Clinical trials: Chronic Obstructive Pulmonary Disease (COPD)
Chronic Obstructive Pulmonary Disease
A 12 Week Study of QVA149 Compared to Fluticasone/Salmeterol (Advair) for Treatment of COPD
Study is to show that QVA149 is superior to the standard of care, fluticasone/salmeterol, in patients with moderate to severe airflow limitation
- Trial name
- NCT01834885
- Testing
- QVA149, fluticasone/salmeterol
- Where
- 29 sites in Austria, Germany
- Sponsor
- Novartis Pharmaceuticals
Pulmonary Disease, Chronic Obstructive (COPD)
Comparative Effects of Pilates Breathing and Pursed Lip Breathing on Chest Expension and Peak Expiratory Flow Rate in Patients With Chronic Obstructive Lung Disease
Chronic Obstructive Pulmonary Disease is a particular type of irreversible disease that may damage or obstruct airways and make it difficult to breath. This respiratiry condition may lead to shallow breathing.
- Trial name
- NCT07177976
- Testing
- Pilates Breathing Technique along with standard pharmacological management, Pursed-lip breathing along with pharmacological management
- Where
- Pakistan
- Volunteers
- 46 people
- Sponsor
- Foundation University Islamabad
Chronic Obstructive Pulmonary Disease (COPD)
Correlation Between Patient Perception and Findings on Clinical Examination in Chronic Obstructive Pulmonary Disease (COPD) Patients
This is a multi-center, prospective, non-interventional study that aims to evaluate in daily clinical practice the possible correlation between patient perception of the ability to perform morning activities and the physician's…
- Trial name
- RELIEF (NCT01703416)
- Where
- 2 sites in Bulgaria
- Volunteers
- 500 people
- Sponsor
- AstraZeneca
Pulmonary Disease, Chronic Obstructive, Lung Diseases, Obstructive
Comparison of Two Programs to Encourage Physical Activity in Individuals With Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) is a chronic lung disease. Symptoms include shortness of breath, wheezing, and difficulty exercising.
- Trial name
- NCT00328484
- Testing
- Lifestyle Activity Program, Exercise Program
- Where
- United States
- Volunteers
- 318 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Pulmonary Disease, Chronic Obstructive
HandiHaler® vs. Metered Dose Inhaler (MDI) in Patients With Chronic Obstructive Pulmonary Disease (COPD)
Trial to compare the administration technique for HandiHaler® vs. MDI, to compare the learning retention of the administration technique for the HandiHaler® vs. MDI and to compare the ease of use for HandiHaler® vs. MDI
- Trial name
- NCT02172404
- Testing
- Ipratropium metered dose inhaler (MDI)
- Volunteers
- 160 people
- Sponsor
- Boehringer Ingelheim
Obstructive Lung Diseases
Can NAVA Mode Reduce Mechanical Ventilation Day in Patients With COPD ?
Background： Neurally Adjusted Ventilatory Assist (NAVA) mode is a new mode of ventilator, using electronic potential of diaphragm to adjust tidal volume.
- Trial name
- NCT05595733
- Testing
- Ventilator mode
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- Fu Jen Catholic University Hospital
Chronic Obstructive Pulmonary Disease
Bufei Yishen Prescription on Patients With Frequent AECOPD in Stable Stage
To evaluate the clinical efficacy and health economic advantages of Lung Replenishing and Kidney Enhancing Formula for the treatment of patients with frequent acute exacerbations in the stabilized phase.
- Trial name
- NCT06326658
- Testing
- Bufei Yishen Prescription Granule
- Volunteers
- 848 people
- Sponsor
- Henan University of Traditional Chinese Medicine
Chronic Obstructive Pulmonary Disease, Bronchiolitis
Noninvasive Positive Pressure Ventilation Using Helium:Oxygen Versus Air:Oxygen in Acute Respiratory Failure in Chronic Obstructive Pulmonary Disease Patients Exposed to Sulfur Mustard
to assess the effectiveness of helium:oxygen mixture adjunct with non-invasive ventilation in sulfur mustard exposed patients with acute decompensation
- Trial name
- NCT00515606
- Testing
- helium:oxygen
- Sponsor
- Baqiyatallah Medical Sciences University
Pulmonary Disease, Chronic Obstructive
Tiotropium (18 Mcg) Once Daily Via the HandiHaler® in Patients With Chronic Obstructive Pulmonary Disease (COPD)
The primary objective of this trial is to determine whether treatment with tiotropium (18 mcg) capsule once daily via the HandiHaler reduces the proportion of patients with COPD experiencing an exacerbation and the proportion of…
- Trial name
- NCT00274547
- Testing
- Tiotropium
- Where
- 26 sites in United States
- Volunteers
- 1,829 people
- Sponsor
- Boehringer Ingelheim
COPD, COPD Exacerbation
Pulmonary Rehabilitation for COPD Patients: Can Performance Predict Exacerbation?
The aim of pulmonary rehabilitation is to improve exercise capacity and reduce dyspnoea. As well as improving the patient's overall condition, pulmonary rehabilitation provides a means to monitor the patient regularly.
