Clinical trials: Chronic Obstruct Airways Disease
Chronic Obstructive Pulmonary Disease (COPD), Pulmonary Rehabilitation
Factors Associated With Acceptance of Home-Based Pulmonary Telerehabilitation in COPD
Pulmonary rehabilitation improves symptoms, exercise capacity, and quality of life in people with chronic obstructive pulmonary disease (COPD), but access and participation may be limited by travel, organizational, logistical…
- Trial name
- ACCEPT-TR (NCT07747571)
- Testing
- No intervention
- Where
- France
- Volunteers
- 50 people
- Sponsor
- ADIR Association
Pulmonary Disease, Chronic Obstructive
The Effects of Inhaled Budesonide-formoterol-glycopyrronium in Moderate-to-severe COPD
The fixed-dose combination product Budesonide/Glycopyrronium/Formoterol Fumarate Inhalation Aerosol, BGF pMDI and dual combination product Glycopyrronium/Formoterol Fumarate Inhalation Aerosol , GFF pMDI are developed for…
- Trial name
- OCT (NCT04675463)
- Testing
- BGF Inhalation Aerosphere, GFF Inhalation Aerosphere
- Where
- China
- Volunteers
- 50 people
- Sponsor
- ShiYue Li
Vestibular Disorder
Does Vestibular System Effected in Chronic Obstructive Pulmonary Disease Patients
. The main question is whether the vestibular system is affected by COPD. If there is an influence, the second question is what is the relationship between balance and vestibular interaction in COPD patients.
- Trial name
- NCT04280211
- Testing
- Respiratory Assessment, Vestibular Assessment, Balance Assessment
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Nimet Sermenli Aydın
COPD Exacerbation, Pneumonia
Comparison of Multiple Oxygenation Targets With Different Oximeters in Chronic Obstructive Pulmonary Disease (COPD) and Non-COPD Patients- Impact on Oxygen Flows
The oximeter is an instrument for monitoring patients receiving oxygen therapy. It displays pulse oxygen saturation (SpO2), which is a reflection of arterial oxygen saturation (SaO2).
- Conditions
- COPD Exacerbation, Pneumonia, Hypoxemia, Respiratory Disease
- Trial name
- NCT05819164
- Testing
- Masimo oximeter, Nellcor oximeter, Nonin oximeter
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Laval University
Chronic Obstructive Pulmonary Disease (COPD)
Respiratory Muscle Function in COPD Exacerbations
There is evidence that noninvasive mechanical ventilation (NIV) is effective in the treatment of severe exacerbations of COPD presenting respiratory acidosis.
- Trial name
- NCT01869387
- Testing
- Non-invasive ventilation
- Where
- Spain
- Volunteers
- 46 people
- Sponsor
- Parc de Salut Mar
COPD
Effects of Lysozyme on Acute Exacerbation of Chronic Obstructive Pulmonary Disease : A Randomised Placebo-Controlled Study
The aim of this study is to assess the effectiveness in preventing exacerbation of 52 weeks lysozyme administration in patients with COPD.
- Trial name
- NCT01645800
- Testing
- Lysozyme hydrochloride
- Where
- 25 sites in Japan
- Volunteers
- 408 people
- Sponsor
- Eisai Co., Ltd.
Acute Exacerbation of Chronic Obstructive Pulmonary Disease
A Clinical Study on the Efficacy and Safety of Xuanfei Baidu Granule in the Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease
This study is a prospective,multicenter, randomized, double-blind, placebo-controlled trial. This study plans to enroll 375 participants who will be randomly assigned in a 2:1 ratio.
- Trial name
- NCT06134063
- Testing
- Xuanfei Baidu granule
- Where
- China
- Volunteers
- 375 people
- Sponsor
- Peking University People's Hospital
Chronic Obstructive Pulmonary Disease
A Phase 1b Study to Evaluate the Safety and PK of MP-376 in Chronic Obstructive Pulmonary Disease (COPD) Patients
Patients with Chronic Obstructive Pulmonary Disease (COPD) suffer from frequent and recurrent acute exacerbations (AECB) which are associated with enormous healthcare expenditures and significant morbidity, specifically an…
- Trial name
- NCT00752414
- Testing
- MP-376 (Levofloxacin solution for Inhalation)
- Where
- 5 sites in United States
- Volunteers
- 21 people
- Sponsor
- Amgen
Chronic Obstructive Pulmonary Disease
A Phase 2a Study to Assess Safety, Daily Symptoms, PK, and Biomarkers of YPL-001 in COPD Patients
This is a Phase 2a, proof-of-concept, multicenter, randomized, double-blind, double dummy, 3-treatment, parallel study, with low and high YPL 001 doses (low dose and high dose twice daily [BID]) and a placebo control in moderate…
- Trial name
- NCT02272634
- Testing
- YPL-001 80 mg, YPL-001 160 mg
- Where
- 4 sites in United States
- Volunteers
- 61 people
- Sponsor
- Yungjin Pharm. Co., Ltd.
COPD Exacerbation Acute, COPD Exacerbation
PSV Versus ASV With Intellisync Mode for Delivery of NIV in AECOPD
Acute exacerbation of chronic obstructive pulmonary disease (COPD) is defined acute worsening of respiratory symptoms requiring additional therapy.
