Clinical trials: Chronic Neuromuscular Pain
Spinal Cord Injuries, Nerve Injury
Closed-Loop Deep Brain Stimulation for Refractory Chronic Pain
Chronic pain affects 1 in 4 US adults, and many cases are resistant to almost any treatment. Deep brain stimulation (DBS) holds promise as a new option for patients suffering from treatment-resistant chronic pain, but traditional…
- Conditions
- Spinal Cord Injuries, Nerve Injury, Pain, Postoperative, Post Herpetic Neuralgia
- Trial name
- NCT04144972
- Testing
- Medtronic Summit RC+S or Percept RC
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of California, San Francisco
Cancer, Chronic Pain
Prospective Multicentre Study of the Use of Ketamine in the Treatment of Refractory Chronic Pain in the French CLCC
The primary objective of this study is to describe the administration practices of the antalgic Ketamine in French CLCC (Centre de Lutte Contre le Cancer) in terms of indication (neuropathic sequelae pains, morphine additional…
- Conditions
- Cancer, Chronic Pain, Neuropathic Pain, Opioid Use
- Trial name
- KETACANCER (NCT04459234)
- Testing
- Ketamine use in CLCC sites (indication and administration protocol)
- Where
- 12 sites in France
- Volunteers
- 81 people
- Sponsor
- Centre Leon Berard
Non Specific Chronic Low Back Pain
Clinical Electrophysiology Assessment for Low Back Pain
Non specific chronic low back pain (LBP) is a debilitating disorder characterized by tremendous personal and socioeconomic impact, with long-term sick leave, low quality of life, and very high financial costs.
- Trial name
- LBP (NCT03511404)
- Testing
- physiotherapy rehabilitation
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The University of Hong Kong
Post Herpetic Neuralgia (PHN)
Transcutaneous Auricular Vagus Nerve Stimulation on Post-Herpetic Neuralgia
The purpose of this study is to evaluate the therapeutic efficacy of transcutaneous auricular vagus nerve stimulation (taVNS) in the treatment of patients with post-herpetic neuralgia (PHN).
- Trial name
- NCT07123987
- Testing
- transcutaneous auricular vagus nerve stimulation (taVNS), traditional medical treatment for PHN
- Where
- Egypt
- Volunteers
- 34 people
- Sponsor
- Mohamed Hosny Ismail Easa
Low Back Pain, Sciatica
Integrated Supported Biopsychosocial Self-Management for Back Related Leg Pain
Guidelines advocate several complementary modalities as alternatives to drugs and other invasive treatments for chronic low back pain (LBP) conditions.
- Conditions
- Low Back Pain, Sciatica, Back Related Leg Pain, Pain, Chronic
- Trial name
- SUPPORT (NCT05022121)
- Testing
- Supported Biopsychosocial Self-Management (SBSM), Medical Care
- Where
- 2 sites in United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Breast Cancer
Genetic, Neurophysiological and Psychological Predictive Factors of Chronic Neuropathic Pain After Surgery for Breast Cancer
The aim of the study is to establish the genetic, neurophysiological and psychological phenotype of the patients presenting a persistent neuropathic pain after surgery of the breast cancer, by comparing the neuropathic painful…
- Trial name
- DOLORISKSEIN (NCT02944721)
- Testing
- Genetical analyses, Chronic pain identification questionnaires, Neurophysiological and psychophysical evaluations
- Where
- 2 sites in France
- Sponsor
- Hopital Foch
Chronic Neuromuscular Pain
HRV Biofeedback in Pain Patients
Pain initiates a stress response that increases sympathetic output and leads to autonomic imbalance. Heart rate variability (HRV) is a easy to perform, valid measure of autonomic function.
- Trial name
- HRVB-PP (NCT02426476)
- Testing
- active heart rate variability biofeedback training
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- VA Office of Research and Development
Small Fiber Neuropathy
Chronic Pain Rehabilitation in Patients With Small Fiber Neuropathy
Small fiber neuropathy (SFN) is a condition that is dominated by invalidating neuropathic pain. Pharmacological neuropathic pain treatment is often disappointing, since pain reduction is mostly slight and side effects can be…
- Trial name
- NCT05798949
- Testing
- Chronic pain rehabilitation: exposure in vivo, Chronic pain rehabilitation: graded activity, Chronic pain rehabilitation: acceptance and commitment therapy
- Where
- 2 sites in Netherlands
- Volunteers
- 10 people
- Sponsor
- Academisch Ziekenhuis Maastricht
Rumination, Chronic Pain
Modulation of Cortical Brain Activity During Attentional Control
The goal of this study is to determine whether an open-loop sham neurofeedback system can effectively modulate EEG alpha rhythms, which are associated with attentional control.
- Conditions
- Rumination, Chronic Pain, Fibromyalgia
- Trial name
- NCT06748976
- Testing
- Control
- Where
- Argentina
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- National Council of Scientific and Technical Research, Argentina
Pain, Post Operative, Pain, Acute
Opioid-free Anesthesia in Thyroidectomies
The aim of this study will be to investigate the effect of an opioid-free anesthesia regimen with a mixture of dexmedetomidine-lidocaine-ketamine in the same syringe versus fentanyl analgesia in elective thyroidectomies.
