Clinical trials: Chronic Nephropathy
End Stage Renal Disease
Glycyrrhetinic Acid-Effect on Serum Potassium and Insulin Resistance in Dialysis Patients
Background: 18B Glycyrrhetinic acid (active compound of Licorice) decreases serum potassium via enhanced renal potassium loss in healthy individuals and thereby inducing renal sodium retention and arterial hypertension.In…
- Trial name
- NCT00384384
- Where
- Switzerland
- Volunteers
- 24 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission
Mycophenolate Mofetil and Cyclosporine in Reducing Graft-Versus-Host Disease in Patients With Hematologic Malignancies or Metastatic Kidney Cancer Undergoing Donor Stem Cell Transplant
This phase I/II trial studies whether stopping cyclosporine before mycophenolate mofetil is better at reducing the risk of life-threatening graft-versus-host disease (GVHD) than the previous approach where mycophenolate mofetil…
- Conditions
- Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission, Adult Acute Myeloid Leukemia in Remission, Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities
- Trial name
- NCT00078858
- Testing
- fludarabine phosphate, total-body irradiation, nonmyeloablative allogeneic hematopoietic stem cell transplantation
- Where
- 10 sites in United States, Germany and 1 more
- Volunteers
- 37 people
- Sponsor
- Fred Hutchinson Cancer Center
Chronic Kidney Disease
Equivalence of Calcium Acetate Oral Solution and Sevelamer Carbonate Tablets in Hemodialysis Patients
The purpose of this study is to demonstrate equivalence of calcium acetate oral solution and sevelamer carbonate in maintaining serum phosphorus levels This is a phase IV, multicenter, randomized, open-label, cross-over study to…
- Trial name
- COS-002 (NCT01427907)
- Testing
- Calcium acetate oral solution (COS), Sevelamer carbonate
- Where
- 4 sites in United States
- Volunteers
- 38 people
- Sponsor
- Fresenius Medical Care North America
End-stage Renal Disease
The Study of Association Between Intradialysis Sodium Balance and Clinical Outcomes in Chronic Hemodialysis Patients
The purpose of this study is to determine whether the change of serum and dialysate sodium level during hemodialysis can influence on blood pressure and intradialytic weight gain in chronic hemodialysis patients.
- Trial name
- NCT02487004
- Testing
- hemodialysis
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Su-Hyun Kim
Diabetes with Diabetic Chronic Kidney Disease (Diagnosis)
Flash Glucose Monitoring in Reduction of Hypoglycaemia in Diabetic Patients with Chronic Kidney Disease
This will be a single centre study at the Prince of Wales Hospital, Hong Kong. Patients will be identified from an existing registry of diabetes patients with CKD.
- Trial name
- NCT04016155
- Testing
- Abbott FreeStyle Libre, Patient Own SMBG
- Where
- Hong Kong
- Volunteers
- 94 people
- Sponsor
- Chinese University of Hong Kong
Anemia, Renal Insufficiency, Chronic
Long Term Extension Study for the Maintenance Treatment of Anemia Associated With Chronic Kidney Disease (CKD) in Hemodialysis Subjects on Epoetin Alfa / Beta Treatment Versus BAY85-3934
Evaluate efficacy and safety up to 36 months of titrated dose treatment with BAY85-3934 versus epoetin alfa/beta. Titration will be based on the subject's hemoglobin (Hb) response and tolerability of the prior dose.
- Trial name
- DIALOGUE5 (NCT02064426)
- Testing
- Molidustat (BAY85-3934), Epoetin alfa/beta
- Where
- 26 sites in United States, Japan
- Volunteers
- 88 people
- Sponsor
- Bayer
Growth Hormone Deficiency
National Cooperative Growth Study in CKD
The purpose of this study is to learn whether growth hormone being administered to children with Chronic Kidney Disease is effective and if it has any side effects.
- Trial name
- NCGS (NCT00616278)
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of California, Davis
Renal Disease
Monocentric Retrospective Cohort Study of the Impact of Advanced Nursing Practice on the Follow-up of the End Stage Chronic Renal Disease Patient
With regard to the fields of competence of advanced practice defined by the Order of October 22, 2021 amending the Order of July 18, 2018 on the system of studies for the State diploma of advanced practice nurse mentioning renal…
- Trial name
- IPASIRC (NCT06036264)
- Testing
- Collected of Datas, semi-structured interview
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
ESRD, Fabry Disease
Kidney Information Network for Disease Research and Education
In this study, Investigators will conduct a prospective cohort study of dialysis patients by collecting research-quality information on patient characteristics, comorbid diseases and laboratory markers used in routine practice…
- Conditions
- ESRD, Fabry Disease, Rare Diseases, Kidney Diseases
- Trial name
- KINDRED (NCT03321604)
- Where
- United States
- Volunteers
- 338 people
- Sponsor
- Massachusetts General Hospital
Diabetes, Hypoglycemia
Insulin Dosing in Diabetic Patients With End Stage Renal Disease (ESRD) or Hemodialysis
The purpose of this study is to assess whether the current recommendation for a 50% dose reduction in insulin for diabetic patients with a creatinine clearance (CrCl) ≤15 mL/min or on hemodialysis results in an increased number…
- Conditions
- Diabetes, Hypoglycemia, Renal Dysfunction, Insulin Dosing
- Trial name
- DOSE-HD (NCT02083133)
- Where
- United States
- Volunteers
- 496 people
- Sponsor
- Cook County Health
IgA Glomerulonephritis
Therapeutic Evaluation of Steroids in IgA Nephropathy Global Study (TESTING Low Dose Study)
This study will evaluate the long-term efficacy and safety of low dose oral methylprednisolone compared to matching placebo, on a background of routine RAS inhibitor therapy, in preventing kidney events in patients with IgA…
- Trial name
- TESTING (NCT01560052)
- Testing
- methylprednisolone
- Where
- 66 sites in Australia, Canada and 4 more
- Volunteers
- 503 people
- Sponsor
- The George Institute
Anaemia
Study to Evaluate the Efficacy, Safety and Pharmacokinetics of Three-times Weekly Dosing of GSK1278863 in Hemodialysis-dependent Subjects With Anemia Associated With Chronic Kidney Disease Who Are Switched From a Stable Dose of an Erythropoiesis-stimulating Agent
GSK1278863 is an orally available, hypoxia-inducible factor - prolyl hydroxylase inhibitor, currently being investigated as a treatment for anemia associated with chronic kidney disease.
