Clinical trials: Chronic Otitis Media
Chronic Rhinosinusitis With Nasal Polyposis (CRSwNP)
Chronic Otitis Media With Effusion in Chronic Sinusitis With Polyps
The relationship between otitis media with effusion (OME) and chronic rhinosinusitis with nasal polyposis (CRSwNP) remains unclear.
- Trial name
- NCT03975842
- Testing
- Sinonasal and otologic evaluation
- Volunteers
- 80 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Otitis Media Chronic, Tympanic Membrane Perforation
Use of Autologous Plasma Rich in Platelets and Extracellular Vesicles in the Surgical Treatment of Chronic Middle Ear Infections
This clinical study evaluates the efficacy of the autologous blood-derived product called platelet- and extracellular vesicle-rich plasma as a supplement to the surgical treatment of chronic tympanic membrane perforations.
- Trial name
- NCT04761562
- Testing
- Platelet- and extracellular vesicle-rich plasma, Control group
- Where
- Slovenia
- Volunteers
- 100 people
- Sponsor
- University Medical Centre Ljubljana
Otitis Media
Host-pathogen Interaction in Otitis Media
Otitis Media (OM) is one of the most frequent diseases in childhood and the primary reason for children to visit a physician. In many countries it is the most common reason to prescribe antibiotics leading to increased…
- Trial name
- OMVac (NCT00847756)
- Testing
- questionnaire, blood sample, collection of middle ear fluid
- Where
- 2 sites in Netherlands
- Volunteers
- 179 people
- Sponsor
- Radboud University Medical Center
Otitis Media Chronic, Temporal Bone
Efficacy of Platelet- and Extracellular Vesicle-rich Plasma in Chronic Postsurgical Temporal Bone Inflammations
This clinical study evaluates the efficacy of the autologous blood-derived product called platelet- and extracellular vesicle-rich plasma (PVRP) for the treatment of chronically inflamed post-surgical temporal bone cavities.
- Trial name
- PvRP-ear (NCT04281901)
- Testing
- Platelet- and extracellular vesicle-rich plasma, Standard conservative treatment
- Where
- Slovenia
- Volunteers
- 25 people
- Sponsor
- University Medical Centre Ljubljana
Chronic Otitis Media Tympanic Membrane Perforation
Effect of Platelet-Rich Plasma on Eardrum Healing and Hearing After Tympanoplasty in Adults
This single-center controlled trial evaluated whether intraoperative application of autologous platelet-rich plasma (PRP)-impregnated absorbable gelatin sponge improves graft take rates and audiological outcomes in adults…
- Trial name
- NCT07664319
- Testing
- Autologous platelet-rich plasma (PRP)-impregnated Spongostan, Dry Spongostan (absorbable gelatin sponge)
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Ebubekir Toprak
Otitis Media, Otorrhea
N-Acetylcysteine as an Adjunct for Refractory Chronic Suppurative Otitis Media
Chronic suppurative otitis media (CSOM) can be particularly difficult to treat as a number of patients do not respond to routine antibiotic or surgical treatments.
- Trial name
- NCT00956748
- Testing
- Ciprodex, Ciprodex and 2% NAC
- Where
- Canada
- Sponsor
- St. Paul's Hospital, Canada
Otitis Media, Otitis Media Chronic
CLIKX® Tympanostomy Tube Delivery System for the Placement of Tympanostomy Tubes
This study looks at the safety and performance of the CLiKX device. The device is used to place ear tubes (also called ventilation tubes) in children and adults.
- Conditions
- Otitis Media, Otitis Media Chronic, Otitis Media Effusion, Otitis Media Recurrent
- Trial name
- NCT07625657
- Testing
- CLiKX® Tympanostomy Tube Delivery System
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- ClinQure, Inc.
Otitis Media Chronic, Cholesteatoma
The Serum Sclerostin Levels in Cholesteatoma Patients
The aim of this study is to investigate the levels of sclerostin in patients with cholesteatoma. So far, there is no study showing the levels of sclerostin in cholesteatoma.
- Trial name
- NCT03954288
- Testing
- serum for sclerostin ELISA test
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Abant Izzet Baysal University
Hearing Impaired Children, Glue Ear
Exploring Interventions for Glue Ear During Covid-19
During the Coronavirus pandemic children's hearing services are closed or reduced and grommet operations are part of the lowest priority group.
- Conditions
- Hearing Impaired Children, Glue Ear, Hearing Loss, Conductive
- Trial name
- BIG-C (NCT04427631)
- Testing
- Bone conduction headphones
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Cambridgeshire Community Services NHS Trust
Otitis Media With Effusion in Children, Quality of Life
Short-term Effects of Ventilation Tubes in Children With Chronic Otitis Media With Effusion
The goal of this clinical, randomized trial is to compare the sleeping patterns and quality of life of children with chronic otitis media with effusion (OME) with or without tympanic tubes insertion.
- Conditions
- Otitis Media With Effusion in Children, Quality of Life, Sleep
- Trial name
- NCT06100159
- Testing
- Tympanostomy tube insertion
- Where
- 2 sites in Denmark
- Volunteers
- 60 people
- Sponsor
- Zealand University Hospital
Vertigo Labyrinthine
Evaluation of Vestibular Function in Patients With C.S.O.M: Safe Type
To evaluate the function of vestibular system in patients with chronic suppurative otitis media safe type.
