Clinical trials: Chronic Obstructive Pulmonary Disease (COPD)
Loneliness
Impact of Pulmonary Rehabilitation on Loneliness in COPD
Loneliness is the feeling of sadness because one wants friends or company. This feeling is common in patients with chronic lung disease, who suffer from breathing difficulty, chronic cough, and reduced physical and mental health.
- Trial name
- NCT05435963
- Testing
- Pulmonary rehabilitation (PR)
- Where
- Canada
- Volunteers
- 45 people
- Sponsor
- McMaster University
Chronic Obstructive Pulmonary Disease
Smartphone-based Self-management in COPD Patients: A Needs Assessment Survey
COPD patients often experience multiple symptoms (e.g. dyspnea, cough, and deteriorating quality of life) and have imposed a substantial economic and social burden on health care.
- Trial name
- NCT05151198
- Where
- Hong Kong
- Volunteers
- 50 people
- Sponsor
- The University of Hong Kong
COPD
Efficacy of NIV Masks in COPD
A randomized controlled pilot study to compare the efficacy and tolerability of a two different NIV masks on carbon dioxide in participants with stable chronic obstructive pulmonary disease (COPD) with chronic type II respiratory…
- Trial name
- NCT04947852
- Testing
- Investigation Mask, Comparator Mask
- Where
- New Zealand
- Volunteers
- 16 people
- Sponsor
- Fisher and Paykel Healthcare
Pulmonary Disease, COPD
Fall Risk Assessment in COPD
People with chronic obstructive pulmonary disease (COPD) have balance problems and are at risk of falling. New guidelines recommend balance assessment be included in pulmonary rehabilitation (PR) however no specific tests are…
- Trial name
- NCT03229473
- Where
- 4 sites in Canada
- Volunteers
- 94 people
- Sponsor
- McMaster University
Chronic Obstructive Pulmonary Disease, Chronic Heart Failure
Using NT-proBNP to Detect Chronic Heart Failure in Patients With Chronic Obstructive Pulmonary Disease
The aim of the present study was to evaluate if the analysis of NT-proBNP might be used as an initial step for the diagnosis of chronic heart failure in patients with COPD in primary health care, and to select patients for a…
- Trial name
- NT-proBNP (NCT01801722)
- Where
- Sweden
- Volunteers
- 75 people
- Sponsor
- Lund University
Chronic Obstructive Pulmonary Disease (COPD)
Study of Bosentan in the Treatment of Stable Severe Chronic Obstructive Pulmonary Disease Patients
Present treatment for chronic obstructive pulmonary disease (COPD) has a certain role in reducing COPD exacerbation and hospitalization, improving the life quality, and postponing the lung function decline.
- Trial name
- BTCOPD (NCT02093195)
- Testing
- Bosentan, Symbicort turbuhaler
- Where
- 5 sites in China
- Volunteers
- 40 people
- Sponsor
- Air Force Military Medical University, China
Cardiovascular Diseases, Cardiovascular Risk Factor
Physical Activity Intervention and Cardiovascular Risk Markers in COPD
The Aim of this study is to examine the feasibility of a future trial comparing the impact of a physical activity intervention and a standard pulmonary rehabilitation programme upon cardiovascular risk and symptoms in COPD.
- Conditions
- Cardiovascular Diseases, Cardiovascular Risk Factor, COPD
- Trial name
- PARC (NCT03869112)
- Testing
- Physical activity intervention, Pulmonary rehabilitation group
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University Hospitals, Leicester
Chronic Obstructive Pulmonary Disease
Role of Endorphins in Perception of Dyspnea With Resistive Loading in Chronic Obstructive Pulmonary Disease (COPD)
Endorphins are released in response to breathing difficulty and can modify the perception of breathlessness. In this randomized placebo-controlled trial, resistive breathing loads are used to provoke breathlessness in patients…
- Trial name
- NCT00958919
- Testing
- naloxone, normal saline
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Pulmonary Arterial Hypertension, Chronic Obstructive Pulmonary Disease
Impact of Inhaled Treprostinil Sodium on Ventilation Perfusion Matching
The purpose of this study is to see how inhaled treprostinil sodium (Tyvaso) affects the amount of air and blood that reach the alveoli, or tiy air sacs, in the lungs of patients with Group 1 Pulmonary Arterial Hypertension with…
- Trial name
- NCT01494896
- Where
- 3 sites in United States
- Volunteers
- 9 people
- Sponsor
- University of Florida
Asthma
Study to Evaluate the Pharmacokinetic Profile of Salbutamol Delivered by Unit Dose Dry Powder Inhaler (UD-DPI) Compared to the Diskus and Metered Dose Inhaler (MDI) in Healthy Volunteers.
This is an open-label, two part, six period- cross over, randomised, single dose, single centre study in healthy subjects. This is the first clinical study for the UD-DPI. This study is divided into two parts.
- Trial name
- NCT01984086
- Testing
- Salbutamol Sulphate 150mcg UD-DPI Blister(1.6% blend), Salbutamol Sulphate 200mcg UD-DPI Blister(1.6% blend), Salbutamol Sulphate 250mcg UD-DPI Blister(1.6% blend)
- Where
- Australia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Chronic Obstructive Pulmonary Disease, Osteoporosis
Case Control Study: Determinants of Osteoporosis in GOLD II COPD Patients.
Patients with COPD have been found to have an increased risk of osteoporosis. The underlying mechanism is not clear yet. This case control study aims to identify risk factors for osteoporosis in GOLD II COPD patients.
- Trial name
- NCT00725673
- Where
- Netherlands
- Volunteers
- 106 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
COPD, Exercise
The Effects of Physical Exercise Training in Patients With Chronic Obstructive Pulmonary Disease
The purpose of the present project is to investigate the physiological effects of two different types of exercise training in COPD patients.
- Conditions
- COPD, Exercise, Resistance Training
- Trial name
- NCT02050945
- Testing
- Resistance training, Endurance training
- Where
- 2 sites in Denmark
- Volunteers
- 30 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Pulmonary Disease, Chronic Obstructive
Effect on Exercise Endurance and Lung Hyperinflation of Tiotropium + Olodaterol in COPD Patients
The primary objective of this trial is to investigate the effect of 6 weeks treatment with tiotropium + olodaterol fixed dose combination inhalation solution on lung hyperinflation and exercise tolerance in patients with COPD
- Trial name
- NCT01533922
- Testing
- Tiotropium, Olodaterol, tiotropium + olodaterol
- Where
- 44 sites in United States, Argentina and 8 more
- Volunteers
- 295 people
- Sponsor
- Boehringer Ingelheim
COPD
Comparative Effects of IMT Vs EMT Along With AIT in COPD Patients
Chronic Obstructive Pulmonary Disease (COPD) is the 3rd leading cause of mortality and 7th leading cause of ill-health worldwide.
- Trial name
- NCT06308302
- Testing
- Group A (Inspiratory Muscles Training + Aerobic Interval Training), Group B (Expiratory Muscles Training +Aerobic Interval Training)
- Where
- Pakistan
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Paediatric Asthma
Design, Development and Evaluation of a Digital Health Assistant for Paediatric Asthma
This study is to evaluate the efficacy of the digital health assistant (DHA) "Alex" in improving asthma control in asthmatic children and adolescents aged 10 to 19 compared to their baseline values.
- Trial name
- ALEX (NCT07472283)
- Testing
- Phase I (months 1-3): DHA core functionality, Phase II (months 3-6): platform augmentation, Embedded qualitative study
- Where
- 5 sites in Romania
- Volunteers
- 42 people
- Sponsor
- University Children's Hospital Basel
COPD
Peak Inspiratory Flow and Dry Powder Inhaler Performance in COPD
The purpose of the study is to determine whether PIF is clinically important when using the Ellipta DPI device. In addition, the study will validate the best/most clinically appropriate way to perform a PIF maneuver, to determine…
- Trial name
- NCT04606394
- Testing
- Trelegy Ellipta 100/62.5/25Mcg Inh 30D, Ventolin 90Mcg/Actuation Inhalation Aerosol
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Pulmonary Research Institute of Southeast Michigan
Healthy
DBM-1152A Inhalation Solution in Healthy Volunteers
This is a single-center, randomized, double-blind, placebo-controlled Phase 1b study to evaluate the safety, tolerability, and pharmacokinetics (PK) of multiple-dose DBM-1152A inhalation solution in healthy Chinese adults.
- Trial name
- NCT07439419
- Testing
- DBM-1152A
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Joincare Pharmaceutical Group Industry Co., Ltd
Chronic Obstructive Pulmonary Disease
Oxygen Portable Concentrator During Exercises in Patients With COPD
The purpose of this study is to compare differences in oxygen delivery between portable oxygen concentrators (POCs) and liquid oxygen (LOs) portable units, pose a question if POCs are equally effective as LOs in reducing…
- Trial name
- NCT00875719
- Testing
- Oxygen concentrators versus constant flow axygen, oxygen concentrator
- Where
- France
- Volunteers
- 19 people
- Sponsor
- Association Nationale pour les Traitements A Domicile, les Innovations et la Recherche
Chronic Obstructive Pulmonary Disease (COPD)
Force Control in Chronic Obstructive Pulmonary Disease
Maximal muscle strength is one of the most commonly assessed neuromuscular parameters in people with COPD due to its accessibility and relevance for prescribing an appropriate workload for resistance training.
- Trial name
- NEUROTIGUE F (NCT06871670)
- Testing
- Submaximal isometric contractions of knee extensors
- Where
- France
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
Lung Cancer, Tuberculosis
Epidemiology and Diagnosis of Haemoptysis: a Multicenter Study
Haemoptysis is the coughing up of blood originating from the respiratory tract. It is a common and worrying clinical symptom which can be due to different aetiologies including lung cancer, tuberculosis, COPD, bronchiectasis…
- Conditions
- Lung Cancer, Tuberculosis, Bronchiectasis, Pneumonia
- Trial name
- NCT02045394
- Testing
- Chest X-ray, computed tomography of the chest, Bronchoscopy
- Where
- 6 sites in Italy
- Volunteers
- 610 people
- Sponsor
- University of Milan
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