Clinical trials: Chronic Nephropathy
Anemia of End Stage Renal Disease
TARGTEPO Treatment for Anemia in End Stage Renal Disease (ESRD) Patients Undergoing Peritoneal Dialysis (PD)
The objectives of this study are to assess safety and to evaluate the biologic activity of TARGTEPO treatment in Peritoneal Dialysis patients
- Trial name
- NCT02378662
- Testing
- MDGN201 TARGTEPO
- Where
- 2 sites in Israel
- Volunteers
- 2 people
- Sponsor
- Aevi Genomic Medicine, LLC, a Cerecor company
End-stage Renal Disease
Sodium Chloride and Protein-Bound Toxin Removal in Hemodiafiltration
An increase of the free fraction may allow a better removal of of protein-bound uremic toxins during dialysis. During predilution hemodiafiltration, the sodium chloride (NaCl) concentration will be increased in the infusion fluid…
- Trial name
- NCT01923961
- Testing
- HDF NaCl, Hemodialysis, Standard Predilution Hemodiafiltration
- Where
- Germany
- Volunteers
- 8 people
- Sponsor
- EXcorLab GmbH
End Stage Renal Failure, Hemodialysis
Catheters Dysfunction Rate After Instillation of Ethanol 60% Lock Solution in Tunneled Silicone Catheter of Chronic Hemodialysis Patients
The primary objective of the study is to examine the risk of catheter dysfunction during the dialysis session that follows the instillation of ethanol 60% as lock solution in tunneled silicone catheters of end stage renal failure…
- Trial name
- Ethanol (NCT00563342)
- Testing
- Ethanol
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Clermont-Ferrand
Kidney Failure, Chronic
Comparison of Daily Nocturnal Hemodialysis With Daily Hemodialysis
Hemodialysis remains associated with a high mortality (approximately 22% per year) and many complications despite improvements over the last twenty years.
- Trial name
- NCT00012441
- Testing
- hemodialysis
- Where
- United States
- Sponsor
- National Center for Research Resources (NCRR)
Dialysis; Complications, Heparin-induced Thrombocytopenia
Multicenter Study on Dialysis Modalities for End-stage Chronic Renal Failure Patients With Heparin-induced Thrombocytopenia
This research is based on the hypothesis that the Hydrolink®-NV dialysis membrane could allow the realization of quality dialysis with a significant reduction in the doses of Orgaran®, or even a total cessation of the…
- Conditions
- Dialysis; Complications, Heparin-induced Thrombocytopenia, Chronic Renal Failure
- Trial name
- MODIATIH (NCT05586854)
- Testing
- Hydrolink NV membrane
- Where
- France
- Volunteers
- 20 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Chronic Kidney Diseases, Heart Transplant
Renal Tubular Injury and Transplant Outcomes in Cardiac Recipients Converting From IR Tacrolimus to XR Tacrolimus
Immediate release (IR) tacrolimus peaks in the first two hours after administration. These peak levels are influenced by CYP3A5 expression with expressors requiring higher total daily doses with higher peak levels compared to…
- Trial name
- NCT04917718
- Testing
- Conversion from IR Tacrolimus to XR Tacrolimus
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Loyola University
Kidney Disease, Chronic
A Study to Test BI 764198 in People With a Type of Kidney Disease Called Focal Segmental Glomerulosclerosis
This study is open to adults with a type of kidney disease called focal segmental glomerulosclerosis (FSGS). The purpose of this study is to find out whether a medicine called BI 764198 improves the health of the kidneys in…
- Trial name
- NCT05213624
- Testing
- BI 764198
- Where
- 54 sites in United States, Australia and 8 more
- Volunteers
- 67 people
- Sponsor
- Boehringer Ingelheim
IgA Nephropathy
Efficacy and Safety of Extended TARPEYO® Treatment Beyond 9 Months in Adult Patients With Primary IgA Nephropathy
The goal of this clinical trial is to assess the efficacy and safety of extended TARPEYO® (delayed-release budesonide capsules) treatment in adult patients with primary IgA nephropathy who have completed 9 months of TARPEYO® 16…
- Trial name
- NefXtend (NCT06712407)
- Testing
- TARPEYO®
- Where
- 38 sites in United States, Puerto Rico
- Volunteers
- 60 people
- Sponsor
- Calliditas Therapeutics AB
Hypertension, Vascular Diseases
SPYRAL GEMINI Pilot Study
The purpose of the SPYRAL GEMINI Pilot Study is to evaluate that multi-organ denervation with the Gemini System is safe and provide evidence of blood pressure reduction when studied in an uncontrolled hypertensive population with…
- Conditions
- Hypertension, Vascular Diseases, Cardiovascular Diseases, Chronic Kidney Diseases
- Trial name
- SPYRAL GEMINI (NCT06907147)
- Testing
- Multi-Organ Denervation Gemini System
- Where
- 18 sites in United States, Australia and 4 more
- Volunteers
- 175 people
- Sponsor
- Medtronic Vascular
CKD (Chronic Kidney Disease) Stage 5D, Uremia; Chronic
Studies on Adsorption International Learning Initiative Global
Use of sorption technologies in patients undergoing maintenance hemodialysis with inflammatory syndrome and clinical manifestations of uremia
- Conditions
- CKD (Chronic Kidney Disease) Stage 5D, Uremia; Chronic, Uremic; Toxemia, Inflammation Chronic
- Trial name
- SAILING (NCT07123909)
- Testing
- Patients will undergo a combined hemodialysis and hemosorption procedure. The study cartridge for hemosorption by Jafron HA130 contains the original adsorbing material.
