Clinical trials: Chronic Obstructive Pulmonary Disease
Asthma
The Clinical Effect of MK0476 With Concomitant Administration of and Removal of Inhaled Beclomethasone in Asthmatic Patients (0476-029)
This study will investigate the additive effect of montelukast (MK0476) taken along with inhaled beclomethasone versus inhaled beclomethasone alone.
- Trial name
- NCT00911547
- Testing
- montelukast sodium, beclomethasone
- Volunteers
- 642 people
- Sponsor
- Organon and Co
Asthma, Chronic Obstructive Pulmonary Disease
Study of the Metabolism of Two Magnesium Supplements in Healthy Volunteers
The present study is part of a project titled 'Magnesium in asthma and chronic obstructive pulmonary disease'. The hypothesis of the main project is that daily magnesium supplement will benefit patients with asthma and chronic…
- Trial name
- NCT01113138
- Testing
- Mablet (Magnesium-supplement), Magnesium Sulfate
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
COPD, Hypoxia
Hypobaric Flight Simulation in COPD Patients
Aim of this study was to evaluate the hypoxic response during hypobaric flight simulation in normal individuals as well as in normocapnic and hypercapnic COPD patients as well as to evaluate the impact of a flight simulation on…
- Conditions
- COPD, Hypoxia, Aviation
- Trial name
- NCT02848391
- Testing
- Environmental
- Where
- Germany
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Krankenhaus Kloster Grafschaft
Chronic Graft Versus Host Disease
A Study to Test an Oral Medicine, Belumosudil, in Combination With Corticosteroids in Participants at Least 12 Years of Age With Newly Diagnosed Chronic Graft Versus Host Disease.
This is a parallel, Phase 3, two-arm study for the treatment of newly diagnosed moderate or severe chronic GVHD. The study duration for a participant includes up to 4 weeks for screening; a treatment period until clinically…
- Trial name
- ROCKnrol-1 (NCT06143891)
- Testing
- Belumosudil, Prednisone, Prednisolone
- Where
- 151 sites in United States, Argentina and 22 more
- Volunteers
- 260 people
- Sponsor
- Sanofi
Pulmonary Disease, Chronic Obstructive
Postmarketing Surveillance Study to Assess Handling and Patient Satisfaction on Berodual® Respimat® Solution for Inhalation in Patients With Chronic Obstructive Pulmonary Disease
New perceptions about handling and patient satisfaction of the everyday use of Berodual® Respimat® in patients with chronic obstructive lung disease (COLD).
- Trial name
- NCT02231320
- Testing
- Berodual® Respimat® - inhaler
- Volunteers
- 236 people
- Sponsor
- Boehringer Ingelheim
Pulmonary Disease, Chronic Obstructive, Congestive Heart Failure
CHF COPD Sip Feed Anabolic Response
Weight loss commonly occurs in patients with chronic heart failure (CHF) and chronic obstructive pulmonary disorder (COPD), negatively influencing their quality of life, treatment response and survival.
- Trial name
- NCT02770092
- Testing
- sip feeding with stable isotope infusion
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Copd, Athletes
Effects of CreaSafe® on Kidney, Muscle, and Cardiopulmonary Function in Athletes and COPD Patients
Creatine supplementation (CS) offers numerous health benefits, with no proven side effects reported to date. CS positively impacts all organs and systems of the body.
- Trial name
- NCT06991426
- Testing
- CreaSafe® creatine
- Where
- Brazil
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Graft-Versus-Host Disease
Histone Deacetylase Inhibitor LBH589 in Addition to Corticosteroids in Patients With Acute Graft Versus Host Disease (GVHD)
To test a new agent, LBH589, in combination with glucocorticoids as initial therapy of acute graft versus host disease (GVHD).
- Trial name
- NCT01111526
- Testing
- Panobinostat (LBH589)
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Chronic Bronchitis
SYMPROVE III: Health Services Research Study for Treatment of the Moderate and Severe Acute Exacerbations of Chronic Bronchitis (AECB)
In this study data of patients with moderate or severe acute exacerbations of chronic bronchitis (AECB) were collected. There were two different cohorts which were compared (Moxifloxacin and other antibiotics) concerning…
- Trial name
- SYMPROVE III (NCT00879008)
- Testing
- Moxifloxacin (Avelox, BAY12-8039)
- Where
- Germany
- Volunteers
- 345 people
- Sponsor
- Bayer
Chronic Obstructive Pulmonary Disease, Hypoxia
Effect of Oxygen Supplementation During Exercise in Chronic Obstructive Pulmonary Disease Patients
The project will test the hypothesis that lung ventilation during exercise is unaffected by oxygen supplementation. In addition, the acute effect of oxygen supplementation on dyspnoea, heart rate and blood pressure will be…
- Trial name
- NCT02108925
- Testing
- Oxygen
- Where
- Norway
- Volunteers
- 16 people
- Sponsor
- LHL Helse
Pulmonary Disease, Chronic Obstructive
The Study for Evaluating Factors Relating to Daily Step Counts and Physical Activity in Japanese Patients With COPD.
