Clinical trials: Chronic Metabolic Disorder
Gout, Arthritis, Gouty
Phase 2b Evaluation of Efficacy and Safety of AR882 in Gout Patients
This study will assess the serum uric acid lowering effect and safety of AR882 in gout patients at two doses compared to placebo over 12 weeks.
- Conditions
- Gout, Arthritis, Gouty, Hyperuricemia, Gout Chronic
- Trial name
- NCT05119686
- Testing
- AR882 Dose 1, AR882 Dose 2
- Where
- 23 sites in United States, Australia and 1 more
- Volunteers
- 140 people
- Sponsor
- Arthrosi Therapeutics
Hypertension, Diabetes Mellitus, Type 2
Enhancing Community Health Through Patient Navigation, Advocacy and Social Support
Some patients who have multiple long-term health conditions have significant challenges accessing needed services despite available primary care and social services resources.
- Conditions
- Hypertension, Diabetes Mellitus, Type 2, Chronic Kidney Diseases, Ischemic Heart Disease
- Trial name
- ENCOMPASS (NCT03077386)
- Testing
- ENCOMPASS Intervention
- Where
- Canada
- Volunteers
- 176 people
- Sponsor
- University of Calgary
Cerebral Palsy (CP)
Whole Body Metabolism in Children With Cerebral Palsy With Low Skeletal Muscle Mass
At the center of pediatrics in Copenhagen the investigators experience that the children with CP with low skeletal muscle mass have more complications and admission after for example surgery is prolonged due to these…
- Trial name
- NCT06486597
- Testing
- Meal
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Chronic Kidney Disease stage4, Chronic Kidney Disease Stage 5
Healthy Diet Rich in Potassium to Chronic Kidney Disease With Sodium Zirconium Cyclosilicate: A Feasibility Study
This is a descriptive single arm open-label interventional trial lasting 6 weeks aiming to test if a low protein healthy K-rich diet with fruits, vegetables, whole grains, and nuts with concomitant use of new potassium binder…
- Conditions
- Chronic Kidney Disease stage4, Chronic Kidney Disease Stage 5, Hyperkalemia
- Trial name
- HELPFUL (NCT04207203)
- Testing
- sodium zirconium cyclosilicate and healthy diet
- Where
- Sweden
- Volunteers
- 26 people
- Sponsor
- Karolinska Institutet
Type 2 Diabetes Mellitus
A Cohort Study of Incretin-based Therapy Combined With Insulin in Type 2 Diabetic Patients for 5 Years
The use of dipeptidyl-peptidase 4 (DPP-4) inhibitors and glucagon like peptide 1 (GLP1) analogues for the treatment of diabetic mellitus (DM) type 2 is growing (1,2).
- Trial name
- NCT01681550
- Testing
- Incretin-based therapy
- Where
- Japan
- Volunteers
- 500 people
- Sponsor
- Nagaoka Red Cross Hospital
Obesity, Metabolic Syndrome
Cardiometabolic Effects of Sweet Cherry Juice
This study aims to determine the effects of consuming sweet cherry juice on cardiovascular function, glucose regulation, and lipid status in overweight human subjects.
- Trial name
- NCT03948061
- Testing
- Cherry juice
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- USDA, Western Human Nutrition Research Center
Wound of Skin
Radial Extracorporeal Shock Wave Therapy for Chronic Soft Tissue Wounds
This study tests the hypothesis that radial extracorporeal shock wave therapy (rESWT) as performed by Zoech (JATROS Orthop 2009;(1):46-47) is effective and safe in treatment of chronic soft tissue wounds, and is statistically…
- Trial name
- NCT03061461
- Testing
- rESWT
- Where
- Malaysia
- Volunteers
- 50 people
- Sponsor
- Kuala Lumpur General Hospital
Diabetes, Cervical Cancer (Early Detection)
Improving Cervical Cancer Prevention Among Women Living With Chronic Conditions.
Our overarching goal is to adapt and test the PINPOINT intervention -PatIent Navigation for the Prevention of CervIcal CaNcer inTervention.
- Conditions
- Diabetes, Cervical Cancer (Early Detection), Obesity & Overweight
- Trial name
- PINPOINT (NCT07351110)
- Testing
- patient navigation and self-collection
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Florida
Iron Deficiency Anemia (IDA), ESRD (End Stage Renal Disease)
Management of Iron Deficiency Anemia in Hemodialysis Patients
The aim of this interventional study is to assess the effectiveness of oral lactoferrin in improving hemoglobin levels and correcting iron deficiency anemia in patients with end-stage renal disease (ESRD) on dialysis and also…
- Trial name
- NCT07706582
- Testing
- Lactoferrin, IV iron sucrose
- Where
- Egypt
- Volunteers
- 108 people
- Sponsor
- Beni-Suef University
Cancer Patients With Advanced Solid Tumors Including Lymphoma or Chronic Hematological Malignancies
A Study to Determine the Absorption, Distribution, Metabolism, and Excretion of LBH589
This single center study will help determine the absorption, metabolism, and excretion of LBH589 and to assess the safety and efficacy of LBH589 in advanced cancer patients for whom no standard therapy exists.
