Clinical trials: Chronic Migraine, Headaches
Migraine
Ultrasound Guided Block of Stellate Ganglion Versus Greater Occipital Nerve in Resistant Migraine and Correlation to Calcitonin Gene Related Peptide
To investigate the efficacy of Ultrasound guided Stellate Ganglion block in chronic resistant migraine patients in comparison to Greater Occipital Nerve Block correlating its effect to serum CGRP level.
- Trial name
- NCT06662461
- Testing
- ultrasound guided Greater occipital nerve block, Ultrasound guided Stellate ganglion block
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Chronic Migraine, Headache
Mesotherapy in the Treatment of Chronic Migraine
Mesotherapy is a type of injection frequently used in clinics. It is a treatment procedure that involves the injection of some drugs under the skin or into the skin.
- Trial name
- NCT06118190
- Testing
- Lidocain
- Where
- Turkey (Türkiye)
- Volunteers
- 27 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Resistant Migraine, Chronic Migraine Headache
A Pivotal Clinical Study to Evaluate the MySalvia System for the Treatment of Resistant Migraine
The purpose of this pivotal clinical study is to evaluate the safety and effectiveness of the MySalvia System, a minimally invasive implantable neuromodulation therapy, for the preventive treatment of adults with resistant…
- Conditions
- Resistant Migraine, Chronic Migraine Headache, Headache (Migraine), Headache, Cluster
- Trial name
- RECLAIM-II (NCT07719608)
- Testing
- Neurostimulator
- Where
- 3 sites in United States
- Volunteers
- 150 people
- Sponsor
- Salvia BioElectronics
Primary Headache Disorder
Feasibility of a Developmentally-tailored Mobile App for Tracking Mood and Pain in Children With Migraine
This study aims to inform the continued development of a mobile app intended to support the treatment of CYP with migraine. After extensive public and patient involvement, Happyr Health has developed a mobile app that allows…
- Trial name
- NCT05337930
- Testing
- Happyr App
- Where
- United Kingdom
- Sponsor
- Happyr Ltd
Headache, Migraine
Psychological Assessment and Treatment of Chronic Benign Headache
Subjects with chronic migraine or tension headaches will receive 12 sessions of biofeedback or relaxation training after fulfilling screening, intake interviews, \& psychological testing requirements.
- Conditions
- Headache, Migraine, Tension Headache, Stress Headache
- Trial name
- NCT00018811
- Testing
- Relaxation training & thermal biofeedback, Surface EMG biofeedback
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Chronic Migraine
A Study of Remote Electrical Neuromodulation for Acute Procedural Pain
The purpose of this study is to assess the effectiveness of using remote electrical neuromodulation, using the Nerivio ® device, to relieve pain associated with receiving onabotulinumtoxinA (Botox) injections for chronic migraine…
- Trial name
- NCT05730556
- Testing
- Nerivio ®
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Mayo Clinic
Headache
Acceptance and Commitment Therapy vs Medical Treatment as Usual Wait-list Control for Primary Headache Sufferers
Research to date suggests that individuals with headache use avoidance as a way to manage their pain. Despite the wide use of avoidance as a coping mechanism of headache triggers, very little empirical evidence exist to support…
- Trial name
- ALGEA (NCT02734992)
- Testing
- ACT+ MTAU, Waitlist Control +MTAU
- Where
- Cyprus
- Volunteers
- 100 people
- Sponsor
- University of Cyprus
Chronic Migraine
Cannabis for the Prophylactic Treatment of Migraine
This study will evaluate the efficacy and safety of cannabis for the treatment of chronic migraine headaches. Study subjects will be randomized to one of three groups: lower dose CBD, higher dose CBD or placebo.
- Trial name
- NCT03972124
- Testing
- CBD 100 mg OD, CBD 200 mg OD
- Where
- Canada
- Volunteers
- 72 people
- Sponsor
- University of Calgary
Pain From onabotulinumtoxinA Injections
Topical Intranasal Anesthetic Block for Reducing the Pain of Botulinum Toxin Injections for Chronic Migraine
People find the injections used in onabotulinumtoxinA (Botox®) uncomfortable. This study will test whether putting a small piece of cotton soaked with 4% lidocaine (a numbing medicine) inside the front of each nostril for 5…
- Trial name
- NCT07571889
- Testing
- onabotulinumtoxinA prophylaxis with Lidocaine, OnabotulinumtoxinA prophylaxis with Saline
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Association of Migraine Disorders
Migraine Disorders
Effects of tDCS and Physical Therapy in Chronic Migraine
The aim of this clinical study is to compare the effects of tDCS, physiotherapy, and their association with the intensity in women with Chronic Migraine.
- Trial name
- NCT05706077
- Testing
- active tDCS, real Physical Therapy
- Where
- Brazil
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Federal University of Paraíba
Headache Disorders
Occipital Nerve Stimulation to Treat Chronic Headaches
The purpose of this study is to evaluate the safety and efficacy of a implantable device, called the bion(R), in the treatment of chronic headache.
