Clinical trials: Chronic Obstructive Pulmonary Disease (COPD)
Pulmonary Disease, Chronic Obstructive
Nutritional Status in Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease
A cross sectional observation study of body composition in COPD patients consecutively hospitalized with acute exacerbation.
- Trial name
- NCT03709498
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- Evangelismos Hospital
Chronic Obstructive Pulmonary Disease, Diastolic Dysfunction
Diastolic Dysfunction and Pauci-inflammatory Acute Exacerbations of COPD
This is a prospective study to determine the relationships between pauci-inflammatory exacerbations and diastolic dysfunction, and their implications in hospitalized patients with acute exacerbations of COPD.
- Trial name
- NCT03110614
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- University of Alabama at Birmingham
Emphysema, Lung Diseases
National Emphysema Treatment Trial (NETT)
To evaluate the long term efficacy, morbidity and mortality associated with medical therapy with lung volume reduction surgery (LVRS) as compared to medical therapy alone and to define patient selection criteria.
- Conditions
- Emphysema, Lung Diseases, Lung Diseases, Obstructive, Chronic Obstructive Pulmonary Disease
- Trial name
- NCT00000606
- Testing
- Lung volume reduction surgery
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Pulmonary Hypertension
Clinical Profile of Patients With Pulmonary Hypertension Due to Lung Diseases ( Single Center Experience)
Development of pulmonary hypertension (PH) in chronic lung diseases has both functional and prognostic implications . PH in Lung diseases is usually mild to moderate with preserved cardiac output, and evolves slowly alongside the…
- Trial name
- NCT02774928
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Cairo University
Pulmonary Disease, Chronic Obstructive
Feasibility of Inspiratory Muscle Training in People With COPD Who Decline Pulmonary Rehabilitation
The feasibility study will involve mixed methods, this means interviews as well as assessment of treatment with inspiratory muscle training therapy (IMT).
- Trial name
- NCT01956565
- Testing
- Inspiratory Muscle training
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
COPD
Digital Tool for Improved Self-management of COPD
Primary aim: To evaluate the feasibility, usability and safety of the investigational device in clinical practice over 6 months in 50 patients.
- Trial name
- FOCUS (NCT07573098)
- Testing
- COPD treatment check
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Björn Nordlund
COPD
A Single-dose Study to Investigate the Effects of 3 Different Doses of Inhaled AZD2115 in COPD Patients
This study in COPD patients will investigate the bronchodilatory effect of AZD2115. AZD2115 will be tested versus placebo and active comparators.
- Trial name
- NCT01498081
- Testing
- AZD2115, Indacaterol, Indacaterol + Tiotropium
- Where
- 6 sites in Poland, Sweden
- Volunteers
- 39 people
- Sponsor
- AstraZeneca
Chronic Obstructive Pulmonary Disease (COPD)
Evaluation of the Safety and Efficacy of HSK39004 Dry Powder Inhaler in Chinese Patients With Chronic Obstructive Pulmonary Disease (COPD)
To evaluate the safety and efficacy of the HSK39004 Dry Powder Inhaler compared with the placebo in the treatment of Chinese patients with COPD.
- Trial name
- NCT07108699
- Testing
- HSK39004 Dry Powder Inhaler-0.75mg, HSK39004 Dry Powder Inhaler-1.5mg, HSK39004 Dry Powder Inhaler Simulant
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Haisco Pharmaceutical Group Co., Ltd.
COPD, Asthma
LungVITamin D and OmegA-3 Trial (lungVITAL)
The VITamin D and OmegA-3 TriaL (VITAL; NCT 01169259) is an ongoing randomized clinical trial in 25,871 U.S. men and women investigating whether taking daily dietary supplements of vitamin D3 (2000 IU) or omega-3 fatty acids…
- Conditions
- COPD, Asthma, Pulmonary Function, Pneumonia
- Trial name
- lungVITAL (NCT01728571)
- Testing
- Vitamin D3, fish oil
- Where
- United States
- Volunteers
- 25,871 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Dyspnea
Vibration Response Imaging (VRI) in Dyspnea Patients Presenting to the ED
For the patient with acute dyspnea in the ED, early differentiation between CHF and non-CHF causes is essential for proper management.
- Trial name
- NCT01206621
- Where
- 8 sites in United States, Israel
- Volunteers
- 530 people
- Sponsor
- Deep Breeze
Emphysema
Assessment of Emphysema Using 1.5T MRI With UTE Pulse Sequences
Emphysema is a major pathological feature of Chronic Obstructive Pulmonary Disease (COPD). Non-invasive assessment of emphysema is a crucial issue for the phenotype and follow-up of COPD patients.