This study is conducted as a multicenter, non-interventional, cross-sectional study. Patients will be enrolled in the study by a continuous registration method after patients provide written informed consent.
- Trial name
- STEP-COPD (NCT03642613)
- Where
- Japan
- Volunteers
- 505 people
- Sponsor
- AstraZeneca
Pulmonary Disease, Chronic Obstructive, Heart Failure
Improving Medication Adherence Through a Transitional Care Pharmacy Practice Model
The purpose of this pilot study is to determine if medication adherence is improved by a transitional care pharmacy practice model designed to integrate hospital and community pharmacists in the care and education of patients…
- Trial name
- NCT02047448
- Testing
- Pharmacist Counseling
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Wilkes University
COPD (Chronic Obstructive Pulmonary Disease), Chronic Obstructive Pulmonary Disease (COPD)
Nebulizer Versus Handheld Maintenance Therapy for Patients With COPD
Multi-site, randomized controlled trial to determine whether patients who report NO symptomatic benefit with their maintenance hand-held inhaler(s), benefit upon switching to nebulized therapy using comparable classes of…
- Trial name
- DELIVERY (NCT07816835)
- Testing
- Nebulized therapy of similar medication solutions, Continue handheld therapy
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- COPD Foundation
Lung Cancer (Diagnosis)
Blood Based Risk Evaluation With AI for Targeted Primary Health Care in Early Lung Cancer Detection
The study is a prospective, non-randomized feasibility study evaluating blood sample and machine learning-based risk stratification for lung cancer in patients with COPD (chronic obstructive pulmonary disease).
- Trial name
- BREATHE (NCT07552584)
- Testing
- Risk stratification
- Where
- 2 sites in Denmark
- Volunteers
- 1,000 people
- Sponsor
- Vejle Hospital
COPD
A Placebo-controlled Trial of Daliresp on Chronic Obstructive Pulmonary Disease (COPD)
The purpose of the study is to propose that roflumilast is associated with meaningful reductions in biomarkers of pulmonary inflammation and sputum neutrophilia, including confirmation of previously described results, and…
- Trial name
- NCT01572948
- Testing
- roflumilast
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of Alabama at Birmingham
COPD
Innovations in Treating COPD Exacerbations: Pilot Project on Action Plans Using New Technology.
The purpose of this project is to conduct a pilot study evaluating the feasibility and potential benefits of a phone assessment/reporting system (tele-system) in addition to a written action plan and nurse case manager support to…
- Trial name
- NCT02275078
- Testing
- COPD self-management using an action plan, Telesystem-Phone self-assessment/reporting system, Nurse case manager support
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Chronic Obstructive Pulmonary Disease, Self-management Behavior
Self-management Behaviors and Resilience Among Chronic Obstructive Pulmonary Disease Patients
This study conducted an assessment of the influencing factors and correlations that affect self-management behaviors and resilience in the COPD population.
- Conditions
- Chronic Obstructive Pulmonary Disease, Self-management Behavior, Resilience
- Trial name
- NCT05459740
- Where
- Taiwan
- Volunteers
- 112 people
- Sponsor
- Shin Kong Wu Ho-Su Memorial Hospital
Pulmonary Disease, Chronic Obstructive
Safety And Efficacy Of GSK233705 Plus Salmeterol Compared With 2 Active Comparators And Placebo In Subjects With Chronic Obstructive Pulmonary Disease (COPD)
The safety, tolerability, pharmacokinetics and pharmacodynamics/efficacy profiles of two different doses of GSK233705 will be compared with 2 active comparators and placebo, all medication delivered via dry powder inhaler.
- Trial name
- NCT00422604
- Testing
- salmeterol, tiotropium, GSK233705
- Where
- 11 sites in Finland, Germany and 3 more
- Volunteers
- 60 people
- Sponsor
- GlaxoSmithKline
Copd
Oral Supplementation During PR Participation in COPD
Chronic obstructive pulmonary disease (COPD) is a very common and chronic lung condition and is a leading cause of morbidity and death.
- Trial name
- NCT06324214
- Testing
- Urolithin A (Mitopure)
- Where
- 3 sites in Canada
- Volunteers
- 22 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Chronic Obstructive Pulmonary Disease
Cross-sectional Study to Investigate the Effects of Chronic Obstructive Pulmonary Disease on Daily Life Activities
The purpose of this study is to investigate the effects of Chronic Obstructive Pulmonary Disease (COPD) on daily life activities in patients with COPD and also to determine the socio-demographic profile, daily life style and…
- Trial name
- COPD LIFE (NCT01325948)
- Where
- 20 sites in Turkey (Türkiye)
- Volunteers
- 497 people
- Sponsor
- AstraZeneca