Clinical trials: Chronic Nephropathy
Renal Anemia in Non-dialysis Chronic Kidney Disease
Use of Pegmolesatide in Renal Anemia: Efficacy and Safety of Switching to Pegmolesatide in Non-dialysis CKD Patients Treated With rhuEPO or HIF-PHI
This was a multicenter, randomized, open label, non inferiority clinical study. It consisted of a 24-week treatment period (0-24 weeks) and a 24-week extension period (25-48 weeks).
- Trial name
- NCT06946394
- Testing
- Pegmolesatide
- Where
- China
- Volunteers
- 160 people
- Sponsor
- The First Affiliated Hospital of Dalian Medical University
Gout, Chronic Kidney Diseases
Anakinra vs. Steroids for the Treatment of Gout Attacks in Patients With Renal Disease (ASGARD): A Feasibility Study
The aim of this study is to determine the feasibility of running a phase III double-blind, double-dummy randomised controlled trial comparing Depo-Medrone 120mg intramuscular injection vs.
- Trial name
- ASGARD (NCT02578394)
- Where
- United Kingdom
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Mid and South Essex NHS Foundation Trust
Chronic Kidney Diseases, Cardiovascular Diseases
Testosterone and Vascular Function in Reproductive-Aged Females With Chronic Kidney Disease
Cardiovascular disease (CVD) is the leading cause of death among women and women with chronic kidney disease are at an even greater risk of CVD.
- Trial name
- NCT06107166
- Where
- Canada
- Volunteers
- 61 people
- Sponsor
- University of Calgary
Chronic Renal Failure, Kidney Transplant Patients
Study of Trabecular Bone Score (TBS) as a Fracture Risk Factor in Chronic Renal Failure
Observational study
- Trial name
- TRIFIR (NCT03356522)
- Where
- France
- Volunteers
- 206 people
- Sponsor
- Rennes University Hospital
End Stage Renal Disease, End Stage Liver Disease
Transplant Patient Registry of Liver, Kidney and/or Pancreas
This is a registry of data collected from patient records, both of those who have a condition which may require transplantation and those who have undergone transplantation of the liver, kidney and/or pancreas.
- Trial name
- NCT00238693
- Where
- United States
- Volunteers
- 13,767 people
- Sponsor
- Virginia Commonwealth University
Kidney Disease
Fibroblast Growth Factor-23 (FGF23) Reduction in Predialysis Chronic Kidney Disease (CKD)
The investigators would like to study the role of phosphorus metabolism in the development of certain hormonal problems in people with chronic kidney disease (CKD).
- Trial name
- NCT00843349
- Testing
- Lanthanum Carbonate, 900 mg Phosphate Diet, Ad Libitum Diet
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Myles Wolf
Kidney Failure, Chronic
Efficacy and Safety of Fosrenol in Treating Elevated Serum Phosphate Levels in Adults With End Stage Renal Disease
The purpose of this study is to test how well lanthanum carbonate reduces the pre-dialysis level of serum phosphorus in subjects undergoing dialysis due to end stage renal disease and to determine the patient and physician's…
- Trial name
- NCT00160121
- Testing
- Lanthanum carbonate
- Volunteers
- 2,500 people
- Sponsor
- Shire
Moderate to Severe Secondary Hyperparathyroidism, Stage 5 Chronic Kidney Diseases
A Pilot Clinical Study Evaluating the Effect of Parathyroid Hormone (PTH) Lowering On Erythropoietin Consumption in Calcitriol-Resistant Patients
To evaluate the effect of PTH lowering on erythropoietin consumption in calcitriol-resistant patients with stage 5 chronic kidney disease.
- Trial name
- NCT01506947
- Testing
- Paricalcitol, Darbepoetin alfa
- Volunteers
- 65 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Chronic Renal Failure
Thrombosis and Haemorrhage in Chronic Hemodialysis Patients
The study T2HD "Thrombosis and Haemorrhage in chronic hemodialysis patients" is a study of pharmacoepidemiology observational, retrospective cohort, multicenter including 12 dialysis centers for adults Lorraine.
- Trial name
- T2HD (NCT02897258)
- Volunteers
- 600 people
- Sponsor
- Central Hospital, Nancy, France
Patients With Cardiovascular Disease, Healthy Participants
OCTA in Cardiovascular Disease and Healthy Controls
This prospective clinical study will involve the non-invasive assessment of retinal vessels using OCTA (Cirrus OCT 6000 AngioPlex) and scanning laser Doppler flowmetry (SLDF) in patients with cardiovascular disease and healthy…
- Trial name
- NCT07359664
- Testing
- Retinal vascular assessment using OCTA and SLDF
- Where
- Germany
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Uremic Pruritus
Treatment of Uremic Pruritus With PA101B
This is a randomized, double blind, placebo-controlled, parallel-arm, multi-center, Phase 2, proof-of-concept efficacy and safety study in patients with end-stage renal disease requiring hemodialysis.
