Clinical trials: Chronic Obstructive Airway Disease
COPD (Chronic Obstructive Pulmonary Disease), Hypoxemia
Inhaled Treprostinil (Tyvaso Nebulizer) For COPD Patients With Hypoxemia
The goal of this clinical trial is to evaluate whether inhaled Treprostinil (Tyvaso) can improve oxygen delivery and blood flow in the lungs in adults (age ≥40) with chronic obstructive pulmonary disease (COPD) and hypoxemia who…
- Trial name
- Tyvaso (NCT07037836)
- Testing
- Inhaled Treprostinil (Tyvaso Nebulizer)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Bastiaan Driehuys
Chronic Obstructive Pulmonary Disease, Nasal High Flow
Investigating the Effect of Nasal High Flow Oxygen Therapy on Regional Lung Function
This study aims to assess the effect of nasal high flow oxygen therapy on regional function measured by volumetric computed tomography, in patients with chronic obstructive pulmonary disease.
- Conditions
- Chronic Obstructive Pulmonary Disease, Nasal High Flow, Dynamic Volumetric Computed Tomography
- Trial name
- INVENT (NCT03821311)
- Testing
- Computed tomography
- Where
- France
- Volunteers
- 8 people
- Sponsor
- University Hospital, Grenoble
All Diagnosed Health Conditions, ADD/ADHD
At-Home Research Study for Patients With Autoimmune, Inflammatory, Genetic, Hematological, Infectious, Neurological, CNS, Oncological, Respiratory, Metabolic Conditions
We are the missing link in clinical trials, connecting patients and researchers seamlessly and conveniently using a mobile health platform to advance medical research.
- Conditions
- All Diagnosed Health Conditions, ADD/ADHD, Alopecia Areata, Ankylosing Spondylitis
- Trial name
- NCT01931644
- Where
- United States
- Volunteers
- 17,667 people, healthy volunteers welcome
- Sponsor
- Sanguine Biosciences
Chronic Obstructive Pulmonary Disease, Fatigue
Effects of Laser Therapy on Muscle Function in COPD Patients
Light-emitting diodes (LEDs) have been used to minimize muscle fatigue in athletes and healthy subjects. Patients with chronic obstructive pulmonary disease (COPD) are susceptible to early muscle fatigue.
- Trial name
- LTCOPD (NCT01448564)
- Testing
- Laser therapy
- Where
- Brazil
- Volunteers
- 27 people
- Sponsor
- Eduardo Foschini Miranda
Pulmonary Disease, Chronic Obstructive
Use of Diagnostic Measures in Chronic Obstructive Pulmonary Disease (COPD) in Routine Practice and Their Impact on Treatment Decisions
This study will evaluate the diagnostic measures (including blood eosinophil counts) commonly used by lung specialist's in routine clinical care of subjects with COPD in Germany and how these diagnostic tests influence the…
- Trial name
- NCT03465332
- Testing
- Doctor's questionnaire, Subject file
- Where
- 26 sites in Germany
- Volunteers
- 251 people
- Sponsor
- GlaxoSmithKline
Chronic Obstructive Pulmonary Disease
A Phase 3 Trial to Evaluate the Safety and Efficacy of Ensifentrine in Patients With COPD
The purpose of this study is to determine if ensifentrine is safe and effective for the treatment of patients with moderate to severe Chronic Obstructive Pulmonary Disease (COPD).
- Trial name
- NCT04542057
- Testing
- Ensifentrine
- Where
- 130 sites in United States, Belgium and 8 more
- Volunteers
- 790 people
- Sponsor
- Verona Pharma, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA
Mixed Anxiety Depression, Diabetes Mellitus, Type 2
Concentrated Cross-disciplinary Group Intervention for Common Health Complaints (Including Post COVID-19 Fatigue)
The health care is faced by a growing challenge in the years to come: increasing age and chronic morbidity raising the costs, combined with decreased work participation.
- Conditions
- Mixed Anxiety Depression, Diabetes Mellitus, Type 2, Low Back Pain, Chronic Obstructive Pulmonary Disease
- Trial name
- NCT05234281
- Testing
- Interdisciplincary concentrated group rehabilitation
- Where
- Norway
- Volunteers
- 1,000 people
- Sponsor
- Helse i Hardanger
COPD, Dyspnea
Pulmonary Rehabilitation, Dyspnoea and Emotional Cognition in COPD
To evaluate whether pulmonary rehabilitation improves emotional cognition, using facial emotions recognition and smile production, by improving the emotional dimension of dyspnoea in patients with chronic obstructive pulmonary…
- Conditions
- COPD, Dyspnea, Rehabilitation; Tobacco Use, Emotional Disturbances
- Trial name
- READ-COG BPCO (NCT03092700)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Association pour le Développement et l'Organisation de la Recherche en Pneumologie et sur le Sommeil
COPD
Evaluation of Airway Gene Expression in COPD and Controlled Populations
To explore potential proteins that may be used to develop novel therapies for COPD. This will be accomplished by acquiring material from the lower respiratory tract via endobronchial brushings.
- Trial name
- NCT00571792
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Chronic Obstructive Pulmonary Disease
Exercise Capacity in COPD
In this study, cardiopulmonary exercise will be assessed to characterize the relevance of severity of COPD and coexisting cardiovascular comorbidities for exercise capacity.
