Clinical trials: Chronic Obstructive Pulmonary
Pulmonary Disease, Chronic Obstructive
A Study Comparing the Closed Triple Therapy, Open Triple Therapy and a Dual Therapy for Effect on Lung Function in Subjects With Chronic Obstructive Pulmonary Disease (COPD)
The primary purpose of this study is to assess the equivalence of closed triple therapy Fluticasone Furoate (FF)/Umeclidinium (UMEC)/Vilanterol (VI) to open triple therapy (FF/VI + UMEC), with a comparison of both triple…
- Trial name
- NCT02731846
- Testing
- Fluticasone furoate 100 mcg + Umeclidinium 62.5 mcg+Vilanterol 25 mcg, Fluticasone furoate 100 mcg + Vilanterol 25 mcg, Umeclidinium 62.5 mcg
- Where
- 11 sites in Canada, Germany
- Sponsor
- GlaxoSmithKline
COPD, Chronic Hypercapnic Respiratory Failure
Short Term Physiological Effects of Nasal High Flow Oxygen on Respiratory Mechanics
Nasal High Oxygen Flow (HOF) has been demonstrated to reduce the re-intubation rate in hypoxic patients and ameliorate breathing pattern in hypercapnic patients.
- Trial name
- NCT02363920
- Testing
- HOF, noninvasive mechanical ventilation (NIV)
- Where
- Italy
- Volunteers
- 14 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
COPD, Breathlessness
Breathibg Exercises and Inhaler Trainingfor Chronic Obstructive Pulmonary Disease (COPD) Patients
The most common symptom of chronic obstructive pulmonary disease (COPD) is shortness of breath and causes a decrease in the patient's quality of life. The best way to relieve shortness of breath is inhaler therapy.
- Conditions
- COPD, Breathlessness, Aerocele
- Trial name
- COPD (NCT04739488)
- Testing
- Inhaler training, Breathing exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 67 people
- Sponsor
- Kirsehir Ahi Evran Universitesi
Malnutrition
COPD: Oral Nutrition Supplements vs. Energy- and Protein Dense in Between Meal Snacks.
At least one fifth of patients in European hospitals are malnourished. Malnutrition is associated with negative consequences, including higher rates of complications, longer hospital stay, impaired wound healing and increased…
- Trial name
- COPD (NCT02251496)
- Testing
- In between meals snacks (Snacks-group), Oral nutrition supplement (ONS-group)
- Where
- Iceland
- Volunteers
- 34 people
- Sponsor
- University of Iceland
Pulmonary Disease, Chronic Obstructive
Helium-3 MRI Imaging Study in COPD
This protocol describes the investigation of the use of hyperpolarised helium magnetic resonance imaging (MRI) in reflecting the regional differences in lung function of moderate to severe Chronic Obstructive Pulmonary Disease…
- Trial name
- NCT02207452
- Testing
- He-3 MRI, Salbutamol, Ipratropium
- Where
- United Kingdom
- Volunteers
- 11 people
- Sponsor
- GlaxoSmithKline
Pulmonary Disease, Chronic Obstructive
RELVAR® 100 ELLIPTA® Special Drug Use Investigation (COPD, Long-term)
This study aims to investigate the long-term safety and efficacy of RELVAR® 100 ELLIPTA® (hereinafter referred to as "Relvar") in daily clinical practice in subjects with chronic obstructive pulmonary disease (COPD), who are…
- Trial name
- NCT03219255
- Testing
- RELVAR 100 ELLIPTA
- Where
- 2 sites in Japan
- Volunteers
- 1,047 people
- Sponsor
- GlaxoSmithKline
COPD
Physiologic Effects of Nasal High Flow on Exercise Tolerance in COPD
This study aims to assess whether to describe the effects of the administration of nasal high flow (NHF) at 70 liters per minute (L/min) in a 6-Minute Walk Test (6-MWT) among Chronic Obstructive Pulmonary Disease (COPD) patients…
- Trial name
- NCT06578156
- Testing
- Nasal High Flow Cannula, Nasal Low Flow Cannula
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Miami
Hematoma, Subdural Hematoma
Patient Registry for Patients With Chronic Subdural Hematoma
All admitted patients diagnosed with unilateral or bilateral chronic subdural hematoma are included into this registry after consent.
- Conditions
- Hematoma, Subdural Hematoma, Chronic
- Trial name
- CSDH-R (NCT04170582)
- Where
- Germany
- Volunteers
- 250 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Chronic Obstructive Pulmonary Disease
A Study to Investigate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single and Repeat Doses of CHF6297 in Healthy Subjects and Patients With COPD
CHF6297 is a potent and selective inhibitor of human MAP kinase p38 being developed as an anti-inflammatory agent for the treatment of inflammatory airways diseases.
- Trial name
- CHF6297 FIH (NCT02815488)
- Testing
- CHF6297 (Part 1 - SAD), CHF6297 (Part 2 - MAD), CHF6297 (Part 3)
- Where
- 2 sites in United Kingdom
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Chiesi Farmaceutici S.p.A.
COPD
Comparative Effectiveness of Symbicort vs. Advair Among COPD Patients
This study is intended to evaluate treatment effectiveness of BFC compared to FSC in COPD patients new to ICS/LABA combination therapy.