- Trial name
- NCT02696499
- Testing
- PA101B
- Where
- 13 sites in United States
- Volunteers
- 70 people
- Sponsor
- Patara Pharma
End-Stage Renal Disease (ESRD)
Aluminum and Auditory Function in ESRD
Hearing impairment either clinical or subclinical is a characteristic of some renal disease patients. The hearing impairment could be result from specific etiologies or chronic renal failure itself.
- Trial name
- NCT00243958
- Where
- 2 sites in Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Renal Insufficiency
Evaluation of the Risk of Nephrogenic Systemic Fibrosis (NSF) in Patients With Chronic Kidney Disease Without Exposure to Gadolinium Based Contrast Agents (GBCA)
The objective of this long term study is to prospectively evaluate the incidence of NSF in patients with severe CKD or kidney failure including patients undergoing dialysis (stages 4 and 5 i.e., with an eGFR below 30)who have not…
- Trial name
- NCT00773409
- Where
- United States
- Volunteers
- 405 people
- Sponsor
- Bracco Diagnostics, Inc
CKD-MBD - Chronic Kidney Disease Mineral and Bone Disorder, Secondary Hyperparathyroidism
The Longitudinal PTH-Study
The main study aim is to quantify the agreement between the analytical results provided by two third generation and two second generation Parathyroid hormone (PTH) assays.
- Conditions
- CKD-MBD - Chronic Kidney Disease Mineral and Bone Disorder, Secondary Hyperparathyroidism, Kidney Replacement
- Trial name
- NCT03464149
- Testing
- One armed study, blood from each patient is analysed by four assays ( two 3rd generation and two 2nd generation assays)
- Where
- Austria
- Volunteers
- 132 people
- Sponsor
- Medical University of Vienna
Renal Insufficiency, Chronic
Pharmacokinetics and Pharmacodynamics Assessment of Drug Eritromax Compared to Eprex in Healthy Subjects.
The epoetin is a glycoprotein and endogenous hormone, which is primarily synthesized by specific epithelial cells lining the kidney peritubular capillaries, and regulates continuous formation of red blood cells.
- Trial name
- NCT03572647
- Testing
- Eritromax, Eprex
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Azidus Brasil
Kidney Failure, Chronic, Anemia
Cholecalciferol Supplementation for Anemia and Mineral and Bone Disorder in Hemodialysis Patients
The purpose of this study is to determine whether cholecalciferol supplementation decrease the blood concentrations of hepcidin-25 in hemodialysis patients.
- Conditions
- Kidney Failure, Chronic, Anemia, Vitamin D Deficiency, Bone Diseases, Metabolic
- Trial name
- CHAMBER (NCT02214563)
- Testing
- Cholecalciferol, Olive oil
- Where
- 7 sites in Japan
- Volunteers
- 90 people
- Sponsor
- Takayuki Hamano
ESRD
Assessment of Gonadal Functions in Uremic Male Patients
1. Study the prevalence of sexual dysfunction in male patients on hemodialysis aged 18-60 years (sexually active male) . 2. Study the effect of hemodialysis on the male patients sexual functions by measurement of serum prolactin…
- Trial name
- NCT04710238
- Volunteers
- 100 people
- Sponsor
- Assiut University
End Stage Chronic Renal Failure, Renal Transplant
Microvasculature Ultrasound Super-resolution in Transplant Delayed Graft Function
This pilot study is testing a new ultrasound imaging method called Super-Resolution Ultrasound (SRU) to look at blood flow and tiny blood vessels in transplanted kidneys in very detailed images after kidney transplant surgery.
- Conditions
- End Stage Chronic Renal Failure, Renal Transplant, Microvascular Changes, Microvascular Circulation
- Trial name
- MUST-D (NCT07645599)
- Testing
- Ultrasound contrast agent (Contrast-enhanced ultrasound), Optison (Perflutren Protein-Type A Microspheres Injectable Suspension), Lumason® contrast agent
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Roderick Tan
Anaemia
Phase III Study of GSK1278863 in Japanese Non-dialysis (ND) and Peritoneal Dialysis (PD) Subjects With Renal Anemia
This is a Phase III, open-label, active-controlled, parallel-group, multi-center study to compare the efficacy and safety of GSK1278863 administered for 52 weeks versus epoetin beta pegol in approximately 286 Japanese ND and 50…
- Trial name
- NCT02791763
- Testing
- 1 to 4 mg tablets of GSK1278863, 6 mg GSK1278863 tablet, Epoetin beta pegol
- Where
- 56 sites in Japan
- Volunteers
- 355 people
- Sponsor
- GlaxoSmithKline
Chronic Kidney Disease, Hepatic Impairment
A Study to Learn About How BAY 3283142 Moves Into, Through, and Out of the Body After a Single Dose in Participants With Reduced Liver Function Compared to Participants With Normal Liver Function
Researchers are looking for a better way to treat people who have chronic kidney disease (CKD). CKD is a condition in which the kidneys' ability to work properly gradually decreases over time.
- Trial name
- NCT06402721
- Testing
- BAY3283142
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Bayer
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