Clinical trials: Chronic Nephropathy
End Stage Renal Disease
Pilot Study of Taste Sensations in Patients With End-stage Renal Disease on Hemodialysis
Individuals on dialysis due to kidney failure have very prescriptive diets. These diets help increase dialysis effectiveness and help patients control blood levels of electrolytes including potassium and phosphate, acid-base…
- Trial name
- NCT03495271
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Purdue University
End-stage Renal Disease, Cardiorenal Syndrome
Cardiorenal Syndrome in End-Stage Kidney Disease
Cardiorenal Syndrome (CRS) is prevalent among end-stage renal disease (ESRD) patients. Recently, its prevalence is rising. There are several different clinical presentations of this syndrome.
- Conditions
- End-stage Renal Disease, Cardiorenal Syndrome, Heart Disease
- Trial name
- NCT02238093
- Where
- Israel
- Volunteers
- 270 people
- Sponsor
- Hillel Yaffe Medical Center
Chronic Kidney Disease, Sarcopenia
Effect of Ketosteril on Sarcopenia in Patients With Chronic Kidney Disease
The investigators hypothesize that Ketosteril can improve sarcopenia in patients with renal disease without increasing the burden on the kidneys and causing deterioration of renal function.
- Trial name
- NCT06329622
- Testing
- low-protein diet + Ketosteril, low-protein diet
- Where
- China
- Volunteers
- 58 people
- Sponsor
- Huashan Hospital
Chronic Kidney Disease, Acute Bleeding
The Strategy to Prevent Hemorrhage Associated With Anticoagulation in Renal Disease Management (STOP HARM) Trial
Patients with severe chronic kidney disease (CKD) who develop atrial fibrillation are at high risk for stroke. The use of blood thinking medication in dialysis patients is controversial and warfarin carries a serious risk for…
- Conditions
- Chronic Kidney Disease, Acute Bleeding, Cerebrovascular Stroke
- Trial name
- STOP-HARM (NCT02885545)
- Testing
- Watchman, Continued therapy with the prescribed oral anticoagulant
- Where
- Canada
- Sponsor
- Population Health Research Institute
Chronic Kidney Disease, Type 2 Diabetes Mellitus
An Observational Study Called FINEROD to Learn More About the Use of the Treatment Finerenone Including How Safe it is and How Well it Works Under Real-world Conditions
This is an observational study, in which data from people in Asia and in the United States with chronic kidney disease (CKD) together with type 2 diabetes (T2D) are studied.
- Trial name
- FINEROD (NCT06278207)
- Testing
- Finerenone (BAY 94-8862)
- Where
- 4 sites in United States, Germany and 2 more
- Volunteers
- 50,000 people
- Sponsor
- Bayer
Nephrogenic Systemic Fibrosis, Renal Insufficiency
Evaluation of Nephrogenic Systemic Fibrosis (NSF) in Patients With Chronic Kidney Disease Following OptiMARK Injection
The objective of this study is to prospectively monitor the incidence of adverse drug reactions, specifically NSF during routine use of gadoversetamide in a large number of patients with moderate renal insufficiency (eGFR 30-59)…
- Trial name
- SHERLOC (NCT00811863)
- Where
- United States
- Sponsor
- Guerbet
End Stage Renal Disease
Goal Directed Fluid Administration for Kidney Transplantation
The goal of the proposed study is to evaluate the efficacy of a goal-directed fluid administration algorithm on early graft function in patients undergoing kidney transplantation.
- Trial name
- NCT02192086
- Testing
- goal directed fluid therapy, Control Group
- Volunteers
- 21 people
- Sponsor
- Medical University of South Carolina
Diabetes Mellitus, Chronic Kidney Diseases
Integrated, Multidisciplinary, Person-centered Care for Patients With Complex Comorbidities: Heart, Kidney and Diabetes
Patient with complex comorbidities present a growing challenge for health-care providers, that the current system is poorly designed to handle.
- Conditions
- Diabetes Mellitus, Chronic Kidney Diseases, Cardiovascular Diseases, Chronic Disease
- Trial name
- CareHND (NCT03362983)
- Testing
- CareHND
- Where
- Sweden
- Volunteers
- 131 people
- Sponsor
- Danderyd Hospital
Kidney Failure, Chronic Therapy; Hemodialysis
A Single Ascending Dose Study of Soluble Ferric Pyrophosphate Administered Intravenously in Healthy Volunteers.
The purpose of this study is to determine the pharmacokinetics of fixed ascending doses of intravenously administered Soluble Ferric Pyrophosphate
- Trial name
- NCT01920854
- Testing
- soluble ferric pyrophosphate
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Rockwell Medical Technologies, Inc.
End-Stage Renal Disease
L-Carnitine in Peritoneal Dialysis
The development of glucose-sparing strategies able to provide an efficacious ultrafiltration profile represents one of the modern goals of peritoneal dialysis therapy.
- Trial name
- NCT00922701
- Testing
- L-carnitine
- Where
- Italy
- Volunteers
- 4 people
- Sponsor
- Iperboreal Pharma Srl
Heart Failure, Congestive, Kidney Failure, Chronic
N-Acetylcysteine in Heart Failure With Coexistent Chronic Renal Failure
Treatment with n-acetylcysteine in patients with heart failure and chronic renal failure leads to improvements in vascular function and in renal function.
