Clinical trials: Chronic Nerve Pain
Spinal; Nerve Root, Pain, Pelvic Pain
Quality of Life and Pain Changes Due to DRG Stimulation for Chronic Pain
ACTIVE study- a prospective observational clinical study examining the changes in quality of life and pain following dorsal root ganglion stimulation for the treatment of chronic intractable pelvic and lower limb pain.
- Conditions
- Spinal; Nerve Root, Pain, Pelvic Pain, Regional Pain Syndrome, Chronic Pain Syndrome
- Trial name
- ACTIVE (NCT03417973)
- Testing
- dorsal root ganglion neuromodulation
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- KM Clinical Research Group
Small-Fiber Neuropathy
Evaluation of Pregabalin in Idiopathic Small Fiber Neuropathy
Idiopathic Small Fiber Neuropathy (called SFN for short), is a condition where nerves that sense pain have become damaged, and often painful.
- Trial name
- NCT00787462
- Testing
- Pregabalin
- Where
- Canada
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Sickle Cell Disease, Solid Tumor
Validating Pain Scales in Children and Young Adults
Background: Assessing pain levels is important to improve treatments for different illnesses. Most pain rating scales are used to determine pain levels in adults. Pain is also a common symptom among children who have cancer.
- Conditions
- Sickle Cell Disease, Solid Tumor, Leukemia, Neurofibromatosis
- Trial name
- NCT01639950
- Where
- United States
- Volunteers
- 252 people
- Sponsor
- National Cancer Institute (NCI)
Knee Osteoarthritis, Chronic Knee Pain
Sonographic Thigh Adjustment Ratio and Subcutaneous Fat Thickness as Predictors of Genicular Nerve Block Response in Knee Osteoarthritis
Knee osteoarthritis (KOA) is a leading cause of chronic pain and disability. Although genicular nerve block (GNB) is an effective treatment for many patients, treatment response varies considerably.
- Trial name
- STAR-GNB (NCT07712419)
- Testing
- Ultrasound-Guided Genicular Nerve Block
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Migraine in Adolescence, Headache
A Wearable Nerve Stimulator for Chronic Migraine/Headache and Mood Disturbance in Adolescents
The aim of this clinical trial is to test a wrist-worn nerve stimulator in adolescents with chronic migraine/headache and mood disturbance.
- Conditions
- Migraine in Adolescence, Headache, Mood Disturbance
- Trial name
- NCT05702528
- Testing
- Apollo Neuro
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of South Carolina
Whiplash Injuries
Is Chronic Whiplash-associated Pain of Neurogenic Origin?
The purpose of this study is to compare the effects of neurolysis with the effects of a exercise program on pain and other symptoms in individuals with chronic whiplash (WAD II-III).
- Trial name
- NCT02692937
- Testing
- Neurolysis, Traditional neck-specific exercise program
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Region Skane
Myofascial Pain Syndrome
Optimal Duration of Stretching Exercises for Chronic Non-specific Neck Pain Patients
A multitude of stretching parameters are used in the clinical setting. However, there is no convincing evidence to suggest which parameters are most effective in the management of chronic myofascial pain syndrome .In this regard…
- Trial name
- NCT04190784
- Testing
- Stretching exercises
- Where
- United Arab Emirates
- Volunteers
- 132 people
- Sponsor
- University of Sharjah
Endometriosis
Treatment of Chronic Pelvic Pain Due to Endometriosis by Transcutaneous Auricular Vagus Nerve Stimulation
6-10% of women of childbearing age suffer from endometriosis, which is mainly manifested by dysmenorrhea, non-menstrual pelvic pain and dyspareunia.
- Trial name
- Stim-Endom (NCT04177511)
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulation
- Where
- France
- Volunteers
- 72 people
- Sponsor
- Hopital Foch
Chronic Pain, Anxiety
Nu-V3 Non-Invasive Nerve Stimulation Device Trial for Chronic Pain, Anxiety, Depression, Sleeplessness
The Nu-V3 Clinical Study is a prospective, single-arm, open-label, multi-center study using the Nu-V3 cranial nerve stimulation treatment device in patients with chronic pain, anxiety, depression, and/or sleeplessness.
- Conditions
- Chronic Pain, Anxiety, Depression, Sleeplessness
- Trial name
- Nu-V3 (NCT05335980)
- Testing
- Nu-V3
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Nu-Life Solutions
Chronic Low Back Pain, Chronic Lumbo-radiculalgia
Pain Reducing Effect of Transcutaneous Electrical Nerve Stimulation in Patients With Chronic Low Back Pain or Lumbo-radiculalgia
Prior studies showed contradictory results about the best type of TENS in chronic pain pathology. Therefore we want to evaluate the efficacy assessment of TENS on patients with chronic low back pain or chronic lumbo-radiculalgia.
