Clinical trials: Chronic Non-Cancer Pain
Chronic Pain
Retrospective Analysis of Spinal Cord Stimulation on Chronic Non-cancer Pain
Since 2014, the Queen Mary Hospital, a tertiary teaching hospital in Hong Kong, has commenced the provision of spinal cord stimulation (SCS) services with structured guidelines, standardized protocols and comprehensive pre- and…
- Trial name
- NCT05411419
- Testing
- Spinal cord stimulation
- Where
- Hong Kong
- Volunteers
- 26 people
- Sponsor
- The University of Hong Kong
Chronic Nociceptive Pain, Neuropathic Pain
A Pilot Study of Ultra Rapid Opioid Rotation and Titration of Oxymorphone
This project will explore the safety and feasibility of performing a successful intravenous patient controlled analgesia (IV PCA) Oxymorphone titration and conversion to oral ER Oxymorphone (extended release or OPANA ER) in the…
- Conditions
- Chronic Nociceptive Pain, Neuropathic Pain, Non-cancer Pain
- Trial name
- NCT00945919
- Testing
- Oxymorphone ER
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Chronic Pain
The Effectiveness and Tolerability of Fentanyl Matrix in Chronic Non-cancer Pain; Assessment of Patient's Pain Treatment Goal Achievement
The purpose of this study is to assess the effectiveness and tolerability of Fentanyl matrix in chronic non-cancer pain.
- Trial name
- NCT01688583
- Testing
- Fentanyl matrix
- Where
- 11 sites in South Korea
- Volunteers
- 410 people
- Sponsor
- Janssen Korea, Ltd., Korea
Chronic Nonmalignant Pain, Pain, Intractable
Post-market, Randomized, Controlled, Prospective Study Evaluating Intrathecal Pain Medication (IT) Versus Conventional Medical Management (CMM) in the Non-cancer, Refractory, Chronic Pain Population
This study is being conducted to compare intrathecal morphine using the commercially available intrathecal drug delivery systems (IDDS), and conventional medical management (CMM) in subjects with non-cancer, refractory chronic…
- Conditions
- Chronic Nonmalignant Pain, Pain, Intractable, Pain, Chronic
- Trial name
- Prosper-001 (NCT04096391)
- Testing
- Flowonix Prometra® II Programmable Infusion System, Pain Medicine
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- Evolve Restorative Center
Chronic Myeloproliferative Disorders, Kidney Cancer
Light-Emitting Diode Therapy in Preventing Mucositis in Children Receiving Chemotherapy With or Without Radiation Therapy Before Bone Marrow Transplantation
RATIONALE: Light-emitting diode (LED) therapy may be able to prevent mucositis of the mouth. PURPOSE: Randomized phase II trial to determine the effectiveness of LED therapy in preventing mucositis of the mouth in children who…
- Conditions
- Chronic Myeloproliferative Disorders, Kidney Cancer, Leukemia, Lymphoma
- Trial name
- NCT00036712
- Testing
- management of therapy complications, pain therapy
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Medical College of Wisconsin
Chronic Non-cancer Pain, Insomnia
Chronic Insomnia in Non-Cancer Pain Patients
Pain and sleep are closely linked physiological processes that support overall health and functioning. Increasing evidence shows a dynamic, bidirectional relationship: poor sleep increases pain sensitivity, while chronic pain…
- Trial name
- PainSomnia (NCT07057232)
- Testing
- Usual care provided from pain specialist or within a dedicated pain unit
- Where
- 15 sites in Spain
- Volunteers
- 385 people
- Sponsor
- Germans Trias i Pujol Hospital
Opioid-Induced Constipation
Phase 2 Randomized, Double-Blind, Placebo-Controlled, Parallel Group Trial of Linaclotide Administered to Patients With Opioid-Induced Constipation Receiving Chronic Opioid Treatment for Non-Cancer Pain
The purpose of this study was to evaluate the safety and efficacy of linaclotide for the treatment of opioid-induced constipation (OIC), in adults receiving stable opioid treatment for chronic non-cancer pain that has been…
- Trial name
- NCT02270983
- Testing
- Linaclotide 145 micrograms, Linaclotide 290 micrograms
- Where
- 77 sites in United States
- Volunteers
- 254 people
- Sponsor
- Forest Laboratories
Chronic Pain
Intrathecal Therapy for Chronic Non-Cancer Pain: An Analysis of Its Efficacy
Our hypothesis is that patients with intrathecal delivery systems for chronic non-cancer pain will report no improvement treatment efficacy when compared to patients with chronic pain managed with oral or systemic opioid…
- Trial name
- NCT01564069
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Brigham and Women's Hospital
Chronic Pain
Effect and Safety of Listening to Music for Chronic Pain Relief
Chronic pain is a multidimensional pathological condition that reduces patients' quality of life and interferes with their daily family and work activities. Opioids are the most powerful analgesics in the treatment of pain.
- Trial name
- NCT05726266
- Testing
- Music, Audiobook
- Where
- Spain
- Volunteers
- 70 people
- Sponsor
- Víctor Fernández-Dueñas
Chronic Pain
Feasibility Study of an Online Self-management Program for Chronic Non-cancer Pain
Based on a mixed-methods design, the objective of this trial is to assess the feasibility and acceptability of the "Agir pour moi" program, an 8-week online self-management program for chronic non-cancer pain (CNCP).
