Clinical trials: Chronic Obstructive Pulmonary Disease (COPD)
Chronic Obstructive Pulmonary Disease
GR Defect in Peripheral Blood Mononuclear Cells in COPD
T.to investigate a possible mechanism of the glucocorticosteroid receptors (GR) defect in patients with severe COPD by studying the effect of dexamethasone (Dex) on GR- binding, interleukin production (IL-6/IL-8) and MKP-1…
- Trial name
- NCT00159237
- Testing
- blood test
- Where
- United Kingdom
- Sponsor
- Imperial College London
Chronic Obstructive Pulmonary Disease, Obstructive Sleep Apnea
Functional Improvement in OSA and COPD With a Telehealth LifeStyle and Exercise Intervention
The investigators will conduct a Type I hybrid effectiveness-implementation study to test an integrated telehealth intervention among 400 overweight and obese patients with Chronic Obstructive Pulmonary Disease (COPD) and…
- Conditions
- Chronic Obstructive Pulmonary Disease, Obstructive Sleep Apnea, Overweight and Obesity
- Trial name
- FOCuSEd (NCT06390345)
- Testing
- FOCuSEd Integrated Intervention, Enhanced Usual Care
- Where
- 5 sites in United States
- Volunteers
- 400 people
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
Pulmonary Disease, Chronic Obstructive
Development and Validation of the GLORI-COPD Score
The objective of this study is to evaluate the diagnostic accuracy of the GLORI-COPD score in ambulatory care, to enable the screening of COPD patients at risk of complications, requiring early management
- Trial name
- GLORI-COPD (NCT04027296)
- Where
- France
- Volunteers
- 462 people
- Sponsor
- University of Paris 5 - Rene Descartes
Obesity, COPD
Evaluation of Muscle Activation Efficiency in Challenging Subjects
The purpose of this study is to determine whether muscle activation can be accomplished more effectively and comfortably in challenging subjects using novel configurations of an activation device.
- Trial name
- NCT01811446
- Testing
- Muscle Activation with Niveus and Intelect Devices
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Niveus Medical, Inc.
COPD, Severe Systemic Illness-induced Respiratory Muscle Wasting
Effects of Inspiratory Muscle Training on Dyspnea Perception During Exercise in Patients With COPD
Patients with chronic obstructive pulmonary disease are often limited in their exercise capacity by intolerable shortness of breath (dyspnea).
- Trial name
- IMTCOCOPD (NCT01900873)
- Testing
- Inspiratory Muscle Strength Training, Inspiratory Muscle Endurance Training
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- KU Leuven
Chronic Obstructive Pulmonary Disease
Multidimensional Individualized Nutritional Therapy for Individuals with Severe COPD
Individuals with severe chronic pulmonary disease often life isolated with a high burden of symptoms. Nutritional risk and low quality of life are common, and both associated with increased societal cost and poor prognosis.
- Trial name
- MINDNUT (NCT04873856)
- Testing
- Intervention
- Where
- Denmark
- Volunteers
- 87 people
- Sponsor
- Nordsjaellands Hospital
Chronic Obstructive Pulmonary Disease
Effects on Ventilation With NHF and Asymmetrical Nasal Cannulas
The aim of this controlled randomized crossover study is to compare the physiological effects of nasal high flow therapy (NHF) with 2 different nasal cannulas in patients with exacerbated chronic obstructive pulmonary disease…
- Trial name
- NHFDuet (NCT05676502)
- Testing
- AIRVO 2
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Kliniken Essen-Mitte
COPD (Chronic Obstructive Pulmonary Disease)
Comparison of Thoracic Squeeze and Manual Diaphragmatic Release Technique in COPD Patients
The goal of this randomized control trial is to evaluate and compare the efficacy of two physiotherapy techniques-Thoracic Squeeze Technique (TST) and Manual Diaphragmatic Release Technique (MDRT)-on improving respiratory…
- Trial name
- NCT06791239
- Testing
- Thoracic squeeze technique, Manual diaphragmatic release technique
- Where
- Pakistan
- Volunteers
- 36 people
- Sponsor
- Riphah International University
COPD
High Flow Nasal Cannula and Hypercapnia
In the present investigation, in 50 COPD with persistent hypercapnia after an acute exacerbation, the investigators want to assess the acceptability of HFNC and its effectiveness in further reducing the level of PaCO2, and to…
- Trial name
- NCT03759457
- Testing
- High Flow Nasal Cannula (AIRVO2)
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Emphysema, Chronic Obstructive Pulmonary Disease
Emphysema Research Registry and Biosample Repository
The Comprehensive Lung Center (CLC) at the University of Pittsburgh Medical Center (UPMC Health System) provides patients with any type of breathing or lung disorder a full range of diagnostic and therapeutic services.
- Conditions
- Emphysema, Chronic Obstructive Pulmonary Disease, Chronic Bronchitis
- Trial name
- NCT00307281
- Where
- United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Chronic Obstructive Pulmonary Disease
FODEPOC Study: Fat-free Mass Index in Copd
General Objective: To compare the prognostic value of the FODE scale for COPD exacerbations, where the fat-free mass index (FFMI) will be measured instead of the body mass index (BMI) in the BODE scale.
