Clinical trials: Chronic Pain Management
Breast Cancer, Chronic Pain
Reducing Pain and Disability After Breast Cancer Surgery
The purpose of this study is to determine if the combination of thoracic paravertebral block and multimodal analgesia will decrease chronic pain and arm morbidity in patients undergoing breast cancer surgery with lymph node…
- Trial name
- RELIeF (NCT01089933)
- Testing
- Thoracic Paravertebral Block (TPVB), Local Anesthetic
- Where
- Canada
- Volunteers
- 129 people
- Sponsor
- Ottawa Hospital Research Institute
Pain
Buprenorphine vs. Opioid Dose Escalation Among Patients With Chronic Pain
This study compares buprenorphine/naloxone to opioid dose escalation among patients with poorly controlled non-cancer pain on 30-100 mg daily morphine equivalent opioid dose.
- Trial name
- Bup (NCT01875848)
- Testing
- buprenorphine/naloxone, opioid dose escalation
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- VA Office of Research and Development
Postoperative Pain
Efficacy Study of Ketamine for Postoperative Pain in Opioid Dependent Patients
Patients who are dependent on opioids often have poor pain relief after major surgery. This study tests the hypothesis that adding intravenous ketamine to a postoperative regimen of intravenous opioids for postoperative pain will…
- Trial name
- NCT01591382
- Testing
- Ketamine, Hydromorphone PCA
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Brigham and Women's Hospital
Chronic Pain, Traumatic Brain Injury
Neuromodulatory Treatments for Pain Management in TBI
Traumatic brain injury (TBI) and chronic pain are common and serious health problems for military veterans and often co-occur, leading to poor post-deployment adjustment.
- Conditions
- Chronic Pain, Traumatic Brain Injury, Posttraumatic Stress Disorder
- Trial name
- NCT03418129
- Testing
- Mindfulness, Neurofeedback, Relaxation
- Where
- United States
- Volunteers
- 254 people
- Sponsor
- Duke University
Temporomandibular Disorders
Erenumab-aooe for Temporomandibular Disorders Management: TMD Cgrp Antibody RElief (TMD CARE)
Evaluate erenumab- aooe efficacy as a therapeutic approach, for the management of painful chronic temporomandibular disorders (TMD).
- Trial name
- TMD CARE (NCT05162027)
- Testing
- Erenumab-Aooe 70 MG in 1 mL Prefilled Syringe
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Maryland, Baltimore
Pain, Advanced Cancer
Long Term Safety of Sativex Oromucosal Spray (Sativex®; Nabiximols) as Adjunctive Therapy in Patients With Uncontrolled Persistent Chronic Cancer Related Pain
This was a six-month open-label extension (OLE) study to evaluate the safety of long-term nabiximols (Sativex®) therapy when used as an adjunctive treatment in participants with advanced cancer.
- Trial name
- NCT01337089
- Testing
- Nabiximols
- Where
- 128 sites in United States, Australia and 16 more
- Volunteers
- 660 people
- Sponsor
- Jazz Pharmaceuticals
Chronic Low Back Pain
Internet-based Behavioral Pain Management
The purpose of the proposed project is to develop and test how well an internet-based behavioral pain self-management program, the Pain EASE program, can be used for treating low back pain in Veterans.
- Trial name
- NCT01918189
- Testing
- behavioral pain self-management intervention Pain EASE
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- VA Office of Research and Development
Chronic Pain
Open-Label Trial Comparing Oxycodone Medications
The investigators hypothesize that subjects will have greater pain relief when taking IR-oxycodone compared with ER-oxycodone for several reasons.
- Trial name
- OUTCOMES (NCT01162304)
- Testing
- Extended Release Oxycodone, Immediate Release Oxycodone
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Rochester
Chronic Pain
Efficacy and Safety of Fentanyl Buccal Tablets Compared With Oxycodone for the Management of Break Through Pain
Evaluate the efficacy of treatment with Fentanyl Buccal Tablets (FBT) compared with immediate release oxycodone in alleviating breakthrough pain in opioid tolerant patients with chronic pain.
- Trial name
- NCT00463047
- Testing
- Fentanyl Buccal Tablets Compared With Immediate-Release Oxycodone
- Where
- 45 sites in United States
- Volunteers
- 323 people
- Sponsor
- Cephalon
Opioid Withdrawal (Disorder)
Randomized, Double-Blind, Placebo-Controlled Pilot Study on the Safety and Effectiveness of LUCEMYRA During an Opioid Taper in Treatment of Withdrawal
Stopping prescription opioid pain medications can be difficult due to withdrawal symptoms. This study will test if LUCEMYRA helps reduce withdrawal symptoms and helps more people reduce their opioid dose compared to placebo.
- Trial name
- TAPER (NCT04070157)
- Testing
- Lofexidine
- Where
- 12 sites in United States
- Volunteers
- 4 people
- Sponsor
- USWM, LLC (dba US WorldMeds)
Acute Pain, Chronic Pain
Defining a PK and PD Model for Peripheral Analgesia After IV Oxytocin
The goal of this clinical trial is to learn about oxytocin ( a naturally occurring hormone made in the brain that transmits messages) and the effects it may have on thermal heat pain after intravenous administration.