- Trial name
- NCT00532688
- Testing
- N-acetylcysteine
- Where
- Australia
- Volunteers
- 10 people
- Sponsor
- Bayside Health
Periodontitis, End-stage Renal Disease
The Role of Toll-like Receptor-4 in Periodontitis Patients With End-stage Renal Disease in a Sample of Egyptian Population
Chronic kidney disease (CKD) is a significant public health issue in Egypt, leading to end-stage renal disease (ESRD). ESRD patients often suffer from oral abnormalities due to the disease and medications.
- Trial name
- NCT06755372
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Kidney Failure Chronic, Arrhythmias Cardiac
Effects of Marine n-3 Fatty Acids on Heart Rate Variability and Arrhythmias in Patients Receiving Chronic Dialysis
Background: End Stage Renal Disease (ESRD) patients have an extremely high mortality and the leading cause of death is cardiovascular disease which accounts for 50% of all deaths.
- Trial name
- NCT02147977
- Testing
- dietary supplement: n-3 PUFA, olive oil
- Where
- Denmark
- Volunteers
- 112 people
- Sponsor
- Aalborg University Hospital
End Stage Kidney Disease
Combined Dose-Finding and CV Outcomes Study With CSL300 (Clazakizumab) in Adult Subjects With ESKD Undergoing Dialysis (POSIBIL6ESKD)
This is a two-part, phase 2b and phase 3 combined prospective, interventional, multicenter, randomized, double-blind, placebo-controlled study. Part 1: Phase 2b is a dose-finding study for CSL300 vs placebo.
- Trial name
- POSIBIL6ESKD (NCT05485961)
- Testing
- CSL300
- Where
- 566 sites in United States, Argentina and 33 more
- Volunteers
- 3,110 people
- Sponsor
- CSL Behring
End Stage Renal Disease, Sars-CoV2
The Impact of COVID-19 on Dialysis Users
To understand the impact of COVID-19 restrictions on the wellbeing, quality of life and physical activity of people with end-stage renal disease, currently dialysing in-centre versus at home in the UK and their experience of…
- Trial name
- NCT04422873
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Portsmouth
Hemodialysis Patient, Fatigue
The Effects of an App-based Acupressure on Alleviating Fatigue, Pruritus, and Sleep Quality Among Hemodialysis Patients
Objectives: To evaluate the effectiveness of an app-based self-guided acupressure intervention in alleviating fatigue and pruritus, and in improving sleep quality among hemodialysis patients.
- Trial name
- NCT07259369
- Testing
- app-based acupressure
- Where
- Vietnam
- Volunteers
- 60 people
- Sponsor
- Taipei Medical University
Metabolic Bone Disease
The Effect of Lanthanum Carbonate on Fibroblast Growth Factor 23 ( FGF23) in Chronic Kidney Disease
The aim of the study is to assess the effects of the drug lanthanum carbonate (a phosphorus binder drug) on c-terminal and on FGF23 levels in patients with Chronic Kidney Disease (CKD).
- Trial name
- NCT01002872
- Testing
- Lanthanum Carbonate (Fosrenol)
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Endeavor Health
ESRD (End Stage Renal Disease)
Ultrasound-Guided T2 Erector Spinae Plane Block Versus Intercostobrachial Block in AV Fistula Surgery.
This study aims to determine whether ultrasound guided ESP block at 2nd thoracic vertebrae is non inferior to ultrasound guided ICBN block as adjunct to supraclavicular brachial plexus block in achieving complete sensory blockade…
- Trial name
- ICBN/ESP (NCT07754357)
- Testing
- Ultrasound Guided Intercostobrachial Nerve Block, Ultrasound Guided Erector Spinae Plane Block at T2 level
- Where
- Egypt
- Volunteers
- 110 people
- Sponsor
- Fatma Hatem Mokhtar
Complication of Renal Dialysis, End Stage Renal Disease
A Study Testing the Use of a Perivascular Sirolimus Formulation (Sirogen) in ESRD Patients Undergoing AV Fistula Surgery
The primary study objective is to evaluate the benefit of the Sirolimus eluting Collagen implant (SeCI; Sirogen), a single dose prophylactic treatment delivered intraoperatively at the time of surgical creation of an…
- Conditions
- Complication of Renal Dialysis, End Stage Renal Disease, End Stage Kidney Disease, ESRD
- Trial name
- ACCESS2 (NCT05425056)
- Testing
- Sirolimus
- Where
- 22 sites in United States, United Kingdom
- Volunteers
- 136 people
- Sponsor
- Vascular Therapies, Inc.
Focal Segmental Glomerulosclerosis, Chronic Kidney Diseases
Stem Cell Therapy for Patients With Focal Segmental Glomerulosclerosis
The purpose of this study is to analyze the safety, renal function, metabolic disorders and quality of life data in patients with focal segmental glomerulosclerosis treated with endovascular infusion of bone marrow derived…
- Trial name
- STEFOG (NCT02693366)
- Testing
- Bone marrow stem cell
- Where
- Brazil
- Volunteers
- 5 people
- Sponsor
- Universidade Federal do Rio de Janeiro
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