Clinical trials: Chronic Obstruct Airways Disease
Diabetes, Asthma
Integrated Care (IC) Models for Patient-Centered Outcomes
Multiple chronic conditions (MCC) are widely recognized as the U.S. public health challenge of the 21st century. These physical and behavioral health conditions take a large toll on those living with chronic diseases, including…
- Conditions
- Diabetes, Asthma, Chronic Obstructive Pulmonary Disease, Hypertension
- Trial name
- IC (NCT03451630)
- Testing
- High-Touch, High-Tech, Optimal Discharge Planning
- Where
- United States
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Chronic Obstructive Pulmonary Disease
Active Cycle of Breathing Techniques With and Without Acapella in COPD Patients
Chronic Obstructive Pulmonary Disease refers to a group of progressive lung diseases the block air flow and make it difficult to breath. It is potentially fatal and fourth leading cause of death in the world.
- Trial name
- NCT06240936
- Testing
- Active Cycle of breathing, Active Cycle of breathing with Acapella
- Where
- Pakistan
- Volunteers
- 42 people
- Sponsor
- Riphah International University
Chronic Obstructive Pulmonary Disease COPD
Long-term Real-world Study of Dupilumab in COPD : Patient Characteristics, Safety and Patient-reported Outcomes
The OBS19236 is a retrospective and prospective, non-interventional observational study in COPD patients treated with dupilumab as part of routine clinical care.
- Trial name
- AURORA (NCT07380711)
- Where
- 28 sites in France
- Volunteers
- 500 people
- Sponsor
- Sanofi
Lung Diseases, Pulmonary Disease, Chronic Obstructive
An Investigational Drug Study In Patients With COPD (Chronic Obstructive Pulmonary Disease) (MK-0873-005)
This is a study to evaluate the effectiveness and tolerability of a once-daily oral medication (MK-0873) for the treatment of COPD (chronic obstructive pulmonary disease) to determine whether the study drug leads to an…
- Trial name
- NCT00132730
- Testing
- MK-0873 2.5 mg, MK-0873 1.25 mg, MK-0873 0.75 mg
- Volunteers
- 604 people
- Sponsor
- Merck Sharp & Dohme LLC
Chronic Obstructive Pulmonary Disease
Symbicort in Chronic Obstructive Pulmonary Disease
Under daily routine conditions and without any intervention by the sponsor regarding the selection of subjects, diagnostic procedures, therapeutic decisions (medicinal and non- medicinal therapy, dose, duration, etc.), routine…
- Trial name
- SYMBOL (NCT00611520)
- Volunteers
- 64,730 people
- Sponsor
- AstraZeneca
Chronic Obstructive Pulmonary Disease
The Impact of Early Pulmonary Rehabilitation on Multidimensional Aspect of Dyspnea in COPD Patients After Exacerbation
Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are associated with severe dyspnea and exercise intolerance.
- Trial name
- NCT03611127
- Testing
- pulmonary rehabilitation
- Volunteers
- 80 people
- Sponsor
- Ain Shams University
NSCLC With COPD
Pembrolizumab as First-line Treatment for Advanced NSCLC Complicated With COPD
This clinical trial aims to evaluate the efficacy and safety of pembrolizumab in the first-line treatment of advanced NSCLC complicated with COPD and its influence on the course of COPD, so as to provide prospective clinical…
- Trial name
- NCT05578222
- Testing
- Pembrolizumab
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Tianjin Chest Hospital
Chronic Obstructive Pulmonary Disease
Prednisone Administration in Quiescent COPD Patients to Determine the Effect on Gene Expression
In this study, prednisone dose, day/time administration will be controlled in a stable COPD patient population to determine its effect on peripheral whole blood gene expression.
- Trial name
- NCT02534402
- Testing
- Prednisone
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of British Columbia
COPD
Ambulatory Interdisciplinary Rehabilitation in Chronic Obstructive Pulmonary Disease (COPD)
This randomised-controlled study is undertaken to investigate the effects of a long term low intensity outpatient training program on physical fitness and quality of life in moderate to severe COPD patients.
- Trial name
- AIR (NCT01195402)
- Testing
- pulmonary outpatient rehabilitation
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Chronic Obstructive Pulmonary Disease
GR Defect in Peripheral Blood Mononuclear Cells in COPD
T.to investigate a possible mechanism of the glucocorticosteroid receptors (GR) defect in patients with severe COPD by studying the effect of dexamethasone (Dex) on GR- binding, interleukin production (IL-6/IL-8) and MKP-1…
- Trial name
- NCT00159237
- Testing
- blood test
- Where
- United Kingdom
- Sponsor
- Imperial College London
Chronic Obstructive Pulmonary Disease, Obstructive Sleep Apnea
Functional Improvement in OSA and COPD With a Telehealth LifeStyle and Exercise Intervention
The investigators will conduct a Type I hybrid effectiveness-implementation study to test an integrated telehealth intervention among 400 overweight and obese patients with Chronic Obstructive Pulmonary Disease (COPD) and…
- Conditions
- Chronic Obstructive Pulmonary Disease, Obstructive Sleep Apnea, Overweight and Obesity
- Trial name
- FOCuSEd (NCT06390345)
- Testing
- FOCuSEd Integrated Intervention, Enhanced Usual Care
- Where
- 5 sites in United States
- Volunteers
- 400 people
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
Chronic Obstructive Pulmonary Disease
Multidimensional Individualized Nutritional Therapy for Individuals with Severe COPD
Individuals with severe chronic pulmonary disease often life isolated with a high burden of symptoms. Nutritional risk and low quality of life are common, and both associated with increased societal cost and poor prognosis.