- Conditions
- Pain, Post Operative, Pain, Acute, Pain, Chronic, Pain, Neuropathic
- Trial name
- NCT05243940
- Testing
- dexmedetomidine-ketamine-lidocaine (DKL), remifentanil infusion
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- Aretaieion University Hospital
Low Back Pain, Recurrent, Neuropathic Pain
CRF vs WCRF or PRF-DRG in CLBP of FJ Origin and RFA Failure of MBDR: Central Sensitization and Aberrant Nerve Sprouting
The investigators will select two study groups from a population of patients with severe chronic low back pain (CLBP) of facet joint (FJ) origin already treated with conventional radiofrequency ablation (CRFA) of the medial…
- Conditions
- Low Back Pain, Recurrent, Neuropathic Pain, Facet Joint Pain, Central Sensitisation
- Trial name
- NCT04542798
- Testing
- Radiofrequency COSMAN
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- Hospital General Universitario de Valencia
Neck Pain, Neck Pain Musculoskeletal
The Effectiveness of Dynamic Neuromuscular Stabilization (DNS) Exercises Compared to Localized Exercises and Standard Care on Pain Intensity, Neck Dysfunction, and Upper Cervical Range of Motion in Patients With Chronic Neck Pain: A Pilot Randomized Controlled Trial (RCT)
Many people experience long-lasting neck pain, which can affect daily life, work, and overall well-being. This study aims to find out which type of exercise program is most effective in reducing neck pain, improving neck…
- Conditions
- Neck Pain, Neck Pain Musculoskeletal, Chronic Neck Pain, Neck Disease
- Trial name
- DYNEX (NCT07395011)
- Testing
- Dynamic Neuromuscular Stabilization (DNS) Exercises, Local Exercises, Usual Care
- Volunteers
- 45 people
- Sponsor
- Hochschule Osnabruck
Sciatica, Lumbar Radiculopathy
Brain Mechanisms Supporting Cannabis-induced Pain Relief
Chronic low back pain is a common and disabling condition that affects millions of people in the United States. Many people with chronic low back pain do not get enough relief from current treatments.
- Conditions
- Sciatica, Lumbar Radiculopathy, Lower Back Pain, Degenerative Disc Disease
- Trial name
- NCT04982965
- Testing
- Active Cannabis
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Fibromyalgia, Chronic Migraine, Headache
Personality, Defences, Central Sensitization, and Trauma in Women With Chronic Migraine, Fibromyalgia, and Vulvodynia
Chronic pain (CP) is a substantial healthcare challenge with considerable economic costs. Recently, the term Nociplastic Pain (NP) has been introduced as a third descriptor of mechanisms related to CP.
- Conditions
- Fibromyalgia, Chronic Migraine, Headache, Vulvodynia
- Trial name
- PSYCHOFIBRO (NCT06138171)
- Testing
- Psychological self-reported measures assesment (questionnaire)
- Where
- Italy
- Volunteers
- 1,006 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Fibromyalgia
Vagus Nerve Stimulation in Fibromyalgia
Vagus nerve stimulation is thought to reduce sympathetic nerve outflow and so can improve sympathetic hyperactivity in fibromyalgia patients.
- Trial name
- NCT06237595
- Testing
- Vagus nerve stimulation, Medical treatment, Combined vagus nerve stimulation and medical treatment
- Where
- Egypt
- Volunteers
- 87 people
- Sponsor
- Kasr El Aini Hospital
Chronic Low-back Pain, Chronic Pain
Chromatic Retinal Stimulation to Reduce Chronic Pain and Pain Sensitivity
Participants with chronic pain conditions including chronic low back pain and fibromyalgia may benefit from light stimuli presented to the retina to reduce chronic pain severity and pain sensitivity.
- Conditions
- Chronic Low-back Pain, Chronic Pain, Fibromyalgia
- Trial name
- NCT05956067
- Testing
- Green Light stimulation, Equal Energy White stimulation, S-cone modulating white light
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of North Carolina, Chapel Hill
Fibromyalgia, Healthy Volunteers
Explosive Synchronization of Brain Network Activity in Chronic Pain
This project is being conducted to evaluate the impact of explosive synchronization (ES) and its treatment with non-invasive brain stimulation in fibromyalgia (FM).
- Trial name
- NCT04606095
- Testing
- EEG, Neuroimaging EEG/fMRI (Aim 1), HD-tDCS treatments
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Chronic Fatigue Syndrome
Use of Xyrem to Improve Sleep in Chronic Fatigue Syndrome
Chronic fatigue syndrome is a disabling illness for which there is no specific treatment. As a group, CFS patients have disturbed sleep with frequent arousals and the sense of not having slept upon awakening.
- Trial name
- NCT00498485
- Testing
- Sodium Oxybate
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of Medicine and Dentistry of New Jersey
Complex Regional Pain Syndrome, Reflex Sympathetic Dystrophy
CREATE-1: A Study to Assess the Efficacy and Safety of AXS-02 in Patients With CRPS-1
This is a randomized, double-blind, placebo-controlled, 24-week study to evaluate the efficacy and safety of AXS-02 in patients with CRPS-I.
- Trial name
- CREATE-1 (NCT02504008)
- Testing
- AXS-02 (oral zoledronate)
- Where
- 44 sites in United States, Australia and 2 more
- Volunteers
- 190 people
- Sponsor
- Axsome Therapeutics, Inc.