- Trial name
- NCT02689206
- Testing
- GSK1278863
- Where
- 38 sites in United States, Canada and 3 more
- Volunteers
- 103 people
- Sponsor
- GlaxoSmithKline
Diabetes Mellitus, Type 2, Renal Insufficiency, Chronic
Dietary Polyphenols and Glycation in Renal Insufficiency
Type 2 diabetes mellitus (T2DM) is associated with an increased risk of kidney failure, with high levels of glycohaemoglobin (HbA1c) presenting a sharper decline in renal function and an increase in the risk of mortality and…
- Trial name
- PoGlyDRI (NCT02524938)
- Testing
- Chlorogenic Acid (CGA) enriched coffee, Conventional coffee
- Where
- 2 sites in United Kingdom
- Volunteers
- 9 people
- Sponsor
- NHS Greater Glasgow and Clyde
Hemodialysis, Chronic Kidney Disease
Effect of Pecha Kucha Education on Fluid and Diet Adherence in Hemodialysis Patients
This randomized controlled trial aims to evaluate the effect of education based on the Pecha Kucha presentation technique on fluid and dietary adherence in patients undergoing hemodialysis.
- Trial name
- NCT07518017
- Testing
- Pecha Kucha Education, Standard Education
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Büşra Ceren DEMİREL YILDIZ
Anemia, Chronic Kidney Disease
Peginesatide for Anemia in Chronic Hemodialysis Patients
The purpose of this study is to evaluate the safety, pharmacodynamics (PD), and pharmacokinetics (PK) of multiple intravenous doses of peginesatide in participants with chronic kidney disease (CKD) who are on hemodialysis.
- Conditions
- Anemia, Chronic Kidney Disease, Chronic Renal Failure
- Trial name
- NCT00228449
- Testing
- peginesatide
- Where
- 14 sites in United States
- Volunteers
- 165 people
- Sponsor
- Affymax
Chronic Kidney Disease
Effects of Low Protein Diet Supplemented Keto-/Amino Acid in Preventing the Progression of Chronic Kidney Disease (CKD)- ELPD Study
The purpose of this study is to determine whether low protein diet and very low protein diet supplemented keto-/amino acid is effective in preventing the progression of chronic kidney disease (CKD , stage 3b and 4).
- Trial name
- ELPD-CKD (NCT01418508)
- Testing
- low protein diet plus α-keto acid, very low protein diet plus α-keto acid
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Peking Union Medical College Hospital
Chronic Renal Insufficiency, Hemodialysis
Effect of a Concurrent Physical Exercise Program in Hemodialysis Patients
Concurrent physical exercise is the method of combining strength and endurance that can be worked with in one session or in an exercise program.
- Trial name
- NCT06664385
- Testing
- concurrent physical exercise
- Where
- Mexico
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Pedro Julian Flores Moreno
Hypertension, Heart Failure
Influence of Catheter-based Renal Denervation in Diseases With Increased Sympathetic Activity
The study is aiming to document the long-term safety and effectiveness of renal denervation in patients with hypertension and other diseases characterized by elevated sympathetic drive.
- Conditions
- Hypertension, Heart Failure, Chronic Kidney Disease, Diabetes
- Trial name
- NCT01888315
- Testing
- Renal denervation with Symplicity Flex Medtronic/Ardian, Renal denervation with EnligHTN St. Jude Medical, Renal denervation with Paradise Recor
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Saarland
Continuous Glucose Monitoring, ESRD (End-Stage Renal Disease)
Continuous Glucose Monitoring and Clinical Outcomes in Diabetes on Peritoneal Dialysis
This prospective, multicenter observational study will evaluate glucose profiles using continuous glucose monitoring (CGM) in 100 adults with diabetes receiving peritoneal dialysis (PD) or planning to start PD within 3 months.
- Conditions
- Continuous Glucose Monitoring, ESRD (End-Stage Renal Disease), Peritoneal Dialysis (PD), Diabetes Mellitus (DM)
- Trial name
- GLANCE-PD (NCT07790276)
- Testing
- Continuous glucose monitoring system
- Where
- Hong Kong
- Volunteers
- 100 people
- Sponsor
- Elaine Chow
Chronic Kidney Diseases
Impact of Dapagliflozin on Intestinal Microbiota Composition and on the Metabolites Derived From the Intestinal Microbiota in Non-diabetic Chronic Renal Failure Patients
Chronic kidney disease (CKD) is a common disease affecting 10-12% of the adult population and characterize with high-risk cardiovascular morbidity and mortality with progression of CKD.
- Trial name
- DAPA-GUT (NCT05965440)
- Testing
- impact of Dapagliflozin on Intestinal Microbiota on chronic renal failure patients
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
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