Clinical trials: Chronic Obstruct Airways Disease
Chronic Obstructive Pulmonary Disease (COPD)
Effects of Long Term Antibiotic Therapy on Exacerbation Rate in Stable COPD Patients
This study investigates if long term use of the antibiotic doxycycline can reduce exacerbations in COPD patients. Half of the patients will receive doxycycline which the other half will receive a placebo.
- Trial name
- NCT02305940
- Testing
- Doxycycline
- Where
- 3 sites in United Kingdom
- Volunteers
- 222 people
- Sponsor
- Imperial College London
COPD
To Compare the Pharmacokinetics of Tiotropium in Subjects With Chronic Obstructive Pulmonary Disease (COPD)
The primary objective of this study is to assess and compare the pharmacokinetics (PK) of Tiotropium delivered via Breath Actuated Inhaler (BAI) (4.5 mcg/day or 9.0 mcg/day), SPIRIVA®, HandiHaler®, (18 mcg/day) and Respimat® Soft…
- Trial name
- NCT01785433
- Testing
- Tiotropium HFA BAI 4.5 mcg, Tiotropium HFA BAI 9.0 mcg, SPIRIVA® HandiHaler® 18 mcg/day
- Where
- 5 sites in Germany
- Volunteers
- 36 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Chronic Obstructive Pulmonary Disease
Efficacy of Telemetry-assisted Care in Home Home Vented COPD
This study in patients suffering of Chronic Obstructive Pulmonary disease (COPD) aims to investigate whether telemonitoring of their non invasive ventilation (NIV) device together with targeted, tailored intervention in case of…
- Trial name
- TeleInterVENT (NCT05287555)
- Testing
- Telemonitoring Care, Standard Care
- Where
- Germany
- Volunteers
- 54 people
- Sponsor
- Georg Nilius, Prof DR med
Chronic Obstructive Pulmonary Disease
Respiratory Disease Management
The aim of this study is to reduce the number of subsequent hospital admissions and/or emergency department (ED) visits for hospitalized patients with chronic obstructive pulmonary disease (COPD) by utilizing a respiratory care…
- Trial name
- NCT01543217
- Testing
- RT management, Ususal care
- Where
- United States
- Volunteers
- 428 people
- Sponsor
- Barnes-Jewish Hospital
Chronic Obstructive Pulmonary Disease, Anxiety
Anxiety and Depression in Patients Hospitalizes for an Acute Exacerbation of COPD
This study will try to elucidate wheter the impact of a psychiatric intervention in patients hospitalized because an acute exacerbation of COPD and anxiety/depression and reconsulting at 1 and 6 month after discharge.
- Conditions
- Chronic Obstructive Pulmonary Disease, Anxiety, Depression
- Trial name
- ADPHA-EPOC (NCT01520376)
- Testing
- Counselling
- Where
- Spain
- Volunteers
- 169 people
- Sponsor
- Nestor Soler Porcar, MD, PhD
Chronic Obstructive Pulmonary Disease
Intellivent ASV in Chronic Obstructive Pulmonary Disease Patients in the ICU
This study will evaluate the effect of a fully closed loop ventilation mode (Intellivent ASV) on the duration of ventilation compared to conventional modes in COPD patients.
- Trial name
- NCT02651935
- Testing
- Intellivent ASV
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people
- Sponsor
- Izmir Dr Suat Seren Chest Diseases and Surgery Education and Research Hospital
Cancer, Chronic Renal Failure
Identification of Palliative Care Needs and Prognostic Factors of Survival in Tailoring Appropriate Interventions in Advanced Oncological, Renal and Pulmonary Diseases
This is a prospective observational study done on 3 patient populations (cancer, chronic pulmonary and renal disease). All patients will be treated and monitored according to the local clinical practice.
- Conditions
- Cancer, Chronic Renal Failure, Chronic Obstructive Pulmonary Disease, Idiopathic Pulmonary Fibrosis
- Trial name
- NCT06909968
- Testing
- palliative care
- Where
- 5 sites in Italy
- Volunteers
- 178 people
- Sponsor
- Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS
COPD (Chronic Obstructive Pulmonary Disease)
A Phase 2 Trial of JKN24011 in COPD
A Randomized, Double-Blind, Placebo-Controlled Phase II Study to Evaluate the Efficacy and Safety of Subcutaneous JKN24011 in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD)
- Trial name
- NCT07440524
- Testing
- JKN24011
- Where
- China
- Volunteers
- 215 people
- Sponsor
- Joincare Pharmaceutical Group Industry Co., Ltd
COPD (Chronic Obstructive Pulmonary Disease), Probiotic Intervention
Probiotics in Pulmonaty Rehabilitation for COPD
This study aims to investigate various aspects of patients with chronic respiratory diseases undergoing pulmonary rehabilitation supplemented with probiotics.
- Conditions
- COPD (Chronic Obstructive Pulmonary Disease), Probiotic Intervention, Body Composition Measurement
- Trial name
- NCT06717659
- Testing
- probiotic supplementation intervention, standard pulmonnary rehabilitation
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Fu Jen Catholic University
Asthma, Chronic Obstructive Pulmonary Disease (COPD)
Bioavailability Study of SYN006, Pulmicort pMDI and Meptin Air in Healthy Adult.
Budesonide + Procaterol HFA MDI is a novel asthma product containing both budesonide and procaterol in a single inhaler. Budesonide is a corticosteroid that treats underlying airway inflammation in asthma.