- Trial name
- PAINT-COPD (NCT06160687)
- Testing
- PSV mode during NIV, ASV intellisync
- Where
- India
- Volunteers
- 55 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Extracorporeal CO2 Removal, Acute Respiratory Distress Syndrome
Effects of Blood Pulsatility on Von Willebrand Factor During ECCO2R
The primary objective of the study is to demonstrate that the ECCO2R pulsatile configuration prevents the Willebrand factor high molecular weight multimers decrease observed under continuous blood flow configurations.
- Conditions
- Extracorporeal CO2 Removal, Acute Respiratory Distress Syndrome, Chronic Obstructive Pulmonary Disease Exacerbation, Pulmonary Disease
- Trial name
- FLOW-ECCO2R (NCT05079009)
- Testing
- ECCO2R pulsatile configuration
- Where
- France
- Volunteers
- 6 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
COPD
The Effect on Small Airways of Addition of Theophylline as Inducer of Histone Deacilase Activity for Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD), Treated With Inhaled Steroids and Long Acting Beta Agonists
Chronic obstructive pulmonary disease (COPD) is a chronic progressive respiratory disorder causing disability with an increasing burden to the patient, his family and to the health services.
- Trial name
- COPD (NCT00893009)
- Testing
- Theophylline
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Assaf-Harofeh Medical Center
COPD
Novel Vascular Manifestations of Chronic Obstructive Pulmonary Disease
Cognitive impairment is a known consequence of cerebral small-vessel disease. Moderate to severe cognitive impairment has been shown in up to 60% of certain individuals with COPD and is likely to profoundly influence an…
- Trial name
- NOVASC COPD (NCT02060292)
- Where
- United Kingdom
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- North Bristol NHS Trust
Chronic Obstructive Pulmonary Disease
A Phase II Study of CM326 in Subjects With Moderate to Severe Chronic Obstructive Pulmonary Disease
This study is a multi-center, randomized, double-blind, placebo-controlled Phase II clinical study to evaluate the efficacy, safety, PK characteristics, PD effects and immunogenicity of CM326 in subjects with moderate to Severe…
- Trial name
- NCT07418736
- Testing
- CM326 dose 1, CM326 dose 2
- Where
- China
- Volunteers
- 318 people
- Sponsor
- CSPC ZhongQi Pharmaceutical Technology Co., Ltd.
COPD
Virtual Exercise Rehabilitation Treatment Program for Post Exacerbation of Chronic Obstructive Pulmonary Disease
Respiratory rehabilitation is an intervention proven to improve quality of life in those with chronic lung disease but access remains poor.
- Trial name
- VERTEX (NCT05045209)
- Testing
- Virtual rehabilitation
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- St. Joseph's Healthcare Hamilton
COPD (Chronic Obstructive Pulmonary Disease)
Oscillometry in the COPD Exacerbator Phenotype With Triple Inhaled Therapy Study
The objective of this observational study is to determine the effectiveness of inhaled corticosteroids in patients with chronic obstructive pulmonary disease (COPD) and frequent worsening of their respiratory symptoms by using a…
- Trial name
- OCTRIS (NCT06931899)
- Where
- Spain
- Volunteers
- 63 people
- Sponsor
- Hospital Universitari de Bellvitge
Pulmonary Disease, Chronic Obstructive
Berodual® Respimat® vs Metered Dose Inhaler in Patients With Chronic Obstructive Pulmonary Disease
Study to compare the effect of 'natural' as opposed to 'optimal' technique on the percentage of the dose received from the Respimat® inhaler and metered dose inhaler
- Trial name
- NCT02176187
- Testing
- Berodual® Respimat® inhaler, Berodual® metered dose inhaler
- Volunteers
- 3 people
- Sponsor
- Boehringer Ingelheim
COPD
The Effect of Inhaled PUL-042 on Rhinovirus-induced Symptoms in Smokers With GOLD Stage 0 COPD
This is a study examining the effect of inhaled PUL-042 on peak lower respiratory symptoms as measured by subject diary in early stage COPD subjects who are experimentally infected with rhinovirus.
- Trial name
- NCT03794557
- Testing
- Sterile Water Injection, PUL-042 Inhalation Solution
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Pulmotect, Inc.
COPD (Chronic Obstructive Pulmonary Disease)
Effect of Rehabilitation on the Respiratory Signal in Patients With COPD and Exercise-Induced Desaturation
The aim is to study the effect of SSOT during a 3-week in-patient pulmonary rehabilitation programme. Further aim is to analyse exercise endurance, distinguishing between those exercising whilst breathing air at 760m "normoxia"…
- Trial name
- NCT07107828
- Testing
- Ambient air, Oxygen, Altitude
- Where
- Kyrgyzstan
- Volunteers
- 52 people
- Sponsor
- Eastern Switzerland University of Applied Sciences
Pulmonary Disease, Chronic Obstructive
Outcomes Associated With Early or Delayed Maintenance Treatment Post-Chronic Obstructive Pulmonary Disease Exacerbation
The timing of initiating short-term treatment for COPD exacerbations with oral corticosteroids and/or antibiotic therapy has been shown to influence the recovery time of exacerbations with early initiation of exacerbation therapy…
- Trial name
- NCT01431911
- Testing
- Early maintenance treatment, Delayed Maintenance treatment
- Volunteers
- 3,806 people
- Sponsor
- GlaxoSmithKline