- Trial name
- NCT03889964
- Testing
- Measurement of lung function, electrocardiography, echocardiography and cardiopulmonary exercise testing
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Klinik für Kardiologie, Pneumologie und Angiologie
COPD
Balance Training in Chronic Obstructive Pulmonary Disease
The aim of the study will be to verify whether the addition of an exercise program aimed to improve balance can reduce the risk of falling in subjects with COPD over 80 years of age compared to the standard rehabilitation…
- Trial name
- NCT05972239
- Testing
- Standard pulmonary rehabilitation program, Balance training added on standard pulmonary rehabilitation
- Where
- Italy
- Volunteers
- 21 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Pulmonary Disease, Chronic Obstructive, Respiratory Insufficiency
High Flow Therapy (HFT) to Treat Respiratory Insufficiency in Chronic Obstructive Pulmonary Disease (COPD)
The aim of this study is to see if the Vapotherm High Flow Therapy (HFT) device is effective to provide breathing support to patients with Chronic Obstructive Pulmonary Disease or COPD.
- Trial name
- NCT00990119
- Testing
- Vapotherm High Flow Therapy, Non-invasive positive pressure ventilation
- Where
- United States
- Sponsor
- Vapotherm, Inc.
Chronic Obstructive Pulmonary Disease
Medicated Aerosol Delivery Using A Jet Nebulizer Versus A Vibrating Mesh Nebulizer in COPD Exacerbation
Delivery of inhaled short-acting bronchodilators (SABD) is standard of care in the emergency department (ED) for exacerbation of COPD, the goal of such being rapid reversal of airflow obstruction.
- Trial name
- NCT03051971
- Testing
- Vibrating Mesh Nebulizer, Jet Nebulizer
- Where
- United States
- Sponsor
- Medstar Health Research Institute
COPD (Chronic Obstructive Pulmonary Disease)
Effects of VR Training on Balance and Fall Risk of Patients With COPD
The aim of this study is to determine whether Virtual Reality (VR) training has significant effects on balance and fall risk of patients with COPD, with a focus on the patient group (GOLD STANDARD I \& II).
- Trial name
- NCT06604754
- Testing
- Assigned Intervention for VR Training, Assigned Intervention for Traditional Physical Therapy Training
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- Riphah International University
Chronic Obstructive Pulmonary Disease
Effect of Portable NIV on Operational Chest Wall Volumes in COPD
The VitaBreath (Philips, Respironics) is a portable, handheld, battery powered, non-invasive ventilation device, that has been shown to reduce activity-related shortness of breath in patients with COPD.
- Trial name
- NCT03848819
- Testing
- VitaBreath device
- Where
- United Kingdom
- Volunteers
- 14 people
- Sponsor
- Northumbria University
COPD
A Placebo-controlled Trial of Daliresp on Chronic Obstructive Pulmonary Disease (COPD)
The purpose of the study is to propose that roflumilast is associated with meaningful reductions in biomarkers of pulmonary inflammation and sputum neutrophilia, including confirmation of previously described results, and…
- Trial name
- NCT01572948
- Testing
- roflumilast
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of Alabama at Birmingham
COPD
Serum Surfactant Protein-D as Predictor of Disease Severity in Hospitalized COPD Patients
evaluation of the serum levels of surfactant protein-D (SP-D), C-reactive protein (CRP), fibrinogen, and peripheral blood neutrophilic and eosinophilic counts in patients with COPD correlation of these biomarkers with clinical…
- Trial name
- NCT07154953
- Testing
- Serum Surfactant Protein-D
- Volunteers
- 75 people
- Sponsor
- Assiut University
Chronic Obstructive Airways Disease Exacerbated, Critical Care
Survival After Failed First-line Non-invasive Ventilation in Acute on Chronic Obstructive Pulmonary Disease
Observational cohort study of mid-to-long term survival of patients with acute on chronic obstructive pulmonary disease, analyzed per type of ventilation support provided during first 24 hours in intensive care.
- Trial name
- NCT03011853
- Testing
- Non-invasive and/or invasive mechanical ventilation
- Where
- Sweden
- Volunteers
- 7,900 people
- Sponsor
- Swedish Intensive Care Registry
COPD
Efficacy and Safety of Two Doses of Formoterol Fumarate MDI (PT005) in Patients With Stable Chronic Obstructive Pulmonary Disease (COPD), Compared to Foradil® Aerolizer® as an Active Control
The purpose of this study is to evaluate the safety and efficacy of inhaled formoterol fumarate (7.2 and 9.6 µg ex-actuator) compared to placebo and Foradil Aerolizer in patients with moderate to very severe chronic obstructive…
- Trial name
- NCT01043601
- Testing
- Inhaled PT005, Formoterol Fumarate 12 µg (Foradil Aerolizer)
- Where
- United States
- Sponsor
- Pearl Therapeutics, Inc.
Chronic Obstructive Lung Disease
Effect of Tadalafil in Chronic Obstructive Lung Disease Patients Suffering From Secondary Pulmonary Hypertension
Tadalafil may lower the pulmonary artery pressure in patients with Chronic Obstructive Lung Disease and secondary pulmonary hypertension and thereby improve patients quality of life.
- Trial name
- NCT00506701
- Testing
- Tadalafil
- Where
- Denmark
- Sponsor
- Herlev Hospital