Clinical trials: Chronic Obstructive Pulmonary Disease (COPD)
COPD, Interstitial Lung Disease
MOBoxy: MoblO2 to Maintain Oxygenation
Many patients with chronic lung disease (e.g., chronic obstructive pulmonary disease (COPD) or interstitial lung disease (ILD)) require supplemental oxygen (O2) at some point during their disease course.
- Trial name
- MOBoxy (NCT07222592)
- Testing
- MoblO2 control
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- National Jewish Health
Quality of Life, Exercise
The Effect of N-Acetylcystein on Quality of Life and Air Trapping During Rest and After Exercise
Treatment of COPD patients depends on the stage of the disease. First of all it is strongly recommended quit smoking, then bronchodilators drugs are added.
- Trial name
- NAC (NCT00476736)
- Testing
- Effect on small airways (N-Acetylcystein)
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Assaf-Harofeh Medical Center
Pulmonary Disease, Chronic Obstructive
Effect of Expiratory Positive Pressure on Dynamic Hyperinflation and Ability to Exercise With Upper Limbs in COPD
The study will evaluate the effect of positive airway expiratory pressure (EPAP) on patients with chronic obstructive pulmonary disease (COPD) during submaximal upper limb exercise.
- Trial name
- NCT03073564
- Testing
- Endurance test for upper limbs, Functional test
- Where
- Brazil
- Volunteers
- 19 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Pulmonary Disease, Chronic Obstructive
Study of GSK961081 in Healthy Volunteer Subjects
GSK961081 is a new long-acting bronchodilator being developed for the treatment of chronic obstructive pulmonary disease (COPD). This study is the first clinical study in humans.
- Trial name
- NCT00887406
- Testing
- GSK961081 15mcg SD, GSK961081 3mcg SD, GSK961081 50mcg SD
- Where
- United Kingdom
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Theravance Biopharma
Chronic Obstructive Pulmonary Disease
Adherence to Medication and Its Impact on Chronic Obstructive Pulmonary Disease (COPD) Exacerbations: The AMICE Prospective Study
Chronic Obstructive Pulmonary Disease (COPD) represents one of the most challenging chronic diseases of the 21st century: it is expected to be the fourth leading cause of death by 2030.
- Trial name
- AMICE (NCT01293890)
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- KU Leuven
COPD (Chronic Obstructive Pulmonary Disease), Pulmonary Rehabilitation
EFFECTIVENESS OF COMBINED CONCENTRIC AND ECCENTRIC AEROBIC EXERCISE ON A TREADMILL IN PATIENTS WITH COPD: A RANDOMIZED CLINICAL TRIAL.
The aim of this study is to demonstrate the effectiveness of combined concentric and eccentric aerobic training in subjects with COPD, in terms of strength, lung capacity, functionality, and short-term health quality.
- Conditions
- COPD (Chronic Obstructive Pulmonary Disease), Pulmonary Rehabilitation, Eccentric Exercise Training
- Trial name
- NCT07627035
- Testing
- Eccentric and concentric aerobic exercice versus only concentric aerobic exercice
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Universidad Europea de Madrid
Chronic Obstructive Pulmonary Disease (COPD)
Identifying REsponders and Exploring Mechanisms of ACTION of the Endobronchial Coil Treatment for Emphysema
Rationale: The PneumRx RePneu Lung Volume Reduction Coil (RePneu LVR-coil) is a bronchoscopic lung volume reduction treatment designed to compress the areas of lung parenchyma most damaged by emphysema.
- Trial name
- REACTION (NCT02179125)
- Testing
- RePneu Lung Volume Reduction Coil System
- Where
- 2 sites in Netherlands, United Kingdom
- Volunteers
- 48 people
- Sponsor
- University Medical Center Groningen
Chronic Obstructive Pulmonary Disease
A Study to Assess the Long-term Safety of QVA149
The study is designed to provide long-term safety data for QVA149 in patients with moderate to severe chronic obstructive pulmonary disease (COPD).
- Trial name
- ENLIGHTEN (NCT01120717)
- Testing
- QVA149
- Where
- 53 sites in Canada, France and 8 more
- Volunteers
- 339 people
- Sponsor
- Novartis Pharmaceuticals
Chronic Obstructive Pulmonary Disease, COPD Exacerbation
Testing a Prediction Algorithm Into a Running Telehealth System for Patients With COPD
This trial will test a COPD prediction algorithm into a telehealth system from the previous Danish large-scale trial, TeleCare North (NCT01984840).
