Clinical trials: Chronic Nerve Pain
Back Pain
Comparison of Intraspinal Nerve Root Stimulation With Dorsal Column Stimulation
This study will systematically evaluate the programming parameters of the Precision Spinal Cord Stimulation Device to optimally relieve pain while minimizing any uncomfortable side effects.
- Trial name
- NCT00370773
- Testing
- Precision Spinal Cord Stimulation System
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Boston Scientific Corporation
Pain, Acute, Pain, Chronic
Development and Validation of a Digital Pain-Reduction Kit for Musculoskeletal Injuries
This study will test the effectiveness of an evidence-based, multi-modal, "digital pain-reduction kit" as a non-pharmacological supplement to managing patients with pain due to musculoskeletal injuries.
- Trial name
- NCT03187132
- Testing
- Digital Pain Reduction Kit, Active Control
- Where
- United States
- Volunteers
- 245 people
- Sponsor
- Cedars-Sinai Medical Center
Anesthesia, Analgesia
Pectoral Nerve Block II and Erector Spine Plane Block in Breast Cancer Surgery
This study evaluates the analgesic effects of pectoralis nerve block (PECS II) and erector spinae plane block (ESP) in patients having segmental mastectomy and sentinel lymph node biopsy (SLNB).
- Conditions
- Anesthesia, Analgesia, Acute Pain, Chronic Pain
- Trial name
- NCT04135157
- Testing
- Pectoralis nerve block II, Erector spine plane block, Control
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Ondokuz Mayıs University
Spinal Cord Injuries, Nerve Injury
Closed-Loop Deep Brain Stimulation for Refractory Chronic Pain
Chronic pain affects 1 in 4 US adults, and many cases are resistant to almost any treatment. Deep brain stimulation (DBS) holds promise as a new option for patients suffering from treatment-resistant chronic pain, but traditional…
- Conditions
- Spinal Cord Injuries, Nerve Injury, Pain, Postoperative, Post Herpetic Neuralgia
- Trial name
- NCT04144972
- Testing
- Medtronic Summit RC+S or Percept RC
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of California, San Francisco
Chronic Migraine, Headache
Comparison of the Efficacy of Ultrasound-guided Greater Occipital Nerve Block and Pulsed Radiofrequency Therapy in Chronic Migraine Patients
Chronic migraine (CM) is related to headache-related disability and reduced quality of life. Therefore, patients with CM require preventive treatment.
- Trial name
- NCT05464212
- Testing
- USG Guided Greater Occipital Nerve Block, USG Guided Greater Occipital Nerve Block and Pulsed Radiofrequency
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Eskisehir Osmangazi University
Myofacial Pain Syndromes
Treatment of Chronic Myofascial Pain Syndrome Over Neck by Using Intravascular Laser Irradiation of Blood
Myofascial pain syndrome (MPS) is characterized by single or multiple trigger points (TrP) in taut bands within the affected muscles.
- Trial name
- NCT02470000
- Testing
- Intravascular laser irradiation of blood (ILIB), Transcutaneous electrical nerve stimulation, Stretching exercise
- Where
- Taiwan
- Volunteers
- 36 people
- Sponsor
- Chang Gung Memorial Hospital
Post Herpetic Neuralgia (PHN)
Transcutaneous Auricular Vagus Nerve Stimulation on Post-Herpetic Neuralgia
The purpose of this study is to evaluate the therapeutic efficacy of transcutaneous auricular vagus nerve stimulation (taVNS) in the treatment of patients with post-herpetic neuralgia (PHN).
- Trial name
- NCT07123987
- Testing
- transcutaneous auricular vagus nerve stimulation (taVNS), traditional medical treatment for PHN
- Where
- Egypt
- Volunteers
- 34 people
- Sponsor
- Mohamed Hosny Ismail Easa
Phantom Limb Pain, Pain, Chronic
Continuous Sciatic Nerve Block vs Epidural Analgesia in Lower Limb Amputation for Postoperative Pain
Controlled clinical trial of two parallel groups, with random assignment 1:1, non-inferiority, blinded for the patient, for who administers the intervention and for who analyzes the data. 112 participants
- Trial name
- Ampupain (NCT05608733)
- Testing
- Epidural catheter, Continuous sciatic nerve block
- Where
- Colombia
- Volunteers
- 112 people
- Sponsor
- Universidad de Antioquia
Chronic Low Back Pain
Intraosseous Basivertebral Nerve Ablation for the Treatment of Chronic Low Back Pain
Objective of study is to evaluate the procedural success rate, clinical effectiveness, and heath-economic profile using the Intercept Intraosseous Nerve Ablation System in adult subjects with chronic low back pain in the…
- Trial name
- CLBP (NCT03630133)
- Testing
- Intracept System Ablation
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Relievant Medsystems, Inc.