- Trial name
- NCT00205894
- Testing
- bion microstimulator
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Boston Scientific Corporation
Migraine
Migraine is Associated With Altered Mechanical Pain Sensitivity. This Study Investigates Mechanical Pain Sensitivity, Headache Burden, and Quality of Life in Episodic and Chronic Migraine, Comparing Pressure Algometry and Algopeg® and Assessing Mechanosensitivity of Peripheral Nerves.
Migraine is one of the most prevalent neurological disorders and is associated with a substantial individual and societal burden.
- Trial name
- MechSens_Migra (NCT07559565)
- Testing
- pressure pain algometry
- Where
- Austria
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Bernhard Taxer
Chronic Pain, Headache, Migraine
Feasibility of Using Holographic Memory Resolution® (HMR) in Patients/Clients With Pain
Study Purpose: This study will explore the feasibility of administering Holographic Memory Resolution® (HMR) to adults who are experiencing chronic pain for 6 months or more.
- Conditions
- Chronic Pain, Headache, Migraine, Stress Disorders, Post-Traumatic
- Trial name
- NCT05001399
- Testing
- Holographic Memory Resolution® (HMR)
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Billings Clinic
Chronic Migraine, Episodic Migraine
Post-Marketing Study to Assess the Safety and Effectiveness of Oral Atogepant in Korean Adult Participants for the Prevention of Chronic or Episodic Migraine
Migraine is a neurological disease characterized by moderate or severe headache, associated with nausea, vomiting, and/or sensitivity to light and sound.
- Conditions
- Chronic Migraine, Episodic Migraine, Migraine
- Trial name
- Atogepant PMSS (NCT06603558)
- Testing
- Atogepant
- Where
- 36 sites in South Korea
- Volunteers
- 3,000 people
- Sponsor
- AbbVie
Asthma, Atrial Fibrillation
The Living With a Long-Term Condition Study
Psychological distress (anxiety and depression) is common in and experienced differently by people living with long-term health conditions (LTCs).
- Conditions
- Asthma, Atrial Fibrillation, Cancer, Cerebrovascular Disorders
- Trial name
- LTC (NCT06072287)
- Testing
- Living with LTC Questionnaire
- Where
- United Kingdom
- Volunteers
- 600 people
- Sponsor
- King's College London
Chronic Migraine, Migraine Disorders
Osteopathic Manipulative Treatment and Migraine Headaches
In this study the investigators hypothesize, that Osteopathic Manipulative Therapy (OMT) will reduce migraine disability and severity scores when compared to standard of care including prophylactic pharmacological agents with…
- Conditions
- Chronic Migraine, Migraine Disorders, Headache Disorders, Headache, Migraine
- Trial name
- NCT04976985
- Testing
- Osteopathic Manipulative Therapy (OMT), Standard of care
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- St. Luke's Hospital, Pennsylvania
Chronic Migraine Headache
Laser Acupuncture for Chronic Migraine: Clinical Response, Traditional Chinese Medicine Syndrome Patterns, and Brain Function
The PRISM-CM study will test whether 810-nanometer laser acupuncture reduces migraine days and related symptoms in adults with chronic migraine.
- Trial name
- PRISM-CM (NCT07891585)
- Testing
- 810 nm laser acupuncture
- Where
- Taiwan
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Taichung Veterans General Hospital
Migraine
Efficacy of Manual Therapy for the Treatment of Migraine.
Introduction According to the World Health Organization (WHO) at least 47% of adults have suffered from headache in the last year.
- Trial name
- MT-Migraine (NCT03555214)
- Testing
- Manual Therapy based on soft tissues, Control group, Manual Therapy based on structural techniques
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- University of Valencia
Migraine Disorders, Headache
A Retrospective Chart Review to Evaluate Diagnosis and Treatment of Chronic Migraine and Headache
This study is a retrospective chart review in patients diagnosed with headache or migraine to evaluate treatment patterns and diagnosis.
- Trial name
- NCT01946126
- Testing
- No Intervention
- Where
- United States
- Volunteers
- 459 people
- Sponsor
- Allergan
Chronic Migraine Headache, Radiofrequency Ablation
The Effect of Interventional Procedures on Serum CGRP and PACAP-38 Levels in Chronic Migraine
The study included 100 patients diagnosed with chronic migraine (CM) who received a diagnosis from the headache clinics of the Neurology Department of Adnan Menderes University Hospitals between May 2025 and May 2026.
- Conditions
- Chronic Migraine Headache, Radiofrequency Ablation, Greater Occipital Nerve Block, Calcitonin Gene-related Peptide
- Trial name
- NCT07395908
- Testing
- Greater occipital nerve Pulse radiofrequency, Greater occipital nerve block
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University