Clinical trials: Chronic Osteoarthritis
Osteoarthritis, Knee Pain Chronic
Effectiveness of Curcumin-based Food Supplement in Reducing Pain and Inflammatory Component in Osteoarthritis
INTRODUCTION The treatment of OA is mostly symptomatic and includes the use of analgesics, NSAIDs, exercise and even surgery. However, the use of long-term NSAIDs is associated with potentially serious side effects.
- Trial name
- FENOXI-1900 (NCT04207021)
- Testing
- Experimental: Curcumin derivate
- Volunteers
- 134 people
- Sponsor
- KOS Care SRL - Istituto di Riabilitazione Santo Stefano
Osteoarthritis, Rheumatoid Arthritis
Evaluation Of Efficacy And Safety Of Norspan In Moderate To Severe Pain Due To Osteoarthritis, Rheumatoid Arthritis, Joint/Muscle Pain
The purpose of this study is to assess the efficacy of the buprenorphine transdermal patch (Norspan® or Sovenor® transdermal patch) in patients with chronic non-malignant pain of moderate to severe intensity due to…
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Lower Back Pain, Joint Pain
- Trial name
- NCT01961271
- Testing
- Buprenorphine transdermal patch
- Where
- 16 sites in Hong Kong, Philippines and 1 more
- Volunteers
- 114 people
- Sponsor
- Mundipharma Pte Ltd.
Chronic Shoulder Pain
Treatment of Shoulder Osteoarthritis
The purpose of this study is to learn if pain can be relieved by delivering small amounts of electricity ("electrical stimulation") to the nerves relaying sensory information to the shoulder.
- Trial name
- NCT05657587
- Testing
- SPRINT PNS
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Gramercy Pain Center
Knee Osteoarthritis, Knee Pain Chronic
Dexamethasone for iPACK Block With ACB in Total Knee Arthroplasty
Effect of adding Dexamethasone to Infiltration between the Popliteal Artery and Capsule of the Knee Block with ACB in Patients undergoing Total Knee Arthroplasty
- Conditions
- Knee Osteoarthritis, Knee Pain Chronic, Knee Arthritis
- Trial name
- NCT06470204
- Testing
- Ropivacaine, Ropivacaine+Dexamethasone
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- Poznan University of Medical Sciences
Pain, Knee Osteoarthritis
A Study to Evaluate the Efficacy and Safety of CG5503 Prolonged Release (PR) in Subjects With Moderate to Severe Chronic Pain Due to Osteoarthritis of the Knee
The purpose of this study is to evaluate whether tapentadol (CG5503) prolonged-release (PR) tablets at doses of 100-250 mg twice daily provide a better pain relief in patients with moderate to severe chronic pain due to…
- Trial name
- NCT00486811
- Testing
- Tapentadol ER (100 to 250 mg twice daily), Oxycodone CR (20 to 50 mg twice daily)
- Where
- 100 sites in Austria, Croatia and 11 more
- Volunteers
- 990 people
- Sponsor
- Grünenthal GmbH
Knee Osteoarthritis, Chronic Post Operative Pain
Opioid Reduction in Orthopaedic Surgery (OREOS) - Knees
Knee replacements are the second most common surgery in Canada. Most patients recover very well but research consistently shows that 1 in 5 patients still have pain many months after surgery.
- Trial name
- OREOS (NCT04968132)
- Testing
- Multicomponent opioid reduction and pain management pathway, Standard care
- Where
- Canada
- Volunteers
- 102 people
- Sponsor
- Kim Madden
Knee Osteoarthritis, Chronic Knee Pain
Nerve to Vastus Medialis Branches in Chronic Knee Pain
This observational cohort study aims to evaluate the clinical effect of adding ultrasound-guided pulsed radiofrequency treatment of the distal superficial and deep sensory branches of the nerve to vastus medialis to conventional…
- Trial name
- NCT07703293
- Testing
- Conventional Genicular Nerve Radiofrequency, Conventional Genicular Nerve Radiofrequency Plus Pulsed Radiofrequency of the Distal Sensory Branches of the Nerve to Vastus Medialis
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Diskapi Teaching and Research Hospital
Chronic Pain
A Study Comparing the Effectiveness and Safety of Extended Release Tramadol HCl at 100 mg, 200 mg and 300 mg Doses to Placebo for the Treatment of Moderate to Severe Pain Due to Osteoarthritis (OA)
The purpose of this study is to compare the analgesic efficacy and safety of tramadol HCl ER 100 mg, 200 mg and 300 mg once a day (QD), with placebo in patients with moderate to severe pain due to OA.
- Trial name
- NCT00348452
- Testing
- tramadol HCl ER; celecoxib
- Volunteers
- 1,000 people
- Sponsor
- Bausch Health Americas, Inc.
Knee Osteoarthritis, Knee Pain Chronic
Effects of Internet / Web-based Exercises on the Population With Knee Arthritis
1. To test whether internet-based exercises reduce the pain in knee OA 2. To check whether internet-based exercises improve the physical activity in the patients with knee OA. 3.
- Conditions
- Knee Osteoarthritis, Knee Pain Chronic, Sleep Disturbance
- Trial name
- Knee OA (NCT03545048)
- Testing
- Internet based exercises
- Where
- United Kingdom
- Volunteers
- 105 people
- Sponsor
- University of Nottingham
Osteoarthritis Pain, Chronic Low Back Pain
Study To Assess Changes In The Number Of Nerves In The Skin At The Site Where Where Tanezumab Is Injected
Subcutaneous administration of tanezumab can result in changes in the number of nerves around the injection site in the thigh.