- Trial name
- NCT04791930
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
Chronic Otitis Media, Age Determined Bacteria
Bacterial Assessment of Middle Ear Fluid in Children Undergoing Ventilation Tube Placement Surgery
Children with chronic otitis media have more resistant bacteria that require surgical intervention to eradicate the infections. The study will evaluate the dominant bacteria and their sensitivities to antibiotics.
- Trial name
- NCT01157910
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Hillel Yaffe Medical Center
Chronic Suppurative Otitis Media, Tympanic Membrane; Wound
Safety Profile of Applied 100% Manuka Honey in Tympanoplasty
Throughout history, honey has been recognized for its healing properties. The use of honey for its medicinal properties dates back to 2200 BCE.
- Trial name
- NCT05657717
- Testing
- Manukamed - Manukapli 100% sterile honey wound dressing - Premium medical grade 16+ Leptospermum Scoparium New Zealand honey
- Where
- Indonesia
- Volunteers
- 64 people
- Sponsor
- Fakultas Kedokteran Universitas Indonesia
Cholesteatoma, Chronic Otitis Media
Combined Access Closed Tympanomastoidectomy: Microsurgery Allied to Endoscopy
Chronic otitis media is a prevalent medical condition, leading to important impact in the lives of the individuals with this condition, and a great amount of patients may need surgical intervention.
- Trial name
- NCT03294421
- Testing
- combined access tympanomastoidectomy, standard closed tympanomastoidectomy
- Where
- Brazil
- Volunteers
- 64 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Post-operative Analgesia, CSOM - Chronic Suppurative Otitis Media
Preemptive Pregabalin in Myringoplasty
The aim of this study was to investigate the effect of preemptive pregabalin on post-operative pain reduction after myringoplasty.
- Trial name
- NCT03603626
- Testing
- Pregabalin 150mg
- Where
- Nepal
- Sponsor
- Dhulikhel Hospital
Complement Deficiency, Antibody Deficiency
Systematic Search for Primary Immunodeficiency in Adults With Infections
Antibody deficiencies and complement deficiencies are the most frequent Primary immunodeficiencies (PIDs) in adults, and are associated with greatly increased susceptibility to recurrent and/or severe bacterial infections …
- Conditions
- Complement Deficiency, Antibody Deficiency, Chronic Sinus Infection, Meningitis, Bacterial
- Trial name
- SPIDAC (NCT02972281)
- Testing
- Immunological diagnosis tests
- Where
- 19 sites in France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Lille
Chronic Suppurative Otitis Media, Hearing Impairment
Prevalence and Associations of Paediatric Chronic Suppurative Otitis Media and Hearing Impairment in Rural Malawi
This community-based cross-sectional survey will estimate the frequency and risk factors of Chronic Suppurative Otitis Media and Hearing Impairment in Children ages 4-6 years in the Chikwawa District.
- Trial name
- NCT02779907
- Testing
- No Intervention
- Where
- Malawi
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Liverpool School of Tropical Medicine
Chronic Otitis Media, Tubotympanic Disease
A Comparative Study of the Outcomes of 2 Surgical Procedures for Safe Type of Chronic Otitis Media
Mastoidotympanoplasty is a recognised surgery that is performed for chronic otitis media. But whether mastoidectomy in addition to tympanoplasty is really necessary in each and every case of quiescent chronic otitis media still…
- Trial name
- NCT00271778
- Testing
- mastoidotympanoplasty and tympanoplasty
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Karnataka Institute of Medical Sciences
Chronic Suppurative Otitis Media, Mastoid Cavity
Study the Impact of the Mastoid and Middle Ear Volume on the Success of Type 1 Tympanoplasty in Pediatric Age, With Comparing Using Cartilage and Fascial Grafts Through This, Strength the Hypothesis of That Total Tympanometry Volume Correlates With Ventilated Mastoid Air Cells Volume on CT Scans
The goal of this observational study is to know the impact of the mastoid and middle ear volume on the success of type 1 tympanoplasty in pediatric age, with a closer view on the comparison of using cartilage and fascial grafts…
- Conditions
- Chronic Suppurative Otitis Media, Mastoid Cavity, Pneumatization, Tympanoplasty
- Trial name
- NCT07806461
- Testing
- tympanoplasty type 1, Audiological Evaluation, HRCT scan temporal bone
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Al-Azhar University
Chronic Suppurative Otitis Media
Mastoid Obliteration Using S53P4 Bioactive Glass Versus Mastoidectomy Alone for Chronic Suppurative Otitis Media
Chronic suppurative otitis media (CSOM) is characterized by intermittent or continuous otorrhea lasting for longer than 6 weeks. Most cases can be treated conservatively using antibiotic drops and oral antibiotics.
- Trial name
- NCT06160505
- Testing
- S53P4 Bioactive glass
- Where
- Netherlands
- Volunteers
- 250 people
- Sponsor
- Diakonessenhuis, Utrecht