Clinical trials: Chronic Obstructive Pulmonary
COPD
Balance Training in Chronic Obstructive Pulmonary Disease
The aim of the study will be to verify whether the addition of an exercise program aimed to improve balance can reduce the risk of falling in subjects with COPD over 80 years of age compared to the standard rehabilitation…
- Trial name
- NCT05972239
- Testing
- Standard pulmonary rehabilitation program, Balance training added on standard pulmonary rehabilitation
- Where
- Italy
- Volunteers
- 21 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Video-assisted Thoracoscopic Surgery, Chronic Obstructive Pulmonary Disease
Effects of Iloprost on Pulmonary Hemodynamics and Oxygenation in Patients of Chronic Obstructive Pulmonary Disease During One-lung Ventilation
The inhaled Iloprost, approved for pulmonary hypertension, caused increase in oxygenation, and increase exercise tolerance in ARDS or chronic obstructive pulmonary disease.
- Trial name
- NCT02490657
- Testing
- Inhaled iloprost, normal saline (Saline 0.9%)
- Where
- South Korea
- Volunteers
- 44 people
- Sponsor
- Yonsei University
COPD
Association of Physical Activity Levels and Inflammatory Markers Following Pulmonary Rehabilitation
COPD is characterised by irreversible airflow limitation that is usually progressive and associated with an enhanced chronic inflammatory response.
- Trial name
- PALI-COPD (NCT03455153)
- Testing
- Physical activity monitoring
- Where
- 3 sites in United Kingdom
- Volunteers
- 18 people
- Sponsor
- University of Lincoln
Airway Remodeling, Chronic Obstructive Pulmonary Disease
Effect of Tiotropium on Airway Remodeling in Patients With Early Stage COPD Accessed by Optical Coherence Tomography
This randomized, open-label, three-arm clinical trial evaluated the effects of tiotropium on airway remodeling in patients with GOLD stage 1 COPD using endobronchial optical coherence tomography (EB-OCT).
- Trial name
- NCT03842839
- Testing
- Tiotropium Inhalation Powder [Spiriva] 0.018mg, Salbutamol sulphate aerosol (Ventolin) 0.1mg
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
Pulmonary Disease, Chronic Obstructive
Changes in Dyspnea, Activity and Sleep in COPD by Video-Based Breathing Exercises
Chronic Obstructive Pulmonary Disease (COPD) is one of the most prevalent and high-mortality chronic diseases worldwide. Symptoms such as dyspnea, cough, sleep disturbances, fatigue, restricted activity levels, anxiety, and…
- Trial name
- NCT06477367
- Testing
- Video-Based Breathing Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Bartın Unıversity
Pulmonary Tuberculosis Suspected, Other Specified Chronic Obstructive Pulmonary Disease
ENOSE in Pulmonary Tuberculosis in Yogyakarta
Electronic noses detecting patterns of volatile molecules have recently been introduced for different diagnostic purposes. The diagnostic accuracy of a prototype e-nose device (Bruins et al (2013) in Bangladesh showed sensitivity…
- Conditions
- Pulmonary Tuberculosis Suspected, Other Specified Chronic Obstructive Pulmonary Disease, Pulmonary Tuberculosis TB (+) Histology, (-) Bacteriology
- Trial name
- YOGYATBNOSE (NCT02219945)
- Testing
- 5 min exhaled breath sampling with soft nose clamp
- Where
- Indonesia
- Volunteers
- 389 people, healthy volunteers welcome
- Sponsor
- Tjip van der Werf
Medication Adherence, Self-care
The Supporting Patient Activation in Transition to Home Intervention
This study evaluates if motivational interviewing sessions aiming to motivate recently discharged patients with either chronic obstructive pulmonary disease or congestive heart failure to be active in post-discharge…
- Conditions
- Medication Adherence, Self-care, Heart Failure, Chronic Obstructive Pulmonary Disease
- Trial name
- [sPATH] (NCT02823795)
- Testing
- Motivational Interviewing
- Where
- 2 sites in Sweden
- Volunteers
- 118 people
- Sponsor
- Karolinska Institutet
Pulmonary Disease, Chronic Obstructive (COPD), Pulmonary Diseases
Effect of Dietary Fiber Supplementation on Systemic Inflammation and Clinical Parameters in COPD
Chronic Obstructive Pulmonary Disease (COPD) is characterized by persistent respiratory symptoms and systemic inflammation. Dietary fiber intake has been associated with beneficial effects on gut microbiota composition and…
- Conditions
- Pulmonary Disease, Chronic Obstructive (COPD), Pulmonary Diseases, Pulmonary Diseases, Obstructive
- Trial name
- NCT07868211
- Testing
- Dietary Fiber Supplementation
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- Júnea Regina Pires Drews
Chronic Obstructive Pulmonary Disease
Factors Determining Quality of Life Related to Respiratory Status According to Gender of Chronic Obstructive Pulmonary Disease (COPD) Patients
The purpose of this study is to evaluate with sufficient precision and according to gender the determining independent factors of quality of life related to respiratory status of patient with moderate to severe COPD.
