Clinical trials: Chronic Metabolic Disorder
Diabetes Mellitus, Chronic Kidney Disease
Berberine Prevent Contrast-induced Nephropathy in Patients With Diabetes
The number of cardiac angiography and percutaneous coronary interventions (PCI) has increased steadily in recent years. This has resulted in the increasing incidence of contrast-induced nephropathy (CIN).
- Trial name
- NCT02808351
- Testing
- Berberine
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Hyperphosphatemia
A Phase1 Study to Explore the Safety of EOS789 in Patients With Chronic Kidney Disease and Hyperphosphatemia on Hemodialysis
This study is a randomized study designed as a 2x2 cross-over in two periods (Period 1 and Period 2) to assess the safety, pharmacokinetics (PK), pharmacodynamics (PD), and efficacy of EOS789 in patients with chronic kidney…
- Trial name
- NCT02965053
- Testing
- EOS789, Renvela
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Chugai Pharmaceutical
Renal Osteodystrophy
Renal Osteodystrophy: A Fresh Approach
There are two major goals of this project: 1. Comparison of DXA and QCT for diagnosis of bone loss in CKD-5 patients and determination of the prevalence of low bone turnover in CKD-5 patients with bone loss. 2.
- Trial name
- NCT00859612
- Where
- United States
- Volunteers
- 464 people
- Sponsor
- Hartmut Malluche, MD
Prediabetes, Chronic Coronary Syndrome
Reversal to Normoglycemia by Treating Prediabetes
Prediabetes is a precursor to diabetes, but compared with diabetes, much less is known about prediabetes. Prediabetes is defined based on a blood sample measuring long-term average glucose levels.
- Trial name
- NCT07392151
- Testing
- Intensified medical follow-up and glucose-lowering drugs, No intervention
- Where
- Denmark
- Volunteers
- 158 people
- Sponsor
- Michael Mæng
Chronic Kidney Diseases, Type2Diabetes
Decision Support for Detection of Chronic Kidney Disease in Type II Diabetes Mellitus
While data from the National Health and Nutrition Examination Survey (NHANES) estimate that 36.9% of patients with diabetes have CKD, only approximately 10% of patients are aware of their kidney disease.
- Trial name
- CKD-DETECT (NCT05342545)
- Testing
- Alert-based computerized decision support
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Brigham and Women's Hospital
Chronic Kidney Diseases, Magnetic Resonance Imaging
Material Balance Study of TQ-B3525
A clinical study to investigate the absorption, metabolism and excretion of [14C] TQ-B3525 in Chinese adult male healthy subjects, aiming to quantitatively analyze the total radioactivity in the excreta of male healthy subjects…
- Trial name
- NCT05675202
- Testing
- TQ-B3525
- Where
- China
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Chronic Hepatitis c, Insulin Resistance
Effects of Metformin, Pegylated Interferon Alpha and Ribavirin for Chronic Hepatitis C With Insulin Resistance
The aim of the study is to investigate the treatment response of metformin, Peg-IFN and ribavirin combination therapy for chronic hepatitis C virus (HCV).
- Trial name
- NCT01664845
- Testing
- metformin, pegylated-IFN, ribavirin
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Decompensated Chronic Obstructive Pulmonary Disease
Effectiveness of Acetazolamide for Reversal of Metabolic Alkalosis in Mechanically Ventilated Chronic Obstructive Pulmonary Disease Patients
The purpose of this study is to determine whether acetazolamide are effective to reduce the length of mechanical ventilation in decompensated Chronic Obstructive Pulmonary Disease (COPD) patients developing pure or mixed…
- Trial name
- DIABOLO (NCT01627639)
- Testing
- Acetazolamide
- Where
- France
- Volunteers
- 380 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Myelodysplastic Syndromes, Hemosiderosis
Safety, Tolerability, and Efficacy of Deferasirox in MDS
Open label, single arm study on Deferasirox treatment in MDS patients with chronic transfusional hemosiderosis. Patients receive daily oral dosis of Deferasirox in order to eliminate the quantity of iron administered during…
- Trial name
- NCT00469560
- Testing
- Deferasirox
- Where
- 17 sites in Italy
- Volunteers
- 158 people
- Sponsor
- Gruppo Italiano Malattie EMatologiche dell'Adulto
First Episode Psychosis (FEP)
Self-administered COgnitive Personalized Training in Early Psychosis
The overall objective of SCOPe is to improve early intervention in psychosis by providing an innovative eHealth tool that will enable personalized cognitive training, adapted to the individual's cognitive abilities.
- Trial name
- SCOPe (NCT06634446)
- Testing
- a mobile application for cognitive training, video games
- Where
- France
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier St Anne
Diabetic Kidney Disease (DKD)
Study to Assess the Effects of ALN-ANG3 in Adult Participants With Diabetic Kidney Disease
This study is researching an experimental drug called ALN-ANG3 (called "study drug"). The study is focused on participants who have diabetic kidney disease.
