Clinical trials: Chronic Obstructive Pulmonary Disease (COPD)
Pulmonary Disease, Chronic Obstructive
MISSION COPD - Modern Innovative SolutionS in Improving Outcomes iN COPD
MISSION is a new and novel way of delivering highly specialised Chronic Obstructive Pulmonary Disease (COPD) care and has the potential to change the way COPD care across the UK is delivered as well as services for other long…
- Trial name
- MISSION-COPD (NCT02534766)
- Where
- United Kingdom
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Portsmouth Hospitals NHS Trust
Pulmonary Hypertension, Chronic Obstructive Pulmonary Disease
Tadalafil for Severe Pulmonary Hypertension Due to Chronic Obstructive Pulmonary Disease
ERASE PH-COPD is a randomized double-blind study, with 2 parallel groups. Patients with severe pulmonary hypertension due to chronic obstructive pulmonary disease, will be randomly assigned to receive Tadalafil orally or placebo.
- Trial name
- ERASE PH-COPD (NCT05844462)
- Testing
- Tadalafil
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pulmonary Disease, Chronic Obstructive
Characterisation of 24-hour FEV1-time Profiles of Inhaled BI 1744 CL and Inhaled Foradil in Patients With Chronic Obstructive Pulmonary Disease
The study is intended to characterize the lung function profile of BI1744 in COPD patients where patients will perform pulmonary function tests at regular intervals for 24 hours at the end of a 6 week treatment period.
- Trial name
- NCT00932646
- Testing
- BI 1744 (Olodaterol) Low Dose, BI 1744 (Olodaterol) Medium Dose, Foradil
- Where
- 13 sites in United States
- Volunteers
- 100 people
- Sponsor
- Boehringer Ingelheim
Chronic Obstructive Pulmonary Disease
Advanced eHealth for Chronic Obstructive Pulmonary Disease (COPD) in Colorado
Chronic obstructive pulmonary disease (COPD) is the 4th leading cause of death in the United States, affects 24 million people and is responsible for up to $32 billion annually in direct and indirect health care costs.
- Trial name
- NCT01044927
- Testing
- Integrated Care, Standard Therapy
- Where
- 2 sites in United States
- Volunteers
- 511 people
- Sponsor
- University of Colorado, Denver
Alpha 1-Antitrypsin, COPD
Genetic Variation in IgG in Alpha 1 Antitrypsin Deficiency
The goal of this study is to learn whether patients who have a genetic mutation in the genes that cause alpha 1 antitrypsin deficiency also have genetic variation in nearby genes that can increase risk for reduced immune function…
- Conditions
- Alpha 1-Antitrypsin, COPD, Antibody Deficiency
- Trial name
- IgG in AATD (NCT07135427)
- Testing
- 20-valent pneumococcal conjugate vaccine
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Alabama at Birmingham
Chronic Obstructive Pulmonary Disease
Long-term Effects of Non-invasive Ventilation in Hypercapnic Chronic Obstructive Pulmonary Disease (COPD) Patients
In this multicenter study the comparison of the mass flow distribution and redistribution versus the relative blood flow per lobe (as a surrogate for Ventilation/ Perfusion (V/Q) matching) with functional respiratory imaging…
- Trial name
- NCT01592656
- Testing
- Functional Respiratory Imaging, Lung compliance measurement, Non-invasive ventilation (Respironics)
- Where
- 2 sites in Belgium, Netherlands
- Volunteers
- 40 people
- Sponsor
- FLUIDDA nv
Pulmonary Disease, Chronic Obstructive
A Phase 2 Study of the Safety and Efficacy of a Tofimilast in Adult Patients With Chronic Obstructive Pulmonary Disease
This an initial proof of concept, phase to study to assess the safety and efficacy of tofimilast for the chronic maintenance treatment of adults with Chronic Obstructive Pulmonary Disease
- Trial name
- NCT00219622
- Testing
- tofimilast
- Where
- 40 sites in United States, Argentina and 4 more
- Volunteers
- 300 people
- Sponsor
- Pfizer
Chronic Obstructive Pulmonary Disease
Effectiveness of Antibiotic Therapy for Exacerbations of Chronic Obstructive Pulmonary Disease
The purpose of this study is to determine the effectiveness of antibiotic therapy for patients with acute exacerbations of mild-to-moderate chronic obstructive pulmonary disease.
- Trial name
- TRANCE (NCT00495586)
- Testing
- Amoxicillin and clavulanic acid
- Where
- 13 sites in Spain
- Volunteers
- 318 people
- Sponsor
- Societat Catalana de Medicina Familiar i Comunitària, Assoc. (CAMFiC)
COPD
Effect of Education and Respiratory Rehabilitation on Quality of Life in COPD Patients
In patients with COPD and a history of recent exacerbation, to compare the quality of life after completing a joint program of health education and respiratory rehabilitation with those patients who only receive respiratory…
- Trial name
- EDUEPOC (NCT03889054)
- Testing
- Education program
- Volunteers
- 66 people
- Sponsor
- Instituto de Investigación Hospital Universitario La Paz
Chronic Obstructive Pulmonary Disease, Metastatic Cancer
Improving End-of-life Care by Continuing Medical Education and Electronic Decision Making Support for General Practitioners
Background: Optimizing the basic palliative care has been shown beneficial to patients in end-of-life care, the general practitioner (GP) having a pivotal role in the health care system, providing comprehensive and continued…
- Trial name
- NCT02050256
- Testing
- continuing medical education and electronic decision support, education and electronic support
- Where
- Denmark
- Sponsor
- University of Aarhus
Chronic Obstructive Pulmonary Disease
Effectivity of Inspiratory Muscle Trainer in the Chronic Obstructive Pulmonary Disease Rehabilitation Program
This study aimed to reveal the role of inspiratory muscles exercise using Inspiratory Muscle Trainer (IMT), which is a form of weight training.
- Trial name
- NCT03739879
- Testing
- Inspiratory Muscle Trainer Philips Respironics
- Where
- Indonesia
- Volunteers
- 15 people
- Sponsor
- Universitas Indonesia
Chronic Obstructive Pulmonary Disease (COPD)
129-Xe MRI Study of Single Triple Therapy Inhaler Effects in COPD Patients With Moderate-severe Dyspnea and/or Poor Health Status With High or Low Risk of Exacerbation
The goal of this study is to study how 12-weeks daily (and optional 48-weeks) single inhaler triple therapy (fluticasone furoate (FF)-an inhaled corticosteroid; umeclidinium (UMEC)-a long-acting muscarinic antagonist; vilanterol…
- Trial name
- MUST (NCT07192016)
- Testing
- fluticasone furoate(FF)/umeclidinium (UMEC)/vilanterol(VI) (100/62.5/25) mcg
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Western University, Canada
COPD
Efficacy of NIV Masks in COPD
A randomized controlled pilot study to compare the efficacy and tolerability of a two different NIV masks on carbon dioxide in participants with stable chronic obstructive pulmonary disease (COPD) with chronic type II respiratory…
- Trial name
- NCT04947852
- Testing
- Investigation Mask, Comparator Mask
- Where
- New Zealand
- Volunteers
- 16 people
- Sponsor
- Fisher and Paykel Healthcare
Pulmonary Disease, Chronic Obstructive
Helium-3 MRI Imaging Study in COPD
This protocol describes the investigation of the use of hyperpolarised helium magnetic resonance imaging (MRI) in reflecting the regional differences in lung function of moderate to severe Chronic Obstructive Pulmonary Disease…
- Trial name
- NCT02207452
- Testing
- He-3 MRI, Salbutamol, Ipratropium
- Where
- United Kingdom
- Volunteers
- 11 people
- Sponsor
- GlaxoSmithKline
Pulmonary Disease, Chronic Obstructive
Effect of BIIL 284 BS on Patients With Chronic Obstructive Pulmonary Disease (COPD)
Study to investigate the effect of 14-day treatment with BIIL 284 BS on sputum neutrophils and specific inflammatory markers in patients with clinically well-defined moderate chronic obstructive pulmonary disease (COPD)
- Trial name
- NCT02249338
- Testing
- BIIL 284 BS
- Volunteers
- 53 people
- Sponsor
- Boehringer Ingelheim
Pulmonary Disease (COPD), Chronic Obstructive, Dance Therapy
Comparison Between Conventional Rehabilitation and Conventional Rehabilitation Through Dance in Patients With COPD
Introduction: Chronic obstructive pulmonary disease (COPD) is recognized as one of the most relevant conditions worldwide, due to its high morbidity and mortality.
- Conditions
- Pulmonary Disease (COPD), Chronic Obstructive, Dance Therapy, Dance
- Trial name
- NCT07198763
- Testing
- Conventional pulmonary rehabilitation
- Where
- Brazil
- Volunteers
- 44 people
- Sponsor
- Centro Universitário Augusto Motta
Chronic Obstructive Pulmonary Disease
Electronic Cigarette-derived Oxidants and Cardiopulmonary Effects
This is a pilot study on the impact of switching from cigarettes to Electronic Cigarettes (EC) on disease-related clinical symptoms and biomarkers of harm in smokers with preexisting Chronic Obstructive Pulmonary Disease (COPD).
- Trial name
- NCT05239793
- Testing
- NJOY e-cigarette
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Milton S. Hershey Medical Center
Chronic Obstructive Pulmonary Disease
Icing and Airflow Stimulation in Obstructive Lung Diseases
A randomized controlled trial in which icing and airflow stimulation for reduction of dyspnea in patients of obstructive lung disease was done which is characterized as condition of infection described by constant improvement of…
- Trial name
- NCT03887364
- Testing
- Group A-Diaphragmatic breathing, Group B-Icing and Airflow Stimulation
- Where
- Pakistan
- Volunteers
- 126 people
- Sponsor
- Riphah International University
Pulmonary Disease, Chronic Obstructive
Behavioral Intervention to Maintain Physical Capacity and Activity in Patients With Chronic Obstructive Pulmonary Disease (COPD)
The purpose of this study is to investigate to what extent patients with COPD, who have participated in physical training for 12 weeks, can maintain their physical activity behaviour and physical capacity on a long-term basis if…
- Trial name
- COPD (NCT01539434)
- Testing
- Behavioural intervention, Usual care group
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Uppsala University
Chronic Obstructive Pulmonary Disease
Lung and Gut Microbiome in Chronic Obstructive Pulmonary Disease
Increasing evidence have implied that microbiota from airway and gut might be involved in the pathogenesis of chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT03310164
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
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