- Trial name
- NCT01921127
- Volunteers
- 3,000 people
- Sponsor
- AstraZeneca
Asthma, COPD
Sputum and Plasma Levels of Nociceptin and Substance P in Patients With Asthma, COPD and Chronic Cough
The aims of this study are to investigate the association between sputum and plasma levels of nociceptin and substance P with cough severity and airway hyperreactivity in patients with asthma, COPD and chronic cough.
- Conditions
- Asthma, COPD, Cough
- Trial name
- NCT00173225
- Where
- Taiwan
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Asthma
Assessment of PFT, Safety, and PK of Zileuton Injection in Asthma Patients
A single intravenous injection of zileuton (150 or 300 mg) will be administered to patients with stable asthma. The goals will be to determine if zileuton i.v.
- Trial name
- NCT00534625
- Testing
- zileuton
- Volunteers
- 36 people
- Sponsor
- Critical Therapeutics
Asthma, Chronic Obstructive Pulmonary Disease (COPD)
Chest Wall Oscillation for Asthma and COPD Exacerbations Trial (COAT)
The objective of this study was to evaluate the use of high frequency chest wall oscillation (HFCWO) early in the treatment of adults hospitalized for acute asthma or chronic obstructive pulmonary disease (COPD).
- Conditions
- Asthma, Chronic Obstructive Pulmonary Disease (COPD), Undifferentiated Asthma/COPD
- Trial name
- NCT00181285
- Testing
- High Frequency Chest Wall Oscillator
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- University of Chicago
Malignant Pain, Non-malignant Pain
To Demonstrate Equivalence in Analgesic Efficacy & Bowel Function Between OXN PR Higher Dose & Lower Dose Tablet Strengths in Subjects With Non-cancer or Cancer Pain
This study is aimed to demonstrate equivalence between combinations of lower strength OXN PR tablets (OXN PR LST) and single higher strength OXN PR tablets (OXN PR HST) taken at the same overall daily dose.
- Trial name
- NCT02321397
- Testing
- Oxycodone, Naloxone
- Where
- Germany
- Volunteers
- 155 people
- Sponsor
- Mundipharma Research GmbH & Co KG
COPD, Chronic Musculoskeletal Pain
The Effect of a Technology-Mediated Integrated Walking and Tai Chi Intervention on Physical Function in Veterans With COPD and Chronic Musculoskeletal Pain
Persons with COPD benefit from being physically active, but they are often limited by chronic musculoskeletal pain. This project will determine whether a non-pharmacologic, integrated, technology-mediated walking and Tai Chi…
- Trial name
- WATCH for Pain (NCT05701982)
- Testing
- Every Step Counts-Tai Chi, Usual Care
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- VA Office of Research and Development
Chronic Obstructive Pulmonary Disease
Effects of Home-based Pulmonary Rehabilitation in Patients With Severe or Very Severe Chronic Obstructive Pulmonary Disease (COPD)
This study will investigate if adding a domiciliary respiratory physiotherapy treatment to standard care in patients with chronic obstructive pulmonary disease (COPD) can improve physical function (walking test) and quality of…
- Trial name
- NCT01198288
- Testing
- domiciliary rehabilitation, Standard Care
- Where
- Italy
- Volunteers
- 182 people
- Sponsor
- Associazione Riabilitatori Insufficienza Respiratoria
COPD, Lung Cancer
Prevalence of COPD in Our Lung Cancer Population, Compared to Controls
This study will investigate the prevalence of chronic obstructive pulmonary disease (COPD) in patients who are newly diagnosed with lung cancer and compare it to the prevalence of COPD in controls recruited from a smoking…
- Conditions
- COPD, Lung Cancer, Smoking
- Trial name
- NCT02603627
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Chronic Idiopathic Constipation
Open-label Extension (OLE) Study of Plecanatide for Chronic Idiopathic Constipation (CIC)
This is a multi-center, open-label, 52-week safety and tolerability study of plecanatide in patients with Chronic Idiopathic Constipation (CIC).
- Trial name
- NCT01919697
- Testing
- Plecanatide
- Where
- 220 sites in United States, Canada
- Volunteers
- 2,370 people
- Sponsor
- Bausch Health Americas, Inc.
Chronic Obstructive Pulmonary Disease
Hydrogen Peroxide and Nitrite Reduction in Exhaled Breath Condensate of COPD Patients
The aim of the study is to investigate the effect of inhaled apocynin on ROS (reactive oxygen species) and NOS (reactive nitrogen species) synthesis in 13 COPD patients.
- Trial name
- NCT01402297
- Volunteers
- 13 people
- Sponsor
- Medical University of Lodz
Pulmonary Disease, Chronic Obstructive, Exacerbation COPD
Respiratory Microbiome and COPD Exacerbations (RESMECOPD)
The global objective of this coordinated project is to test the following hypotheses: 1) the lung microbiome in chronic obstructive pulmonary disease (COPD) is different in patients suffering from frequent exacerbations (FE)…
- Trial name
- RESMECOPD (NCT03432234)
- Testing
- Biomarkers
- Where
- 6 sites in Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Corporacion Parc Tauli
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