Clinical trials: Chronic Pain, completed
Low Back Pain, Osteoarthritis
Long-term Open-Label Safety Study to Evaluate EN3409
The purpose of the long-terms study is to evaluate the safety, tolerability, and analgesic efficacy of EN3409 in subjects with moderate to severe chronic pain requiring continuous around-the-clock opioid analgesia for an extended…
- Conditions
- Low Back Pain, Osteoarthritis, Neuropathic Pain
- Trial name
- NCT01755546
- Testing
- EN3409
- Where
- 57 sites in United States
- Volunteers
- 304 people
- Sponsor
- BioDelivery Sciences International
Back Pain, Spinal Stenosis
Perioperative ACT for Preventing CPSP
The present study aims to adapt and modify a brief perioperative Acceptance and Commitment Therapy (ACT) intervention aimed at preventing the transition to Chronic Post-Surgical Pain (CPSP) and reducing long-term opioid use.
- Conditions
- Back Pain, Spinal Stenosis, Spondylosis, Spondylolisthesis
- Trial name
- PREPS (NCT06750874)
- Testing
- Acceptance and Commitment Therapy
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Samantha Meints
Osteoarthritis of the Knee
Extended and Controlled Release Liposomal Formulated Dexamethasone for Chronic Knee OA Pain
Phase 3 randomized, double-blind, placebo- and active comparator-controlled study of TLC599.
- Trial name
- EXCELLENCE (NCT04123561)
- Testing
- TLC599, DSP, Normal Saline
- Where
- 46 sites in United States, Australia
- Volunteers
- 504 people
- Sponsor
- Taiwan Liposome Company
Fibromyalgia
Online Mindfulness Training Versus Health Education for Fibromyalgia
The purpose of this study is to compare an online 12-module intervention designed to improve emotion regulation and social relations via mindfulness training with a 12-module program that provides information about health…
- Trial name
- EGIFT (NCT01748786)
- Testing
- Mindfulness Emotion Regulation, Health Education
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Arizona State University
Chronic Low-back Pain
Effectiveness of Cat-Cow Yoga in Managing Chronic Low Back Pain
A randomized control trial is planned to investigate the effectiveness of Cat-Cow yoga as a treatment for chronic low back pain CLBP.
- Trial name
- NCT04723225
- Testing
- Cat-Cow Yoga
- Where
- Pakistan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Karachi
Endometriosis
Endometriosis and Pain
Endometriosis is a condition affecting about 10% of childbearing age women. It can begin a few months to a few years after puberty.
- Trial name
- EndoDOL (NCT03993197)
- Testing
- Psychological and corporal group management
- Where
- France
- Volunteers
- 91 people
- Sponsor
- Hospices Civils de Lyon
Chronic Pain
A Study to Examine the Safety, Pharmacokinetics and Pharmacodynamics of AMG 403 in Healthy Subject
This study is to evaluate the safety of AMG 403 in healthy adult subjects. The study consists of a 21 day screening period followed by administration of the investigational product and up to 154 day evaluation period.
- Trial name
- NCT02348879
- Testing
- AMG 403
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Amgen
Cerebral Palsy
Pain Burden in Children and Adolescents With Cerebral Palsy
Pain in children and adolescents with cerebral palsy (CP) is a significant health challenge that so far has received too little attention.
- Trial name
- CPPain (NCT04219020)
- Testing
- Co-created intervention
- Where
- 5 sites in United States, Canada and 3 more
- Volunteers
- 588 people
- Sponsor
- Sykehuset Telemark
Chronic Pain, Back Pain
Yoga for Chronic Low Back Pain in the Cleveland Clinic Employee Health Plan
This study uses clinical trial and implementation science methodology to specifically assess the effectiveness of yoga into the management of chronic low back pain (cLBP) within the Cleveland Clinic Employee Health Plan.
- Trial name
- NCT05319691
- Testing
- Yoga
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Robert Saper
Chronic Low Back Pain
Spinal Kinematics Variability
This study will test the within and between day variability of spinal kinematics and trunk muscle activity in healthy subjects and chronic low back pain patients during various daily-life activities.
- Trial name
- NCT03507296
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Haute Ecole de Santé Vaud
Low Back Pain
Analgesic Efficacy and Management of Opioid-induced Constipation (OIC) for Uncontrolled Moderate - Severe Low Back Pain
The primary objective is to assess the efficacy of oxycodone/naloxone (OXN) for the management of opioid-induced constipation (OIC) compared to oxycodone controlled-release tablets (OXY) in subjects with moderate to severe low…
- Trial name
- NCT01427270
- Testing
- Oxycodone/Naloxone controlled-release, Oxycodone HCl controlled-release
- Where
- 194 sites in United States, Czechia and 2 more
- Volunteers
- 455 people
- Sponsor
- Purdue Pharma LP
Chronic Pain, Mild Cognitive Impairment
Managing Pain and Cognitions in Older Adults With Mild Cognitive Impairment or Memory Related Problems and Chronic Pain
We aim to conduct a pilot randomized controlled trial comparing 2 symptom management programs for older adults with self-reported memory problems and chronic pain, Active Brains 1 and Active Brains 2.
- Conditions
- Chronic Pain, Mild Cognitive Impairment, Older Adults, Physical Activity
- Trial name
- NCT04044183
- Testing
- Active Brains 1, Active Brains 2
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Massachusetts General Hospital
Lung Cancer, Acute Pain
US-Guided Serratus Anterior Plane Block Versus Thoracic Epidural in Patients Undergoing Thoracotomy
Thoracic surgeries is known to be one of the most painful surgeries . Multiple analgesic techniques have been used for post operative analgesia including Thoracic epidural , Patient Controlled Analgesia and systemic opioids.
- Conditions
- Lung Cancer, Acute Pain, Chronic Pain
- Trial name
- NCT05672394
- Testing
- Continuous Serratus anterior plane block, Thoracic Epidural, Bupivacaine
- Where
- Egypt
- Volunteers
- 74 people
- Sponsor
- National Cancer Institute, Egypt
Chronic Low Back Pain, Post-traumatic Stress
Effectiveness of Pain Neuroscience Education (PNE) to Veterans With Post-Traumatic Stress and Low Back Pain
This trial compared traditional pain and stress education plus physical therapy to pain neuroscience education plus physical therapy in individuals with post-traumatic stress and chronic low back pain.
- Trial name
- NCT05086159
- Testing
- Pain Neuroscience Education, Exercise, Traditional Education
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Keller Army Community Hospital
Hyperalgesia, Opioid Use
Hyperalgesia, Persistent Pain, and Fentanyl Dosing in On-Pump Coronary Artery Bypass Grafting
Randomized, double-blinded, three arm study in adult patients undergoing first time coronary artery bypass grafting (CABG) surgery with median sternotomy.
- Conditions
- Hyperalgesia, Opioid Use, Pain, Postoperative, Pain, Chronic
- Trial name
- NCT03450161
- Testing
- Fentanyl dosing schemes
- Where
- Belgium
- Volunteers
- 80 people
- Sponsor
- University Hospital, Ghent
Neck Pain, Mechanical/Motor Problems With Neck and Trunk
The Effects of Cupping Massage in Patients With Chronic Neck Pain - A Randomized Controlled Trial
The study aims to investigate the influence of 5 cupping massage treatments on chronic non specific neck pain. 50 patients with neck pain are randomised into cupping treatment and waiting list control group.
- Trial name
- SKM (NCT02651766)
- Testing
- Cupping massage
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Universität Duisburg-Essen
Chronic Pain, Central Sensitisation
Mechanisms Of Change in Adolescent Pain Self-management
The MOCAS Study aims to describe the mechanisms through which sleep deficiency affects youth responses to an online pain self-management intervention over a 6-month period.
- Conditions
- Chronic Pain, Central Sensitisation, Headache
- Trial name
- MOCAS (NCT04043962)
- Testing
- Web-based CBT (Web-MAP)
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- Seattle Children's Hospital
Chronic Non-specific Low Back Pain
Efficacy and Safety of VER-01 in the Treatment of Patients With Chronic Non-specific Low Back Pain
Analysis of the efficacy, maintenance of efficacy, long-term safety, and investigation of the potential for dependence and abuse and the effect of abrupt drug withdrawal of VER-01 in the treatment of patients with chronic…
- Trial name
- NCT04940741
- Testing
- VER-01
- Where
- Germany
- Volunteers
- 820 people
- Sponsor
- Vertanical GmbH
Chronic Pain
BraveNet Multi-Center Study on Integrative Medicine Treatment Approaches for Pain
Preliminary results from an ongoing cross-sectional survey of nine of the BraveNet Outpatient Clinics indicate that pain was the leading reason for patient visits.
- Trial name
- SIMTAP (NCT01186341)
- Where
- 9 sites in United States
- Volunteers
- 418 people
- Sponsor
- Duke University
Paraspinous Block, Pelvis Pain Chronic
Paraspinous Anesthetic Block for Non-Responsive Pelvic Pain
This study examines randomized triple-blind clinical trial and the efficacy of paraspinous anesthetic block on the treatment of chronic pelvic pain in patients non-responsive to pharmacological management.
- Trial name
- NCT01635205
- Testing
- paraspinous anesthetic block, subcutaneous puncture with no anesthetic effect
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
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