Clinical trials: Chronic Pain Management
Idiopathic Chronic Pancreatitis, Pain
TMS Treatment for Pain in Chronic Pancreatitis
The researchers aim to study the effects of repetitive transcranial magnetic stimulation (rTMS) on chronic visceral pain in patients with idiopathic chronic pancreatitis.
- Trial name
- NCT00250484
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Beth Israel Deaconess Medical Center
Knee Osteoarthritis, Knee Pain Chronic
Biomechanical and Clinical Evaluation of a Gait Modifying Device for Treating Knee Pain
The goal of this clinical trial is to determine if gait-modification therapy via custom shoe intervention can reduce knee pain and improve gait parameters in individuals experiencing chronic (>6 month) knee pain.
- Conditions
- Knee Osteoarthritis, Knee Pain Chronic, Knee Pain Arthritis
- Trial name
- NCT06598696
- Testing
- Gait-Modifying Shoe Intervention
- Volunteers
- 42 people
- Sponsor
- Scientific Motion Technologies, Inc.
Low Back Pain
Long Term Safety and Efficacy Study of Tanezumab in Japanese Adult Subjects With Chronic Low Back Pain
This study will investigate the long-term safety and efficacy of a fixed dose of tanezumab 5 mg and 10 mg administered subcutaneously (SC) seven times at 8 week intervals.
- Trial name
- TANGO (NCT02725411)
- Testing
- Celecoxib, Tanezumab 5 mg, Tanezumab 10 mg
- Where
- 55 sites in Japan
- Volunteers
- 277 people
- Sponsor
- Pfizer
Pain, Advanced Cancer
A Two-Part Study of Sativex® Oromucosal Spray for Relieving Uncontrolled Persistent Pain in Patients With Advanced Cancer
The primary objective of this study was to evaluate the efficacy of nabiximols (Sativex®), compared with placebo, when used as an adjunctive measure in relieving uncontrolled persistent chronic pain (not breakthrough pain) in…
- Trial name
- NCT01424566
- Testing
- Nabiximols
- Where
- 65 sites in Australia, Bulgaria and 11 more
- Volunteers
- 406 people
- Sponsor
- Jazz Pharmaceuticals
Acute Pain, Low Back Pain, Mechanical
Spinal Manipulation and Patient Self-Management for Preventing Acute to Chronic Back Pain
This is a study of adults with acute low back pain flare-up at risk of becoming chronic and disabling. The study tests how well spinal manipulation and guided selfcare work compared to standard medical care.
- Trial name
- PACBACK (NCT03581123)
- Testing
- Supported-Self Management (SSM), Spinal Manipulation Therapy (SMT), SMT + SSM
- Where
- 3 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- University of Minnesota
Chronic Pain, Osteoarthritis
Hormone Function in Men Treated for Pain With Opioids or Placebo
This study will examine hormone function in men with osteoarthritis pain and how it is affected by opioid medication (such as Percocet, Vicodin, MS Contin and morphine) versus placebo.
- Trial name
- NCT00737737
- Testing
- MS Contin
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- National Institute of Nursing Research (NINR)
Post Herpetic Neuralgia (PHN)
Transcutaneous Auricular Vagus Nerve Stimulation on Post-Herpetic Neuralgia
The purpose of this study is to evaluate the therapeutic efficacy of transcutaneous auricular vagus nerve stimulation (taVNS) in the treatment of patients with post-herpetic neuralgia (PHN).
- Trial name
- NCT07123987
- Testing
- transcutaneous auricular vagus nerve stimulation (taVNS), traditional medical treatment for PHN
- Where
- Egypt
- Volunteers
- 34 people
- Sponsor
- Mohamed Hosny Ismail Easa
Chronic Pain, PTSD
Management of Chronic Pain and PTSD in Gulf War Veterans With tDCS+Prolonged Exposure
Gulf War Veterans (a DoD/VA defined service era corresponding to the first Gulf War under operations Desert Storm and Desert Shield 1990-1991), especially those who present with Post-Traumatic Stress Disorder (PTSD), are…
- Trial name
- NCT04236284
- Testing
- Home-based tDCS, Prolonged Exposure Therapy
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Chronic Low Back Pain
Virtual Reality Therapy for Chronic Low Back Pain
This study will test the efficacy of an evidence-based virtual reality (VR) therapy program as a non-pharmacological supplement for the management of chronic lower back pain.