- Conditions
- Chronic Obstructive Pulmonary Disease, COPD Exacerbation, COPD Exacerbation Acute, COPD
- Trial name
- NCT05218525
- Testing
- Algorithm
- Where
- Denmark
- Volunteers
- 138 people
- Sponsor
- Aalborg University
Chronic Obstructive Pulmonary Disease, Asthma
Impact of Air Pollution on Chronic Respiratory Diseases
The aim of this study is to evaluate the impact of air pollution on the occurrence and clinical course of chronic respiratory diseases, and discover new biomarkers from various devices such as CT images that can indicate the…
- Conditions
- Chronic Obstructive Pulmonary Disease, Asthma, Idiopathic Pulmonary Fibrosis
- Trial name
- NCT03813810
- Testing
- Non
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Pulmonary Disease, Chronic Obstructive
Postmarketing Surveillance Study of Atrovent® in Chronic Obstructive Airways Disease
Study to obtain further information on the tolerability and efficacy of Atrovent® unit dose vial 500 µg in the treatment of Chronic Obstructive Airways Disease under conditions of daily practice
- Trial name
- NCT02236715
- Testing
- Atrovent®
- Volunteers
- 1,039 people
- Sponsor
- Boehringer Ingelheim
Chronic Obstructive Pulmonary Disease, Hypoxia
Effect of Oxygen Supplementation During Exercise in Chronic Obstructive Pulmonary Disease Patients
The project will test the hypothesis that lung ventilation during exercise is unaffected by oxygen supplementation. In addition, the acute effect of oxygen supplementation on dyspnoea, heart rate and blood pressure will be…
- Trial name
- NCT02108925
- Testing
- Oxygen
- Where
- Norway
- Volunteers
- 16 people
- Sponsor
- LHL Helse
Chronic Obstructive Pulmonary Disease (COPD)
A Trial to Evaluate the Safety and Efficacy of HL231 Solution for Inhalation in Patients with COPD
To evaluate the efficacy and safety of HL231 Solution for Inhalation vs Ultibro in Chinese patients with moderate to severe COPD.
- Trial name
- NCT06619210
- Testing
- HL231 Dose 1/2/3/4
- Where
- China
- Volunteers
- 102 people
- Sponsor
- Haisco Pharmaceutical Group Co., Ltd.
Chronic Obstructive Pulmonary Disease
A Study to Show That Flutiform is Well Tolerated and Effective in the Treatment of COPD
Efficacy of Fluticasone/Formoterol in COPD Treatment. The Effect study.
- Trial name
- NCT01946620
- Testing
- Flutiform, Formoterol
- Where
- 15 sites in Bulgaria, Germany and 13 more
- Volunteers
- 1,767 people
- Sponsor
- Mundipharma Research Limited
Chronic Obstructive Pulmonary Disease (COPD)
Anti-platelet Therapy in the Prevention of Cardiovascular Disease in Patients With COPD (APPLE-COPD: ICON 2)
Patients with COPD (chronic bronchitis and/or emphysema) are known to be at an increased risk of heart disease and death due to heart attacks.
- Trial name
- NCT03487406
- Testing
- Ticagrelor, Aspirin
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- Newcastle-upon-Tyne Hospitals NHS Trust
Pulmonary Disease, Chronic Obstructive
Staphylococcus and Neisseria Tablets in the Treatment of Acute Exacerbations of Chronic Obstructive Pulmonary Disease.
It is planned to enroll 495 acute exacerbation of chronic obstructive pulmonary disease patients, and they will be randomly assigned to the high-dose test group, normal dose test group or control group at a ratio of 1:1:1, with…
- Trial name
- NCT05543343
- Testing
- High dose or normal dose staphylococcus albicans
- Where
- China
- Volunteers
- 495 people
- Sponsor
- Qu Yiqing
Chronic Obstructive Pulmonary Disease
IN UTERO SMOKING AND PREMATURE CELLULAR SENESCENCE
Actually, there is an increasing number of arguments for a premature origin of chronic adult's diseases, as the chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT01865435
- Testing
- cord blood sample
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
COPD
Assessing Exercise Capacity After PulseHaler™ Treatment in GOLD II-IV COPD Patients
Prospective, sham controlled, interventional study to evaluate the extent to which PulseHaler improves the functional status of Chronic Obstructive Lung Disease (GOLD) II-IV Chronic obstructive pulmonary disease (COPD) patients.
- Trial name
- NCT04236076
- Testing
- PulseHaler
- Volunteers
- 104 people
- Sponsor
- Respinova LTD
Hypercapnic Respiratory Failure, COPD
Feasibility Study of the Hemolung Respiratory Assist System
The purpose of this study is to evaluate the safety and efficacy of the Hemolung Respiratory Assist System in patients with hypercapnic respiratory failure associated with acute exacerbation of chronic obstructive pulmonary…
- Trial name
- NCT00987740
- Testing
- Hemolung Respiratory Assist System
- Where
- India
- Volunteers
- 2 people
- Sponsor
- Alung Technologies
Chronic Obstructive Pulmonary Disease
Alveolar-capillary Reserve After Exercise in Chronic Obstructive Pulmonary Disease (COPD) (COP-DTPA)
It is unknown whether individuals with COPD exhibit abnormal alveolar-capillary breaching during exercise, and whether this contributes to exertional dyspnoea.
- Trial name
- NCT06287476
- Testing
- Acute exercise bout on visit 2 and 3
- Where
- Denmark
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet