Clinical trials: Chronic Obstructive Pulmonary Disease (COPD)
COPD
Umbilical Cord Mesenchymal Stem Cells Transplantation in the Treatment of Chronic Obstructive Pulmonary Disease
This trial is to investigate the safety and potential therapeutic efficacy of allogeneic administration of umbilical cord-derived MSCs (UC-MSCs) as a supplementary intervention in combination with standard COPD medication…
- Trial name
- NCT04433104
- Testing
- Umbilical Cord Mesenchymal Stem Cells transplantation, drug therapy according to Vietnamese MOHS procedure
- Where
- Vietnam
- Volunteers
- 40 people
- Sponsor
- Vinmec Research Institute of Stem Cell and Gene Technology
COPD
Sarcopenia in COPD Patients: a French Study
The prevalence of sarcopenia is high in many organ pathologies such as COPD, but remains little studied in acute respiratory failure.
- Trial name
- SARCOBS (NCT03111849)
- Testing
- sarcopenia
- Where
- France
- Volunteers
- 54 people
- Sponsor
- University Hospital, Clermont-Ferrand
COPD
A Phase II, 5-way Cross-over Study to Evaluate the Pharmacodynamics of "Nexthaler" Dry Powder Inhaler in COPD Patients
The study aim is to compare the pharmacodynamic effects (cardiovascular effects- primary variable: Heart rate over 4 hours post dosing- ) after administration of BDP and formoterol administered as CHF 1535 100/6 NEXThaler DPI or…
- Trial name
- NEXThaler (NCT02000609)
- Testing
- CHF 1535 NEXThaler 800/48, CHF 1535 NEXThaler 200/12, CHF 1535 pMDI 200/12
- Where
- United Kingdom
- Volunteers
- 49 people
- Sponsor
- Chiesi Farmaceutici S.p.A.
Pulmonary Disease, Chronic Obstructive
Six-Minute Walk Test Comparing Helium/Oxygen to Nitrogen/Oxygen for COPD Rehabilitation
The purpose of this study is to evaluate effects of inspired gas mixtures on the distance walked by patients with severe Chronic Obstructive Pulmonary Disease (COPD) during a Six-Minute Walk test.
- Trial name
- rehabilitate (NCT01355809)
- Testing
- Inhalation gas, Inhalation Nitrogen/Oxygen, Inhalation Helium/Oxygen
- Where
- Germany
- Volunteers
- 3 people
- Sponsor
- Air Liquide SA
Inflammatory Diseases
A Study to Investigate the Safety, Tolerability, and Pharmacokinetics (PK) of Oral AZD6793 in Healthy and Chronic Obstructive Pulmonary Disease Participants, to Assess the Relative Oral Bioavailability Between Two Formulations, and the Food Effect on the PK of AZD6793 Compared to Fasting State.
The purpose of the study is to assess the safety and tolerability of AZD6793 suspension following oral administration of Single Ascending Dose (SAD) [Part 1] and Multiple Ascending Dose (MAD) [Part 2] in healthy participants.
- Trial name
- NCT05662033
- Testing
- AZD6793
- Where
- 2 sites in United Kingdom
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Chronic Obstructive Pulmonary Disease, Inflammation
Doxycycline and Airway Inflammation in Chronic Obstructive Pulmonary Disease (COPD)
COPD is a progressive pulmonary disease that is characterized by an inflammatory process in the airways and the lungs which leads to progressive airway obstruction. The inflammation is associated with tissue loss and remodelling.
- Conditions
- Chronic Obstructive Pulmonary Disease, Inflammation, Pulmonary Emphysema
- Trial name
- NCT00857038
- Testing
- Doxycycline
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Medical Center Alkmaar
Chronic Obstructive Pulmonary Disease, Muscle Oxygenation
The Effect of Clinical Parameters on Muscle Oxygenation in Patients With COPD
The aim of this study is to examine the peripheral muscle oxygenation of patients with Chronic Obstructive Pulmonary Disease at rest, during submaximal exercise and recovery, and to examine the effects of disease severity and…
- Conditions
- Chronic Obstructive Pulmonary Disease, Muscle Oxygenation, Disease Severity, Respiratory Function
- Trial name
- NCT06041126
- Where
- Turkey (Türkiye)
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Bandırma Onyedi Eylül University
Pulmonary Disease, Chronic Obstructive
Single Dose Ranging Study of BI 1744 CL (Olodaterol) in Chronic Obstructive Pulmonary Disease
Primary objective: To investigate bronchodilator effect and safety of single doses of BI 1744 CL inhaled via Respimat inhaler, Secondary objective: to characterize pharmacokinetics of BI 1744 CL.
- Trial name
- NCT01809262
- Testing
- single dose of 5 mcg, single dose of 40 mcg, single dose of 20 mcg
- Where
- Netherlands
- Volunteers
- 36 people
- Sponsor
- Boehringer Ingelheim
Chronic Obstructive Pulmonary Disease (COPD)
COPD Research Registry
The COPD Research Registry is a confidential database of individuals diagnosed with COPD or at risk of developing COPD. The Registry was established in 2007 by the COPD Foundation with the purpose of providing a mechanism for…
- Trial name
- NCT01785706
- Where
- United States
- Volunteers
- 50,000 people
- Sponsor
- COPD Foundation
Chronic Obstructive Pulmonary Disease
Comparing Treatment Efficacy With HD/MD Flu Plus Sal in Chronic Obstructive Pulmonary Disease (COPD) Patients
Chronic obstructive pulmonary disease is characterized as inflammatory airway with not fully reversible airflow limitation.Combination treatment with inhaled corticosteroid (ICS) and long-acting β2 agonists (LABA)attains an…
- Trial name
- NCT01131806
- Testing
- fluticasone/ salmeterol 125/25 mcg/puff, fluticasone/ salmeterol 250/25 mcg/puff
- Where
- Taiwan
- Volunteers
- 124 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
COPD (Chronic Obstructive Pulmonary Disease)
The Safety and Effectiveness of Taneasy and Actein in COPD Patients
To evaluate the safety and efficacy of Taneasy 600mg granules and Actein effervescent tablets 600MG administered twice daily for 14 days in treatment of COPD Disease.