- Trial name
- LOBOTENS (NCT00452010)
- Testing
- CEFAR PRIMO TENS Class IIA (active), CEFAR PRIMO TENS Class IIA (no active)
- Where
- 8 sites in France
- Volunteers
- 236 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Acute Postoperative Pain, Chronic Postoperative Pain
Femoral and Epidural Block After Total Knee Arthroplasty
Total knee prosthetic replacement causes severe postoperative pain. Various analgesic techniques have been used in pain control.
- Trial name
- NCT02115945
- Testing
- DN4 test, The SF 12 test, HAD scale
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Osteoarthritis, Knee, Chronic Pain
3-point vs 6-point GNRFA for Chronic KOA
The goal of this clinical trial is to compare three-point and six-point Genicular Nerve Radiofrequency Ablation (GNRFA) in adults with chronic knee osteoarthritis (KOA).
- Trial name
- NCT05930756
- Testing
- Radiofrequency ablation
- Where
- Canada
- Sponsor
- McMaster University
Anesthesia, Analgesia
Pectoral Nerve Block II and Erector Spine Plane Block in Breast Cancer Surgery
This study evaluates the analgesic effects of pectoralis nerve block (PECS II) and erector spinae plane block (ESP) in patients having segmental mastectomy and sentinel lymph node biopsy (SLNB).
- Conditions
- Anesthesia, Analgesia, Acute Pain, Chronic Pain
- Trial name
- NCT04135157
- Testing
- Pectoralis nerve block II, Erector spine plane block, Control
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Ondokuz Mayıs University
Osteoarthritis
Effects of Transcutaneous Electrical Nerve Stimulation on Pain and Disability in Patients With Osteoarthritis
The purpose of this study is to determine the effects of transcutaneous electrical nerve stimulation (TENS) on pain and mobility by comparing different stimulation sitesP: 1. the location with the lowest resistance 2.
- Trial name
- NCT01137266
- Testing
- TENS
- Where
- Netherlands
- Volunteers
- 72 people
- Sponsor
- Maxima Medical Center
Fibromyalgia
Vagus Nerve Stimulation for Treating Adults With Severe Fibromyalgia
Fibromyalgia syndrome (FMS) is a long-term disorder that is characterized by widespread body pain and tender points in joints, muscles, tendons, and other soft tissues.
- Trial name
- NCT00294281
- Testing
- Vagus Nerve Stimulation (VNS) Therapy
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Medicine and Dentistry of New Jersey
Pudendal Neuralgia, Neuralgia
Perioperative Medical Program to Optimize Nerve Regeneration After Robot-assisted Laparoscopic Neurolyses of Pudendal and/or Inferior Cluneal Nerves for Chronic Neuralgias: Results After 1-year Follow-up
Pudendal and inferior cluneal neuralgias are responsible for chronic pelvicperineal pain. These two neuralgias are associated in approximately 25% of cases.
- Trial name
- REGEN (NCT06796595)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- UBOSGA
Low Back Pain
SMART Clinical Study: Surgical Multi-center Assessment of RF Ablation for the Treatment of Vertebrogenic Back Pain
To evaluate the safety and efficacy of RF ablation using the Intracept Intraosseous Nerve Ablation System to ablate intraosseous nerves for the relief of chronic axial low back pain.
- Trial name
- SMART (NCT01446419)
- Testing
- Intracept Treatment
- Where
- 13 sites in United States
- Volunteers
- 225 people
- Sponsor
- Relievant Medsystems, Inc.
Tennis Elbow
Comparative Study Between Different Mobilization Techniques for Patients With Chronic Tennis Elbow
Background: Tennis elbow is a common musculoskeletal disorder affecting the functional activities of daily living through common extensor tendinopathy.
- Trial name
- RCT (NCT06812377)
- Testing
- Maitland joint mbilization, mulligan mobilization, radial nerve mobilization
- Where
- Saudi Arabia
- Volunteers
- 45 people
- Sponsor
- Prince Sattam Bin Abdulaziz University
Phantom Limb Pain
Study of Phantom Limb Pain Suppression Using Neuromodulation Methods
This study assesses the effectiveness of neuromodulation in alleviating pain through the stimulation of peripheral nerves. The research involves implanting electrodes for test stimulation of peripheral nerves (PNS - Peripheral…
- Trial name
- NCT06644807
- Testing
- Motor Cortex Stimulation, Spinal cord stimulation, Peripheral Nerve Stimulation
- Where
- 2 sites in Russia
- Volunteers
- 50 people
- Sponsor
- Skolkovo Institute of Science and Technology
Fibromyalgia (FM), Chronic Pain
Effects of Transcutaneous Auricular Vagus Nerve Stimulation on Symptom Severity, Sleep Quality, Central Sensitization, and Kinesiophobia in Fibromyalgia
Fibromyalgia is a chronic condition characterized by widespread musculoskeletal pain, fatigue, sleep disturbances, and sensitivity to touch. Current treatments often provide only partial relief.
- Trial name
- NCT07173400
- Testing
- Active Transcutaneous Auricular Vagus Nerve Stimulation (TaVNS)
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Hatice Betigul Meral