Clinical trials: Chronic Obstr Lung Disease
Pulmonary Disease, Chronic Obstructive
Tiotropium (Spiriva) Rehabilitation Study
The study was designed to determine whether tiotropium inhalation capsules, compared to placebo, enhances the improvement in exercise tolerance seen in patients with chronic obstructive pulmonary disease (COPD) who participate in…
- Trial name
- NCT00274521
- Testing
- Tiotropium
- Where
- 19 sites in United States
- Volunteers
- 108 people
- Sponsor
- Boehringer Ingelheim
Chronic Obstructive Pulmonary Disease, Alpha1-antitrypsin Deficiency
Stage 1 Study of ARALAST NP and GLASSIA in A1PI Deficiency
The purpose of this study is to conduct a pilot study to evaluate the safety and efficacy of weekly administration of Alpha1-Proteinase Inhibitor (A1PI) augmentation therapy in subjects with A1PI deficiency and emphysema/ chronic…
- Trial name
- NCT02722304
- Testing
- ARALAST NP 60 mg/kg, ARALAST NP 120 mg/kg, GLASSIA 60 mg/kg
- Where
- 17 sites in United States, Australia and 1 more
- Volunteers
- 7 people
- Sponsor
- Baxalta now part of Shire
Depression in Patients With Chronic Obstructive Pulmonary Disease
Evaluation of Depression In Chronic Obstructive Pulmonary Disease
Background: Several clinical studies show high rates of anxiety and depressive disorders in Chronic Obstructive Pulmonary Disease (COPD), that suggest common underlying pathogenetic mechanisms of COPD and depressive disorders.
- Trial name
- EDIC (NCT02147912)
- Testing
- Aerobic Exercise
- Volunteers
- 154 people
- Sponsor
- University Hospital, Catania
Emphysema, Chronic Obstructive Pulmonary Disease
Emphysema Research Registry and Biosample Repository
The Comprehensive Lung Center (CLC) at the University of Pittsburgh Medical Center (UPMC Health System) provides patients with any type of breathing or lung disorder a full range of diagnostic and therapeutic services.
- Conditions
- Emphysema, Chronic Obstructive Pulmonary Disease, Chronic Bronchitis
- Trial name
- NCT00307281
- Where
- United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Pulmonary Hypertension, COPD
SPHERIC-1. Sildenafil and Pulmonary HypERtension In COPD
Although pulmonary hypertension (PH) is a quite frequent complication of advanced pulmonary diseases, and it is an independent prognostic factor, until now no evidence-based treatment approach exists for those patients.
- Trial name
- SPHERIC-1 (NCT01441934)
- Testing
- Sildenafil citrate, Sugar pills
- Where
- 10 sites in Italy
- Volunteers
- 32 people
- Sponsor
- Italian Association of Hospital Pneumologists
Chronic Obstructive Pulmonary Disease (COPD), Respiration Disorders
Retrospective Evaluation of the Implementation of a Digital Solution Supporting the Delivery of Pulmonary Rehabilitation Programs in Private Physiotherapy Practice
Pulmonary rehabilitation improves exercise capacity, functional status, symptoms and quality of life in individuals with chronic respiratory diseases.
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Respiration Disorders, Pulmonary Rehabilitation, Chronic Respiratory Diseases
- Trial name
- DIGILIB-RR (NCT07687836)
- Testing
- TELEREHAPP-supported pulmonary rehabilitation
- Where
- France
- Volunteers
- 50 people
- Sponsor
- ADIR Association
Chronic Obstructive Pulmonary Disease
Hydrolyzed Casein and Whey Protein Supplementation and the Addition of Leucine to Induce Protein Anabolism in Malnourished COPD Patients
The aim of this study is the first aim of a NIH project that consists of 3 aims. The first aim examines the acute effects of two high-quality milk proteins (casein vs.
- Trial name
- NCT01154400
- Testing
- Casein protein hydrolysates, Whey protein hydrolysates, Casein protein hydrolysates + LEU
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Texas A&M University
Pulmonary Disease, Chronic Obstructive, Emphysema
Examining the Genetic Factors That May Cause Chronic Obstructive Pulmonary Disease (COPD)
Chronic obstructive pulmonary disease (COPD) is a long-term lung disease that is often caused by cigarette smoking. The purpose of this study is to evaluate whether certain genetic factors predispose some smokers to develop COPD…
- Conditions
- Pulmonary Disease, Chronic Obstructive, Emphysema, Bronchitis, Chronic
- Trial name
- COPDGene (NCT00608764)
- Where
- 20 sites in United States
- Volunteers
- 10,718 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Chronic Obstructive Pulmonary Disease, Cardiovascular Diseases
An Open Prospective Longitudinal Pulmonary-cardiovascular Cohort Study
This is an observational study aiming to identify and validate biomarkers (including imaging and clinical descriptors) for chronic obstructive pulmonary disease (COPD), cardiovascular disease (CVD) and lung cancer.
- Conditions
- Chronic Obstructive Pulmonary Disease, Cardiovascular Diseases, Lung Cancer
- Trial name
- BIG3 (NCT01460264)
- Where
- Sweden
- Volunteers
- 10,000 people
- Sponsor
- Region Skane
Asthma (Diagnosis), COPD (Chronic Obstructive Pulmonary Disease)
Quantitative Chest CT and Multi-Omics to Distinguish Asthma From COPD and Predict Treatment Response
This study aims to improve the diagnosis and treatment prediction of asthma and chronic obstructive pulmonary disease (COPD) by combining quantitative chest computed tomography (CT) imaging with multi-omics data.