- Trial name
- NCT06688292
- Testing
- Taneasy 600mg granules, Actein effervescent 600mg
- Where
- Taiwan
- Volunteers
- 42 people
- Sponsor
- Bun Yao Biotechnology Co., Ltd
COPD (Chronic Obstructive Pulmonary Disease), Asthma (Diagnosis)
Validation of 1 Minute Sit-to Stand Test for Assessment of Breathlessness at Exertion in Individuals With Chronic Lung Disease
Breathlessness is a common symptom in people with chronic lung and heart diseases. It can affect daily activities, quality of life, and overall health.
- Conditions
- COPD (Chronic Obstructive Pulmonary Disease), Asthma (Diagnosis), Interstitial Lung Disease (ILD)
- Trial name
- V1BE (NCT07836764)
- Testing
- 1MSTS
- Where
- Sweden
- Volunteers
- 120 people
- Sponsor
- Jacob Sandberg
Airway Obstruction, Asthma
Effects of Combined Respiratory Muscle Training and Steam Inhalation
The purpose of this investigation is to obtain more information on the efficacy and safety of respiratory training methods with WellO2 in patients with asthma and COPD.
- Conditions
- Airway Obstruction, Asthma, COPD
- Trial name
- NCT04584398
- Testing
- Respiratory muscle training with steam inhalation
- Where
- Finland
- Volunteers
- 60 people
- Sponsor
- WellO2 Oy
Chronic Obstructive Pulmonary Disease
Two Different Dosages of Nebulized Steroid Versus Parenteral Steroid in the Management of COPD Exacerbations
Chronic obstructive pulmonary disease (COPD) is a common disease that has a chronic and progressive course. Patients with COPD may have exacerbations one to four times in a year.
- Trial name
- NCT01865500
- Testing
- Budesonide 4 mg, Budesonide 8 mg, Metil prednisolone
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Ataturk University
Chronic Obstructive Pulmonary Disease
Study of Microbiological Diversity in Exhaled Air in COPD and Free of COPD
COPD and non-COPD patients will be included in the study after collection of their non-objection. The exhalation will be collected to study the microbiological diversity of human exhalations.
- Trial name
- EXHALBIO (NCT05437198)
- Testing
- collection of human exhalation
- Where
- France
- Volunteers
- 240 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Pulmonary Disease, Chronic Obstructive, Asthma COPD
Impact of a Mobile Phone and Educational Intervention
The purpose of this pilot study was to: 1. partner with African American churches to increase awareness of COPD. 2. use a community-based approach to facilitate early detection of COPD in the church setting.
- Trial name
- NCT06878898
- Testing
- Education and mobile phone text-messaging, Education only
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Kent State University
Chronic Obstructive Pulmonary Disease
Effects of Knee-extensor Exercise Training in Chronic Obstructive Pulmonary Disease (COPD) Patients
COPD patients have a reduced exercise tolerance due to a ventilatory limitation. Several studies have shown altered skeletal muscle function.
- Trial name
- NCT01079221
- Testing
- High intensity knee-extensor training
- Volunteers
- 12 people
- Sponsor
- Norwegian University of Science and Technology
Chronic Obstructive Pulmonary Disease (COPD)
COPD Exacerbation Modelling Using Unobtrusive Sensors - the TOLIFE Clinical Study A
This work is a multicentric prospective cohort study designed to improve chronic obstructive pulmonary disease (COPD) treatment and management. The study involves 150 patients diagnosed with COPD who are at risk of exacerbations.
- Trial name
- CSA (NCT06172712)
- Testing
- Variations in daily life activity signals detected by unobtrusive sensors
- Where
- 3 sites in Germany, Italy and 1 more
- Volunteers
- 150 people
- Sponsor
- Barcelona Institute for Global Health
Chronic Obstructive Pulmonary Disease
This Study Include Chronic Obstructive Pulmonary Disease(COPD) Patients . Patients Were Vitamin D Deficient Age Range 40 to 80 Years, Smokers Patients Were Advised to Take Either Placebo or Vitamin D3 . Antioxidant Enzymes Were Assessed at Baseline and at 26th Weeks.
Vitamin D3 supplementation dose not increase plasma antioxidant enzymes level in COPD patients was the null hypothesis of the research.
- Trial name
- BSMMU (NCT04011930)
- Testing
- cholecalciferol
- Where
- Bangladesh
- Volunteers
- 40 people
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Pulmonary Disease, Chronic Obstructive
Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Effects of GSK573719 (LAMA) and GW642444 (LABA)Administered Individually and Concurrently in Healthy Japanese Subjects
GW642444 is a potent and selective long-acting beta2 agonist; GSK573719 is a long-acting, inhaled, muscarinic receptor antagonist (or anticholinergic) bronchodilator.
- Trial name
- DB2113208 (NCT00976144)
- Testing
- GSK573719
- Where
- Australia
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
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