- Trial name
- ANCHOR-POC (NCT07271186)
- Testing
- ALN-ANG3, Evinacumab
- Where
- 59 sites in United States
- Volunteers
- 195 people
- Sponsor
- Regeneron Pharmaceuticals
End Stage Renal Disease, Hyperparathyroidism, Secondary
Mineral and Bone Disorders Outcomes in Stage 5D of Chronic Kidney Disease
The MBD-5D is a prospective observational study with a case-cohort and a cohort design. Eligible patients are receiving hemodialysis and have secondary hyperparathyroidism.
- Trial name
- MBD-5D (NCT00995163)
- Where
- Japan
- Volunteers
- 8,020 people
- Sponsor
- Kyowa Kirin Co., Ltd.
End Stage Renal Disease (ESRD), Metabolic Acidosis
the Effect of Interdialytic Serum Bicarbonate Correction on Vascular Calcification in Hemodialysis Patients
the investigators will test the effect of interdialytic metabolic acidosis correction on vascular calcification in hemodialysis patients
- Trial name
- NCT07765459
- Testing
- Oral sodium bicarbonate
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Metabolic Syndrome
Study Protocol of the EMPOWER-SUSTAIN Project
A pilot randomised controlled trial will be conducted in UiTM Primary Care Clinic, Selayang Campus, Selangor, Malaysia. A total of 232 patients with Metabolic Syndrome (MetS) will be recruited; 116 will be randomised to receive…
- Trial name
- NCT04120779
- Testing
- The EMPOWER-SUSTAIN e-Health Self-Management Intervention
- Volunteers
- 232 people
- Sponsor
- Universiti Teknologi Mara
Polycystic Ovary Syndrome, Periodontitis
Non-surgical Periodontal Therapy and Myo-inositol in Polycystic Ovary Syndrome Women Having Chronic Periodontitis
The Purpose of this study is to assess the correlation between the inflammatory periodontal status and the medical treatment status in Polycystic Ovary Syndrome(PCOS) women with systemic inflammation and to evaluate the effect of…
- Conditions
- Polycystic Ovary Syndrome, Periodontitis, Insulin Resistance
- Trial name
- NCT02633462
- Testing
- scaling and root planing , Myo-inositol, Myo-inositol
- Volunteers
- 56 people
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Diabetes, Hypertension
Pharmacy Interventions to Improve Chronic Disease Medication Refill
Compare the effectiveness of 3 strategies by pharmacists to decrease the time to refill of prescriptions for common chronic diseases (diabetes, hypertension, hyperlipidemia, heart failure, depression, psychoses).
- Conditions
- Diabetes, Hypertension, Hyperlipidemia, Heart Diseases
- Trial name
- NCT00469365
- Testing
- pharmacist contact with the patient via telephone, Pharmacist contact with the patient's physician via fax, Usual care
- Where
- United States
- Volunteers
- 3,048 people
- Sponsor
- Medical University of South Carolina
Renal Osteodystrophy
Cholecalciferol Versus Doxercalciferol in the Treatment of Secondary Hyperparathyroidism in Chronic Kidney Disease
The majority of patients with moderate to severe chronic kidney disease (CKD) (stages 3 and 4) develop secondary hyperparathyroidism (2°HPT), but the optimal therapy to control hyperparathyroidism in this group is unknown.
- Trial name
- NCT00285467
- Testing
- doxercalciferol, Cholecalciferol
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Indiana University
Brain Injury, Cerebral Palsy
Combination Therapy of Cord Blood and G-CSF for Patients With Brain Injury or Neurodegenerative Disorders
This open label trial is conducted to investigate the efficacy and safety of the combination therapy of allogeneic umbilical cord blood (UCB) and granulocyte-colony stimulating factor (G-CSF) for patients with brain injury or…
- Conditions
- Brain Injury, Cerebral Palsy, Amyotrophic Lateral Sclerosis, Parkinson's Disease
- Trial name
- NCT02236065
- Testing
- Umbilical cord blood therapy, Filgrastim
- Where
- South Korea
- Volunteers
- 10 people
- Sponsor
- MinYoung Kim, M.D.
Obesity, Immune Deficiency
Immunoglobulin G Therapy Dose Optimization
The overall goal of this proposal is to investigate effects of obesity on pharmacokinetics of immunoglobulin G (IgG) and to develop strategies for optimization of dosing of IgG in obese patients.
- Trial name
- NCT04818177
- Testing
- Institutional standard intravenous immune globulin treatment
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Rutgers, The State University of New Jersey
Type 1 Diabetes, Cardiovascular Diseases
Repurposing Colchicine for Reduction of Residual Inflammatory Risk in Type 1 Diabetes
The aim of this clinical trial is to evaluate if colchicine in addition to standard of care improves markers of inflammation and cardiovascular disease in persons with type 1 diabetes.
- Conditions
- Type 1 Diabetes, Cardiovascular Diseases, Chronic Inflammation
- Trial name
- REC1TE (NCT05949281)
- Testing
- Colchicine 0.5 MG Oral Tablet
- Where
- Denmark
- Volunteers
- 102 people
- Sponsor
- Asger Lund, MD
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