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- Botkin Hospital
End Stage Kidney Disease, End Stage Renal Disease
Assisted Peritoneal Dialysis: A Feasibility Study
Patients with End-Stage Kidney Disease (ESKD) wishing to choose Peritoneal Dialysis (PD) may not be able to perform this modality due to advanced age, physical function/dexterity, vision, cognition, mobility, or psychosocial…
- Trial name
- NCT04319185
- Testing
- Assistance to perform Peritoneal Dialysis (PD) at home
- Where
- 6 sites in United States
- Volunteers
- 20 people
- Sponsor
- Satellite Healthcare
Acute Kidney Injury, Arterial Hypertension
Study Evaluating Novel Biomarkers of AKI (Acute Kidney Injury) in Post-operative Patients
To validate the use of [TIMP-2]●[IGFBP-7] to predict AKI in patients undergoing major intra abdominal surgery.
- Conditions
- Acute Kidney Injury, Arterial Hypertension, Obesity, Cardio Vascular Disease
- Trial name
- NCT02499185
- Testing
- Nephro Check Test, serum creatinine measurement
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Universitair Ziekenhuis Brussel
End Stage Renal Disease, End Stage Renal Disease on Dialysis
First Evaluation of the Moda-Flx Hemodialysis System™ in Real World Clinical Settings
This is a non-significant risk study utilizing a device cleared for use by the FDA under its 510(k) clearance. Consented patients will complete their usual dialysis treatment under professional care in an ICHD (In-Center…
- Conditions
- End Stage Renal Disease, End Stage Renal Disease on Dialysis, End Stage Kidney Disease
- Trial name
- NCT06581393
- Testing
- Moda-flx Hemodialysis System
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Diality Inc.
Peritoneal Dialysis Complication, End Stage Kidney Disease
meChANisms and sAfety of SGLT2 Inhibition in peRitoneal dialYsis
The primary aim of this study is to determine the safety and mechanisms of SGLT2 inhibition in individuals on peritoneal dialysis (PD) with residual kidney function (RKF).
- Conditions
- Peritoneal Dialysis Complication, End Stage Kidney Disease, Sodium-glucose Co-transporter-2 Inhibitors, Kidney Dysfunction
- Trial name
- CANARY (NCT05715814)
- Testing
- Empagliflozin 25 MG
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University Health Network, Toronto
Kidney Transplantation, Kidney Failure, Chronic
Combined Kidney and Bone Marrow Transplantation to Prevent Kidney Transplant Rejection
In small initial studies, combined kidney and bone marrow transplants from the same donor have permitted some individuals to stop taking anti-rejection medicines without rejecting their transplant.
- Trial name
- NCT00801632
- Testing
- Kidney Transplantation, Bone marrow transplantation, MEDI-507
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Hemodialysis Complication, End Stage Renal Disease
Inferior Vena Cava Sonography in Hemodialysis Patients and Quality of Life
Determination of dry weight in patients with end-stage renal disease treated with hemodialysis is an unmet challenge in clinical nephrology.
- Trial name
- NCT03061552
- Testing
- sonographic measurement of inferior vena cava diameter
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Hadassah Medical Organization
Chronic Kidney Disease
Study to Collect Samples for MIST Analysis of Zibotentan and Bioavailability of Zibotentan and Dapagliflozin in Heatlhy Participants
The study will have 2 independent parts: Part 1 of the study is intended to collect samples for Metabolites in Safety Testing (MIST) analysis after administration of multiple doses of zibotentan.
- Trial name
- NCT04991571
- Testing
- Zibotentan (Treatment A), Dapagliflozin (Treatment A), Zibotentan/Dapagliflozin - Formulation 1 (Treatment B)
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Chronic Renal Failure
Clinical Study to Compare the Pharmacokinetics and Safety of D113 With CKD-349 in Healthy Volunteers
This study is a randomized, open-label, single dosing, 3-treatment, 6-sequence, 3-period, crossover-design study to compare the pharmacokinetics and safety of D113 with CKD-349 in healthy volunteers.
- Trial name
- NCT04952506
- Testing
- CKD-349 F1 Tab., CKD-349 F2 Tab., D113 Tab.
- Where
- South Korea
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Chong Kun Dang Pharmaceutical
Chronic Peritoneal Dialysis
Method of Exit Site Care in Chronic Peritoneal Dialysis Patients
Peritoneal dialysis accounts for more than 70% of the dialysis modality in Hong Kong. Exit site infection (ESI) is one of the causes leading to peritoneal catheter removal. Appropriate exit-site care can prevent ESI.
- Trial name
- NCT00416338
- Testing
- film dressing by adhesive
- Where
- Hong Kong
- Volunteers
- 11 people
- Sponsor
- Chinese University of Hong Kong
Kidney Failure, Chronic, Dietary Modification
Dietary Sodium (DS) Intervention to Reduce Volume Overload and Tissue Sodium in Magnetic Resonance Imaging (MRI) for Hemodialysis (HD) Patients
Sodium-adapted magnetic resonance imaging (23Na-MRI) studies have demonstrated that sodium accumulates in certain tissues, including the skin and skeletal muscle, but may be manipulated by lifestyle factors or therapeutic…
- Trial name
- DSMRI (NCT03189758)
- Testing
- Observational Control Diet, Controlled Dietary Sodium Restriction
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Illinois at Urbana-Champaign
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