- Trial name
- NCT02165046
- Testing
- Budesonide, Procaterol
- Where
- Taiwan
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Intech Biopharm Ltd.
Postoperative Pain, Satisfaction with Care
Thoracic Spinal Versus Thoracic Epidural Anesthesia for Patients with Chronic Obstructive Pulmonary Disease Undergoing Supine Percutaneous Nephrolithotomy for Management of Renal Stones.
Owing to the elevated risk of perioperative comorbidities, chronic obstructive and restrictive pulmonary disorders can be a challenging task for the anesthetist.
- Trial name
- NCT06663488
- Testing
- Thoracic epidural anesthesia, Thoracic spinal anesthesia
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Chronic Obstructive Pulmonary Disease (COPD)
Dyspnea Self-Management: Internet or Face-to-Face
Chronic obstructive pulmonary disease, including emphysema and chronic bronchitis, is the fourth most common cause of death and the second leading cause of disability in the United States.
- Trial name
- NCT00461162
- Testing
- Internet DSMP, Face-to-Face Dyspnea Self-management, Attention Control
- Where
- 2 sites in United States
- Volunteers
- 125 people
- Sponsor
- University of California, San Francisco
Emphysema, Chronic Obstructive Pulmonary Disease
Safety and Efficacy of Endobronchial Valve for Bronchoscopic Lung Volume Reduction Surgery: a Prospective Pilot Study
The goal of this pliot study al is to preliminarily evaluate the effectiveness and safety of transbronchial lung volume reduction surgery using the self-devloped endobronchial valves for chronic obstructive pulmonary disease…
- Trial name
- NCT06349174
- Testing
- bronchoscopic lung volume reduction surgery using endobronchial valve
- Where
- China
- Volunteers
- 10 people
- Sponsor
- China-Japan Friendship Hospital
Pulmonary Disease, Chronic Obstructive
EVALUATION OF RESPIRATORY MECHANICS AND FUNCTIONALITY IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE
To associate a lean mass, peripheral muscle strength, kinematic thoracic-abdominal, respiratory metabolic response, mobility and diaphragmatic thickness, verifying its relation with the obstruction level of COPD
- Trial name
- NCT03086590
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Universidade Federal de Pernambuco
Pulmonary Embolism (Diagnosis), Respiratory Failure With Hypoxia
Screening for Pulmonary Embolism Using Single-channel Electrocardiogram
It is a prospective, controlled, single-center, observational, non-randomized study. The study is planned to include at least 500 patients 18 years old and older (300 patients in the training sample and 200 patients in the test…
- Conditions
- Pulmonary Embolism (Diagnosis), Respiratory Failure With Hypoxia, Chronic Obstructive Pulmonary Disease (COPD)
- Trial name
- NCT07412418
- Where
- Russia
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Chronic Obstructive Pulmonary Disease (COPD)
Effect of Supplemental Vitamin D on Skeletal Muscle Function in Chronic Obstructive Pulmonary Disease (COPD) Patients
The purpose of this study is to determine whether or not vitamin D supplementation can improve physical performance in persons with severe chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT00914810
- Testing
- Vitamin D (cholecalciferol)
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Minneapolis Veterans Affairs Medical Center
Chronic Obstructive Pulmonary Disease
Transcutaneous Electrical Muscle Stimulation In Chronic Obstructive Pulmonary Disease (COPD)
Transcutaneous electrical muscle stimulation (TCEMS) is well established intervention for rehabilitation of clinically stable patients with chronic obstructive pulmonary disease.
- Trial name
- NCT01226342
- Testing
- Transcutaneous electrical muscle stimulation
- Where
- Slovenia
- Volunteers
- 19 people
- Sponsor
- The University Clinic of Pulmonary and Allergic Diseases Golnik
Chronic Obstructive Pulmonary Disease
Randomized, Double-blind, Placebo-controlled Study to Evaluate the Effect of Roflumilast on Endothelial Function in Patients With Chronic Obstructive Pulmonary Disease
REVASC is a randomized, double-blind, placebo-controlled study which will involve 150 patients with chronic bronchitis and COPD diagnosed cardiovascular disease.
- Trial name
- REVASC (NCT01595750)
- Testing
- Roflumilast 500
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- Spanish Research Center for Respiratory Diseases
Chronic Obstructive Pulmonary Disease
Efficacy Study of the Effect of Budesonide on Emphysema
To assess the effect of up to 4 years treatment with budesonide on progression of emphysema in patients with Chronic Obstructive Lung Disease.
- Trial name
- NCT00232674
- Testing
- Pulmicort (budesonide) Turbuhaler
- Where
- Denmark
- Volunteers
- 240 people
- Sponsor
- AstraZeneca
COPD
Glycopyrronium and Formoterol Fumarate (GFF) Metered Dose Inhaler (MDI) Dose Indicator Study in Adults With Moderate to Very Severe COPD
This is an open-label, multi-center study to evaluate the accuracy, reliability and functionality of the Glycopyrronium and Formoterol Fumarate (GFF) Metered Dose Inhaler (MDI) dose indicator in adult subjects with moderate to…
- Trial name
- NCT02268396
- Testing
- Glycopyrronium and Formoterol Fumarate Metered-dose Inhaler
- Where
- 10 sites in United States
- Volunteers
- 138 people
- Sponsor
- Pearl Therapeutics, Inc.