Clinical trials: Chronic Obstr Lung Disease
Copd, Hypertension, Pulmonary
Lung Hyperinflation and Response to Pulmonary Vasodilator Therapy
The goal of this retrospective observational study is to evaluate if lung distension disorders can be a predictive factor of bad response to vasodilator therapy in patients with pulmonary hypertension (PH) associated with chronic…
- Conditions
- Copd, Hypertension, Pulmonary, Hyperdistention
- Trial name
- NCT06613321
- Testing
- Respiratory function tests before introduction of vasodilator therapy, 3 month follow up evaluation of response to treatment.
- Where
- France
- Volunteers
- 47 people
- Sponsor
- Central Hospital, Nancy, France
COPD (Chronic Obstructive Pulmonary Disease), Cardiometry
Cardio-circulatory and Respiratory Monitoring for Prediction of Outcome in Mechanically Ventilated Chronic Obstructive Pulmonary Disease Patients
Chronic Obstructive Pulmonary Disease (COPD) remains a leading cause of morbidity and mortality worldwide, often necessitating invasive mechanical ventilation (MV) during acute exacerbations.
- Conditions
- COPD (Chronic Obstructive Pulmonary Disease), Cardiometry, Weaning Invasive Mechanical Ventilation
- Trial name
- NCT07109206
- Where
- Egypt
- Volunteers
- 104 people
- Sponsor
- Assiut University
Pulmonary Emphysema
US 10 mL Bronchoscopic Lung Volume Reduction (BLVR) Phase 1 Emphysema Study - Initial Formulation
The purpose of this study is to determine whether the Aeris Bronchoscopic Lung Volume Reduction (BLVR) System is safe in patients with advanced emphysema.
- Trial name
- NCT00085852
- Testing
- BLVR
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- Aeris Therapeutics
Chronic Obstructive Pulmonary Disease (COPD)
Umbilical Cord Mesenchymal Stem Cells as Adjuvant Therapy in Group E COPD Patients
This study aims to evaluate the efficacy and safety of allogeneic human UC-MSC to treat stage E Chronic Obstructive Pulmonary Disease (COPD).
- Trial name
- UCMSC-COPD (NCT07441226)
- Testing
- Umbilical Cord Mesenchymal Stem Cells
- Where
- Indonesia
- Volunteers
- 20 people
- Sponsor
- RSUP Persahabatan
Pulmonary Disease, Chronic Obstructive, Asthma
Evaluation of the Respimat Inhaler vs. a HFA MDI Using Berodual in Patients With COPD With Poor MDI Technique.
The objective of this trial is to compare the total and regional deposition of aerosol in the lungs and oropharynx of patients with COPD and known poor MDI inhalation technique following inhalation of Berodual delivered via the…
- Trial name
- NCT00267917
- Testing
- Berodual Respimat, Berodual HFA-MDI
- Where
- Germany
- Volunteers
- 13 people
- Sponsor
- Boehringer Ingelheim
COPD
The Improving Care in Chronic Obstructive Lung Disease Study A Cluster Randomized Trial
Background The Swiss health ministry launched a national quality program "QualiCCare" in 2011 to improve healthcare for patients with COPD.
- Trial name
- CAROL (NCT01921556)
- Testing
- active comparator, QualiCCare education
- Where
- Switzerland
- Volunteers
- 216 people
- Sponsor
- University of Zurich
Respiratory Syncytial Virus, Chronic Obstructive Pulmonary Disease, Congestive Heart Failure
An Observational Study to Assess RSV-associated Illness in Adults With COPD and/or CHF
The primary objective of this observational study is to determine the incidence of medically attended (inpatient or outpatient) acute respiratory illnesses or events leading to worsening cardiorespiratory status (ie, acute…
- Trial name
- CD-1089 (NCT01455402)
- Where
- 60 sites in United States, Bulgaria and 7 more
- Volunteers
- 476 people
- Sponsor
- MedImmune LLC
Chronic Obstructive Pulmonary Disease, Physical Activity
Physical Activity Coaching in Chronic Obstructive Pulmonary Disease (COPD)
This study is designed to explore a new approach to help people with chronic obstructive pulmonary disease (COPD) become more physically active.
- Conditions
- Chronic Obstructive Pulmonary Disease, Physical Activity, Health Behavior
- Trial name
- PACC (NCT01349608)
- Testing
- Telephonic health coaching
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Mayo Clinic
Pulmonary Disease, Chronic Obstructive
Bioavailability of Tiotropium + Olodaterol Fixed-dose Combination (5 μg/ 5 μg) in Chinese COPD Patients
The primary objective of this study is to assess the pharmacokinetics of tiotropium + olodaterol fixed-dose combination (FDC) (5 μg/ 5 μg) delivered by the RESPIMAT inhaler after single dose and at steady state in Chinese…
- Trial name
- NCT02969317
- Testing
- Tiotropium, Olodaterol
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Boehringer Ingelheim
Moderate to Very Severe Chronic Obstructive Pulmonary Disease
Efficacy and Safety of Benralizumab in Moderate to Very Severe Chronic Obstructive Pulmonary Disease (COPD) With Exacerbation History
The purpose of the study is to determine if benralizumab reduces COPD exacerbation rate in symptomatic patients with moderate to very severe COPD who are receiving standard of care therapies.