- Conditions
- Acute Pain, Chronic Pain, Healthy Volunteer
- Trial name
- NCT05929339
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Chronic Post Surgical Pain
A Post Market Study to Assess the Spinal Modulation Dorsal Root Ganglion Stimulator System in Chronic Post Surgical Pain
20-SMI-2013 is a post market, observational, questionnaire based study to assess the effectiveness of the commercially available Axium neurostimulator in the management of chronic post surgical pain
- Trial name
- NCT02335229
- Testing
- Axium DRG Neurostimulator
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Abbott Medical Devices
Chronic Leukemia, Hematopoietic and Lymphoid System Neoplasm
Evaluation of a Pain Management Intervention Preparatory to a Future Pragmatic Trial, ASCENT Study
This clinical trial tests how well a pain management intervention preparatory to a future pragmatic trial works in rural dwelling and Hispanic cancer survivors.
- Conditions
- Chronic Leukemia, Hematopoietic and Lymphoid System Neoplasm, Lymphoma, Malignant Solid Neoplasm
- Trial name
- NCT06063603
- Testing
- Acupuncture Therapy, Cancer Pain Management, Cognitive Behavior Therapy
- Where
- 2 sites in United States
- Volunteers
- 51 people
- Sponsor
- Mayo Clinic
Chronic Interstitial Cystitis, Bladder Pain Syndrome
Optimizing Psychosocial Treatment of Interstitial Cystitis/Bladder Pain Syndrome
Interstitial cystitis/bladder pain syndrome (IC/BPS) is a severe pain condition affecting 3-8 million people in the United States lacking treatments that work.
- Conditions
- Chronic Interstitial Cystitis, Bladder Pain Syndrome, Cystitis, Interstitial, Painful Bladder Syndrome
- Trial name
- NCT04275297
- Testing
- Psychosocial Treatment, Attention Control
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Vanderbilt University Medical Center
Chronic Pain, Depression, Anxiety
Cognitive Behavioral Therapy and Real-Time Pain Management Intervention for Sickle Cell Via Mobile Applications
The investigators are conducting a comparative effectiveness trial among adult patients with sickle cell disease (SCD) who report chronic pain (N = 350), randomized to receive either mobile phone-delivered computerized cognitive…
- Conditions
- Chronic Pain, Depression, Anxiety, Opioid Use
- Trial name
- CaRISMA (NCT04419168)
- Testing
- cCBT, m-Education
- Where
- 7 sites in United States
- Volunteers
- 359 people
- Sponsor
- University of Pittsburgh
Chronic Pain
Patient Activation to Address Chronic Pain and Opioid Management in Primary Care
Will a primary care-based behavioral intervention for patient activation and engagement and self-management, for patients with chronic pain who are taking opioid pain medication, result in better patient outcomes than Usual Care?
- Trial name
- NCT02290223
- Testing
- Behavioral Based Treatment Model
- Where
- 2 sites in United States
- Volunteers
- 376 people
- Sponsor
- Kaiser Permanente
Chronic Non-malignant Pain
Safety and Efficacy of Buprenorphine Transdermal System (BTDS) in Subjects With Chronic Nonmalignant Pain
The objective of this study is to demonstrate the effectiveness and tolerability of the buprenorphine transdermal system (5, 10 and 20) in comparison to matching placebo transdermal system in subjects with chronic nonmalignant…
- Trial name
- NCT00312195
- Testing
- Buprenorphine transdermal patch
- Where
- 42 sites in United States, United Kingdom
- Volunteers
- 267 people
- Sponsor
- Purdue Pharma LP
Low Back Pain, Pain
D-cycloserine in the Management of Chronic Low Back Pain
Pre-clinical studies in rats suggest that D-cycloserine (DCS) is effective in the management of chronic neuropathic pain. This pilot study will attempt to determine the effect of D-cycloserine in the treatment of chronic low back…
- Trial name
- NCT00125528
- Testing
- D-cycloserine
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Thomas J. Schnitzer
Inguinal Hernia, Postoperative Pain
Preoperative Etanercept Before Inguinal Hernia Surgery
Inguinal hernia repair is one of the most frequently performed operations in young men. Persistent pain after inguinal surgery represents a significant cause of disability, occurring in between 15%-35% of cases.
- Trial name
- NCT00825344
- Testing
- Etanercept, Saline
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- Johns Hopkins University
Pain
A Study of the Effectiveness and Safety of Sustained-release Hydromorphone (a Strong Opioid) in Patients With Chronic Noncancer Pain.
The purpose of this study is to compare the effectiveness and safety of sustained- release hydromorphone, formulated to release slowly over time, taken once daily, and controlled- release oxycodone taken twice daily, in patients…
- Trial name
- NCT00261495
- Testing
- OROS hydromorphone HCl, Oxycodone
- Where
- 52 sites in Czechia, Denmark and 8 more
- Volunteers
- 504 people
- Sponsor
- Janssen Pharmaceutica N.V., Belgium