Clinical trials: Chronic Periodontitis, active
Chronic Apical Periodontitis
Effect of Different Chelation Protocols on the Healing of Periapical Lesions in Teeth With Chronic Apical Periodontitis
The aim of this study is to evaluate the effects of different irrigation protocols using ethylenediaminetetraacetic acid (EDTA) and etidronic acid (HEBP) on periapical lesion healing and postoperative pain in single-rooted…
- Trial name
- NCT07353008
- Testing
- Final irrigation with 2.5% NaOCl and 17% EDTA, Final irrigation with 2.5% NaOCl and 9% HEBP, Irrigation with 2.5% NaOCl-9% HEBP during both preparation and final irrigation
- Where
- Turkey (Türkiye)
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Mustafa Kemal University
Edentulous Mouth, Periodontal Diseases
Changes in Microbial Status From Dentate, Edentulous and After Dental Implant Placement
The objectives of this study are to analyze the oral microbiome modulations occurring during the transition from partial (with some residual teeth) to full edentulous (without remaining teeth) status and implant placement in…
- Conditions
- Edentulous Mouth, Periodontal Diseases, Periodontitis, Adult, Microbial Colonization
- Trial name
- NCT06149585
- Testing
- Microbial Sampling
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
Chronic Kidney Disease, Periodontitis
Effectiveness of Subgingival Instrumentation on Delaying End-stage Renal Disease Among Chronic Kidney Disease Patients
Chronic kidney disease (CKD) and periodontitis share a bidirectional inflammatory relationship, with cytokines such as IL-6, TNF-α, and hsCRP driving progression in both conditions.
- Conditions
- Chronic Kidney Disease, Periodontitis, End Stage Renal Disease (ESRD)
- Trial name
- NCT07635797
- Testing
- Subgingival Instrumentation, Oral Hygiene Instructions
- Where
- India
- Volunteers
- 40 people
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Chronic Periapical Periodontitis, Alveolar Ridge Preservation
Rotary Versus Manual Degranulation in Alveolar Ridge Preservation
After a tooth is taken out, the empty socket needs to heal. Sometimes unhealthy soft tissue (called granulation tissue) is left behind and can slow down healing. This study compares two ways to clean the socket: 1.
- Trial name
- NCT07607314
- Testing
- Rotary Degranulation, Manual Curettage
- Where
- Saudi Arabia
- Volunteers
- 50 people
- Sponsor
- Imam Abdulrahman Bin Faisal University
Periodontal Diseases, Periodontitis
HALP Score, Blood-Based Inflammatory Indices, and Salivary MMP-8 in Periodontal Disease and Healing After Non-Surgical Therapy
This observational clinical study aims to investigate the relationship between the HALP score (Hemoglobin × Albumin × Lymphocyte / Platelet), several blood-based inflammatory indices (including NLR, PLR, LMR, and SII), and…
- Conditions
- Periodontal Diseases, Periodontitis, Gingivitis; Chronic
- Trial name
- NCT07312045
- Testing
- Non-surgical Periodontal Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Ömer Faruk Okumuş
Necrotic Teeth With Chronic Apical Periodontitis
Regenerative Endodontics in Mature Necrotic Teeth
The goal of this clinical trial is to learn if nanochitosan can achieve regeneration in mature necrotic teeth. It will also provide data about the healing potential \& postoperative pain after using different irrigation…
- Trial name
- NCT07584928
- Testing
- Intervention 1: 1% nanochitosan, Intervention 2: 1% nanochitosan & 17% EDTA
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Suez Canal University
Chronic Apical Periodontitis
Effects of Irrigation Activation Methods on Periapical Healing in Chronic Apical Periodontitis
This study aims to evaluate the effects of different irrigation activation methods on periapical healing in teeth with chronic apical periodontitis.
- Trial name
- NCT07850895
- Testing
- Sonic Irrigation Activation, Passive Ultrasonic Irrigation, Laser-Activated Irrigation
- Where
- Turkey (Türkiye)
- Volunteers
- 108 people
- Sponsor
- Recep Tayyip Erdogan University
Psoriasis (PsO), Periodontal Disease
Evaluation of TNF-α, IL-17A, and YKL-40 in GCF and Serum of Psoriasis Patients and Healthy Controls
Background: Psoriasis is a chronic inflammatory skin disease that affects 2-3% of the global population and is linked to immune dysregulation and systemic inflammation.
- Trial name
- NCT06897722
- Testing
- TNF-α analysis in GCF, IL-17A analysis in GCF, YKL-40 analysis in GCF
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Zhala Vatankha Sain
Chronic Periodontitis, Depression
Comparing Inflammatory Markers in Patients With and Without Depression With Chronic Periodontitis
This study will evaluate whether use of antidepressants can reduce gingival inflammation in patients with periodontal (gum) disease.
- Trial name
- NCT03553095
- Testing
- Periodontal Surgery
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Chronic Apical Periodontitis, Pulp Necrosis
Clinical and Inflammatory Outcomes of Regenerative Endodontic Treatment Using Injectable Platelet-Rich Fibrin in Mature Necrotic Teeth With Chronic Apical Periodontitis.