- Trial name
- NCT04409353
- Testing
- Distraction-Based VR, Skills-Based VR, Activity Tracker
- Where
- United States
- Volunteers
- 413 people
- Sponsor
- Cedars-Sinai Medical Center
Cardiac Failure, Heart Failure
Insomnia Self-Management in Heart Failure
Chronic insomnia may contribute to the development and exacerbation of heart failure (HF), incident mortality and contributes to common and disabling symptoms (fatigue, dyspnea, anxiety, depression, excessive daytime sleepiness…
- Conditions
- Cardiac Failure, Heart Failure, Congestive Heart Failure, Heart Failure, Congestive
- Trial name
- HSS (NCT02660385)
- Testing
- Cognitive Behavioral Therapy for Insomnia, Self-Management Education for Heart Failure
- Where
- United States
- Volunteers
- 195 people
- Sponsor
- Yale University
Neuropathic Pain, Chronic Pain
Trial of Analgesia With Lidocaine or Extended-release Oxycodone for Neuropathic Pain Treatment in Multiple Sclerosis
This study will determine whether treatment with an extended-release opioid or topical lidocaine is effective in relieving distal symmetric lower extremity burning pain associated with multiple sclerosis (MS).
- Conditions
- Neuropathic Pain, Chronic Pain, Multiple Sclerosis
- Trial name
- NCT00414453
- Testing
- Lidocaine patch 5%, Extended-release oxycodone
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Rochester
Chronic Pain
Single-arm Study to Assess the Safety of Hydromorphone Hydrochloride by Intrathecal Administration
The purpose of this study is to evaluate the long-term safety of hydromorphone hydrochloride administered by intrathecal delivery.
- Trial name
- NCT01709747
- Testing
- Hydromorphone Hydrochloride, Programmable Implantable pump
- Where
- United States
- Volunteers
- 364 people
- Sponsor
- Piramal Critical Care, Ltd.
Chronic Pain
Support, Training, and Education for Pain Self-Management Using Podcasts: A Pilot Trial
This randomized Stage 1 pilot trial tests the feasibility of a community health worker (CHW) delivered chronic pain self-management intervention for older adults ("STEP-UP"; Support, Training, and Education for Pain…
- Trial name
- STEP-UP (NCT06185101)
- Testing
- STEP-UP
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Michigan
Neck Pain, Low Back Pain
Partners for Pain & Wellbeing Equity: A Randomized Trial of Community Supported Complementary and Integrative Health Self-management for Back Pain
The focus of this project is on developing and optimizing community-based programs for the self-management of back or neck pain for individuals from populations that experience health disparities (BP-PEHD).
- Conditions
- Neck Pain, Low Back Pain, Chronic Pain
- Trial name
- NCT05786508
- Testing
- Partners4Pain program, Key to Wellbeing program
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- University of Minnesota
Vulvar Pain Symptoms, Vulvodynia (Chronic Vulvar Pain)
To Evaluate if the Medication Gabapentin Lessens Vulvar Pain
The purpose of this research study is to evaluate if the medication gabapentin lessens the vulvar pain some women experience.
- Trial name
- NCT00390013
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Colleen Stockdale
Pain
Battlefield Auricular Acupressure (BAApress) Feasibility Study
The purpose of this research study is to find out what effects (good and bad) acupressure applied to the outside of the ear (Auricular Acupressure), in addition to the standard of care medication regimen, will have on pain.
- Trial name
- NCT05939388
- Testing
- Auricular Acupressure Pads
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Wake Forest University Health Sciences
Chronic Pain, Osteoarthritis
Acupuncture Approaches for Chronic Pain
Chronic pain is a major public health problem that places many burdens on individuals, including impairment of physical and psychological functioning, lost productivity, and side effects of medications used to treat pain.
- Conditions
- Chronic Pain, Osteoarthritis, Neck Pain, Back Pain
- Trial name
- AADDOPT-2 (NCT02456727)
- Testing
- Group/Community Acupuncture, Individual Acupuncture
- Where
- United States
- Volunteers
- 779 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
Chronic Pain
Veterans' Pain Care Organizational Improvement Comparative Effectiveness Study
Background and significance: Treatment with opioid pain medications (like hydrocodone and morphine) is common for severe pain, but studies show these medications may not always help and can cause serious problems.
- Trial name
- VOICE (NCT03026790)
- Testing
- Medication management, Non-pharmacological pain management, Buprenorphine-Naloxone
- Where
- United States
- Volunteers
- 820 people
- Sponsor
- University of Minnesota
Pain, Chronic Disease
Improving Chronic Pain Treatment in Primary Care
The primary objective of this study is to determine to what extent a collaborative intervention improves chronic pain-related outcomes in a VA primary care setting.
- Conditions
- Pain, Chronic Disease, Depression
- Trial name
- SEACAP (NCT00129480)
- Testing
- Assistance with Pain treatment
- Where
- United States
- Volunteers
- 401 people
- Sponsor
- VA Office of Research and Development
Knee Osteoarthritis
Maximizing Analgesia to Reduce Pain in Knee Osteoarthritis
This research is being done to evaluate whether combining medications that are FDA approved, but have not yet been approved for combination treatment, can be effective in reducing pain.
- Trial name
- NCT03098563
- Testing
- Blinded study medication
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Johns Hopkins University