- Trial name
- NCT00472368
- Testing
- LBH589
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Novartis Pharmaceuticals
Osteoporosis
The Relationship Between Osteoporosis and Chronic Oral Anticoagulation Therapy With Warfarin
The purpose of this study is to determine if osteoporosis is an unrecognized complication of chronic anticoagulation with warfarin.
- Trial name
- NCT00665613
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Chronic Obstructive Pulmonary Disease
Effect of Erythromycin on the Absorption, Metabolism and Elimination of CHF6001 in Healthy Volunteers
The objective of this study is to investigate the effect of the interaction of Erythromycin (CYP3A4/5 moderate inhibitor) on the pharmacokinetic of CHF6001 (CYP3A4/5 substrate) in Healthy Volunteers.
- Trial name
- NCT06395610
- Testing
- CHF6001 DPI, Erythromycin
- Where
- Bulgaria
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Chiesi Farmaceutici S.p.A.
Sleep Apnea
Hepatic Drug Biotransformation in Children With Obstructive Sleep Apnea
The purpose of this research study is to determine the effect of chronic nighttime low oxygen saturations on selected body systems (liver) that break down drugs in children with obstructive sleep apnea syndrome (OSAS).
- Trial name
- NCT00310323
- Testing
- Dextromethorphan, Caffeine
- Where
- 2 sites in United States
- Volunteers
- 69 people
- Sponsor
- Virginia Commonwealth University
Brain and Central Nervous System Tumors, Chronic Myeloproliferative Disorders
Donor Natural Killer Cells After Donor Stem Cell Transplant in Treating Patients With Advanced Cancer
RATIONALE: Giving an infusion of natural killer cells from a donor after a donor stem cell transplant may help kill any remaining cancer cells after the transplant.
- Conditions
- Brain and Central Nervous System Tumors, Chronic Myeloproliferative Disorders, Leukemia, Lymphoma
- Trial name
- NCT00823524
- Testing
- donor natural killer cell infusion
- Where
- South Korea
- Volunteers
- 47 people
- Sponsor
- Asan Medical Center
Diabetes, Foot Ulcer
Hyperbaric Oxygen Therapy as Adjunctive Treatment of Chronic Diabetic Foot Ulcers
The purpose of this study is to evaluate if hyperbaric oxygen therapy heels more foot ulcers as compared to placebo in patients with diabetes mellitus and chronic foot ulcers.
- Conditions
- Diabetes, Foot Ulcer, Healing
- Trial name
- HODFU (NCT00953186)
- Testing
- hyperbaric air, HBOT
- Where
- Sweden
- Volunteers
- 94 people
- Sponsor
- Mrs. Thelma Zoegas Foundation
Diabetes Mellitus, Type 2, Chronic Kidney Disease
A Research Study to Find Out How Semaglutide Works in the Kidneys Compared to Placebo, in People With Type 2 Diabetes and Chronic Kidney Disease (the REMODEL Trial)
We are doing this study to learn more about how semaglutide may help fight chronic kidney disease in people with type 2 diabetes. We are doing this by looking into how semaglutide works in the kidneys.
- Trial name
- REMODEL (NCT04865770)
- Testing
- Semaglutide
- Where
- 49 sites in United States, Canada and 6 more
- Volunteers
- 106 people
- Sponsor
- Novo Nordisk A/S
Diabetic Foot Ulcer
Efficacy Study of IZN-6D4 Gel for the Treatment of Diabetic Foot Ulcers
The purpose of this study is to determine if topical application of a hydrogel that contains plant extracts will improve healing of diabetic foot ulcers when compared to treatment with a hydrogel alone.
- Trial name
- NCT01427569
- Testing
- IZN-6D4 Gel
- Where
- Israel
- Volunteers
- 82 people
- Sponsor
- Izun Pharma Ltd
Chronic Kidney Disease
Risk Factors for Foot Ulceration in the Chronic Kidney Disease (CKD) Population
Foot ulceration is a risk factor that has been associated with early death in patients with chronic kidney disease. Little is known about the relationship between these risk factors that develop in patients with kidney failure…
- Trial name
- NCT01089829
- Testing
- Foot examination
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- Cardiff University
Iron Deficiency Anemia, Chronic Kidney Disease
Endovenous Versus Liposomal Iron in CKD
Anemia is a common complication in patients with chronic kidney disease (CKD). In addition to erythropoietin deficiency, many studies have identified iron deficiency as a cause of anemia in CKD patients.
- Trial name
- NCT01864161
- Testing
- gluconate iron, Liposomal iron
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Federico II University
Obesity
Chronic Inflammation After Obesity Surgery
To evaluate the impact of obesity surgery on chronic inflammation.
- Trial name
- NCT02697695
- Testing
- Laboratory Examination
- Volunteers
- 500 people
- Sponsor
- Sana Klinikum Offenbach