- Trial name
- NCT05319652
- Testing
- Pain self-management program
- Where
- Canada
- Volunteers
- 63 people
- Sponsor
- CHU de Quebec-Universite Laval
Chronic Pain, Chronic Pain Management
Improved Treatment for Patients With Long-term Opioid Therapy for Non-cancer Pain in Primary Care
The goal of this clinical trial is to reduce inappropriate long term opioid treatment (LTOT) and to optimize pain management in patients with LTOT for chronic non-cancer pain in primary care through a new person-centred and…
- Conditions
- Chronic Pain, Chronic Pain Management, Primary Care
- Trial name
- Opi-Prim (NCT06856733)
- Testing
- Person-centred team-based approach
- Where
- 4 sites in Sweden
- Volunteers
- 110 people
- Sponsor
- Uppsala County Council, Sweden
Non-cancer Pain, Chronic Non-cancer Pain
Multidisciplinary Intervention for Non-Cancer Chronic Pain: Pilot Study
Introduction: Non-cancer chronic pain (NCCP) persists beyond the injury that caused it, affecting approximately 20% of the global population (around 1.6 billion people) and 17-18% in Spain (about 8 million people).
- Trial name
- MICNP (NCT07273084)
- Testing
- Multidisciplinary Intervention Program for Chronic Non-Cancer Pain
- Where
- Spain
- Volunteers
- 12 people
- Sponsor
- Victor Ortiz Mallasen
Inappropriate Dose of Drug Administered, Pain, Chronic
Trial Applying Policy to Eliminate or Reduce Inappropriate Narcotics in the General-population
To assess the effectiveness of a government-led population-based opioid intervention on discontinuation of opioid medication in community-dwelling adults with chronic non-cancer pain.
- Conditions
- Inappropriate Dose of Drug Administered, Pain, Chronic, Health Behavior
- Trial name
- TAPERING (NCT03400384)
- Testing
- Direct-to-consumer educational brochure
- Where
- Canada
- Volunteers
- 4,255 people
- Sponsor
- Centre de Recherche de l'Institut Universitaire de Geriatrie de Montreal
Chronic Pain
Ultra-low Dose Oral Ketamine for Chronic Pain in the Primary Care Setting
This project is a pilot study to evaluate the analgesic and opioid-sparing effects of ketamine in an ultra-low dose oral formulation as a novel intervention for treatment of chronic non-cancer pain in opioid-tolerant patients in…
- Trial name
- Ketamine (NCT02303847)
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Washington
Chronic Non-cancer Pain
Pilot Trial of Opioid Taper Support
The proposed research will develop, demonstrate the feasibility of, and pilot test in a randomized controlled trial a prescription opioid taper support intervention.
- Trial name
- POTS (NCT01883882)
- Testing
- opioid taper support
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Washington
Lumbar Post-Laminectomy Syndrome, Chronic Low Back Pain
Determining the Prognostic Value of Continuous Intrathecal Infusion
The purpose of this study will be to determine the efficacy and the prognostic value of a continuous intrathecal prognostic infusion test in an in-hospital setting for selecting patients who would have better long term outcomes…
- Conditions
- Lumbar Post-Laminectomy Syndrome, Chronic Low Back Pain, Vertebral Compression Fracture, Failed Back Surgery Syndrome
- Trial name
- NCT03523000
- Testing
- Continuous intrathecal prognostic infusion test, Bupivacaine, Fentanyl
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University Hospitals Cleveland Medical Center
Back Pain, Chronic Pain
Improving Outcomes and Lowering Costs by Integration of Primary Care Providers and Pain Medicine Physicians for Pain Pts
This study will demonstrate that functional improvement measures over a 6-month period for chronic low back patients under the care of Primary Care Provider (PCP), using a therapeutic plan formulated initially by the Pain…
- Conditions
- Back Pain, Chronic Pain, Pain, Intractable
- Trial name
- NCT02484937
- Testing
- Group 2 (PCP Treatment), Group 1 (PMS Treatment)
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Rush University Medical Center
Chronic Musculoskeletal Pain, Posttraumatic Stress Disorder (PTSD)
Neurobiological and Psychological Benefits of Exercise in Chronic Pain and PTSD
The wars in Iraq and Afghanistan are creating a new generation of Veterans, including an increasing number of women Veterans, who present with comorbid PTSD and chronic pain conditions from recent deployment-related physical…
- Conditions
- Chronic Musculoskeletal Pain, Posttraumatic Stress Disorder (PTSD), Mild or Moderate Traumatic Brain Injury
- Trial name
- EXCPPTSD (NCT03283163)
- Testing
- Exercise Testing and Training
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Pain, Opioids
The Immune and Endocrine Systems in Chronic Non-cancer Patients Treated With Opioids
The primary aim is to investigate the dose and time dependent effects of different opioids on the immune and endocrine systems. The secondary aim is to investigate whether associations between the function of the immune and…
- Conditions
- Pain, Opioids, Immune System, Endocrine System
- Trial name
- NCT02277080
- Volunteers
- 82 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Chronic Non-Cancer Pain
Pre-habilitation Interventions to Empower Patients With Chronic Pain
The development of alternative methods to address simple clinical needs and easy interventions of self-application are desired in the pre-habilitation period (waiting list).
- Trial name
- NCT05178082
- Testing
- Educational Video-based Pain Program, Empowered Relief Program
- Where
- Denmark
- Volunteers
- 163 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet