Clinical trials: Chronic Obstructive Pulmonary
COPD, Dyspnea
Device-guided Breathing for Shortness of Breath in COPD
Although drug therapies and pulmonary rehabilitation have greatly improved COPD symptoms, as many as 50% of patients with severe COPD have inadequately controlled dyspnea.
- Conditions
- COPD, Dyspnea, Hyperinflation
- Trial name
- NCT01286181
- Testing
- Twice daily practice of device-guided slow breathing.
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Mayo Clinic
Chronic Lung Disease
Nutritional Supplementation in Patients With Chronic Respiratory Disease
The aim of this study is to investigate the nutritional status of patients with chronic pulmonary disease undergoing regular outpatient pulmonary rehabilitation.
- Trial name
- NCT06112730
- Testing
- Standard pulmonnary rehabilitation, Nutritional supplementation intervention
- Where
- Taiwan
- Volunteers
- 35 people
- Sponsor
- Fu Jen Catholic University
Chronic Obstructive Pulmonary Disease
Osteopathy in Chronic Obstructive Pulmonary Disease (COPD) Rehabilitation Trial
The purpose of this trial is to verify if an osteopathic treatment added to usual pulmonary rehabilitation trial is able to improve the walking ability of COPD patients and if there is any influence on lung functionality.
- Trial name
- NCT00637299
- Testing
- Active osteopathic treatment (OMT+PR): Active Comparator
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Fondazione Salvatore Maugeri
Chronic Obstructive Pulmonary Disease, Lung Disease
Investigation of the Effect of Oral Treatment With 100 mg AZD2423 in Subjects With Mild Chronic Obstructive Pulmonary Disease (COPD)
The purpose of the study is to find out if AZD2423 can reduce inflammation in the lungs of patients with mild COPD.
- Trial name
- NCT01153321
- Testing
- AZD2423
- Where
- Germany
- Volunteers
- 71 people
- Sponsor
- AstraZeneca
COPD
Boosting Regional Integration for COP D Care Through Guided Implementation and Audit of Post Exacerbation Transition Bundle
This is a cluster randomized interventional study. Intervention is implemented at a hospital level and will change overall daily practice.
- Trial name
- BRIDGE-COPD (NCT06646419)
- Where
- 37 sites in China
- Volunteers
- 1,368 people
- Sponsor
- AstraZeneca
COPD (Chronic Obstructive Pulmonary Disease)
Photon-counting CT in Chest Imaging
Purpose and objective: This project aims to evaluate photon-counting computed tomography (PCCT) quantitative accuracy using COPDGene subjects.
- Trial name
- NCT07031336
- Testing
- Photon-counting CT, Energy-integrating CT
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Duke University
Chronic Obstructive Pulmonary Disease
Active Cycle of Breathing Techniques With and Without Acapella in COPD Patients
Chronic Obstructive Pulmonary Disease refers to a group of progressive lung diseases the block air flow and make it difficult to breath. It is potentially fatal and fourth leading cause of death in the world.
- Trial name
- NCT06240936
- Testing
- Active Cycle of breathing, Active Cycle of breathing with Acapella
- Where
- Pakistan
- Volunteers
- 42 people
- Sponsor
- Riphah International University
Chronic Obstructive Pulmonary Disease, COPD
Lung Function and Patient Preference With QVA149 vs. Tiotropium in COPD Patients
The study is a multicenter, randomized, 2-period, open-label, two arm, cross-over study to show the superior effect of a 4 week treatment each with QVA149 versus tiotropium on lung function.
- Trial name
- FAVOR (NCT02125734)
- Testing
- QVA149, Tiotropium
- Where
- 18 sites in Germany
- Volunteers
- 88 people
- Sponsor
- Novartis Pharmaceuticals
Hepatitis C, Chronic
Addition of ISIS 14803 to Therapy With Peginterferon and Ribavirin for Chronic Hepatitis C (HCV) Patients Not Responding Adequately to the Two Drugs
The purposes of this Phase 1/2 study are to examine the safety, tolerability, and antiviral activity of ISIS 14803, when given in combination with peginterferon alfa and ribavirin, to patients who either failed to have at least a…
- Trial name
- NCT00062816
- Testing
- ISIS 14803, peginterferon alfa, ribavirin
- Where
- 25 sites in United States
- Volunteers
- 22 people
- Sponsor
- Ionis Pharmaceuticals, Inc.
Diabetes, Heart Failure
Avoidable Hospitalizations/ Emergency Department Visits- Systematic Review and Meta-synthesis of Qualitative Research
The aim of the study is to synthesize qualitative evidence related to preventable hospitalizations/ emergency department visits from the perspectives of patients, their families/caregivers, health care providers, and…
- Conditions
- Diabetes, Heart Failure, Chronic Obstructive Pulmonary Disease, Asthma
- Trial name
- NCT05456906
- Testing
- No intervention
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Kaohsiung Medical University
Chronic Obstructive Pulmonary Disease
Comparison of Corticosteroids vs Placebo on Duration of Ventilatory Support During Severe Acute Exacerbations of COPD Patients in the ICU
The main objective of this study is to determine if the systemic (intravenous) administration of corticosteroids, as compared to placebo, increases the number of ventilator-free days (VFD) and alive at day 28 in COPD patients…
- Trial name
- Corticop (NCT04163536)
- Testing
- Methylprednisolone
- Where
- 23 sites in France
- Volunteers
- 440 people
- Sponsor
- Versailles Hospital
Asthma
Chronic Dosing Cross-Over Study to Assess the Efficacy and Safety of Glycopyrronium (PT001) in Adult Subjects With Intermittent Asthma or Mild to Moderate Persistent Asthma
A Randomized, Double-Blind, Chronic Dosing (14 days), 5-Period, 7-Treatment, Placebo-Controlled, Incomplete Block, Cross-Over, Multi-center, Dose-ranging Study to Assess the Efficacy and Safety of Glycopyrronium MDI (PT001)…
- Trial name
- NCT02433834
- Testing
- Glycopyrronium MDI, Serevent Diskus 50 μg
- Where
- 43 sites in United States
- Volunteers
- 248 people
- Sponsor
- Pearl Therapeutics, Inc.
Chronic Obstructive Pulmonary Disease
Cardiovascular Risk and Chronic Obstructive Pulmonary Disease
The principal objective of the study is to measure parameters of inflammation, oxidative stress, and vascular, respiratory, and peripheral muscle function parameters, and identify parameters indicative of evolving cardiovascular…
- Trial name
- ECO-COPD (NCT03014609)
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Grenoble
COPD (Chronic Obstructive Pulmonary Disease)
Effectiveness of Active Cycle of Breathing Techniques in Patients With Chronic Obstructive Pulmonary Disease: A Randomized Controlled Trial
This study aims to examine the effects of Active Cycle of Breathing Technique (ACBT) on pulmonary function, sleep quality, depressive symptoms, and dyspnea in patients with Chronic Obstructive Pulmonary Disease.
- Trial name
- NCT07818187
- Testing
- ACBT+OPEP, Usual Care (Standard Medical Care)
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Yang Ming Chiao Tung University Hospital
Pulmonary Disease, Chronic Obstructive
A 16-Week Study to Evaluate the Effect of Advair DISKUS™ 250/50mcg on Arterial Stiffness in Subjects With Chronic Obstructive Pulmonary Disease (COPD)
The purpose of this study is to evaluate in patients with Chronic Obstructive Pulmonary Disease (COPD) if Advair DISKUS™ 250/50mcg BID modifies arterial stiffness which is a measure associated with risk of heart disease.
- Trial name
- NCT00857766
- Testing
- ADVAIR DISKUS™ 250/50mcg
- Where
- 24 sites in United States
- Volunteers
- 249 people
- Sponsor
- GlaxoSmithKline
Asthma, COPD
The Effects of Positive Airway Pressure on the Mucolytic Effects of NAC (TEAM)
The goal of this clinical trial is to determine if positive pressure during inspiration will improve penetration of aerosolized N-Acetylcysteine (NAC) into airway mucus plugs in the lungs of patients with asthma or Chronic…
- Trial name
- TEAM (NCT06152653)
- Testing
- n-acetylcystine (NAC)+ albuterol, AeroEclipse-VersaPAP System
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of California, San Francisco
COPD
Comparison of Anterior Chest Compression Assist and Abdominal Thrust Assist Technique COPD
A total 34 patients will be taken. 2 groups will be created to apply intervention. After signing consent form, 17 patients in group A will be given abdominal thrust assist technique and 17 patients in group B will be given…
- Trial name
- NCT05936801
- Testing
- Anterior Chest Compression technique, Abdominal Thrust Technique
- Where
- Pakistan
- Volunteers
- 34 people
- Sponsor
- Riphah International University
Chronic Obstructive Pulmonary Disease Exacerbation
The CATALINA Study
The CATALINA study is a prospective cohort study embedded within CICERO (Collaboration In COPD ExaceRbatiOns, a European Respiratory Society supported Clinical Research Collaboration), designed to collect standardised…
- Trial name
- NCT05008081
- Where
- 22 sites in Austria, Belgium and 9 more
- Volunteers
- 1,000 people
- Sponsor
- Wim Janssens
Pain, Healthy
Predicting Central Pain Among People With a Spinal Cord Injury by Evaluating Mechanisms Regulating Pain and Efficacy Testing of the TENS Apparatus
People with a Spinal Cord Injury can develop chronic pain within months of the injury. Up to 80% of the patients will develop chronic pain called "central pain" and describe the pain as: burning, stabbing, or "like electricity."…
- Trial name
- NCT01726881
- Testing
- Thermal stimulation, Mechanical stimulation, Transcutaneous Electrical Nerve Stimulator (TENS)
- Where
- Israel
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Asthma, Chronic Obstructive Pulmonary Disease
Integrated Primary Care for Chronic Lung Disease: PACK Brazil
This study will evaluate a complex intervention based on a patient management tool (PMT), combined with educational outreach to primary care doctors, nurses and other health workers, in the Brazilian city of Florianopolis.
- Trial name
- PACKBrazilR (NCT02786030)
- Testing
- Outreach education training, No outreach education training
- Where
- Brazil
- Volunteers
- 1,950 people
- Sponsor
- University of Sao Paulo General Hospital
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