- Trial name
- VITALITE (NCT01007734)
- Where
- 178 sites in France
- Volunteers
- 449 people
- Sponsor
- AstraZeneca
Chronic Obstructive Pulmonary Disease
Is COPD a Risk Factor for Cardiovascular Disease?
Patients with chronic obstructive pulmonary disease suffer from significant cardiovascular morbidity and mortality. This study wants to determine whether chronic obstructive pulmonary disease might be a risk factor for coronary…
- Trial name
- NCT02162095
- Where
- Switzerland
- Volunteers
- 162 people
- Sponsor
- University of Zurich
Chronic Bronchitis/Bronchiectasis, Chronic Obstructive Pulmonary Disease
Efficacy of Vakum Technology in Patients With Chronic Hypersecretion
Mechanical devices to increase the individual's bronchial hygiene are commonly used to assist patients with chronic retention of secretions.
- Trial name
- NCT01718067
- Testing
- VAKÜM system, conventional manual ELTGOL technique
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Villa Pineta Hospital
Asthma, COPD
Acoustic Waveform Respiratory Evaluation
The study will evaluate the feasibility of using smartphone speakers and microphones to evaluate the caliber of the airways, detect airway obstruction, aid in airway disease diagnosis, and identify disease exacerbations.
- Conditions
- Asthma, COPD, Cystic Fibrosis, Ciliary Motility Disorders
- Trial name
- AWARE (NCT06512064)
- Testing
- AWARE
- Where
- 2 sites in United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Indiana University
Emphysema
Assessment of Emphysema Using 1.5T MRI With UTE Pulse Sequences
Emphysema is a major pathological feature of Chronic Obstructive Pulmonary Disease (COPD). Non-invasive assessment of emphysema is a crucial issue for the phenotype and follow-up of COPD patients.
- Trial name
- EMPHYREM (NCT02100800)
- Testing
- MR and CT measurements of emphysema quantification
- Where
- France
- Volunteers
- 33 people
- Sponsor
- University Hospital, Bordeaux
COPD
Portable Oxygen Concentrator to Improve Quality of Life in Chronic Obstructive Pulmonary Disease
Evaluate subjects in an prospective observational study Subjects will be administered scientifically validated questionnaires Determine the affect of the Portable Oxygen Concentrator (POC) on improvements in: 1.
- Trial name
- NCT01948544
- Where
- 3 sites in United States
- Volunteers
- 27 people
- Sponsor
- StratiHealth
Gingivitis; Chronic
The Effect of Probiotics on Gingivitis: Part 2
The aim of the study is to assess the effect of oral probiotics containing Streptococcus salivarius M18 on gingivitis and oral hygiene in young adults.
- Trial name
- NCT05919134
- Testing
- Dentoblis
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
COPD
Air Pollution and Inhaled Corticosteroids in COPD
Studies have shown that people with chronic obstructive pulmonary disease (COPD) have worse symptoms after breathing polluted air. People with COPD also often need to go to the hospital if they get a virus or other bug.
- Trial name
- APIC (NCT06552364)
- Testing
- LABA+LAMA, LABA+LAMA+ICS, Filtered Air
- Volunteers
- 48 people
- Sponsor
- University of British Columbia
Chronic Obstructive Pulmonary Disease
Flutiform® Compared With Seretide® in the Treatment of COPD
The purpose of this study is to investigate whether flutiform® is effective and safe in the treatment of chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT02195375
- Testing
- Flutiform 500/20 µg BID, Flutiform 250/10 µg BID, Seretide Accuhaler 50/500 µg BID
- Where
- 5 sites in Australia, China and 3 more
- Volunteers
- 923 people
- Sponsor
- Mundipharma Research Limited
Chronic Obstructive Pulmonary Disease
Non-invasive Mechanical Ventilation as a Rescue Therapy to Relieve Dyspnea in Patients With Stable Severe COPD
The purpose of this study is to determine whether non-invasive mechanical ventilation(NIV), playing the role as a rescue therapy , are effective in relieving exertional dyspnea in stable severe COPD patients.
- Trial name
- NCT02012101
- Testing
- niv plus oxygen therapy, oxygen therapy
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
Chronic, Non-neuropathic Back Pain
Effects of Behavioral Interventions on Mechanisms of Pain Regulation and Hedonic Regulation
The overarching aim of this project is to conduct a randomized controlled study to determine whether Mindfulness-Oriented Recovery Enhancement (MORE) vs.
- Trial name
- NCT02935465
- Testing
- Mindfulness-Oriented Recovery Enhancement (MORE), Support Group
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of Utah
COPD, CT
Effects of Nycthemeral Variations on Computed Tomography (CT) Parameters Reflecting Airways Remodelling, and Pulmonary Emphysema Extent in Chronic Obstructive Pulmonary Disease (COPD)
Computed tomography (CT) studies considering bronchial dimensions in chronic obstructive pulmonary disease (COPD) have never considered nycthemeral variations.
- Conditions
- COPD, CT, Nycthemeron
- Trial name
- NCT01192932
- Testing
- Chest CT scan
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Erasme University Hospital
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