- Trial name
- CTOMICS (NCT07602192)
- Where
- 2 sites in South Korea
- Volunteers
- 200 people
- Sponsor
- Korea University Guro Hospital
Chronic Obstructive Pulmonary Disease
Effect of Tiotropium on Inflammation and Exacerbations in COPD
Patients with COPD experience exacerbations that are a major cause of morbidity. Exacerbations are associated with increased airway and systemic inflammation and those experiencing frequent exacerbations demonstrate increased…
- Trial name
- NCT00405236
- Testing
- tiotropium
- Where
- United Kingdom
- Volunteers
- 220 people
- Sponsor
- Royal Free and University College Medical School
COPD
Effects of Roflumilast in Hospitalized Chronic Obstructive Pulmonary Disease( COPD) on Mortality and Re-hospitalization
Background: COPD exacerbations add considerably to patients' burden because they: (1) cause frequent hospital admissions and relapses or readmissions, (2) contribute directly to the death of many patients, either during…
- Trial name
- NCT01973998
- Testing
- Roflumilast
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Temple University
Chronic Obstructive Pulmonary Disease
Cognitive Status in Chronic Obstructive Pulmonary Disease's Patients
Chronic obstructive pulmonary disease (COPD) is a chronic condition involving an impairment in functionality and in the execution of activities of daily life.
- Trial name
- COPD (NCT02143700)
- Testing
- Cognitive assessment
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Universidad de Granada
Chronic Obstructive Pulmonary Disease, Hypercapnic Respiratory Failure
Home Non Invasive Ventilation for COPD Patients
Chronic Obstructive Pulmonary Disease (COPD) patients are more likely to develop acute hypercapnic respiratory failure. In the acute phase, non invasive ventilation has been shown to improve mortality and reduce intubation rate.
- Trial name
- NIVOLD (NCT03221101)
- Testing
- Home ventilator
- Where
- 4 sites in France
- Volunteers
- 86 people
- Sponsor
- University Hospital, Rouen
Sleep Apnea Syndrome, Obstructive Sleep Apnea
Impact of Positive Airway Pressure Therapy on Clinical Outcomes in Older Veterans With Chronic Obstructive Pulmonary Disease and Comorbid Obstructive Sleep Apnea (Overlap Syndrome)
Obstructive sleep apnea (OSA) and Chronic Obstructive Pulmonary Disease (COPD) are highly prevalent chronic respiratory diseases in the Veteran population.
- Conditions
- Sleep Apnea Syndrome, Obstructive Sleep Apnea, COPD, Overlap Syndrome
- Trial name
- NCT04179981
- Testing
- Positive airway pressure, Conservative care (control arm)
- Where
- United States
- Volunteers
- 668 people
- Sponsor
- VA Office of Research and Development
Malnutrition
Chronic Obstructive Pulmonary Disease (COPD) Nutrition Support Trial
The purpose of this study is to determine the best form of dietary intervention to undernourished individuals with COPD. The research aims to test the null hypothesis that there is no difference between oral nutritional…
- Trial name
- NCT00538200
- Testing
- Oral Nutritional Supplements (Fortisip), Dietary Advice
- Where
- United Kingdom
- Volunteers
- 85 people
- Sponsor
- University of Southampton
Pulmonary Disease, Chronic Obstructive
Burden of Disease Among Subjects With Eosinophilic Chronic Obstructive Pulmonary Disease (COPD)
This observational study is designed to more specifically describe the burden of the disease and the use of healthcare resources of subjects with eosinophilic COPD that may be eligible in the future for a biologic treatment.
- Trial name
- NCT03436511
- Where
- 4 sites in Spain
- Volunteers
- 341 people
- Sponsor
- GlaxoSmithKline
Chronic Obstructive Pulmonary Disease
AZD9668 Relative Bioavailability
This clinical study will aid future formulation development and optimisation of AZD9668 tablets by evaluating possible effects of minor changes to the formulation and process on the rate and extent of absorption.
- Trial name
- NCT01035411
- Testing
- AZD9668
- Where
- Germany
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Emphysema, Acute Respiratory Distress Syndrome
Use of the Hattler Respiratory Assist Catheter in Severe Respiratory Failure
A new artificial lung device has been developed that potentially provides added support to mechanical ventilation for severely damaged lungs.
- Conditions
- Emphysema, Acute Respiratory Distress Syndrome, Chronic Obstructive Pulmonary Disease, Asthma
- Trial name
- NCT00288964
- Testing
- Hattler Respiratory Assist Catheter
- Where
- United Kingdom
- Sponsor
- Alung Technologies
COPD, COPD Exacerbation
Ultrasonographic Evaluation of Diaphragm and Quadriceps in Chronic Obstructive Pulmonary Disease (COPD) Patients
The purpose of this study is to evaluate the prognostic role of echographic diaphragmatic assessment and vastus lateralis muscle ultrasound (US) in two independent populations of patients hospitalized for exacerbated Chronic…
- Trial name
- EDIFEB (NCT04509128)
- Volunteers
- 200 people
- Sponsor
- IRCCS San Raffaele Roma
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