Clinical trials: Chronic Metabolic Disorder
Chronic Kidney Failure, End-stage Renal Disease
Fosrenol and Phosphorus Balance - Lanthanum Carbonate
Positive phosphorus balance and hyperphosphatemia (increased serum phosphorus levels) are very common complications of people with advanced chronic kidney disease (i.e., stage 5 CKD), including chronic dialysis patients, and are…
- Conditions
- Chronic Kidney Failure, End-stage Renal Disease, Disorders Associated With Peritoneal Dialysis
- Trial name
- NCT01581996
- Testing
- lanthanum carbonate
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Chronic Periodontitis
Changes of GCF Levels of RANKL and Osteoprotegerin in Postmenopausal Osteoporosis
The investigators evaluated the effect of initial periodontal treatment on clinical findings and receptor activator of Nuclear Factor-kappa B ligand (RANKL) and osteoprotegerin (OPG) in gingival crevicular fluid (GCF) of patients…
- Trial name
- NCT02808988
- Testing
- periodontal phase 1 therapy, gingival crevicular fluid collection, zoledronic acid
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Metabolic Adaptation to High-Intensity Interval Training, Metabolic Associated-dysfunction Steatotic Liver Disease (MASLD)
Rehabilitation With Exercise-Based Intervention for Nonalcoholic Chronic Hepatic Esteatosis
This study proposes a single-blind randomized clinical trial designed to evaluate the effects of high-intensity interval training (HIIT) on liver health in adults with overweight or obesity, while also assessing the usefulness of…
- Trial name
- RENACE (NCT07552727)
- Testing
- High-intensity interval training
- Where
- Chile
- Volunteers
- 30 people
- Sponsor
- Universidad San Sebastián
Immunologic Deficiency Syndromes, Chediak-Higashi Syndrome
Allogeneic Bone Marrow Transplantation in Patients With Primary Immunodeficiencies
OBJECTIVES: I. Provide curative immunoreconstituting allogeneic bone marrow transplantation for patients with primary immunodeficiencies. II.
- Conditions
- Immunologic Deficiency Syndromes, Chediak-Higashi Syndrome, Common Variable Immunodeficiency, Graft Versus Host Disease
- Trial name
- NCT00006054
- Testing
- anti-thymocyte globulin, busulfan, cyclophosphamide
- Where
- United States
- Sponsor
- Fairview University Medical Center
Scheduled Cardiac Surgery, Sternotomy
Postoperative Rehabilitation After Cardiac Surgery in Patients at Risk of Respiratory Complications. Effects of a Continuous Bi-laterosternal Infusion of Ropivacaine Through Multihole Catheters
Postoperative pain after cardiac surgery is a risk factor for postoperative complications. In cardiac surgery, pain is more intense during the first 48 hours and disturbs the patient's capacity of coughing, deep breathing, and…
- Conditions
- Scheduled Cardiac Surgery, Sternotomy, Elderly Patients, Obesity
- Trial name
- BLS-Sterno (NCT01828788)
- Testing
- Ropivacaine
- Where
- France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Clermont-Ferrand
Cirrhosis, Chronic Liver Disease
Copper Supplementation in Cirrhosis
End stage liver disease or cirrhosis is a major cause of mortality in the United States and the world. Other than targeting the underlying cause, such as alcohol cessation and antiviral therapy, very few medical treatments can…
- Conditions
- Cirrhosis, Chronic Liver Disease, Fibrosis, Infection
- Trial name
- NCT07471542
- Testing
- Copper Gluconate
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Washington
Long COVID, Insulin Resistance
Obesity, Insulin Resistance, and PASC: Persistent SARS-CoV-2
The investigators are studying the pathophysiologic links between obesity, insulin resistance (IR), adipose tissue infection, and post-acute sequelae of COVID-19 (PASC).
- Conditions
- Long COVID, Insulin Resistance, Insulin Sensitivity
- Trial name
- NCT05833217
- Testing
- Adipose Tissue Biopsy, Steady State Plasma Glucose (SSPG) Test
- Where
- 2 sites in United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Stanford University
Low Back Pain, Obesity
The Effect of Traction Forces in People With Obesity Suffering From Chronic Low Back Pain
The purpose of the research study is to assess the impact of traction forces on changes in systemic markers concentrations of spinal structure damage in people with obesity.
- Trial name
- NCT04507074
- Testing
- lumbar traction therapy
- Where
- Poland
- Volunteers
- 49 people
- Sponsor
- Poznan University of Physical Education
Chronic Obstructive Pulmonary Disease
Association Study Between CYP1A2 Gene Polymorphisms and Metabolism of Theophylline
The aim of this study is to determine whether common CYP1A2 gene polymorphisms effect metabolism of theophylline in Han and Uygur Patients with chronic obstructive pulmonary disease patients.
- Trial name
- NCT03015090
- Testing
- Theophylline
- Where
- China
- Volunteers
- 110 people
- Sponsor
- XiaoGuang Zou
Restless Leg Disorder, Renal Disease Bone
Cholecalciferol Supplementation in Restless Leg Syndrome in Patients With Chronic Kidney Disease
Restless leg syndrome (RLS) is sleep disorder characterized by an unpleasant feeling in the lower limbs, which can be accompanied by paresthesias, and need for urgent movement of the legs.