This randomized clinical trial aims to compare regenerative endodontic treatment using injectable platelet-rich fibrin (i-PRF) with conventional root canal treatment in mature necrotic anterior teeth with chronic apical…
- Trial name
- REGEN-iPRF (NCT07913399)
- Testing
- Conventional Root Canal Treatment, Regenerative Endodontic Treatment with i-PRF, Injectable Platelet-Rich Fibrin (i-PRF)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Medipol University
Stage II, Grade B Periodontitis, Chronic Periodontitis
Metformin Versus Chlorhexidine Gel as Adjuncts to Scaling and Root Planing in Stage II Grade B Periodontitis
This clinical trial is designed to evaluate two locally delivered gels, metformin and chlorhexidine, as adjunctive therapies to scaling and root planing (SRP) in patients with Stage II, Grade B periodontitis.
- Trial name
- MET-CHX Perio (NCT07215156)
- Testing
- Arm 1 Scaling and Root Planing (SRP), Arm 2 Metformin Gel 1% (locally delivered), Arm 3 Chlorhexidine Gel 0.2% (locally delivered)
- Volunteers
- 60 people
- Sponsor
- Kafrelsheikh University
Periodontal Disease, Periodontitis
Periodontal Disease in Rare Renal Disorders (PERIO-RA-RE)
This study aims to evaluate the burden and phenotypic spectrum of periodontal disease in patients with rare kidney disorders (such as Alport syndrome, Fabry disease, and tuberous sclerosis complex) and systemic lupus…
- Conditions
- Periodontal Disease, Periodontitis, CKD, Chronic Kidney Disease
- Trial name
- PERIO-RA-RE (NCT07575347)
- Testing
- Observational assessment
- Where
- Romania
- Volunteers
- 100 people
- Sponsor
- Stefan Lujinschi
Periodontitis, Psoriasis
Evaluation of Salivary and Serum Levels of TNF-α, IL-17A, and YKL-40 in Individuals With Psoriasis
Background: Periodontitis is a chronic inflammatory disease triggered by microbial infections that lead to the destruction of tissues supporting the teeth.
- Trial name
- NCT06984237
- Testing
- TNF-α Analysis in saliva, IL-17A analysis in saliva, YKL-40 Analysis in saliva
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Periodontitis, End-stage Renal Disease
The Role of Toll-like Receptor-4 in Periodontitis Patients With End-stage Renal Disease in a Sample of Egyptian Population
Chronic kidney disease (CKD) is a significant public health issue in Egypt, leading to end-stage renal disease (ESRD). ESRD patients often suffer from oral abnormalities due to the disease and medications.
- Trial name
- NCT06755372
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Periodontitis
Electrolysed Saline Rinse as an Adjunct for Treatment of Chronic Periodontitis
The study will be conducted as a prospective, double-blind, parallel, randomized, placebo-controlled study at the Dental Clinic of University Medical Centre Ljubljana.
- Trial name
- EOSPERIO (NCT06692582)
- Testing
- Electrolysed saline rinse, Distilled water group, Chlorhexidine 0,12%
- Where
- Slovenia
- Volunteers
- 60 people
- Sponsor
- University of Ljubljana
Single-visit, Periapical Periodontitis
Postoperative Pain and Success of Single-Visit Root Canal Treatment Using Different Root Canal Sealers in Asymptomatic Teeth
This study evaluates the postoperative pain and long-term clinical and radiographic success of single-visit primary root canal treatment in asymptomatic teeth with periapical lesions.
- Trial name
- NCT07868315
- Testing
- One-Fill, TotalFill, AH Plus + Single Cone
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Istanbul Medipol University Hospital
Periodontal Disease, Intrabony Periodontal Defects
A Novel Proline-rich Peptide Hydrogel for Periodontal Regeneration in Adult Periodontitis Patients
The goal of this clinical trial is to learn if a novel peptide-rich hydrogel works to achieve periodontal regeneration in adults. It will also learn about the safety of the hydrogel.
- Trial name
- PERIHEAL (NCT07581613)
- Testing
- Hydrogel
- Where
- 2 sites in Norway, Spain
- Volunteers
- 40 people
- Sponsor
- Siddharth Shanbhag
Periodontitis, Chronic Periodontitis (Disorder)
Cofilin-2 (rs80358250) and Lactoferrin (rs1126478) Polymorphism and Protein Levels With Non Surgical Periodontal Therapy in Periodontitis Patients With and Without CHD
Periodontitis is a chronic multifactorial inflammatory disease associated with the accumulation of dental plaque and characterized by progressive destruction of the teeth-supporting apparatus, including the periodontal ligament…
- Conditions
- Periodontitis, Chronic Periodontitis (Disorder), Coronary Heart Disease
- Trial name
- NCT07353606
- Testing
- Scaling and root planing
- Where
- 2 sites in India
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Meenakshi Ammal Dental College and Hospital
Periodontitis, Adult, Periodontitis
Evaluation of Changes in Oral Health-related Quality of Life During the Treatment of Periodontitis.
Periodontitis is a chronic inflammatory disease affecting the supporting tissues of the teeth and may negatively affect patients' oral health-related quality of life.
- Conditions
- Periodontitis, Adult, Periodontitis, Oral Disease, Quality of Life
- Trial name
- PAROQoL (NCT07868042)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Clermont-Ferrand
Periodontitis, Adult, Prediabetes / Type 2 Diabetes
HbA1c Screening in Dental Care and Primary Care Referral in Patients With Advanced Periodontitis
This study will evaluate whether HbA1c screening can be performed in dental care to detect elevated blood glucose in patients with advanced periodontitis and support referral to primary care.
- Trial name
- DENT-PC (NCT07688278)
- Testing
- Point-of-care HbA1c screening, Conditional standardized primary care referral
- Where
- Sweden
- Volunteers
- 600 people
- Sponsor
- Region Skane