- Conditions
- Osteoarthritis Pain, Chronic Low Back Pain, Pain Due to Interstitial Cystitis
- Trial name
- NCT01030640
- Testing
- tanezumab
- Where
- 2 sites in United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Pfizer
Osteoarthritis, Knee, Osteoarthritis, Hip
Helping Osteoarthritis Patients to Walk With NSAID
There is a lack of effective analgesic treatments to help walking patients with painful hip/knee osteoarthritis. Our team therefore imagined a new strategy lying on a multimodal rehabilitation walking program with the help of a…
- Conditions
- Osteoarthritis, Knee, Osteoarthritis, Hip, Chronic Pain
- Trial name
- PERIPATEI (NCT05761015)
- Testing
- therapeutic program including intermittent drug intake and multimodal rehabilitation program
- Where
- France
- Volunteers
- 55 people
- Sponsor
- University Hospital, Clermont-Ferrand
Osteoarthritis, Knee
A Phase 3 Efficacy and Safety Study of Intra-articular CNTX-4975-05 (Capsaicin) vs Placebo in Subjects With OA Knee Pain
This is a phase 3, randomized, double-blind, placebo-controlled, single injection, 52-week study to evaluate the analgesic efficacy and safety of a single intra-articular (IA) CNTX-4975-05 (capsaicin), compared to IA placebo, in…
- Trial name
- NCT03429049
- Testing
- CNTX-4975-05
- Where
- 33 sites in United States
- Volunteers
- 332 people
- Sponsor
- Centrexion Therapeutics
Pain, Acute, Pain, Chronic
Evaluation of the Effect of the AI500™ SINGLE-DOSE GEL Medical Device in Patients With Reduced Knee Function
Evaluation of the effect of the AI500™ SINGLE-DOSE GEL medical device in patients with reduced knee function
- Conditions
- Pain, Acute, Pain, Chronic, Knee Injuries, Knee Osteoarthritis
- Trial name
- NCT05886608
- Testing
- AI 500™ SINGLE-DOSE GEL
- Where
- Italy
- Volunteers
- 35 people
- Sponsor
- Contrad Swiss SA
Gonarthrosis
Efficacy of Ultrasound-Guided Genicular Nerve Radiofrequency Ablation Therapy
The main symptom of knee osteoarthritis, which occurs after damage to the joint cartilage with age, is pain, but this symptom often becomes chronic.
- Trial name
- NCT06914960
- Testing
- 2-point Radiofrequency Ablation, 3-point Radiofrequency Ablation, 5-point Radiofrequency Ablation
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Bengu Turemenogullari
Hip Arthropathy, Hip Osteoarthritis
NLR and PLR Levels Following PENG Block in Hip Arthroplasty
Effect of PENG block on NLR and PLR following hip arthroplasty
- Conditions
- Hip Arthropathy, Hip Osteoarthritis, Hip Pain Chronic
- Trial name
- NCT07023107
- Testing
- 0.9% Sodium Chloride Injection, Ropivacaine 0.2% Injectable Solution
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- Poznan University of Medical Sciences
Chronic Pain Syndrome
Thermal Micro-cautery for Painful Knee Osteoarthritis
To trial a traditional pain management technique from Ayurveda in a modern way - the technique involves micro - cautery to painful areas in knee osteoarthritis for patients on a waiting list for knee replacement.
- Trial name
- TMC-PKO (NCT03460717)
- Testing
- Peripheral Nerve Field Stimulation by Thermal Micro-Cautery
- Where
- Ireland
- Volunteers
- 30 people
- Sponsor
- The National Children's Hospital, Tallaght
Osteoarthritis, Knee, Osteo Arthritis Knee
Study to Evaluate Resiniferatoxin in Patients With Knee Osteoarthritis Whose Total Knee Replacement Surgery is Delayed
Efficacy and safety study of resiniferatoxin versus placebo to manage pain in patients with knee osteoarthritis whose TKR surgery is delayed
- Conditions
- Osteoarthritis, Knee, Osteo Arthritis Knee, Knee Pain Chronic
- Trial name
- NCT04386980
- Testing
- Resiniferatoxin
- Sponsor
- Sorrento Therapeutics, Inc.
Chronic Pain
A Study Comparing the Effectiveness and Safety of Extended Release Tramadol Versus Placebo for the Treatment of Osteoarthritis (OA) of the Knee
The purpose of this study is to compare the analgesic effectiveness and safety of tramadol HCl ER to placebo in patients with moderate to severe pain due to osteoarthritis (OA).
- Trial name
- NCT00348010
- Testing
- Tramadol HCl ER
- Volunteers
- 245 people
- Sponsor
- Bausch Health Americas, Inc.
Hip Osteoarthritis, Hip Arthropathy
PENG Block for Total Hip Arthroplasty
This randomized, double-blinded, placebo-controlled trial seeks to evaluate the efficacy of the pericapsular nerve group block on postoperative rehabilitation.
- Conditions
- Hip Osteoarthritis, Hip Arthropathy, Hip Disease, Hip Pain Chronic
- Trial name
- NCT05944380
- Testing
- Ropivacaine 0.5% Injectable Solution, 0,9% normal saline
- Where
- Poland
- Volunteers
- 556 people, healthy volunteers welcome
- Sponsor
- Poznan University of Medical Sciences
Osteoarthritis, Knee, Osteoarthritis
Intra-articular Pulsed Radiofrequency in Chronic Knee Pain
The aim of this study is to investigate the additional effect of Intra-articular Pulsed Radiofrequency (IAPRF) on pain and functional activities in addition to intra-articular steroids in patients with grade II and III knee…
- Conditions
- Osteoarthritis, Knee, Osteoarthritis, Pain, Chronic
- Trial name
- NCT06017674
- Testing
- Intra-articular Pulsed Radiofrequency, Steroid Injection
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Başakşehir Çam & Sakura City Hospital