Knee Osteoarthritis
Cocogen Trial: COoled Versus COnventional Radiofrequency Treatment of the GENicular Nerves for Chronic Knee Pain
Knee osteoarthritis is a progressive degenerative process that affects joint cartilage and the subchondral bone. Approximately 10% to 30% of all osteoarthritis patients suffer from disabling symptoms such as pain, stiffness and…
- Trial name
- NCT03865849
- Testing
- Cooled radiofrequent treatment, Conventional radiofrequent treatment
- Where
- 3 sites in Belgium, Netherlands
- Volunteers
- 49 people
- Sponsor
- Ziekenhuis Oost-Limburg
Low Back Pain, Recurrent, Neuropathic Pain
CRF vs WCRF or PRF-DRG in CLBP of FJ Origin and RFA Failure of MBDR: Central Sensitization and Aberrant Nerve Sprouting
The investigators will select two study groups from a population of patients with severe chronic low back pain (CLBP) of facet joint (FJ) origin already treated with conventional radiofrequency ablation (CRFA) of the medial…
- Conditions
- Low Back Pain, Recurrent, Neuropathic Pain, Facet Joint Pain, Central Sensitisation
- Trial name
- NCT04542798
- Testing
- Radiofrequency COSMAN
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- Hospital General Universitario de Valencia
Gonarthrosis; Primary, Genicular Nerve Block
Genicular Nerve Block in Chronic Knee Osteoarthritis
The goal of this clinical trial is to evaluate whether genicular nerve block (GNB) is effective in reducing pain in patients with knee osteoarthritis. It will also assess the comparative efficacy of different injection protocols.
- Conditions
- Gonarthrosis; Primary, Genicular Nerve Block, Gonarthritis
- Trial name
- GNB-KOA-RCT (NCT07174167)
- Testing
- Genicular nerve block with prilocaine, genicular nerve block with prilocaine and triamcinolone
- Where
- Turkey (Türkiye)
- Volunteers
- 81 people
- Sponsor
- Haydarpasa Numune Training and Research Hospital
Chronic Migraine, Headache
Comparison Between Greater Occipital Nerve Block and Pulsed Radiofrequency in the Management of Chronic Migraine
Comparative Study of Greater Occipital Nerve Block and Pulsed Radiofrequency in the Management of Chronic Migraine : Clinical Outcomes and Neurophysiological Correlates A Prospective Randomized Study
- Trial name
- NCT07512219
- Testing
- Greater occiptal nerve block, Pulsed radiofrequency
- Volunteers
- 70 people
- Sponsor
- Sohag University
Chronic Pain, Cesarean Section Complications
Intra-epidermal Nerve Fibre Density and Its Relationship to Post-caesarean Section Pain
Chronic pain is a significant burden to the individual and society with post-surgical pain identified as a research priority for the speciality of anaesthesia.
- Trial name
- NCT03715075
- Testing
- Caesarean Section
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Royal Infirmary of Edinburgh
Osteo Arthritis Knee, Chronic Pain
Addition of Transcranial Direct Current Stimulation and Transcutaneous Electrical Nerve Stimulation to an Education and Exercise Program in Subjects With Chronic Pain Due to Knee Osteoarthritis
Knee osteoarthritis has a very high prevalence in the population over 50 years of age. Patients with osteoarthritis often suffer from chronic pain that becomes disabling, affecting both quality of life and mental and physical…
- Trial name
- NCT05138471
- Testing
- transcranial direct current stimulation (tDCS), TENS, Exercise and General Education
- Where
- Spain
- Volunteers
- 65 people
- Sponsor
- Universidad de Murcia
Fibromyalgia
Vagus Nerve Stimulation in Fibromyalgia
Vagus nerve stimulation is thought to reduce sympathetic nerve outflow and so can improve sympathetic hyperactivity in fibromyalgia patients.
- Trial name
- NCT06237595
- Testing
- Vagus nerve stimulation, Medical treatment, Combined vagus nerve stimulation and medical treatment
- Where
- Egypt
- Volunteers
- 87 people
- Sponsor
- Kasr El Aini Hospital
Chronic Neck Pain
The Effectiveness of the Polyvagal Theory in Chronic Neck Pain
This study aimed to examine the effectiveness of a polyvagal theory-based exercise approach on joint position sense, pain, range of motion, functionality, depression, and quality of life in individuals with chronic neck pain.
- Trial name
- NCT07272551
- Testing
- Control, Intervention 1, Intervention 2
- Where
- Turkey (Türkiye)
- Volunteers
- 33 people
- Sponsor
- Medipol University
Migraine
(Botox) Mechanisms of Action in Altering the Molecular Environment in Which Pain Fibers Exist
To compare Botox-treated and Botox-untreated symptomatic tissues (defined as areas where the head hurts and the pain is felt) of chronic migraine (CM) patients using molecular studies.
- Trial name
- NCT03381261
- Testing
- Botulinum toxin type A
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Massachusetts General Hospital
Breast Carcinoma, Chronic Pain
Evaluation of the Effect of Pectoral Nerve Block II on Acute and Chronic Pain in Patients Undergoing Oncological Breast Surgery
The aim of this observational study is to evaluate the effect of Pectoral Nerve Block II (PECSII) on the development of pain in the acute and chronic periods in female patients over the age of 18 who underwent oncological breast…
- Trial name
- NCT06718868
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people
- Sponsor
- Irem Erkan