- Trial name
- EMPHYREM (NCT02100800)
- Testing
- MR and CT measurements of emphysema quantification
- Where
- France
- Volunteers
- 33 people
- Sponsor
- University Hospital, Bordeaux
Pulmonary Disease, Chronic Obstructive
Efficacy and Safety Comparison of Tiotropium Daily + Salmeterol Daily or Twice Daily Versus Tiotropium Daily in Patients With COPD
The primary objective of this trial is to establish superiority of the once-daily Tiotropium plus Salmeterol Inhalation Powder in daytime lung function response and non-inferiority in night-time lung function response over the…
- Trial name
- NCT00662792
- Testing
- Tiotropium (Tio18GEL), Salmeterol MDPI (Salm50DPI), Tiotropium (T18GEL) + Salmeterol MDPI (S_DPI)
- Where
- 12 sites in Germany
- Volunteers
- 147 people
- Sponsor
- Boehringer Ingelheim
COPD, Exacerbation
A Pilot Safety Study of Inhaled Dry Powder Mannitol in Acute Exacerbations of COPD
COPD is a major cause of ill health and death in Australia with 40,000 hospital admissions, and a national cost of $898,000,000 annually.
- Trial name
- NCT00446667
- Testing
- mannitol
- Where
- 2 sites in Australia
- Sponsor
- Syntara
Emphysema, Chronic Obstructive Pulmonary Disease
Bronchoscopic Thermal Vapor Ablation (BTVA) for Lung Volume Reduction
To establish and confirm the safety and clinical utility of BTVA applied unilaterally for lung volume reduction in patients with upper lobe predominate heterogeneous severe emphysema.
- Trial name
- BTVA (NCT01102712)
- Testing
- BTVA System
- Where
- 10 sites in Australia, Austria and 2 more
- Volunteers
- 34 people
- Sponsor
- Uptake Medical Corp
Disease, Pulmonary
Study to Evaluate the Safety and Pharmacokinetics of Inhaled Ciprofloxacin in Patients With Mild to Moderate Chronic Obstructive Pulmonary Disease (COPD)
Objectives of the study are to investigate the safety, tolerability and levels of ciprofloxacin in the lung after single and multiple inhalative administration to patients with mild to moderate COPD (stage I-II according to GOLD…
- Trial name
- NCT01052298
- Testing
- Ciprofloxacin (Cipro inhale, BAYQ3939)
- Where
- Germany
- Volunteers
- 25 people
- Sponsor
- Bayer
COPD
Breath Analysis in Chronic Obstructive Lung Disease (COPD)
To answer the question whether a disease specific profile of breath in patients with COPD can be detected by an untargeted metabolomic study using exhaled breath analysis by mass spectrometry.
- Trial name
- NCT02186639
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Pulmonary Disease, Chronic Obstructive
Dose Finding Study of Nemiralisib (GSK2269557) in Subjects With an Acute Moderate or Severe Exacerbation of Chronic Obstructive Pulmonary Disease (COPD)
Nemiralisib is being developed as an anti-inflammatory drug for the treatment of inflammatory airways disease. This study is designed to assess the dose response, efficacy, safety, and pharmacokinetics of nemiralisib across a…
- Trial name
- NCT03345407
- Testing
- Nemiralisib ELLIPTA 50 µg, Nemiralisib ELLIPTA 100 µg, Nemiralisib ELLIPTA 250 µg
- Where
- 161 sites in United States, Argentina and 14 more
- Volunteers
- 943 people
- Sponsor
- GlaxoSmithKline
COPD
Incentive Spirometry in Routine Management of COPD Patients
The incentive spirometer is a device that encourages patients, with visual and other positive feedback, to maximally inflate their lungs and sustain that inflation.
- Trial name
- NCT05679609
- Testing
- incentive spirometry
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Menoufia University
Chronic Obstructive Pulmonary Disease
Smartphone-based Self-management in COPD Patients: A Needs Assessment Survey
COPD patients often experience multiple symptoms (e.g. dyspnea, cough, and deteriorating quality of life) and have imposed a substantial economic and social burden on health care.
- Trial name
- NCT05151198
- Where
- Hong Kong
- Volunteers
- 50 people
- Sponsor
- The University of Hong Kong
COPD, Pulmonary Rehabilitation
Effects of Respiratory Rehabilitation by Gender in COPD Patients
Without calling into question the effectiveness of pulmonary rehabilitation in women, the difference in outcome by gender was not established due to insufficient evidence .
- Trial name
- REHABGENRE (NCT04297514)
- Where
- France
- Volunteers
- 504 people
- Sponsor
- University Hospital, Brest
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