Clinical trials: Chronic Migraine, Headaches
Chronic Migraine
Assessment of LBR-101 In Chronic Migraine
The purpose of the study is to determine whether monthly subcutaneous administration of LBR-101 (fremanezumab) is safe and provides migraine prevention in patients with chronic migraine.
- Trial name
- NCT02021773
- Testing
- LBR-101 High Dose, LBR-101 Low Dose
- Where
- 57 sites in United States
- Volunteers
- 264 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Chronic Migraine
First Evaluation of a Craniofacial Nerve Stimulation System in Chronic Migraine
The purpose of this study is to demonstrate the safe use of the PRIMUS system in subjects with chronic migraine. This is a single-center, open label, prospective, early feasibility study to collect initial clinical data on the…
- Trial name
- SalviaBio (NCT05858801)
- Testing
- PRIMUS
- Where
- Belgium
- Volunteers
- 7 people
- Sponsor
- Salvia BioElectronics
Greater Occipital Nerve Block, Medical Treatment
Chronic Migraine Prophylaxis: Ultrasound-Guided Greater Occipital Nerve Block Versus Medical Treatment
The aim of this work is to assess the efficacy of ultrasound guided greater occipital nerve block either by local anesthetic or by botulinum toxin in comparison to medical treatment in prevention of chronic migraine.
- Conditions
- Greater Occipital Nerve Block, Medical Treatment, Chronic Migraine
- Trial name
- NCT06122545
- Testing
- Greater Occipital Nerve Block, Medical Treatment, bupivacaine or onabotulinum toxin A injection.
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Tanta University
Migraine Disorders
An Observational Study of BOTOX® as Headache Prophylaxis for Chronic Migraine
This is an observational study to describe the long term use of Onabotulinumtoxin A (BOTOX®) as prescribed by the physician for headache prophylaxis in adults with chronic migraine. All treatment decisions lie with the physician.
- Trial name
- NCT01686581
- Testing
- botulinum toxin Type A
- Where
- 77 sites in Germany, Italy and 5 more
- Volunteers
- 641 people
- Sponsor
- Allergan
Transformed Migraine, Chronic Daily Headache
Sphenopalatine Ganglion Nerve Block vs. Elavil for Treatment of Transformed Migraines
This study will compare a local anesthetic technique that has been used to treat subjects suffering from transformed migraines (chronic migraines) versus medical management with traditional antidepressant Amitriptyline / Elavil.
- Trial name
- NCT02090998
- Testing
- SPG Block with 5% Lidocaine gel, Amitriptyline
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Rutgers, The State University of New Jersey
Chronic Migraine
Suppressive Functions of Regulatory T Cells in Migraine
Migraine is a frequent, disabling condition, of great social and economical impact worldwide. This condition is more frequent in women and subjects with autoimmune and/or inflammatory diseases.
- Trial name
- SIIM-reg (NCT07067112)
- Testing
- Blood sampling, questionnaire and phone call
- Where
- France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Chronic Pain, Migraine Disability
Chronic Pain in the General Population of Chile
The present study seeks to follow up the cohort of adults representative of Chile's urban population whose levels of chronic pain were evaluated in March 2023 (baseline) as part of the Mental Health Thermometer (MHT) study.
- Conditions
- Chronic Pain, Migraine Disability, Neuropathic Pain, Fibromyalgia
- Trial name
- RDC (NCT06353100)
- Where
- Chile
- Volunteers
- 2,365 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Migraine Disorders
Evaluation of ALD403 (Eptinezumab) in the Prevention of Chronic Migraine
The purpose of this study is to assess the efficacy and safety of ALD403 in the prevention of migraine headache in chronic migraineurs.
- Trial name
- PROMISE 2 (NCT02974153)
- Testing
- ALD403 (Eptinezumab)
- Where
- 144 sites in United States, Belgium and 11 more
- Volunteers
- 1,121 people
- Sponsor
- Alder Biopharmaceuticals, Inc.
Migraine, Migraine With Aura
Monoclonal CGRP Antibodies for Migraine Prevention - a Nationwide Real Life Study
The present non-interventional study on migraine prevention with monoclonal CGRP antibodies adresses questions concering safety, swichting from one CGRP mab to another, efficacy on auras in the real world setting.
- Conditions
- Migraine, Migraine With Aura, Migraine Without Aura, Chronic Migraine
- Trial name
- NCT05281770
- Testing
- Erenumab, Fremanezumab, Galcanezumab
- Where
- 3 sites in Austria
- Volunteers
- 1,500 people
- Sponsor
- Austrian Migraine Registry Collaboration
Pain
A Pilot Study of Switching From One Pain Medication to Another (Opioid Rotation)
The purpose of this study is to see if changing from one pain medication like morphine or oxycodone to another pain medication, oxymorphone (OPANA®), will be helpful to patients.