- Trial name
- FODEPOC (NCT05853081)
- Testing
- Bioelectrical impedance analysis
- Where
- Spain
- Volunteers
- 237 people
- Sponsor
- Hospital General Universitario Gregorio Marañon
Chronic Obstructive Pulmonary Disease, Respiratory Failure
Automated Oxygen Titration During Walking in Patients With COPD
Purpose: to evaluate the immediate effect of automated oxygen titration compared to usual fixed-dose oxygen treatment during exercise in patients with COPD on long-term oxygen treatment.
- Trial name
- NCT04123730
- Testing
- Fixed-dose compared to variable oxygen flow supplementation during walking
- Where
- Denmark
- Volunteers
- 35 people
- Sponsor
- Hvidovre University Hospital
Asthma, Chronic Obstructive Pulmonary Disease
Study in Patients' With Persistent Asthma and Chronic Obstructive Pulmonary Disease
The study is to evaluate the percentage of patients with asthma or COPD achieving disease control
- Trial name
- SPRINT (NCT02419872)
- Testing
- Marketed antagonists
- Where
- 141 sites in Croatia, Denmark and 8 more
- Volunteers
- 1,743 people
- Sponsor
- Teva Pharmaceuticals Europe
Chronic Obstructive Pulmonary Disease
Cognitive Status in Chronic Obstructive Pulmonary Disease's Patients
Chronic obstructive pulmonary disease (COPD) is a chronic condition involving an impairment in functionality and in the execution of activities of daily life.
- Trial name
- COPD (NCT02143700)
- Testing
- Cognitive assessment
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Universidad de Granada
Chronic Bronchitis, Chronic Obstructive Pulmonary Disease
A Clinical Evaluation of the RheOx Bronchial Rheoplasty System
This is a prospective, multicenter, single arm and open-label clinical trial to evaluate the performance, effectiveness and safety of RheOx™ system in the treatment of the symptoms of chronic bronchitis in adult moderate to…
- Trial name
- NCT05641207
- Testing
- RheOx™ with the RheOx™ Catheter treated in the trial
- Where
- 7 sites in China
- Volunteers
- 40 people
- Sponsor
- Energenx Medical LTD.
Chronic Obstructive Pulmonary Disease
Functional Applications of Hyperpolarized 129Xe MRI
The overall objectives of our study are to determine the capabilities of hyperpolarized 129Xe MRI to measure lung function and its potential to sensitively detect pulmonary disease and its progression in COPD.
- Trial name
- NCT01697332
- Testing
- Hyperpolarized 129Xe gas
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Copd, Adherence, Medication
Triple Therapy Convenience by the Use of One or Multiple Inhalers and Digital Support in Chronic Obstructive Pulmonary Disease
TRICOLON is an investigator initiated, prospective, interventional, open-label, randomized, real-world, multi-centre, 3-arms study in the Netherlands.
- Trial name
- TRICOLON (NCT05495698)
- Testing
- single-inhaler triple therapy (Trimbow), E-health application: Curavista app & FindAir e-device, multi-inhaler triple therapy (Qvar + Bevespi)
- Where
- Netherlands
- Volunteers
- 300 people
- Sponsor
- Franciscus Gasthuis
Diabetes Mellitus, Chronic Obstructive Pulmonary Disease
Medlink for Diagnosing of Diabetes Mellitus, COPD, CHF, Myasthenia Gravis and Hypertension
MEDLINK IS A POCKET-SIZED MEDLINK is a pocket-sized, verbally interactive, programmable medical device that allows physicians to select which medical measurements they would like to take for a specific patient.
- Conditions
- Diabetes Mellitus, Chronic Obstructive Pulmonary Disease, Congestive Heart Failure, Myasthenia Gravis
- Trial name
- Medlink (NCT06256172)
- Testing
- Medlink
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Olawuyi Racett Nigeria Ltd
Chronic Obstructive Pulmonary Disease (COPD), TB - Tuberculosis
COPD-PTB Screening Trial in Henan, China
The goal of this trial is to evaluate the effectiveness of an active case-finding (ACF) strategy for detecting pulmonary tuberculosis (PTB) among patients with chronic obstructive pulmonary disease (COPD) in primary care settings…
- Trial name
- NCT07706972
- Testing
- ACF strategy
- Volunteers
- 25,000 people
- Sponsor
- Henan Provincial People's Hospital
Chronic Obstructive Pulmonary Disease
Molecular Signatures Associated With Response to ICS Treatment in Patients With COPD Stratified by Eosinophil Levels
The 3TR-ICS COPD study is an international, multicentre, randomized, parallel, controlled study that will recruit clinically stable former smokers COPD patients (with no exacerbations in the previous 8 weeks) on treatment with…
- Trial name
- 3TR-ICS-COPD (NCT06334575)
- Testing
- Budesonide
- Where
- 6 sites in Germany, Netherlands and 2 more
- Volunteers
- 135 people
- Sponsor
- Maria Joyera Rodríguez
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.