- Conditions
- COPD, COPD Exacerbation, Pulmonary Rehabilitation
- Trial name
- PREDICT (NCT05492149)
- Testing
- Performance follow-up
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Groupe Hospitalier du Havre
Chronic Obstructive Pulmonary Disease, Comorbidities and Coexisting Conditions
Xishui Project for IDM of COPD and Comorbidities
Study Population: 4000 stable COPD patients, and among them approximately 2000 subjects with hypertension and/or type 2 diabetes complications.
- Trial name
- NCT06456749
- Testing
- Integrated Disease Management
- Volunteers
- 4,000 people
- Sponsor
- China-Japan Friendship Hospital
Chronic Obstructive Lung Disease, Respiratory Insufficiency
The Edi Level and Cardiopulmonary Function Between HHHFNC and Unheated Humidified High-Flow Oxygen Mask in COPD
Patients with COPD exacerbation usually need respiratory support after extubation. Recently, HHHFNC has been used in both adult and neonates with post-extubation respiratory support.
- Trial name
- NCT03811158
- Testing
- HHHFNC, UHFOM
- Where
- Taiwan
- Volunteers
- 2 people
- Sponsor
- Fu Jen Catholic University
Critical Illness, Ventilation Perfusion Mismatch
Arterial and End-Tidal CO2 Gradient as a Mortality Predictor in Critical Care Patients
Scoring systems (SOFA, APACHE-II etc.) are used to estimate the mortality rates of patients treated in the intensive care unit. . In the scoring systems used, the disfunction level of the organs of the patients is measured.
- Conditions
- Critical Illness, Ventilation Perfusion Mismatch, Shock, Pulmonary Embolism
- Trial name
- NCT05341258
- Testing
- EtCO2, PaCO2
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Chronic Obstructive Lung Disease (COLD)
Long-Term Safety and Efficacy of HSK39004 Dry Powder Inhaler in COPD
This clinical trial evaluates the long-term safety and efficacy of 0.75 mg HSK39004 Dry Powder Inhaler administered twice daily for 52 weeks in subjects aged 40 to 80 years with moderate-to-severe stable chronic obstructive…
- Trial name
- NCT07425210
- Testing
- HSK39004 Dry Powder Inhaler -0.75mg BID
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Haisco Pharmaceutical Group Co., Ltd.
Chronic Obstructive Pulmonary Disease
Iron and Chronic Obstructive Pulmonary Disease (COPD) Exercise Trial
This phase II single centre, double blind, placebo-controlled, randomised trial aims to test the hypothesis that intravenous iron improves exercise performance in Chronic Obstructive Pulmonary Disease (COPD) as measured by…
- Trial name
- ICE-T (NCT03050424)
- Testing
- Ferric Carboxymaltose, Sodium Chloride 0.9%
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Congestive Heart Failure, Metastatic Cancer
Advance Care Planning in the Emergency Department
This is a two-armed, parallel-design, pre-/post-intervention assessment study. The investigators will conduct a randomized controlled trial for ED GOAL on a cohort of 120 older adults with serious illness to collect…
- Conditions
- Congestive Heart Failure, Metastatic Cancer, Chronic Kidney Disease Requiring Chronic Dialysis, Chronic Obstructive Pulmonary Disease
- Trial name
- NCT05209880
- Testing
- ED GOAL
- Where
- United States
- Volunteers
- 141 people
- Sponsor
- Brigham and Women's Hospital
COPD, Lung Cancer
Randomized Clinical Trial of 8 Weeks Pulmonary Rehabilitation in Advanced Stage Lung Cancer Patients With COPD During Cytotoxic Chemotherapy
Pulmonary rehabilitation might be benificial in advanced lung cancer patients with COPD who undergo cytotoxic chemotherapy. We will compare two groups, 8 week pulmonary rehabilitation group and usual care group.
- Trial name
- NCT02121379
- Testing
- pulmonary rehabilitation
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Seoul National University Hospital
Tuberculosis, Pulmonary, Undernutrition
The INSTITUT Study Tuberculosis Nutritional Support
Undernutrition is a leading global risk factor of tuberculosis (TB) and a prevalent comorbidity associated with TB. In Benin, the National TB Program systematically provides nutritional support to all persons with TB (PWTB)…
- Trial name
- INSTITUT (NCT06084715)
- Testing
- Nutritional support
- Where
- 2 sites in Benin, Togo
- Volunteers
- 769 people
- Sponsor
- Boston Medical Center
Pulmonary Disease, Chronic Obstructive
Effect of GSK704838 In Healthy Volunteers
GSK704838C is a potent, pan-active mAChR antagonist, which is being developed for once-daily treatment of chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT00539825
- Testing
- GSK704838
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Copd
Effect of Sublingual Fentanyl on Breathlessness in COPD
There is actually no physiologic or clinical data in the literature to clearly define the potential benefits and side effects of sublingual fentanyl in patients with COPD.
- Trial name
- NCT04004117
- Testing
- Fentanyl citrate solution sublingual
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
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