- Trial name
- NCT00580294
- Testing
- Oxymorphone
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Migraine, Chronic Pain
Mindfulness and Migraine Research Study
The primary aim of this study is to conduct a randomized controlled feasibility trial of MBSR for patients with moderate-to- severe migraine headache.
- Trial name
- M&M (NCT02824250)
- Testing
- MBSR
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- California Pacific Medical Center Research Institute
Chronic Migraine
Mechanism-Based Cervical Rehabilitation for Chronic Migraine
To investigate the effectiveness of mechanism-based cervical sensorimotor rehabilitation on cervical muscle activation, cervical proprioception, and migraine burden.
- Trial name
- NCT07762690
- Testing
- cervical sensorimotor rehabilitation, conventional physiotherapy programme
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University
Headache
Non-pharmacological Management of Chronic Migraine
Chronic migraine (CM) is a very disabling disorder with grave socioeconomic consequences. Pharmacological approaches can affect mechanisms of pain production, while rehabilitation such as Transcutaneous Electrical Nerve…
- Trial name
- MIGRANE (NCT02953015)
- Testing
- Manipulative articulatory (ART) and myofascial techniques, Transcutaneous Electrical Nerve Stimulation, OnabotulinumtoxinA (Prophylaxis therapy)
- Where
- Italy
- Volunteers
- 16 people
- Sponsor
- Universita di Verona
High Frequency Episodic Migraine and Chronic Migraine
TI-001 (Intranasal Oxytocin) for Treatment of High Frequency Episodic Migraine and Chronic Migraine
This study evaluates the use of oxytocin, given as a nasal spray, for treatment of high frequency episodic migraine and chronic migraine.
- Trial name
- NCT01839149
- Testing
- TI-001
- Where
- 6 sites in Australia, Chile and 1 more
- Volunteers
- 240 people
- Sponsor
- Trigemina, Inc
Migraine
Clinical Effectiveness of Osteopathic Manipulative Treatment in Chronic Migraine
The aim of the present study is to determine the extend to which OMT is effective on a sample of subjects affected by migraine evaluated using the headache impact test (HIT-6) questionnaire.
- Trial name
- NCT01851148
- Testing
- osteopathic manipulative treatment, triptans
- Where
- Italy
- Volunteers
- 105 people
- Sponsor
- European Institute for Evidence Based Osteopathic Medicine
Chronic Migraine
A Two-Arm Study Evaluation H.P. Acthar Injection Gel in Treatment of Chronic Migraines
This small study is to investigate the efficacy of Acthar in the treatment of chronic migraine in patients who have failed multiple treatments, including Botox (which is defined as having <30% reduction from baseline in the…
- Trial name
- NCT01813591
- Testing
- H.P. Acthar Gel
- Where
- 4 sites in United States
- Volunteers
- 20 people
- Sponsor
- Dent Neuroscience Research Center
Headache, Headache Disorders
Mind Body Balance for Pediatric Migraine
This study uses a factorial research design to evaluate a nurse delivered mind body intervention using different doses of 3 treatment components to determine the optimized treatment for headache day reduction.
- Conditions
- Headache, Headache Disorders, Headache, Migraine, Migraine
- Trial name
- NCT04715685
- Testing
- 40 minute session, 20 minute session, home practice e-health
- Where
- 2 sites in United States
- Volunteers
- 260 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Migraine, Musculoskeletal Pain
Overlapping Pain Trajectory Study
The goal of this observational study is to learn about spatial and temporal nociceptive filtering in adolescents with chronic overlapping pain conditions (COPCs). The main questions it aims to answer are: 1.
- Conditions
- Migraine, Musculoskeletal Pain, Functional Abdominal Pain Disorders, Chronic Pain
- Trial name
- COPC (NCT05752396)
- Testing
- Conditioned Pain Modulation, Offset Analgesia, Spatial Summation
- Where
- United States
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Migraine Disorders, Chronic Migraine Headache
EMBRACE-OBS: Single-Site Observational Registry of Patient-Reported Outcomes Following MMA Embolization for Migraine
EMBRACE-OBS is the first phase of the EMBRACE research program. This single-site observational registry accesses and analyzes patient-reported outcome data already collected through routine clinical care from adults with migraine…
- Conditions
- Migraine Disorders, Chronic Migraine Headache, Migraine
- Trial name
- EMBRACE-OBS (NCT07652034)
- Testing
- Middle Meningeal Artery Embolization
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Cortex Neurovascular
Migraine Disorders
Chronic Migraine Epidemiology and Outcomes Study
This is a population internet-based study to characterize migraine clinical course and impact on family.
- Trial name
- NCT01648530
- Testing
- No Treatment
- Volunteers
- 16,789 people
- Sponsor
- Allergan