- Trial name
- MINDNUT (NCT04873856)
- Testing
- Intervention
- Where
- Denmark
- Volunteers
- 87 people
- Sponsor
- Nordsjaellands Hospital
Chronic Obstructive Pulmonary Disease
Effects on Ventilation With NHF and Asymmetrical Nasal Cannulas
The aim of this controlled randomized crossover study is to compare the physiological effects of nasal high flow therapy (NHF) with 2 different nasal cannulas in patients with exacerbated chronic obstructive pulmonary disease…
- Trial name
- NHFDuet (NCT05676502)
- Testing
- AIRVO 2
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Kliniken Essen-Mitte
COPD (Chronic Obstructive Pulmonary Disease)
Comparison of Thoracic Squeeze and Manual Diaphragmatic Release Technique in COPD Patients
The goal of this randomized control trial is to evaluate and compare the efficacy of two physiotherapy techniques-Thoracic Squeeze Technique (TST) and Manual Diaphragmatic Release Technique (MDRT)-on improving respiratory…
- Trial name
- NCT06791239
- Testing
- Thoracic squeeze technique, Manual diaphragmatic release technique
- Where
- Pakistan
- Volunteers
- 36 people
- Sponsor
- Riphah International University
Emphysema, Chronic Obstructive Pulmonary Disease
Emphysema Research Registry and Biosample Repository
The Comprehensive Lung Center (CLC) at the University of Pittsburgh Medical Center (UPMC Health System) provides patients with any type of breathing or lung disorder a full range of diagnostic and therapeutic services.
- Conditions
- Emphysema, Chronic Obstructive Pulmonary Disease, Chronic Bronchitis
- Trial name
- NCT00307281
- Where
- United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Chronic Obstructive Pulmonary Disease
FODEPOC Study: Fat-free Mass Index in Copd
General Objective: To compare the prognostic value of the FODE scale for COPD exacerbations, where the fat-free mass index (FFMI) will be measured instead of the body mass index (BMI) in the BODE scale.
- Trial name
- FODEPOC (NCT05853081)
- Testing
- Bioelectrical impedance analysis
- Where
- Spain
- Volunteers
- 237 people
- Sponsor
- Hospital General Universitario Gregorio Marañon
Chronic Obstructive Pulmonary Disease, Respiratory Failure
Automated Oxygen Titration During Walking in Patients With COPD
Purpose: to evaluate the immediate effect of automated oxygen titration compared to usual fixed-dose oxygen treatment during exercise in patients with COPD on long-term oxygen treatment.
- Trial name
- NCT04123730
- Testing
- Fixed-dose compared to variable oxygen flow supplementation during walking
- Where
- Denmark
- Volunteers
- 35 people
- Sponsor
- Hvidovre University Hospital
Asthma, Chronic Obstructive Pulmonary Disease
Study in Patients' With Persistent Asthma and Chronic Obstructive Pulmonary Disease
The study is to evaluate the percentage of patients with asthma or COPD achieving disease control
- Trial name
- SPRINT (NCT02419872)
- Testing
- Marketed antagonists
- Where
- 141 sites in Croatia, Denmark and 8 more
- Volunteers
- 1,743 people
- Sponsor
- Teva Pharmaceuticals Europe
Chronic Obstructive Pulmonary Disease
Cognitive Status in Chronic Obstructive Pulmonary Disease's Patients
Chronic obstructive pulmonary disease (COPD) is a chronic condition involving an impairment in functionality and in the execution of activities of daily life.
- Trial name
- COPD (NCT02143700)
- Testing
- Cognitive assessment
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Universidad de Granada
Chronic Bronchitis, Chronic Obstructive Pulmonary Disease
A Clinical Evaluation of the RheOx Bronchial Rheoplasty System
This is a prospective, multicenter, single arm and open-label clinical trial to evaluate the performance, effectiveness and safety of RheOx™ system in the treatment of the symptoms of chronic bronchitis in adult moderate to…
- Trial name
- NCT05641207
- Testing
- RheOx™ with the RheOx™ Catheter treated in the trial
- Where
- 7 sites in China
- Volunteers
- 40 people
- Sponsor
- Energenx Medical LTD.
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