- Conditions
- Restless Leg Disorder, Renal Disease Bone, Renal Disease, End Stage, Hyperparathyroidism, Secondary
- Trial name
- RLS (NCT03063190)
- Testing
- Vitamin D
- Where
- Brazil
- Sponsor
- University of Sao Paulo General Hospital
Diabetic Retinopathy, Macular Degeneration
Advancing Understanding of Transportation Options
This Stage II randomized, controlled, longitudinal trial seeks to assess the acceptability, feasibility, and effects of a driving decision aid use among geriatric patients and providers.
- Conditions
- Diabetic Retinopathy, Macular Degeneration, Glaucoma, Retinitis Pigmentosa
- Trial name
- AUTO (NCT04141891)
- Testing
- Driving Decision Aid, Older Drivers Website
- Where
- 3 sites in United States
- Volunteers
- 529 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Heart Failure, Hyperuricemia
Treatment of Hyperuricemia in Patients With Heart Failure
The study aims to assess (I) the contribution of UA itself to the CHF pathophysiology and (II) to test the effect of lowering UA by uricosuric treatment in CHF.
- Trial name
- NCT00422318
- Testing
- Benzbromarone (drug)
- Where
- Japan
- Sponsor
- Tottori University Hospital
Type 2 Diabetes Mellitus (T2D) and Chronic Kidney Disease (CKD)
SPRING - Assess the Clinical Care Pathway of Population With T2D and CKD in Four European Countries Using Real-world Data
This study is being carried out in 4 countries (France, Italy, Spain and the UK) to understand the clinical care pathway of population living with type 2 diabetes who also have evidence of chronic kidney disease.
- Trial name
- NCT06769646
- Testing
- No tretament given
- Where
- India
- Volunteers
- 110,074 people
- Sponsor
- Novo Nordisk A/S
Chronic Kidney Disease, Vitamin D Deficiency
Vitamin D, Chronic Kidney Disease (CKD) and the Microcirculation
Overall research aims: This study will examine the effect of vitamin D supplementation on the function of the endothelium and microcirculation of patients with chronic kidney disease and vitamin D deficiency.
- Trial name
- NCT00882401
- Testing
- Ergocalciferol (Vitamin D)
- Where
- United Kingdom
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Barts & The London NHS Trust
Hyperphosphatemia, Chronic Kidney Disease
A Study of HS219 in Chronic Kidney Disease Patients on Hemodialysis With Hyperphosphatemia
This was a study to evaluate the efficacy and safety of HS219, chitosan-loaded chewing gum, when given three times a day for 3 weeks to the hemodialysis (HD) patients with hyperphosphatemia whose serum inorganic phosphorus was…
- Trial name
- NCT01039428
- Testing
- HS219
- Where
- 11 sites in Japan
- Volunteers
- 68 people
- Sponsor
- KDL Inc.
Inclusion Body Myositis, Myotonic Dystrophy
Development and Validation of the FBIndex to Determine the Risk of Falls for Patients With Neuromuscular Disorders
Currently, there are no standardised fall risk scores or guidelines on when to use appropriate assistive gait devices (AGDs) for people with neuromuscular disorders (NMDs).
- Conditions
- Inclusion Body Myositis, Myotonic Dystrophy, Limb-girdle and Facioscapulohumeral Muscular Dystrophies, Pompe Disease
- Trial name
- FBIndex (NCT06605612)
- Testing
- FBIndex
- Where
- Germany
- Volunteers
- 108 people
- Sponsor
- LMU Klinikum
Obstructive Sleep Apnea, Chronic Obstructive Pulmonary Disease
Fat Metabolism in OSA and COPD
Obstructive sleep apnea (OSA) is the most common type of sleep apnea and is caused by an obstruction of the upper airways. The obstruction results in periods of intermittent hypoxia and re-oxygenation, which lead to increased…
- Conditions
- Obstructive Sleep Apnea, Chronic Obstructive Pulmonary Disease, Obesity
- Trial name
- NCT02157844
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Kidney Diseases, Chronic Renal Insufficiency
Study to Compare Sevelamer Carbonate Powder to Sevelamer Hydrochloride Tablets in Patients With CKD on Hemodialysis
Approximately 207 patients with chronic kidney disease (CKD) on hemodialysis will be entered into this study at approximately 26 centers in the United States.
- Conditions
- Kidney Diseases, Chronic Renal Insufficiency, End-Stage Renal Disease
- Trial name
- NCT00268957
- Testing
- Sevelamer carbonate (Renvela®), Sevelamer hydrochloride (Renagel®)
- Where
- 29 sites in United States
- Volunteers
- 217 people
- Sponsor
- Genzyme, a Sanofi Company
Alcohol Abuse, Drug Abuse
Reducing Problematic Substance Use in Youth With Chronic Medical Conditions
The investigators goal is to pilot a substance use-related brief intervention (BI) for youth with chronic medical conditions, obtaining preliminary evidence of feasibility, acceptability and impacts of the approach for reducing…
- Trial name
- NCT01709201
- Testing
- Brief Intervention
- Where
- United States
- Sponsor
- Boston Children's Hospital
Early Gastric Cancer
Effect of Gastrectomy and Anastomosis on Diabetes and Hypertension in Early Gastric Cancer Patients
The purpose of this study is to determine whether the extent of gastrectomy and anastomosis type affect chronic metabolic disease such as diabetes and hypertension in early gastric cancer patients.
- Trial name
- NCT01643811
- Testing
- gastrectomy, Endoscopic submucosal dissection
- Where
- South Korea
- Volunteers
- 159 people
- Sponsor
- National Cancer Center, Korea
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