stop growing or die. Chemoprotective drugs, such as amifostine, may protect normal cells from the side effects of chemotherapy.
- Conditions
- Chronic Myeloproliferative Disorders, Drug/Agent Toxicity by Tissue/Organ, Leukemia, Lymphoma
- Trial name
- NCT00004036
- Testing
- sargramostim, amifostine trihydrate, carboplatin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- The Cleveland Clinic
Chronic Iron Overload Due to Transfusion-dependant Anemias
Phase II Study to Investigate the Benefits of an Improved Deferasirox Formulation (Film-coated Tablet)
Assessed the new film-coated tablet formulation to the currently approved dispersible tablet formulation with regards to overall safety, Gastrointestinal (GI) tolerability, palatability, satisfaction and compliance
- Trial name
- NCT02125877
- Testing
- Deferasirox dispersible tablet, Defearisox film-coated tablet
- Where
- 51 sites in United States, Argentina and 14 more
- Volunteers
- 173 people
- Sponsor
- Novartis Pharmaceuticals
Diabetes
Involvement of Community Pharmacists in Complex Care Plans for Diabetic Patients, a Pilot Study
This project is an initiative to bring physicians, nurses, community pharmacists and patients together in collaborative planning in the management of diabetes, which aligns with the collaborative, team based aspects of family…
- Trial name
- NCT02399332
- Testing
- Community pharmacist involvement
- Volunteers
- 16 people
- Sponsor
- University of Calgary
Hypertension, Type 2 Diabetes Mellitus (T2DM)
Community-Empowerment and Environmental Enrichment-based Co-management (CEEEC) Model and Mechanisms for Improving Health of Older Stroke Patients With Multimorbidity
This study is a cluster randomized controlled trial with a 2×2 factorial design conducted in community health centers in Kunshan, Wuhan and Shanghai, China.
- Conditions
- Hypertension, Type 2 Diabetes Mellitus (T2DM), Multimorbidity, Stroke
- Trial name
- CEEEC (NCT06975501)
- Testing
- Exercise Intervention, Cognitive Intervention
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Duke Kunshan University
Diabetes Mellitus
Glucose to Goal: A Model to Support Diabetes Management in Primary Care
Diabetes education is a very important part of diabetes care. Most people with diabetes receive care in primary care practices where diabetes education is not always available.
- Trial name
- NCT02715934
- Testing
- Glucose to Goal, Usual Care
- Where
- United States
- Volunteers
- 4,994 people
- Sponsor
- University of Pittsburgh
Type 2 Diabetes, Chronic Obstructive Pulmonary Disease (COPD)
Measurements Before and After Participation in a Health Intervention Programme in Halsnaes Municipality
Based on the Danish Health Authority's quality standards for municipal prevention services for citizens with chronic diseases, Steno Diabetes Center Copenhagen (SDCC), Halsnaes Municipality, North Zealand Hospital, and others…
- Conditions
- Type 2 Diabetes, Chronic Obstructive Pulmonary Disease (COPD), Cardiovascular Disease
- Trial name
- NCT07641309
- Where
- Denmark
- Volunteers
- 194 people
- Sponsor
- Steno Diabetes Center Copenhagen
Pre Diabetes
Supplementation of Eriocitrin in Intestinal Microbiota
Pre-diabetes is characterized by high plasma concentration of glucose and glycated hemoglobin and is the main risk factor for the development of type 2 diabetes.
- Trial name
- NCT03925909
- Testing
- Eriocitrin
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- São Paulo State University
SCID, Omenn's Syndrome
Allogeneic Hematopoietic Stem Cell Transplant for Patients With Primary Immune Deficiencies
This is a standard of care treatment guideline for allogeneic hematopoetic stem cell transplant (HSCT) in patients with primary immune deficiencies.
- Conditions
- SCID, Omenn's Syndrome, Reticular Dysgenesis, Wiskott-Aldrich Syndrome
- Trial name
- NCT01652092
- Testing
- Alemtuzumab 0.3 mg, Cyclophosphamide, Busulfan
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Hemodialysis-Induced Symptom, Mitochondrial Diseases
Mitochondria and Chronic Kidney Disease
The overarching goal of this study is to determine the role of chronic kidney disease and the activation of the kallikrein-kinin system during hemodialysis on the development of mitochondrial dysfunction; the investigators will…
- Trial name
- MitoCKD (NCT03177798)
- Testing
- Icatibant
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Vanderbilt University Medical Center
Cognition, Affect (Mental Function)
BiomeBakery Project
This study aims to investigate the chronic effects of prebiotic fibre-fortified functional bakery product on cognitive, affective, inflammatory, metabolic, and anthropometric outcomes in healthy adults aged 60-75 years with mild…
- Conditions
- Cognition, Affect (Mental Function), C Reactive Protein
- Trial name
- NCT06796712
- Testing
- Prebiotic fibre fortified bread roll, Regular bread roll
- Where
- United Kingdom
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Reading
Generalized Chronic Periodontitis, Osteoporosis
A Study to Assess the Disturbances in Calcitonin Gene in Patients With Gum Disease and Osteoporosis
Osteoporosis and Periodontitis are multifactorial diseases which share common risk factors.The aim of the present study is to ellucidate polymorphisms in Calcitonin receptor gene? in patients with Osteoporosis and Periodontitis.
- Trial name
- CTROP (NCT02273128)
- Testing
- CTR Gene
- Where
- India
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre
Overweight in Preschool Age Children, Risk of Overweight in Preschool Age Children
Improving Primary Care to Prevent Childhood Obesity
To determine the extent to which a clinical intervention based on the Chronic Care Model (CCM), compared with the usual care control condition, results in a smaller age-associated increase in body mass index (BMI) over a 1 year…
- Trial name
- NCT00377767
- Testing
- To change structure and roles of primary care teams to optimize prevention of obesity
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Atrial Fibrillation (AF), Hypertension
Integrated Approach in Frail Older People with Atrial Fibrillation
The study will verify if a structured multidisciplinary approach (called iABC), aimed to improve the appropriate management of elderly AF patients with multimorbidity (the i-ABC group), would provide a clear evidence of an…
- Conditions
- Atrial Fibrillation (AF), Hypertension, Coronary Arterial Disease (CAD), Heart Failure
- Trial name
- AFFIRMO (NCT06775028)
- Testing
- iABC platform use
- Where
- 50 sites in Bulgaria, Denmark and 4 more
- Volunteers
- 1,250 people
- Sponsor
- Heart Care Foundation
CLL (Chronic Lymphocytic Leukemia)
CLL-IMPACT: A Clinical Nutrition Trial Investigating Immune and Metabolic Changes in Early-Stage CLL
The goal of this clinical trial is to investigate whether a short-term (4-week) whole-food, plant-based (WFPB) diet has an effect on metabolism, immune function, and disease activity in early-stage chronic lymphocytic leukemia…
- Trial name
- CLL-IMPACT (NCT07487428)
- Testing
- Diet
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Technical University of Munich
Healthy
Impact of Purple Wheat Consumption on Markers of Inflammation and Oxidative Stress in Adults.
The main purpose of this study is to determine the effect of consumption of purple wheat anthocyanin-rich products for eight weeks by human participants with an elevated level of chronic inflammation, on oxidative stress and…
- Trial name
- NCT02840357
- Testing
- Purple Wheat Convenience Bars, Control Wheat Convenience Bars
- Where
- Canada
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Guelph
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