Clinical trials: Chronic Myocardial Ischemia
Coronary Artery Disease, Acute Coronary Syndromes
Aspirin 50mg vs 100mg Combined With P2Y12 Inhibitor After PCI
This is a randomized, open-label, active-controlled, non-inferiority clinical trial (the ASPIRE-LD trial) conducted in China. It aims to compare the efficacy and safety of low-dose aspirin (50 mg once daily) versus standard-dose…
- Conditions
- Coronary Artery Disease, Acute Coronary Syndromes, Chronic Coronary Syndrome, Percutaneous Coronary Intervention
- Trial name
- ASPIRE-LD (NCT07846462)
- Testing
- Aspirin, P2Y12 inhibitor
- Where
- China
- Volunteers
- 2,640 people
- Sponsor
- Jilin University
Heart Diseases, Heart Valve Diseases
Acute Kidney Injury After Cardiac Surgery
The study aims to identify the Following: - 1. incidence and mortality of cardiac Surgery associated -AKI based on the new consensus diagnostic systems of KDIGO (Kidney Disease Improving Global Outcomes). 2.
- Conditions
- Heart Diseases, Heart Valve Diseases, Heart Shock, Cardiac Disease
- Trial name
- NCT05079724
- Testing
- Cardiac Surgery
- Volunteers
- 200 people
- Sponsor
- Assiut University
Coronary Artery Disease, Chronic Total Occlusions
Prognostic Impact of Chronic Total Occlusions
The purpose of this study is to determine the prognostic impact of the presence of chronic total occlusions (CTO) of the coronary arteries in patients undergoing coronary angiography and PCI.
- Trial name
- NCT02084888
- Where
- Sweden
- Volunteers
- 91,154 people
- Sponsor
- Sahlgrenska University Hospital
Cardio-Renal Syndrome, Coronary Angiography
Risk Factors and Prognosis of Adverse Cardiovascular and Kidney Events After Coronary Intervention
As a single center, retrospective observation study in Guangdong Institute of Cardiovascular Diseases, this study included the main study population of patients who underwent coronary angiography and / or coronary intervention…
- Conditions
- Cardio-Renal Syndrome, Coronary Angiography, Coronary Artery Disease, Kidney Diseases
- Trial name
- NCT04407936
- Where
- China
- Volunteers
- 88,938 people
- Sponsor
- Guangdong Provincial People's Hospital
Cardiovascular Disease, Coronary Artery Disease
Radial Artery Versus Saphenous Vein Grafts in Coronary Artery Bypass Surgery
VA patients with coronary artery disease and who have agreed to undergo coronary artery bypass graft surgery would be randomized to receive either radial artery or saphenous vein to the study vessel.
- Trial name
- NCT00054847
- Testing
- saphenous vein graft, radial artery graft
- Where
- 11 sites in United States
- Volunteers
- 733 people
- Sponsor
- US Department of Veterans Affairs
Coronary Artery Disease, Acute Coronary Syndrome
South East (Zuid Oost) Netherlands Heart Registry
Rationale: Patients undergoing percutaneous coronary intervention (PCI) for chronic coronary syndrome (CCS) or acute coronary syndrome (ACS) have a residual risk of ischemic events after PCI due to the progression of…
- Conditions
- Coronary Artery Disease, Acute Coronary Syndrome, Chronic Coronary Syndrome
- Trial name
- ZON-HR (NCT06512493)
- Where
- 4 sites in Netherlands
- Volunteers
- 99,999 people
- Sponsor
- Radboud University Medical Center
Heart Failure, Myocardial Infarction
A Multinational Trial To Evaluate The Parachute Implant System
The primary objective is to assess the safety of the CardioKinetix Parachute Implant and Delivery System in the partitioning of the left ventricle in patients with heart failure due to ischemic heart disease.
- Trial name
- PARACHUTE (NCT01286116)
- Testing
- Parachute Implant
- Where
- 13 sites in France, Germany and 6 more
- Volunteers
- 59 people
- Sponsor
- CardioKinetix, Inc
Coronary Artery Disease, Myocardial Ischemia
BIOFLOW III Asia Registry Orsiro Stent System
Cliflical evaluation of th' Orsiro LESS 10 diabetic subjects requiring coronary revasculariza t ion with Drug Eluting Stefl ts (DES) .880 subjects will be enrolled in this registry.
- Conditions
- Coronary Artery Disease, Myocardial Ischemia, Diabetes Mellitus Type 1 or 2
- Trial name
- NCT01941290
- Where
- 19 sites in China, India and 3 more
- Volunteers
- 387 people
- Sponsor
- BIOTRONIK Asia Pacific Pte Ltd
Coronary Artery Disease, Coronary Disease
Sirolimus-Eluting Stents for Chronic Total Coronary Occlusions
Primary intracoronary stent placement after successfully crossing chronic total occlusions (CTO) decreases the high restenosis rate at long-term follow-up compared with conventional balloon angioplasty.