- Trial name
- TERRANOVA (NCT02155660)
- Testing
- Benralizumab Arm A, Benralizumab Arm B, Benralizumab Arm C
- Where
- 356 sites in United States, Argentina and 24 more
- Volunteers
- 2,255 people
- Sponsor
- AstraZeneca
COPD, Physical Activity
Transcutaneous Electrical Nerve Stimulation During Exercise in Patients With COPD
Early pulmonary rehabilitation is recommended after an episode of severe exacerbation of chronic obstructive pulmonary disease (COPD). However, its implementation is challenging particularly as regard exercise training.
- Conditions
- COPD, Physical Activity, Rehabilitation, TEN
- Trial name
- proTENS (NCT03548870)
- Testing
- CWRT with low frequency transcutaneous electrical nerve stimulation
- Where
- France
- Volunteers
- 2 people
- Sponsor
- Groupe Hospitalier du Havre
Pulmonary Disease, Chronic Obstructive
A Randomized Study, Comparing Fluticasone Furoate/Umeclidinium/Vilanterol (FF/UMEC/VI) Single Inhaler Triple Therapy, Versus Multiple Inhaler Therapy (Budesonide/Formoterol Plus Tiotropium) in Subjects With Chronic Obstructive Pulmonary Disease (COPD)
The primary purpose of this study is to evaluate lung function and health related quality of life (HRQoL) after 84 days of treatment with a single inhaler triple therapy combination of FF/UMEC/VI [100/62.5/25 microgram (mcg)]…
- Trial name
- NCT03478683
- Testing
- budesonide/formoterol, albuterol/salbutamol, FF/UMEC/VI
- Where
- 57 sites in United States, Czechia and 2 more
- Volunteers
- 729 people
- Sponsor
- GlaxoSmithKline
Chronic Obstructive Pulmonary Disease
Safety and Efficacy of Adipose Derived Stem Cells for Chronic Obstructive Pulmonary Disease
The intent of this clinical study is to answer the questions: 1) Is the proposed treatment safe and 2) Is treatment effective in improving the health of patients with human Chronic Obstructive Pulmonary Disease.
- Trial name
- NCT01559051
- Testing
- Lipoaspiration with Local anesthesia
- Where
- United States
- Sponsor
- Ageless Regenerative Institute
Chronic Obstructive Pulmonary Disease
Decision Support on End-of-life Care Planning in Older Adults
This study aims to test the effects of a patient decision aid (PDA) on planning for end-of-life (EOL) care among older adults with COPD. The main questions it aims to answer are: 1.
- Trial name
- NCT06314035
- Testing
- COPD Patient Decision Aid, General Health Coaching Intervention
- Volunteers
- 60 people
- Sponsor
- National Taipei University of Nursing and Health Sciences
Chronic Obstructive Pulmonary Disease
Helium-Hyperoxia and 6MWT Distance in COPD
We assessed the effect of altering inspired gas on the 6MWT distance in COPD. We hypothesized that HeO2 would improve walking distance and reduce shortness of breath compared to both RA and O2, and potentially improve quality of…
- Trial name
- NCT00394225
- Testing
- Oxygen, Helium
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- University of Saskatchewan
Pulmonary Disease, Chronic Obstructive
Telemedicine for Patients Suffering From COPD (Danish Telecare North Trial)
There are two main aims in this study. The first objective is to evaluate whether a particular telehealth solution, in addition to standard treatment and care, lead to a significant decrease in the mortality and an increase in…
- Trial name
- TCN (NCT01984840)
- Testing
- Telemedicine
- Where
- Denmark
- Volunteers
- 1,225 people
- Sponsor
- Aalborg University
Chronic Obstructive Pulmonary Disease
Neuromuscular Electrical Stimulation in Chronic Obstructive Pulmonary Disease (COPD)
The purpose of this study is to elucidate whether combination of usual pulmonary rehabilitation and neuromuscular electrical stimulation of quadriceps may improve exercise capacity in patients affected by chronic obstructive…
- Trial name
- NCT00677690
- Testing
- neuromuscular electrical stimulation (NMES)
- Where
- Italy
- Volunteers
- 83 people
- Sponsor
- Fondazione Salvatore Maugeri
COPD
Protein Supplementation to Enhance Exercise Capacity in COPD
Chronic obstructive pulmonary disease (COPD) is a common smoking-related lung disease. Pulmonary Rehabilitation (PR) is a six-week supervised group exercise and education class.
- Trial name
- NCT04027413
- Testing
- fortisip compact protein, preOp
- Where
- United Kingdom
- Volunteers
- 68 people
- Sponsor
- University College, London
Cystic Fibrosis, Primary Ciliary Dyskinesia
Multiple Breath Washout, a Clinimetric Dataset
Monitoring patients with chronic, inflammatory airways disease particularly in the early stages is hampered by the relative insensitivity of current outcome measures to detect subtle changes.
- Conditions
- Cystic Fibrosis, Primary Ciliary Dyskinesia, Bronchiectasis, Asthma
- Trial name
- NCT03320382
- Testing
- Multiple breath washout testing
- Where
- United Kingdom
- Volunteers
- 530 people, healthy volunteers welcome
- Sponsor
- Imperial College London
COPD
Helmet Ventilation During Self-Paced Walking Test
The aim of this study is to investigate the use helmet ventilation (HV) in walking test and analysis of effect patients with COPD.
- Trial name
- NCT04156724
- Testing
- Helmet vetilation
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- Fu Jen Catholic University
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