- Conditions
- Coronary Artery Disease, Coronary Disease, Coronary Stenosis
- Trial name
- NCT00258596
- Testing
- sirolimus-eluting stent
- Where
- 2 sites in Netherlands
- Volunteers
- 200 people
- Sponsor
- R&D Cardiologie
Chronic Stable Angina
Danhong Injection in the Treatment of Chronic Stable Angina
The purpose of this study is to evaluate the effect of Danhong Injection on the relief of angina with the use of the Seattle Angina Questionnaire among patients with stable angina patients
- Trial name
- NCT01681316
- Testing
- Danhong injection, Standard medical care
- Where
- 31 sites in China
- Volunteers
- 920 people
- Sponsor
- China Academy of Chinese Medical Sciences
Periodontal Diseases, Coronary Disease
Quantification of Micro-RNA 146-a in Chronic Periodontitis and Coronary Heart Disease Subjects
The expression and quantification of Micro-RNA 146-a, was analyzed in the subgingival plaque samples of generalized chronic periodontitis patients with and without coronary heart disease.
- Trial name
- NCT03721159
- Where
- India
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Meenakshi Ammal Dental College and Hospital
Kidney Failure, Chronic, Coronary Artery Disease
Prophylactic Effect of Nifedipine on Further Decline in Renal Function in Patients Undergoing Open-Heart Surgery
To compare renal function (51Cr-EDTA clearance) 48 hours post open-heart surgery (coronary bypass or valve surgery) in patients with impaired renal function after randomization to either nifedipine infusion at start of surgery…
- Trial name
- NCT00244530
- Testing
- Nifedipine
- Where
- Norway
- Volunteers
- 20 people
- Sponsor
- University of Oslo School of Pharmacy
Coronary Occlusion, Angioplasty, Balloon, Coronary
Functional Assessment-guided Angioplasty in Patients With Coronary Chronic Total Occlusion
The aim of this study is to investigate the role of functional evaluation for predicting clinical outcome in patients with coronary chronic total occlusion (CTO) undergoing percutaneous coronary intervention (PCI), and to…
- Trial name
- FAGA-CTO (NCT03522038)
- Testing
- percutaneous coronary intervention
- Volunteers
- 300 people
- Sponsor
- Shanghai Zhongshan Hospital
Coronary Artery Disease
The Evaluation of Fractional Flow Reserve and D SPECT for the Intervention of Chronic Total Occlusion
Coronary chronic total occlusions (CTOs) are defined as an occluded coronary vessel with TIMI defined as an occluded coronary vessel with TIMI (Thrombolysis in Myocardial Infarction) grade flow 0 and an estimated duration of at…
- Trial name
- NCT03803020
- Testing
- fractional flow reserve and SPECT detection
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Shanghai Zhongshan Hospital
Asthma, Coronary Artery Disease
A Study of the Safety and Tolerance of Regadenoson in Subjects With Asthma or Chronic Obstructive Pulmonary Disease
This study is intended to determine the safety and tolerance of regadenoson in subjects with asthma or chronic obstructive pulmonary disease.
- Conditions
- Asthma, Coronary Artery Disease, Pulmonary Disease, Chronic Obstructive
- Trial name
- NCT00862641
- Testing
- Regadenoson
- Where
- 48 sites in United States
- Volunteers
- 1,009 people
- Sponsor
- Astellas Pharma Inc
Acute Coronary Syndrome
Electrolytes in Chronic Kidney Disease Patients With Acute Coronary Syndrome
Study of serum calcium and phosphorus level in chronic kidney disease patients and its relation to occurrence of acute coronary syndrome in them.
- Trial name
- NCT05134220
- Testing
- Serum Calcium
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Platelet Aggregation, Adenosine
Platelet Aggregation in Patients With Coronary Artery Disease and Kidney Dysfunction Taking Clopidogrel or Ticagrelor
About 35% of patients hospitalized with Acute Coronary Syndromes (ACS) have some degree of renal dysfunction. Chronic kidney disease (CKD) is not only associated to worse prognosis in ACS patients, but leads also to an increased…
- Conditions
- Platelet Aggregation, Adenosine, Coronary Artery Disease, Kidney Dysfunction
- Trial name
- NCT03039205
- Testing
- Clopidogrel, Ticagrelor
- Where
- Brazil
- Volunteers
- 90 people
- Sponsor
- University of Sao Paulo
Coronary Heart Disease
Testosterone and Myocardial Perfusion in Coronary Heart Disease (CHD)
Testosterone has traditionally been regarded as a risk factor for heart disease due to the fact that males have a higher incidence of this disease than women, at least until the menopause.
- Trial name
- NCT00239590
- Testing
- Testosterone undecanoate
- Where
- United Kingdom
- Volunteers
- 28 people
- Sponsor
- Imperial College London
Chronic Stable Angina, Refractory Angina
Wave Crossover ECP Study for Simplified Therapy
The purpose of this study is to demonstrate substantial equivalence between Pression's Wave PRO System and a commercially available predicate ECP device to support a U.S. 510(k) submission for the Wave PRO System.
- Trial name
- WaveCRESST (NCT06571370)
- Testing
- External Counterpulsation
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Pression
Ischemic Heart Disease
Study to Evaluate the Safety and Effectiveness of the Biosensors Microcatheter in Coronary Chronic Total Occlusions (CTO) - BIOMICS
Biosensors, the Sponsor would like to determine if the Biosensors Microcatheter is safe and effective in treating patients with CTO by assessing a composite of in-hospital cardiac death or myocardial infarction and device success…
- Trial name
- BIOMICS (NCT04966273)
- Testing
- Microcatheter
- Where
- 9 sites in United Kingdom
- Volunteers
- 101 people
- Sponsor
- Biosensors Europe SA